ID27035A - Indolinona tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi farmasi - Google Patents
Indolinona tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi farmasiInfo
- Publication number
- ID27035A ID27035A IDW20002523A ID20002523A ID27035A ID 27035 A ID27035 A ID 27035A ID W20002523 A IDW20002523 A ID W20002523A ID 20002523 A ID20002523 A ID 20002523A ID 27035 A ID27035 A ID 27035A
- Authority
- ID
- Indonesia
- Prior art keywords
- indolinona
- production
- new substituted
- pharmacy composition
- pharmacy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19824922A DE19824922A1 (de) | 1998-06-04 | 1998-06-04 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ID27035A true ID27035A (id) | 2001-02-22 |
Family
ID=7869856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW20002523A ID27035A (id) | 1998-06-04 | 1999-05-28 | Indolinona tersubstitusi baru, pembuatannya dan penggunaannya sebagai komposisi farmasi |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP1100779A1 (bg) |
JP (1) | JP2002516906A (bg) |
KR (1) | KR20010043973A (bg) |
CN (1) | CN1303374A (bg) |
AU (1) | AU764782B2 (bg) |
BG (1) | BG104938A (bg) |
BR (1) | BR9910898A (bg) |
CA (1) | CA2328291A1 (bg) |
CO (1) | CO5050294A1 (bg) |
DE (1) | DE19824922A1 (bg) |
EA (1) | EA003514B1 (bg) |
EE (1) | EE200000723A (bg) |
HR (1) | HRP20000831A2 (bg) |
HU (1) | HUP0102210A3 (bg) |
ID (1) | ID27035A (bg) |
IL (1) | IL138702A0 (bg) |
NO (1) | NO20006138L (bg) |
PL (1) | PL344467A1 (bg) |
SK (1) | SK18222000A3 (bg) |
TR (1) | TR200003515T2 (bg) |
WO (1) | WO1999062882A1 (bg) |
YU (1) | YU73900A (bg) |
ZA (1) | ZA200005435B (bg) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19816624A1 (de) * | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
JP2004517049A (ja) | 2000-09-01 | 2004-06-10 | グラクソ グループ リミテッド | チロシンキナーゼ阻害剤としての置換オキシインドール誘導体 |
AU8664701A (en) | 2000-09-01 | 2002-03-22 | Glaxo Group Ltd | Oxindole derivatives |
DE10117204A1 (de) * | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE60227709D1 (de) * | 2001-06-29 | 2008-08-28 | Ab Science | Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen |
ES2266553T3 (es) * | 2001-06-29 | 2007-03-01 | Ab Science | Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias. |
ATE376182T1 (de) | 2001-06-29 | 2007-11-15 | Ab Science | C-kit inhibitoren |
DE60215648T2 (de) * | 2001-06-29 | 2007-08-23 | Ab Science | Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen |
CA2452371A1 (en) | 2001-06-29 | 2003-01-09 | Ab Science | Use of tyrosine kinase inhibitors for treating allergic diseases |
JP2005508336A (ja) | 2001-09-27 | 2005-03-31 | アラーガン、インコーポレイテッド | キナーゼ阻害物質としての3−(アリールアミノ)メチレン−1,3−ジヒドロ−2h−インドール−2−オン類 |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
DE102004012070A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
US8299241B2 (en) * | 2006-12-05 | 2012-10-30 | Arena Pharmaceuticals, Inc. | Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof |
GB0706072D0 (en) * | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
CN101735071A (zh) * | 2009-12-04 | 2010-06-16 | 大连凯飞精细化工有限公司 | 一种生产4-n,n-二甲胺基甲基苯胺的方法 |
CN103102352B (zh) * | 2011-11-15 | 2015-08-12 | 山东亨利医药科技有限责任公司 | 酪氨酸激酶抑制剂吲哚满酮衍生物 |
CN103130775B (zh) * | 2011-11-22 | 2015-09-30 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
