HUT60258A - Aminokumaran derivatives and process for producing aminokumaran derivatives and pharmaceutical compositions comprising such compounds - Google Patents
Aminokumaran derivatives and process for producing aminokumaran derivatives and pharmaceutical compositions comprising such compoundsInfo
- Publication number
- HUT60258A HUT60258A HU913436A HU343691A HUT60258A HU T60258 A HUT60258 A HU T60258A HU 913436 A HU913436 A HU 913436A HU 343691 A HU343691 A HU 343691A HU T60258 A HUT60258 A HU T60258A
- Authority
- HU
- Hungary
- Prior art keywords
- group
- derivatives
- aminokumaran
- compounds
- producing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- PMSFWAVZWVEZHA-UHFFFAOYSA-N 2,3-dihydro-1-benzofuran-2-amine Chemical class C1=CC=C2OC(N)CC2=C1 PMSFWAVZWVEZHA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29865090 | 1990-11-01 | ||
| JP24566791 | 1991-09-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU913436D0 HU913436D0 (en) | 1992-01-28 |
| HUT60258A true HUT60258A (en) | 1992-08-28 |
Family
ID=26537343
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU913436A HUT60258A (en) | 1990-11-01 | 1991-10-31 | Aminokumaran derivatives and process for producing aminokumaran derivatives and pharmaceutical compositions comprising such compounds |
| HU95P/P00528P HU211480A9 (en) | 1990-11-01 | 1995-06-29 | Aminocoumaran derivatives, their production and use |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU95P/P00528P HU211480A9 (en) | 1990-11-01 | 1995-06-29 | Aminocoumaran derivatives, their production and use |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US5376681A (forum.php) |
| EP (1) | EP0483772B1 (forum.php) |
| JP (1) | JP2672423B2 (forum.php) |
| KR (1) | KR100202463B1 (forum.php) |
| AT (1) | ATE127797T1 (forum.php) |
| CA (1) | CA2054619C (forum.php) |
| DE (1) | DE69112989T2 (forum.php) |
| DK (1) | DK0483772T3 (forum.php) |
| ES (1) | ES2077138T3 (forum.php) |
| GR (1) | GR3017981T3 (forum.php) |
| HU (2) | HUT60258A (forum.php) |
| IE (1) | IE68675B1 (forum.php) |
| TW (1) | TW199152B (forum.php) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE192446T1 (de) * | 1990-12-28 | 2000-05-15 | Teijin Ltd | Kondensierte benzoxa-ringverbindung, deren herstellung sowie diese enthaltendes arzneimittel |
| US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
| EP0635009B1 (en) * | 1992-04-06 | 1997-09-17 | Merrell Pharmaceuticals Inc. | Novel derivatives of 2,3-dihydro-2,2,4,6,7-pentaalkyl-5-benzofuranols |
| JP3198395B2 (ja) | 1992-05-28 | 2001-08-13 | 武田薬品工業株式会社 | アミノクマラン誘導体 |
| TW334433B (en) * | 1992-12-09 | 1998-06-21 | Takeda Pharm Industry Co Ltd | Crystalline salt of (S)-(+)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo(b)furan dihydrochloride their production and use |
| EP0640609A1 (en) * | 1993-08-24 | 1995-03-01 | Ono Pharmaceutical Co., Ltd. | Fused phenol derivatives having inhibitory activity on TXA2 synthetase, and 5-lipoxygenase and scavenging activity on oxygen species |
| EP0653417B1 (de) * | 1993-11-11 | 1998-03-04 | BASF Aktiengesellschaft | P-Hydroxyanilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen oder Schädlingen |
| DK0653418T3 (da) * | 1993-11-11 | 1997-04-28 | Basf Ag | P-hydroxyanilinderivater, fremgangsmåder til deres fremstilling og deres anvendelse til bekæmpelse af skadelige svampe eller skadedyr |
| PT682664E (pt) * | 1993-12-08 | 2001-06-29 | Alcon Laboratoires Inc | Compostos possuindo actividade potente como antagonistas do calcio e anti-oxidantes e sua utilizacao como agentes citoprotectores |
| US6017953A (en) * | 1993-12-28 | 2000-01-25 | Allergan Sales, Inc. | Thromboxane ligands |
