HUT76637A - Bezoxazoles and pyridine derivatives, pharmaceutical compositions containing them, process for producing them and their use and the intermediates of the compounds - Google Patents
Bezoxazoles and pyridine derivatives, pharmaceutical compositions containing them, process for producing them and their use and the intermediates of the compounds Download PDFInfo
- Publication number
- HUT76637A HUT76637A HU9700264A HU9700264A HUT76637A HU T76637 A HUT76637 A HU T76637A HU 9700264 A HU9700264 A HU 9700264A HU 9700264 A HU9700264 A HU 9700264A HU T76637 A HUT76637 A HU T76637A
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutically acceptable
- formula
- compound
- benzoxazolyl
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9415330A GB9415330D0 (en) | 1994-07-29 | 1994-07-29 | Novel compounds |
GBGB9425599.9A GB9425599D0 (en) | 1994-12-19 | 1994-12-19 | Novel compounds |
GBGB9509923.0A GB9509923D0 (en) | 1995-05-17 | 1995-05-17 | Novel compounds |
PCT/GB1995/001323 WO1996004261A1 (en) | 1994-07-29 | 1995-06-07 | Benzoxazoles and pryridine derivatives useful in the treatment of the type ii diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
HUT76637A true HUT76637A (en) | 1997-10-28 |
Family
ID=27267309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9700264A HUT76637A (en) | 1994-07-29 | 1995-07-28 | Bezoxazoles and pyridine derivatives, pharmaceutical compositions containing them, process for producing them and their use and the intermediates of the compounds |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0772605A1 (xx) |
AP (1) | AP776A (xx) |
BR (1) | BR9508468A (xx) |
CA (1) | CA2196079A1 (xx) |
CZ (1) | CZ25497A3 (xx) |
DZ (1) | DZ1916A1 (xx) |
FI (1) | FI970357A (xx) |
HU (1) | HUT76637A (xx) |
IL (3) | IL114759A (xx) |
MA (1) | MA23632A1 (xx) |
MX (1) | MX9700763A (xx) |
NO (1) | NO307827B1 (xx) |
OA (1) | OA10470A (xx) |
PL (1) | PL318766A1 (xx) |
SK (1) | SK12297A3 (xx) |
WO (2) | WO1996004261A1 (xx) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
CA2251468A1 (en) * | 1996-04-04 | 1997-10-16 | Sankyo Company, Limited | Phenylalkylcarboxylic acid derivatives |
US6160000A (en) * | 1996-12-23 | 2000-12-12 | Merck & Co., Inc. | Antidiabetic agents based on aryl and heteroarylacetic acids |
US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
BR9813019A (pt) | 1997-10-02 | 2000-09-05 | Sankyo Co | Derivados do ácido amidocarboxìlico, agentes para diminuir a glicose do sangue, redutor de lipìdio, para melhorar a resistência à insulina, anti-inflamatório, para imuno regulagem, para inibir a aldose reductase, para inibir a 5-lipoxigenase, para a geração de supressor de peróxido de lipìdio, para ativar a ppar, para minorar a osteoporose, e, composições para a terapia ou prevenção da diabete melito, da hiperlipemia, da obesidade, da tolerância à glicose prejudicada, da resistência à insulina que não a igt, do fìgado gorduroso, de complicações diabéticas, da arterioesclerose, da diabete melito gestacional, da sìndrome do ovário policìstico, da artroesteìte, da artrite reumática, de doenças alérgicas, da asma, do câncer, de doenças auto imunes, da pancreatite, e de cataratas |
CN1280574A (zh) | 1997-10-27 | 2001-01-17 | 雷迪研究基金会 | 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物 |
BR9812770A (pt) | 1997-10-27 | 2000-12-12 | Reddy Research Foundation | Compostos bicìclicos, processo para seu preparo e composições farmacêuticas contendo os mesmos |
US6440961B1 (en) | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
US6369067B1 (en) | 1997-10-27 | 2002-04-09 | Dr. Reddy's Research Foundation | Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
WO1999019313A1 (en) * | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
US6265401B1 (en) | 1997-10-27 | 2001-07-24 | Reddy-Cheminor, Inc. | Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
US6444816B1 (en) | 1997-10-27 | 2002-09-03 | Dr. Reddy's Research Foundation | Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof |
KR100517644B1 (ko) * | 1997-10-27 | 2005-09-28 | 닥터 레디스 레보러터리즈 리미티드 | 신규의 삼원 화합물 및 그 약학적 용도, 그 제조방법 및이들을 포함하는 약제학적 조성물 |
NZ504106A (en) * | 1998-05-27 | 2003-02-28 | Dr | Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing them |
