ID25469A - Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya - Google Patents

Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya

Info

Publication number
ID25469A
ID25469A IDW20001303A ID20001303A ID25469A ID 25469 A ID25469 A ID 25469A ID W20001303 A IDW20001303 A ID W20001303A ID 20001303 A ID20001303 A ID 20001303A ID 25469 A ID25469 A ID 25469A
Authority
ID
Indonesia
Prior art keywords
sefalosporine
christalography
amorf
stories
making
Prior art date
Application number
IDW20001303A
Other languages
English (en)
Indonesian (id)
Inventor
Masahiro Onodera
Masamichi Sukegawa
Kiyoshi Yasui
Tatsuo Watanabe
Toyomi Sato
Yasushi Muria
Katsuharu Iinuma
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of ID25469A publication Critical patent/ID25469A/id

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IDW20001303A 1998-01-07 1999-01-07 Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya ID25469A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP192098 1998-01-07

Publications (1)

Publication Number Publication Date
ID25469A true ID25469A (id) 2000-10-05

Family

ID=11515039

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20001303A ID25469A (id) 1998-01-07 1999-01-07 Komposisi sefalosporin amorf yang stabil secara kristalografi dan proses pembuatannya

Country Status (23)

Country Link
US (2) US6342493B1 (fr)
EP (1) EP1051978B1 (fr)
JP (1) JP3413406B2 (fr)
KR (1) KR100435315B1 (fr)
CN (1) CN1151845C (fr)
AU (1) AU736555B2 (fr)
BR (1) BRPI9907084B8 (fr)
CA (1) CA2316841C (fr)
CZ (1) CZ302082B6 (fr)
EA (1) EA002881B1 (fr)
ES (1) ES2393972T3 (fr)
HK (1) HK1035148A1 (fr)
HU (1) HU230295B1 (fr)
ID (1) ID25469A (fr)
IL (2) IL137004A0 (fr)
NZ (1) NZ505871A (fr)
PL (1) PL194097B1 (fr)
PT (1) PT1051978E (fr)
SK (1) SK286631B6 (fr)
TR (1) TR200001903T2 (fr)
TW (1) TW587946B (fr)
UA (1) UA70311C2 (fr)
WO (1) WO1999034832A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL194097B1 (pl) * 1998-01-07 2007-04-30 Meiji Seika Kaisha Kompozycja zawierająca krystalograficznie trwałą amorficzną cefalosporynę i sposób jej wytwarzania
JP4803935B2 (ja) 1999-10-08 2011-10-26 アフィニアム・ファーマシューティカルズ・インコーポレイテッド Ｆａｂｉ阻害剤
EP1560584B1 (fr) 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Inhibiteurs de fab i
ES2389179T3 (es) 2001-04-26 2012-10-23 Meiji Seika Pharma Co., Ltd. Composición de cefditoren pivoxilo amorfo y procedimiento para producir el mismo
DE60334391D1 (de) * 2002-10-02 2010-11-11 Meiji Seika Kaisha Antibakterielle medizinische zusammensetzung mit erhöhtem oralem absorptionsvermögen
DK1575951T3 (da) 2002-12-06 2014-09-15 Debiopharm Int Sa Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
JP4880448B2 (ja) * 2003-03-17 2012-02-22 アフィナム ファーマシューティカルズ，インコーポレーテッド 複数の抗生物質を含む組成物、及びそれを用いる方法
US20070167402A1 (en) * 2003-06-20 2007-07-19 Meiji Seika Kaisha, Ltd. Product of coprecipitation of sparingly soluble substance and water-soluble polymer and process for producing the same
ES2379631T3 (es) 2003-10-08 2012-04-30 Meiji Seika Pharma Co., Ltd. Composición antibacteriana no cristalina que contiene cefditoren pivoxilo
CN1902207A (zh) * 2003-11-07 2007-01-24 兰贝克赛实验室有限公司 高纯度3－(2－取代乙烯基)头孢菌素的制备方法
JP2005162696A (ja) * 2003-12-04 2005-06-23 Nichiko Pharmaceutical Co Ltd 溶出性に優れたセフジトレンピボキシル製剤
WO2005082330A2 (fr) * 2004-02-19 2005-09-09 Ranbaxy Laboratories Limited Cefditoren pivoxil amorphe coprecipite et formes posologiques comprenant celui-ci
WO2007053131A2 (fr) 2004-06-04 2007-05-10 Affinium Pharmaceuticals, Inc. Agents thérapeutiques et méthodes pour les fabriquer et les utiliser
US20080069879A1 (en) * 2006-05-02 2008-03-20 Ravishekhar Bhiwgade Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof
CA2658506C (fr) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Derives d'acrylamide en tant qu'inhibiteurs de fab 1
WO2008057058A1 (fr) * 2006-11-10 2008-05-15 Nobel Ilac Sanayii Ve Ticaret As Compositions pharmaceutiques orales
US8263613B2 (en) 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
CN101560216B (zh) * 2009-05-27 2011-06-15 上海交通大学 头孢妥仑酯的制备方法
US20130143857A1 (en) * 2010-07-23 2013-06-06 Lupin Limited Pharmaceutical compositions of cefditoren pivoxil
SG188662A1 (en) 2010-09-30 2013-05-31 Toyama Chemical Co Ltd Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide
ES2554630T3 (es) 2010-09-30 2015-12-22 Toyama Chemical Co., Ltd. Sal sódica de 6-fluoro-3-hidroxi-2-pirazinocarboxamida
KR101720885B1 (ko) 2012-06-19 2017-03-28 데비오팜 인터네셔날 에스 에이 (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체
US9951009B2 (en) * 2013-08-29 2018-04-24 Cadila Healthcare Limited Polymorphic form of pyrrole derivative and intermediate thereof
WO2016114727A1 (fr) 2015-01-16 2016-07-21 Öğün Yusuf Toktamiş Compositions de cefditoren pivoxil à stabilité améliorée et procédés de fabrication de celles-ci
LT3419628T (lt) 2016-02-26 2021-01-25 Debiopharm International Sa Medikamentas diabetinėms pėdų infekcijoms gydyti
CN109053768A (zh) * 2018-08-07 2018-12-21 中国医药集团总公司四川抗菌素工业研究所 一种无定型头孢妥仑酯的制备方法
CN110251467A (zh) * 2019-06-26 2019-09-20 北京济美堂医药研究有限公司 一种无定形态头孢妥仑匹酯组合物的制备方法
CN112190539B (zh) * 2020-11-10 2021-11-02 深圳立健药业有限公司 一种头孢妥仑匹酯组合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678234B2 (ja) * 1988-04-19 1994-10-05 明治製菓株式会社 経口投与用抗菌組成物
JPH05306227A (ja) * 1992-04-27 1993-11-19 Lion Corp 徐放性口腔内疾患治療剤
JP2576927B2 (ja) * 1992-05-15 1997-01-29 ファイザー製薬株式会社 細粒核
JPH06316517A (ja) * 1993-02-22 1994-11-15 Grelan Pharmaceut Co Ltd 放出制御製剤
JPH0717866A (ja) * 1993-06-16 1995-01-20 Meiji Seika Kaisha Ltd 医薬組成物
AR004014A1 (es) * 1995-10-13 1998-09-30 Meiji Seika Kaisha Una composicion antibacteriana de cefditoren pivoxilo para administracion oral y metodo para obtener dicha composicion
AU714735B2 (en) * 1996-09-20 2000-01-13 Meiji Seika Pharma Co., Ltd. A crystalline substance of cefditoren pivoxyl and the production of the same
PL194097B1 (pl) * 1998-01-07 2007-04-30 Meiji Seika Kaisha Kompozycja zawierająca krystalograficznie trwałą amorficzną cefalosporynę i sposób jej wytwarzania