| IL114026A (en) | 1994-06-08 | 1999-06-20 | Lundbeck & Co As H | 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzo thiophenemethyl) piperidines tetrahydropyridines or piperazines and pharmaceutical compositions containing them |
| US6743808B1 (en) | 1994-06-08 | 2004-06-01 | H. Lundbeck A/S | 4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) tetrahydropyridines or piperazines |
| MX9706744A (es) * | 1995-03-10 | 1997-11-29 | Hoechst Marion Roussel Inc | Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol. |
| ATE234298T1 (de) * | 1996-08-29 | 2003-03-15 | Takeda Chemical Industries Ltd | Zyklische etherverbindungen als natriumkanal- modulatoren |
| ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| EP0988289A2 (en) | 1997-06-05 | 2000-03-29 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds, their production and use |
| WO1999024419A1 (en) * | 1997-11-12 | 1999-05-20 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| KR20010072080A (ko) | 1998-07-31 | 2001-07-31 | 쓰끼하시 다미까따 | 페닐아졸 화합물, 그의 제조 방법 및 고지혈증용 약제 |
| HU226652B1 (en) * | 1998-12-04 | 2009-05-28 | Takeda Pharmaceutical | Benzofuran derivatives, process for preparation of the same and uses thereof |
| SE9902267D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | New compounds |
| DE19935692A1 (de) * | 1999-07-29 | 2001-02-01 | Merck Patent Gmbh | Nitrierung in einem statischen Mikromischer |
| DE60014936T2 (de) * | 1999-08-20 | 2005-10-13 | Takeda Chemical Industries, Ltd. | Trizyklische dihydrobenzofurane, verfahren zu deren herstellung und mittel |
| JP4721494B2 (ja) * | 1999-08-20 | 2011-07-13 | 武田薬品工業株式会社 | 三環性ジヒドロフラン誘導体、その製造法及び剤 |
| EP1125905A1 (en) * | 2000-02-16 | 2001-08-22 | Pepscan Systems B.V. | Segment synthesis |
| EP1197755A1 (en) * | 2000-10-11 | 2002-04-17 | Pepscan Systems B.V. | Identification of protein binding sites |
| CA2432410A1 (en) * | 2000-12-28 | 2002-07-11 | Takeda Chemical Industries, Ltd. | Process for preparing optically active 2,3-dihydro- benzofuran compounds |
| DE10115408A1 (de) | 2001-03-29 | 2002-10-02 | Bayer Ag | Benzofuran-Derivate |
| WO2003006448A1 (fr) | 2001-07-13 | 2003-01-23 | Takeda Chemical Industries, Ltd. | Procede de production d'un derive de benzofuranne |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| ATE423109T1 (de) | 2003-04-14 | 2009-03-15 | Nippon Soda Co | Diaminderivat, herstellungsverfahren und antioxidations-arzneimittel |
| DK1637527T3 (da) | 2003-06-26 | 2013-07-01 | Takeda Pharmaceutical | Cannabinoid receptor modulator. |
| CA2534263A1 (en) * | 2003-08-01 | 2005-02-10 | Nippon Soda Co., Ltd. | Phenylazole compounds, production process and antioxidants |
| US7485711B2 (en) * | 2005-08-12 | 2009-02-03 | Mayo Foundation For Medical Education And Research | CYP19A1 polymorphisms |
| US20100172909A1 (en) * | 2005-10-24 | 2010-07-08 | Masahiro Nishibori | Cerebral edema suppressant |
| JP3882090B1 (ja) * | 2006-05-19 | 2007-02-14 | 国立大学法人 岡山大学 | 脳血管攣縮抑制剤 |
| DE102007018833A1 (de) | 2007-04-20 | 2008-10-23 | Febit Holding Gmbh | Verbesserte molekularbiologische Prozessanlage |
| DE102006062089A1 (de) | 2006-12-29 | 2008-07-03 | Febit Holding Gmbh | Verbesserte molekularbiologische Prozessanlage |
| EA201171020A1 (ru) | 2009-03-10 | 2012-03-30 | Такеда Фармасьютикал Компани Лимитед | Производные бензофурана |
| JP2009215301A (ja) * | 2009-04-27 | 2009-09-24 | Morinaga Milk Ind Co Ltd | プロテアーゼ阻害剤 |
| US8563705B2 (en) | 2010-05-12 | 2013-10-22 | Mayo Foundation For Medical Education And Research | Ribonucleic acid binding motif protein 20 sequence variants |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3476760A (en) * | 1967-03-06 | 1969-11-04 | Smithkline Corp | Substituted piperidinoalkylthianaphthenes and benzofurans |
