HUT72896A - Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia - Google Patents
Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia Download PDFInfo
- Publication number
- HUT72896A HUT72896A HU9502832A HU9502832A HUT72896A HU T72896 A HUT72896 A HU T72896A HU 9502832 A HU9502832 A HU 9502832A HU 9502832 A HU9502832 A HU 9502832A HU T72896 A HUT72896 A HU T72896A
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- formula
- group
- hydrogen
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3844893A | 1993-03-29 | 1993-03-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
HU9502832D0 HU9502832D0 (en) | 1995-11-28 |
HUT72896A true HUT72896A (en) | 1996-06-28 |
Family
ID=21900014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9502832A HUT72896A (en) | 1993-03-29 | 1994-03-28 | Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0691987A1 (no) |
JP (1) | JPH08508498A (no) |
AU (1) | AU6415894A (no) |
CA (1) | CA2159070A1 (no) |
FI (1) | FI954556A0 (no) |
HU (1) | HUT72896A (no) |
NO (1) | NO953832L (no) |
NZ (1) | NZ263456A (no) |
PL (1) | PL310896A1 (no) |
WO (1) | WO1994022910A1 (no) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0691986B1 (en) * | 1993-03-29 | 1998-12-02 | The Du Pont Merck Pharmaceutical Company | NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
ES2230624T5 (es) * | 1996-11-27 | 2010-10-25 | Aventis Pharmaceuticals Inc. | Composicion farmaceutica que comprende un compuesto que tiene actividad anti-xa y un compuesto antagonista de la agregacion plaquetaria. |
US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
GB0623607D0 (en) | 2006-11-27 | 2007-01-03 | Haemostatix Ltd | Tissue adhesive |
CA2939778C (en) | 2007-01-31 | 2019-01-29 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
US11673914B2 (en) | 2009-11-10 | 2023-06-13 | Allegro Pharmaceuticals, LLC | Peptide therapies for reduction of macular thickening |
KR102237243B1 (ko) | 2009-11-10 | 2021-04-07 | 알레그로 파마슈티칼스, 인코포레이티드. | Rgd 바인딩 부위에 대한 세포 부착의 저해 또는 진단제 또는 치료제의 유도를 위한 조성물 및 방법 |
WO2012021874A1 (en) | 2010-08-13 | 2012-02-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with thioether linkers |
CN104080467B (zh) | 2011-05-09 | 2020-09-15 | 急速制药公司 | 整联蛋白受体拮抗剂及其使用方法 |
MX358886B (es) | 2011-10-18 | 2018-08-31 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos. |
CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
KR102570210B1 (ko) | 2014-09-24 | 2023-08-23 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 제제 |
CN112245565A (zh) | 2014-09-24 | 2021-01-22 | 艾瑞朗医疗公司 | 拟肽大环化合物及其用途 |
WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2636066B1 (fr) * | 1988-09-02 | 1991-10-25 | Centre Nat Rech Scient | Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active |
US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
CA2027936C (en) * | 1989-10-23 | 2001-07-24 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
IL103252A (en) * | 1991-09-30 | 1997-03-18 | Du Pont Merck Pharma | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1994
- 1994-03-28 EP EP94911703A patent/EP0691987A1/en not_active Withdrawn
- 1994-03-28 AU AU64158/94A patent/AU6415894A/en not_active Abandoned
- 1994-03-28 WO PCT/US1994/003223 patent/WO1994022910A1/en not_active Application Discontinuation
- 1994-03-28 NZ NZ263456A patent/NZ263456A/en not_active IP Right Cessation
- 1994-03-28 HU HU9502832A patent/HUT72896A/hu unknown
- 1994-03-28 CA CA002159070A patent/CA2159070A1/en not_active Abandoned
- 1994-03-28 PL PL94310896A patent/PL310896A1/xx unknown
- 1994-03-28 JP JP6522195A patent/JPH08508498A/ja not_active Ceased
-
1995
- 1995-09-26 FI FI954556A patent/FI954556A0/fi unknown
- 1995-09-28 NO NO953832A patent/NO953832L/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI954556A (fi) | 1995-09-26 |
AU6415894A (en) | 1994-10-24 |
WO1994022910A1 (en) | 1994-10-13 |
JPH08508498A (ja) | 1996-09-10 |
CA2159070A1 (en) | 1994-10-13 |
NO953832D0 (no) | 1995-09-28 |
NZ263456A (en) | 1996-11-26 |
HU9502832D0 (en) | 1995-11-28 |
FI954556A0 (fi) | 1995-09-26 |
PL310896A1 (en) | 1996-01-08 |
EP0691987A1 (en) | 1996-01-17 |
NO953832L (no) | 1995-11-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DFC4 | Cancellation of temporary prot. due to refusal |