CA2159070A1 - Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia - Google Patents
Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiiaInfo
- Publication number
- CA2159070A1 CA2159070A1 CA002159070A CA2159070A CA2159070A1 CA 2159070 A1 CA2159070 A1 CA 2159070A1 CA 002159070 A CA002159070 A CA 002159070A CA 2159070 A CA2159070 A CA 2159070A CA 2159070 A1 CA2159070 A1 CA 2159070A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- asp
- substituted
- compound
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3844893A | 1993-03-29 | 1993-03-29 | |
| US08/038,448 | 1993-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2159070A1 true CA2159070A1 (en) | 1994-10-13 |
Family
ID=21900014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002159070A Abandoned CA2159070A1 (en) | 1993-03-29 | 1994-03-28 | Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0691987A1 (no) |
| JP (1) | JPH08508498A (no) |
| AU (1) | AU6415894A (no) |
| CA (1) | CA2159070A1 (no) |
| FI (1) | FI954556A0 (no) |
| HU (1) | HUT72896A (no) |
| NO (1) | NO953832L (no) |
| NZ (1) | NZ263456A (no) |
| PL (1) | PL310896A1 (no) |
| WO (1) | WO1994022910A1 (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08509708A (ja) * | 1993-03-29 | 1996-10-15 | ザ・デュポン・メルク・ファーマシュウティカル・カンパニー | 血小板糖蛋白▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ抑制剤の調製のための新規な方法および中間体化合物 |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| KR100512671B1 (ko) * | 1996-11-27 | 2005-09-07 | 아벤티스 파마슈티칼스 인크. | 항 Ｘａ 활성을 지닌 화합물 및 혈소판 응집 길항제 화합물을포함하는 약제학적 조성물 |
| US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| GB0623607D0 (en) | 2006-11-27 | 2007-01-03 | Haemostatix Ltd | Tissue adhesive |
| CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| US11673914B2 (en) | 2009-11-10 | 2023-06-13 | Allegro Pharmaceuticals, LLC | Peptide therapies for reduction of macular thickening |
| ES2730927T3 (es) | 2009-11-10 | 2019-11-13 | Allegro Pharmaceuticals Llc | Composiciones y métodos para inhibir la adhesión celular o dirigir agentes diagnósticos o terapéuticos a sitios de unión a RGD |
| SI2603600T1 (sl) | 2010-08-13 | 2019-04-30 | Aileron Therapeutics, Inc. | Peptidomimetični makrocikli |
| JP6106159B2 (ja) | 2011-05-09 | 2017-03-29 | アレグロ ファーマシューティカルズ インコーポレイテッドＡｌｌｅｇｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｒ−ｇ−システイン酸ペプチドを含む医薬組成物 |
| TWI643868B (zh) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | 擬肽巨環化合物 |
| US8987414B2 (en) | 2012-02-15 | 2015-03-24 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| KR102112373B1 (ko) | 2012-02-15 | 2020-05-18 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방체 마크로사이클 |
| AU2013337388B2 (en) | 2012-11-01 | 2018-08-02 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| MX2017011834A (es) | 2015-03-20 | 2018-04-11 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y usos de los mismos. |
| JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2636066B1 (fr) * | 1988-09-02 | 1991-10-25 | Centre Nat Rech Scient | Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active |
| US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
| AU6470590A (en) * | 1989-10-23 | 1991-04-26 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
| IL103252A (en) * | 1991-09-30 | 1997-03-18 | Du Pont Merck Pharma | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1994
- 1994-03-28 EP EP94911703A patent/EP0691987A1/en not_active Withdrawn
- 1994-03-28 WO PCT/US1994/003223 patent/WO1994022910A1/en not_active Application Discontinuation
- 1994-03-28 AU AU64158/94A patent/AU6415894A/en not_active Abandoned
- 1994-03-28 JP JP6522195A patent/JPH08508498A/ja not_active Ceased
- 1994-03-28 PL PL94310896A patent/PL310896A1/xx unknown
- 1994-03-28 HU HU9502832A patent/HUT72896A/hu unknown
- 1994-03-28 NZ NZ263456A patent/NZ263456A/en not_active IP Right Cessation
- 1994-03-28 CA CA002159070A patent/CA2159070A1/en not_active Abandoned
-
1995
- 1995-09-26 FI FI954556A patent/FI954556A0/fi unknown
- 1995-09-28 NO NO953832A patent/NO953832L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08508498A (ja) | 1996-09-10 |
| PL310896A1 (en) | 1996-01-08 |
| FI954556A (fi) | 1995-09-26 |
| EP0691987A1 (en) | 1996-01-17 |
| FI954556A0 (fi) | 1995-09-26 |
| HU9502832D0 (en) | 1995-11-28 |
| WO1994022910A1 (en) | 1994-10-13 |
| HUT72896A (en) | 1996-06-28 |
| AU6415894A (en) | 1994-10-24 |
| NO953832L (no) | 1995-11-28 |
| NZ263456A (en) | 1996-11-26 |
| NO953832D0 (no) | 1995-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2159070A1 (en) | Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia | |
| AU672178B2 (en) | Cyclic compounds useful as inhibitors of platelet glycoprotein IIb/IIIa | |
| Koivunen et al. | Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins | |
| EP0692982B1 (en) | RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS | |
| RU2157379C2 (ru) | Циклопептиды, способ их получения, содержащая их фармацевтическая композиция, способ ее получения | |
| US5635477A (en) | Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA | |
| CZ397991A3 (en) | Cyclic anti-aggregation peptides | |
| US5849693A (en) | Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein IIb/IIIa | |
| US6056958A (en) | Method of treatment of arterial and venous thromboembolic disorders | |
| WO1995023811A1 (en) | Novel carbocyclic compounds which inhibit platelet aggregation by interaction with the gpiib/iiia receptor complex | |
| NZ265753A (en) | Preparation of platelet glycoprotein iib/iiia inhibitors containing methylarginine | |
| US5817749A (en) | Processes and intermediate compounds for the preparation of platelet glycoprotein IIb/IIIa inhibitors | |
| RU2096415C1 (ru) | Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция | |
| AU6663794A (en) | Processes and intermediate compounds useful for the preparation of platelet glycoprotein iib/iiia inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |