CA2159070A1 - Composes cycliques utiles comme inhibiteurs iib/iiia de glycoproteines de plaquettes - Google Patents

Composes cycliques utiles comme inhibiteurs iib/iiia de glycoproteines de plaquettes

Info

Publication number
CA2159070A1
CA2159070A1 CA002159070A CA2159070A CA2159070A1 CA 2159070 A1 CA2159070 A1 CA 2159070A1 CA 002159070 A CA002159070 A CA 002159070A CA 2159070 A CA2159070 A CA 2159070A CA 2159070 A1 CA2159070 A1 CA 2159070A1
Authority
CA
Canada
Prior art keywords
alkyl
asp
substituted
compound
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002159070A
Other languages
English (en)
Inventor
William Frank Degrado
Sharon Anne Jackson
Shaker Ahmed Mousa
Anju Parthasarathy
Michael Sworin
Maria Rafalski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2159070A1 publication Critical patent/CA2159070A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002159070A 1993-03-29 1994-03-28 Composes cycliques utiles comme inhibiteurs iib/iiia de glycoproteines de plaquettes Abandoned CA2159070A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3844893A 1993-03-29 1993-03-29
US08/038,448 1993-03-29

Publications (1)

Publication Number Publication Date
CA2159070A1 true CA2159070A1 (fr) 1994-10-13

Family

ID=21900014

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002159070A Abandoned CA2159070A1 (fr) 1993-03-29 1994-03-28 Composes cycliques utiles comme inhibiteurs iib/iiia de glycoproteines de plaquettes

Country Status (10)

Country Link
EP (1) EP0691987A1 (fr)
JP (1) JPH08508498A (fr)
AU (1) AU6415894A (fr)
CA (1) CA2159070A1 (fr)
FI (1) FI954556A0 (fr)
HU (1) HUT72896A (fr)
NO (1) NO953832L (fr)
NZ (1) NZ263456A (fr)
PL (1) PL310896A1 (fr)
WO (1) WO1994022910A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2159072A1 (fr) * 1993-03-29 1994-10-13 Lin-Hua Zhang Nouveaux procedes et composes intermediaires utilises pour la preparation d'inhibiteurs iib/iiia de glycoproteines de plaquettes
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
AU754936B2 (en) * 1996-11-27 2002-11-28 Aventis Pharmaceuticals Inc. Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
AU2008210434C8 (en) 2007-01-31 2014-03-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
CN105106934A (zh) 2009-11-10 2015-12-02 急速制药公司 用于抑制细胞粘附至rgd结合位点或引导诊断剂或治疗剂至rgd结合位点的组合物和方法
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
PT2603600T (pt) 2010-08-13 2019-02-27 Aileron Therapeutics Inc Macrociclos peptidomiméticos
RU2721907C2 (ru) 2011-05-09 2020-05-25 Аллегро Фармасьютикалс, Инк. Антагонисты интегриновых рецепторов и их применение
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
AR089993A1 (es) 2012-02-15 2014-10-01 Aileron Therapeutics Inc Macrociclos peptidomimeticos
CN104144695A (zh) 2012-02-15 2014-11-12 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
MX2015005244A (es) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos.
SG10201902598VA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3347372A4 (fr) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques en tant que modulateurs de mcl-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636066B1 (fr) * 1988-09-02 1991-10-25 Centre Nat Rech Scient Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
CA2027936C (fr) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Peptides cycliques anti-agregants
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
HUT72896A (en) 1996-06-28
NO953832D0 (no) 1995-09-28
EP0691987A1 (fr) 1996-01-17
FI954556A (fi) 1995-09-26
AU6415894A (en) 1994-10-24
PL310896A1 (en) 1996-01-08
JPH08508498A (ja) 1996-09-10
WO1994022910A1 (fr) 1994-10-13
HU9502832D0 (en) 1995-11-28
FI954556A0 (fi) 1995-09-26
NO953832L (no) 1995-11-28
NZ263456A (en) 1996-11-26

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Koivunen et al. Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins
EP0692982B1 (fr) ANTAGONISTES RADIOMARQUES DES RECEPTEURS PLAQUETTAIRES GPIIb/IIIa, UTILISES COMME AGENTS DE VISUALISATION POUR LE DIAGNOSTIC DES AFFECTIONS THROMBOEMBOLIQUES
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US6056958A (en) Method of treatment of arterial and venous thromboembolic disorders
WO1995023811A1 (fr) Nouveaux composes carbocycliques inhibant l'agregation plaquettaire par interaction avec le complexe recepteur gpiib/iiia
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RU2096415C1 (ru) Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция
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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead