PL310896A1 - Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors - Google Patents

Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors

Info

Publication number
PL310896A1
PL310896A1 PL94310896A PL31089694A PL310896A1 PL 310896 A1 PL310896 A1 PL 310896A1 PL 94310896 A PL94310896 A PL 94310896A PL 31089694 A PL31089694 A PL 31089694A PL 310896 A1 PL310896 A1 PL 310896A1
Authority
PL
Poland
Prior art keywords
compounds useful
cyclic compounds
glycoprotein inhibitors
platelet iib
iiia glycoprotein
Prior art date
Application number
PL94310896A
Other languages
English (en)
Inventor
William Frank Degrado
Sharon Anne Jackson
Shaker Ahmed Mousa
Anju Parthasarathy
Michael Sworin
Maria Rafalski
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of PL310896A1 publication Critical patent/PL310896A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
PL94310896A 1993-03-29 1994-03-28 Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors PL310896A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3844893A 1993-03-29 1993-03-29

Publications (1)

Publication Number Publication Date
PL310896A1 true PL310896A1 (en) 1996-01-08

Family

ID=21900014

Family Applications (1)

Application Number Title Priority Date Filing Date
PL94310896A PL310896A1 (en) 1993-03-29 1994-03-28 Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors

Country Status (10)

Country Link
EP (1) EP0691987A1 (xx)
JP (1) JPH08508498A (xx)
AU (1) AU6415894A (xx)
CA (1) CA2159070A1 (xx)
FI (1) FI954556A0 (xx)
HU (1) HUT72896A (xx)
NO (1) NO953832L (xx)
NZ (1) NZ263456A (xx)
PL (1) PL310896A1 (xx)
WO (1) WO1994022910A1 (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE174036T1 (de) * 1993-03-29 1998-12-15 Du Pont Merck Pharma Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DK0946185T4 (da) * 1996-11-27 2010-08-30 Aventis Pharma Inc Farmaceutisk præparat, som omfatter en forbindelse med anti-Xa-aktivitet og en blodpladeaggregations antagonistforbindelse
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
KR101525754B1 (ko) 2007-03-28 2015-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
EP3586879A1 (en) 2009-11-10 2020-01-01 Allegro Pharmaceuticals, LLC Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
JP6106159B2 (ja) 2011-05-09 2017-03-29 アレグロ ファーマシューティカルズ インコーポレイテッドＡｌｌｅｇｒｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｒ−ｇ−システイン酸ペプチドを含む医薬組成物
KR20140100937A (ko) 2011-10-18 2014-08-18 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN104159595A (zh) 2012-02-15 2014-11-19 爱勒让治疗公司 拟肽大环化合物
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
WO2016049355A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3347372A4 (en) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636066B1 (fr) * 1988-09-02 1991-10-25 Centre Nat Rech Scient Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
JPH08508498A (ja) 1996-09-10
AU6415894A (en) 1994-10-24
HUT72896A (en) 1996-06-28
NO953832D0 (no) 1995-09-28
FI954556A (fi) 1995-09-26
WO1994022910A1 (en) 1994-10-13
EP0691987A1 (en) 1996-01-17
HU9502832D0 (en) 1995-11-28
NZ263456A (en) 1996-11-26
CA2159070A1 (en) 1994-10-13
FI954556A0 (fi) 1995-09-26
NO953832L (no) 1995-11-28

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