HUP0104108A2 (hu) | 1998-09-17 | 2002-03-28 | Bristol-Myers Squibb Company | Eljárás diabétesz kezelésére egy aP2 inhibitor vagy kombinációja alkalmazásával |
US6468996B1 (en) | 1998-10-21 | 2002-10-22 | Novo Nordisk A/S | Substituted hetero-polycyclic compounds as PPARα and PPARγ activators |
US6300339B1 (en) | 1998-10-21 | 2001-10-09 | Novo Nordisk A/S | Compounds, their preparation and use |
US6248781B1 (en) | 1998-10-21 | 2001-06-19 | Novo Nordisk A/S | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) |
US6214820B1 (en) | 1998-10-21 | 2001-04-10 | Novo Nordisk A/S | Compounds, their preparation and use |
JP2002527502A (ja) * | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、それらの調製及び使用 |
JP2002527501A (ja) | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、その製造及び利用 |
US6365586B1 (en) | 1998-10-21 | 2002-04-02 | Novo Nordisk A/S | Compounds, their preparation and use |
EP1123297A1 (en) * | 1998-10-21 | 2001-08-16 | Novo Nordisk A/S | New compounds, their preparation and use |
EP1123279A1 (en) * | 1998-10-21 | 2001-08-16 | Novo Nordisk A/S | New compounds, their preparation and use |
AU6325599A (en) * | 1998-10-21 | 2000-05-08 | Dr. Reddy's Research Foundation | New compounds, their preparation and use |
JP2002527503A (ja) * | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物類、それらの調製及び使用 |
US6531596B1 (en) | 1998-10-29 | 2003-03-11 | Dr. Reddy's Laboratories Ltd. | Process for the preparation of new antidiabetic agents |
WO2000026200A1 (en) | 1998-10-29 | 2000-05-11 | Dr. Reddy's Research Foundation | An improved process for the preparation of new antidiabetic agents |
WO2000063193A1 (en) * | 1999-04-16 | 2000-10-26 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
US7414128B2 (en) | 1999-04-20 | 2008-08-19 | Dr. Reddy's Laboratories, Limited | Crystalline R-guanidines, Arginine or (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H -phenoxazin-10-yl)ethoxy]phenyl}propanoate |
US6369055B1 (en) | 1999-04-20 | 2002-04-09 | Novo Nordisk A/S | Compounds, their preparation and use |
US6274608B1 (en) | 1999-04-20 | 2001-08-14 | Novo Nordisk A/S | Compounds, their preparation and use |
CZ20013558A3 (cs) * | 1999-04-20 | 2002-05-15 | Novo Nordisk A/S | Sloučenina, farmaceutický prostředek, způsob léčby, jejich příprava a vyuľití |
US6972294B1 (en) | 1999-04-20 | 2005-12-06 | Novo Nordisk, A/S | Compounds, their preparation and use |
JP2002542237A (ja) * | 1999-04-20 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 新規な化合物、それらの製造及び使用 |
WO2000063209A1 (en) * | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
CZ20013832A3 (cs) * | 1999-04-28 | 2002-04-17 | Dr. Reddy's Research Foundation | Substituované bicyklické heterocyklické sloučeniny, způsob jejich přípravy a jejich pouľití jako antiobezitních a hypocholesterolemických činidel |
AU7073400A (en) | 1999-08-27 | 2001-03-26 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
BRPI0108024B8 (pt) * | 2000-01-19 | 2021-05-25 | Cadila Healthcare Ltd | composto, processo para a preparação de um composto, composição farmacêutica, uso do composto, novo intermediário e processo para a preparação de um novo intermediário |
US6555577B1 (en) | 2000-01-28 | 2003-04-29 | Novo Nordisk A/S | Compounds, their preparation and use |
BR0107902A (pt) * | 2000-01-28 | 2002-11-05 | Novo Nordisk As | Composto, composição farmacêutica, métodos para o tratamento de doenças, e para o tratamento e/ou prevençao de, condições mediadas por receptores nucleares, e diabetes e/ou obesidade, uso de uim composto, processo para a preparação de um composto, e, método para tratar diabetes de tipo i, diabetes de tipo ii, tolerância prejudicada à glucose, resistência à insolina ou obesidade |
US6569901B2 (en) | 2000-01-28 | 2003-05-27 | Novo Nordisk A/S | Alkynyl-substituted propionic acid derivatives, their preparation and use |
US6509374B2 (en) | 2000-04-17 | 2003-01-21 | Novo Nordisk A/S | Compounds, their preparation and use |
EP1280783A2 (en) * | 2000-05-12 | 2003-02-05 | Ortho-McNeil Pharmaceutical, Inc. | Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators |
ES2288957T3 (es) | 2000-05-12 | 2008-02-01 | Ortho-Mcneil Pharmaceutical, Inc. | 4h-benzo(1.4)oxazin-3-ina biologicamente activas. |
US6599899B2 (en) | 2000-05-12 | 2003-07-29 | Ortho-Mcneil Pharmaceutical, Inc. | Benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment |
US6908908B2 (en) | 2000-05-12 | 2005-06-21 | Ortho-Mcneil Pharmaceutical, Inc. | Biologically active 4H-benzo [1,4] oxazin-3-ones |
US6987123B2 (en) * | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
US6869967B2 (en) | 2001-07-30 | 2005-03-22 | Novo Nordisk A/S | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives |
US7067530B2 (en) | 2001-07-30 | 2006-06-27 | Novo Nordisk A/S | Compounds, their preparation and use |
US7220877B2 (en) | 2001-10-17 | 2007-05-22 | Novo Nordisk A/S | Compounds, their preparation and use |
AU2002351752A1 (en) | 2001-12-29 | 2003-07-30 | Novo Nordisk A/S | Combined use of a glp-1 compound and another drug for treating dyslipidemia |
US7015345B2 (en) | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
US7816385B2 (en) | 2002-12-20 | 2010-10-19 | High Point Pharmaceuticals, Llc | Dimeric dicarboxylic acid derivatives, their preparation and use |
US6653334B1 (en) | 2002-12-27 | 2003-11-25 | Kowa Co., Ltd. | Benzoxazole compound and pharmaceutical composition containing the same |
JPWO2008139879A1 (ja) * | 2007-04-26 | 2010-07-29 | ファルマフロンティア株式会社 | G蛋白質共役型レセプター抑制剤および医薬 |
CN103354757A (zh) | 2011-01-31 | 2013-10-16 | 卡迪拉保健有限公司 | 脂肪代谢障碍的治疗 |
JP6246895B2 (ja) | 2013-04-22 | 2017-12-13 | カディラ・ヘルスケア・リミテッド | 非アルコール性脂肪性肝疾患(nafld)のための新規組成物 |
ES2889916T3 (es) | 2013-05-30 | 2022-01-14 | Cadila Healthcare Ltd | Un procedimiento para la preparación de pirroles con actividades hipolipidémicas e hipocolesterémicas |
TW201636015A (zh) | 2013-07-05 | 2016-10-16 | 卡地拉保健有限公司 | 協同性組成物 |
IN2013MU02470A (xx) | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
IN2013MU02905A (xx) | 2013-09-06 | 2015-07-03 | Cadila Healthcare Ltd | |
US10385017B2 (en) | 2015-10-14 | 2019-08-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
JP6840853B2 (ja) | 2016-12-09 | 2021-03-10 | カディラ・ヘルスケア・リミテッド | 原発性胆汁性胆管炎の治療 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
NZ253742A (en) * | 1992-07-03 | 1997-06-24 | Smithkline Beecham Plc | Heterocyclylaminoalkoxy substituted phenyl derivatives and pharmaceutical compositions |
-
1995
- 1995-06-07 WO PCT/GB1995/001323 patent/WO1996004261A1/en active Search and Examination
- 1995-06-07 BR BR9508468A patent/BR9508468A/pt unknown
- 1995-07-26 DZ DZ950094A patent/DZ1916A1/fr active
- 1995-07-27 MA MA23972A patent/MA23632A1/fr unknown
- 1995-07-27 IL IL11475995A patent/IL114759A/xx unknown
- 1995-07-27 IL IL12552595A patent/IL125525A/xx unknown
- 1995-07-28 MX MX9700763A patent/MX9700763A/es unknown
- 1995-07-28 CA CA002196079A patent/CA2196079A1/en not_active Abandoned
- 1995-07-28 EP EP95930436A patent/EP0772605A1/en not_active Withdrawn
- 1995-07-28 CZ CZ97254A patent/CZ25497A3/cs unknown
- 1995-07-28 PL PL95318766A patent/PL318766A1/xx unknown
- 1995-07-28 WO PCT/EP1995/003038 patent/WO1996004260A1/en not_active Application Discontinuation
- 1995-07-28 AP APAP/P/1997/000918A patent/AP776A/en active
- 1995-07-28 SK SK122-97A patent/SK12297A3/sk unknown
- 1995-07-28 HU HU9700264A patent/HUT76637A/hu unknown
-
1997
- 1997-01-28 NO NO970373A patent/NO307827B1/no not_active IP Right Cessation
- 1997-01-28 FI FI970357A patent/FI970357A/fi unknown
- 1997-01-29 OA OA60957A patent/OA10470A/en unknown
-
1998
- 1998-07-27 IL IL12552598A patent/IL125525A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
IL114759A0 (en) | 1995-12-31 |
SK12297A3 (en) | 1997-08-06 |
FI970357A (fi) | 1997-03-26 |
CA2196079A1 (en) | 1996-02-15 |
MX9700763A (es) | 1997-05-31 |
CZ25497A3 (en) | 1997-09-17 |
IL125525A0 (en) | 1999-03-12 |
OA10470A (en) | 2002-04-08 |
MA23632A1 (fr) | 1996-04-01 |
DZ1916A1 (fr) | 2002-02-17 |
IL114759A (en) | 1999-10-28 |
IL125525A (en) | 2000-02-29 |
FI970357A0 (fi) | 1997-01-28 |
WO1996004261A1 (en) | 1996-02-15 |
NO970373L (no) | 1997-03-18 |
AP9700918A0 (en) | 1997-01-31 |
EP0772605A1 (en) | 1997-05-14 |
NO307827B1 (no) | 2000-06-05 |
AP776A (en) | 1999-10-28 |
NO970373D0 (no) | 1997-01-28 |
WO1996004260A1 (en) | 1996-02-15 |
BR9508468A (pt) | 1997-11-25 |
PL318766A1 (en) | 1997-07-07 |
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