Also Published As

Publication number Publication date
IL137004A0 (en) 2001-06-14
EP1051978A1 (fr) 2000-11-15
AU1784599A (en) 1999-07-26
SK286631B6 (sk) 2009-02-05
PL194097B1 (pl) 2007-04-30
IL137004A (en) 2008-11-03
NZ505871A (en) 2002-10-25
CA2316841C (fr) 2007-11-20
KR100435315B1 (ko) 2004-06-10
US20020037322A1 (en) 2002-03-28
US6342493B1 (en) 2002-01-29
ES2393972T8 (es) 2013-02-25
EA200000742A1 (ru) 2001-02-26
CN1290177A (zh) 2001-04-04
TW587946B (en) 2004-05-21
HK1035148A1 (en) 2001-11-16
TR200001903T2 (tr) 2000-11-21
US6486149B2 (en) 2002-11-26
ES2393972T3 (es) 2013-01-03
KR20010033961A (ko) 2001-04-25
UA70311C2 (uk) 2004-10-15
CN1151845C (zh) 2004-06-02
WO1999034832A8 (fr) 1999-10-28
CZ302082B6 (cs) 2010-09-29
BRPI9907084B8 (pt) 2021-05-25
HUP0101272A2 (hu) 2001-12-28
EP1051978A4 (fr) 2007-05-02
CA2316841A1 (fr) 1999-07-15
WO1999034832A1 (fr) 1999-07-15
HUP0101272A3 (en) 2002-07-29
PL341589A1 (en) 2001-04-23
EP1051978B1 (fr) 2012-08-22
AU736555B2 (en) 2001-08-02
EA002881B1 (ru) 2002-10-31
CZ20002542A3 (cs) 2000-12-13
SK10262000A3 (sk) 2001-01-18
PT1051978E (pt) 2012-11-20
JP3413406B2 (ja) 2003-06-03
BR9907084A (pt) 2000-10-17
BRPI9907084B1 (pt) 2017-04-25
HU230295B1 (hu) 2015-12-28

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