GB201208775D0 (en) | 2012-05-18 | 2012-07-04 | Uni I Oslo | Chemical compounds |
CN103848814B (zh) * | 2012-12-06 | 2016-08-17 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的取代吲哚满酮衍生物 |
US20240150368A1 (en) * | 2022-09-02 | 2024-05-09 | Deciphera Pharmaceuticals, Llc | Ulk inhibitors and methods of use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE838623A (fr) * | 1976-02-16 | 1976-06-16 | Derives de 3-hydroxymethylene-2-indolinone et procede pour leur production | |
US4145422A (en) * | 1977-09-06 | 1979-03-20 | Abbott Laboratories | Aminomethylene oxindoles |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
EP1247803A3 (en) * | 1996-08-23 | 2002-10-16 | Sugen, Inc. | Indolinone compounds suitable for modulation of protein kinases |
GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
-
1998
- 1998-06-04 DE DE19824922A patent/DE19824922A1/de not_active Withdrawn
-
1999
- 1999-05-28 WO PCT/EP1999/003692 patent/WO1999062882A1/de not_active Application Discontinuation
- 1999-05-28 CA CA002328291A patent/CA2328291A1/en not_active Abandoned
- 1999-05-28 YU YU73900A patent/YU73900A/sh unknown
- 1999-05-28 BR BR9910898-4A patent/BR9910898A/pt not_active IP Right Cessation
- 1999-05-28 CN CN99806884A patent/CN1303374A/zh active Pending
- 1999-05-28 EA EA200100001A patent/EA003514B1/ru not_active IP Right Cessation
- 1999-05-28 EE EEP200000723A patent/EE200000723A/xx unknown
- 1999-05-28 PL PL99344467A patent/PL344467A1/xx unknown
- 1999-05-28 ID IDW20002523A patent/ID27035A/id unknown
- 1999-05-28 TR TR2000/03515T patent/TR200003515T2/xx unknown
- 1999-05-28 SK SK1822-2000A patent/SK18222000A3/sk unknown
- 1999-05-28 IL IL13870299A patent/IL138702A0/xx unknown
- 1999-05-28 HU HU0102210A patent/HUP0102210A3/hu unknown
- 1999-05-28 EP EP99926454A patent/EP1100779A1/de not_active Withdrawn
- 1999-05-28 AU AU43707/99A patent/AU764782B2/en not_active Ceased
- 1999-05-28 JP JP2000552094A patent/JP2002516906A/ja active Pending
- 1999-05-28 KR KR1020007013597A patent/KR20010043973A/ko not_active Application Discontinuation
- 1999-06-04 CO CO99035396A patent/CO5050294A1/es unknown
-
2000
- 2000-10-05 ZA ZA200005435A patent/ZA200005435B/en unknown
- 2000-11-13 BG BG104938A patent/BG104938A/bg active Pending
- 2000-12-01 HR HR20000831A patent/HRP20000831A2/hr not_active Application Discontinuation
- 2000-12-01 NO NO20006138A patent/NO20006138L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL138702A0 (en) | 2001-10-31 |
DE19824922A1 (de) | 1999-12-09 |
SK18222000A3 (sk) | 2001-08-06 |
EP1100779A1 (de) | 2001-05-23 |
HUP0102210A2 (hu) | 2001-11-28 |
ZA200005435B (en) | 2002-01-07 |
BR9910898A (pt) | 2001-02-13 |
KR20010043973A (ko) | 2001-05-25 |
EE200000723A (et) | 2002-04-15 |
YU73900A (sh) | 2003-04-30 |
JP2002516906A (ja) | 2002-06-11 |
EA200100001A1 (ru) | 2001-08-27 |
TR200003515T2 (tr) | 2001-06-21 |
CN1303374A (zh) | 2001-07-11 |
HRP20000831A2 (en) | 2001-12-31 |
CO5050294A1 (es) | 2001-06-27 |
NO20006138D0 (no) | 2000-12-01 |
NO20006138L (no) | 2001-02-01 |
EA003514B1 (ru) | 2003-06-26 |
PL344467A1 (en) | 2001-11-05 |
HUP0102210A3 (en) | 2002-12-28 |
WO1999062882A1 (de) | 1999-12-09 |
AU764782B2 (en) | 2003-08-28 |
CA2328291A1 (en) | 1999-12-09 |
BG104938A (bg) | 2001-06-29 |
AU4370799A (en) | 1999-12-20 |
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