| US3686188A (en) * | 1970-06-30 | 1972-08-22 | Ciba Geigy Corp | N-benzofurylmethyl-arylalkyleneimines |
| CA1337429C (en) * | 1983-12-05 | 1995-10-24 | Guy Rosalia Eugene Van Lommen | Derivatives of 2,2'-iminobisethanol |
| CA1297877C (en) * | 1983-12-22 | 1992-03-24 | Daniel Lednicer | Benzofurancarboxamides useful as antiemetic or antipsychotic agents |
| US4888353A (en) * | 1986-02-28 | 1989-12-19 | Erbamont, Inc. | Carboxamides useful as antiemetic or antipsychotic agents |
| US5087638A (en) * | 1984-06-20 | 1992-02-11 | Merck Frosst Canada, Inc. | Benzofuran derivatives |
| CA1281325C (en) * | 1984-06-20 | 1991-03-12 | Patrice C. Belanger | Benzofuran derivatives |
| JPS6133183A (ja) * | 1984-07-25 | 1986-02-17 | Mitsubishi Chem Ind Ltd | ２，３−ジヒドロ−７−アミノベンゾフランの製造法 |
| US4772730A (en) * | 1985-04-19 | 1988-09-20 | Fmc Corporation | Tetrafluoro-2,3-dihydrobenzofurans |
| GB8515388D0 (en) * | 1985-06-18 | 1985-07-17 | Ici Plc | Heterocyclic compounds |
| US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
| EP0273647B1 (en) * | 1986-12-27 | 1992-03-11 | Takeda Chemical Industries, Ltd. | Coumaran derivatives, their production and use |
| US4873255A (en) * | 1987-02-04 | 1989-10-10 | Sankyo Company Limited | Thiazolidinone derivatives, their preparation and their use |
| GB8704572D0 (en) * | 1987-02-26 | 1987-04-01 | Lundbeck & Co As H | Organic compounds |
| JP2855341B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | 新規２―置換クマラン誘導体 |
| JP2855340B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | ２―置換クマラン誘導体 |
-
1991
- 1991-10-24 TW TW080108393A patent/TW199152B/zh active
- 1991-10-24 IE IE372491A patent/IE68675B1/en not_active IP Right Cessation
- 1991-10-29 DK DK91118448.9T patent/DK0483772T3/da active
- 1991-10-29 JP JP3282880A patent/JP2672423B2/ja not_active Expired - Fee Related
- 1991-10-29 EP EP91118448A patent/EP0483772B1/en not_active Expired - Lifetime
- 1991-10-29 ES ES91118448T patent/ES2077138T3/es not_active Expired - Lifetime
- 1991-10-29 AT AT91118448T patent/ATE127797T1/de active
- 1991-10-29 DE DE69112989T patent/DE69112989T2/de not_active Expired - Fee Related
- 1991-10-30 US US07/784,988 patent/US5376681A/en not_active Expired - Fee Related
- 1991-10-31 CA CA002054619A patent/CA2054619C/en not_active Expired - Fee Related
- 1991-10-31 HU HU913436A patent/HUT60258A/hu unknown
- 1991-11-01 KR KR1019910019416A patent/KR100202463B1/ko not_active Expired - Fee Related
-
1994
- 1994-09-14 US US08/305,717 patent/US5478844A/en not_active Expired - Fee Related
-
1995
- 1995-05-23 US US08/447,450 patent/US5594154A/en not_active Expired - Fee Related
- 1995-06-29 HU HU95P/P00528P patent/HU211480A9/hu unknown
- 1995-11-08 GR GR950403090T patent/GR3017981T3/el unknown
-
1996
- 1996-09-17 US US08/715,216 patent/US5770772A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2077138T3 (es) | 1995-11-16 |
| US5376681A (en) | 1994-12-27 |
| EP0483772B1 (en) | 1995-09-13 |
| US5594154A (en) | 1997-01-14 |
| DE69112989T2 (de) | 1996-02-15 |
| KR920009815A (ko) | 1992-06-25 |
| CA2054619C (en) | 2003-06-10 |
| US5770772A (en) | 1998-06-23 |
| GR3017981T3 (en) | 1996-02-29 |
| US5478844A (en) | 1995-12-26 |
| KR100202463B1 (ko) | 1999-06-15 |
| JPH05140142A (ja) | 1993-06-08 |
| TW199152B (forum.php) | 1993-02-01 |
| IE913724A1 (en) | 1992-05-22 |
| ATE127797T1 (de) | 1995-09-15 |
| HU913436D0 (en) | 1992-01-28 |
| IE68675B1 (en) | 1996-07-10 |
| DK0483772T3 (da) | 1996-01-22 |
| JP2672423B2 (ja) | 1997-11-05 |
| EP0483772A1 (en) | 1992-05-06 |
| HU211480A9 (en) | 1995-11-28 |
| DE69112989D1 (de) | 1995-10-19 |
| CA2054619A1 (en) | 1992-05-02 |
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