HUT54210A - Improved process for producing polypeptides - Google Patents

Improved process for producing polypeptides

Info

Publication number
HUT54210A
HUT54210A HU892077A HU207789A HUT54210A HU T54210 A HUT54210 A HU T54210A HU 892077 A HU892077 A HU 892077A HU 207789 A HU207789 A HU 207789A HU T54210 A HUT54210 A HU T54210A
Authority
HU
Hungary
Prior art keywords
improved process
producing polypeptides
production
yeast strains
transformed
Prior art date
Application number
HU892077A
Other languages
English (en)
Other versions
HU218731B (hu
Inventor
Hansjoerg Treichler
Kenji Takabayashi
Dieter Heinrich Wolf
Jutta Heim
Original Assignee
Ciba Geigy Ag
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888810524A external-priority patent/GB8810524D0/en
Priority claimed from GB888812627A external-priority patent/GB8812627D0/en
Priority claimed from GB898907110A external-priority patent/GB8907110D0/en
Application filed by Ciba Geigy Ag, Ucp Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of HUT54210A publication Critical patent/HUT54210A/hu
Publication of HU218731B publication Critical patent/HU218731B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
HU077/89A 1988-05-04 1989-05-03 Élesztőtörzs és eljárás az élesztőre heterológ fehérjék előállítására HU218731B (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888810524A GB8810524D0 (en) 1988-05-04 1988-05-04 Improvements in production of polypeptides
GB888812627A GB8812627D0 (en) 1988-05-27 1988-05-27 Improvements in production of polypeptides
GB898907110A GB8907110D0 (en) 1988-05-04 1989-03-29 Improvements in the production of polypeptides

Publications (2)

Publication Number Publication Date
HUT54210A true HUT54210A (en) 1991-01-28
HU218731B HU218731B (hu) 2000-11-28

Family

ID=27263890

Family Applications (1)

Application Number Title Priority Date Filing Date
HU077/89A HU218731B (hu) 1988-05-04 1989-05-03 Élesztőtörzs és eljárás az élesztőre heterológ fehérjék előállítására

Country Status (16)

Country Link
EP (1) EP0341215B1 (hu)
JP (1) JPH0824565B2 (hu)
AT (1) ATE124086T1 (hu)
AU (1) AU614121B2 (hu)
CA (1) CA1340016C (hu)
DE (1) DE68923123T2 (hu)
DK (1) DK175701B1 (hu)
ES (1) ES2072918T3 (hu)
FI (1) FI103129B (hu)
HU (1) HU218731B (hu)
IE (1) IE66044B1 (hu)
IL (1) IL90170A (hu)
MX (1) MX169508B (hu)
NO (1) NO180593C (hu)
NZ (1) NZ228955A (hu)
PT (1) PT90436B (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
US5879926A (en) * 1989-03-31 1999-03-09 Transgene S.A. Yeast strains for the production of mature heterologous proteins, especially hirudin
FR2645174B1 (fr) * 1989-03-31 1994-01-07 Transgene Sa Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
FR2645175B1 (fr) * 1989-03-31 1994-02-18 Transgene Sa Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
CA2067224C (en) * 1989-12-01 2001-02-13 Manfred Kurfuerst Hirudin/polyalkylene glycol conjugates
US5580734A (en) * 1990-07-13 1996-12-03 Transkaryotic Therapies, Inc. Method of producing a physical map contigous DNA sequences
DE69114500T2 (de) * 1990-07-13 1996-06-13 Transkaryotic Therapies Inc Verfahren zum absuchen einer bibliothek.
JPH06500470A (ja) * 1990-09-04 1994-01-20 メルク　エンド　カンパニー　インコーポレーテッド メチロトローフ酵母細胞におけるインスリン様成長因子の産生
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
DK0511393T3 (da) 1990-11-08 1996-12-09 Japan Energy Corp Hirudin-mutant, fremstilling af denne, antikoagulant, sekretorisk vektor, mikroorganisme transformeret af vektoren og fremstilling af produkt ud fra mikroorganismen
SG84484A1 (en) * 1991-02-25 2001-11-20 Ciba Geigy Ag Improved yeast vectors
AU661844B2 (en) * 1991-04-01 1995-08-10 Merck Sharp & Dohme Corp. Genes which influence (pichia) proteolytic activity, and uses therefor
HU214698B (hu) * 1992-04-09 1998-06-29 Gyógyszerkutató Intézet Kft. Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
EP0592358B1 (en) * 1992-09-04 2000-10-11 Novartis AG Process for the production of protease inhibitors
TW282490B (hu) * 1992-12-15 1996-08-01 Ciba Geigy Ag
NZ271088A (en) * 1993-08-04 1996-10-28 Ciba Geigy Ag Desulphatohirudin muteins, their production, conjugates thereof and pharmaceutical compositions
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
JP3732516B2 (ja) * 1995-02-09 2006-01-05 ノバルティス・アクチエンゲゼルシャフト タンパク質の製造法
CN1225550C (zh) * 1995-03-20 2005-11-02 诺沃奇梅兹有限公司 表达降低水平的金属蛋白酶的宿主细胞和在蛋白质产生中使用该宿主细胞的方法
DE19529997C1 (de) * 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
AU7112796A (en) * 1995-09-27 1997-04-17 Chiron Corporation Method of making a protease deficient host
EP0985513B1 (en) 1996-01-31 2003-01-02 Sumitomo Bakelite Company Limited Method of producing epoxy resin-encapsulated semiconductor device
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
GB2338236B (en) 1998-06-13 2003-04-09 Aea Technology Plc Microbiological cell processing
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
JP5850848B2 (ja) * 2009-11-25 2016-02-03 ノヴォ ノルディスク アー／エス ポリペプチドの製造方法
JP7234932B2 (ja) * 2017-10-10 2023-03-08 味の素株式会社 タンパク質の製造法
AU2021289499A1 (en) 2020-06-11 2023-02-02 Ajinomoto Co., Inc. Method for producing protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
JPS62224284A (ja) * 1986-03-25 1987-10-02 Agency Of Ind Science & Technol 微生物
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
GB8817161D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Modified proteins
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins

Also Published As

Publication number Publication date
JPH02104279A (ja) 1990-04-17
PT90436A (pt) 1989-11-30
NO891837L (no) 1989-11-06
CA1340016C (en) 1998-08-25
PT90436B (pt) 1994-11-30
MX169508B (es) 1993-07-08
EP0341215B1 (en) 1995-06-21
ES2072918T3 (es) 1995-08-01
IE66044B1 (en) 1995-12-13
AU3382889A (en) 1989-11-09
HU218731B (hu) 2000-11-28
NO891837D0 (no) 1989-05-03
FI103129B1 (fi) 1999-04-30
FI892114A0 (fi) 1989-05-03
IL90170A (en) 1995-12-31
AU614121B2 (en) 1991-08-22
DK217589A (da) 1989-11-05
DK217589D0 (da) 1989-05-03
EP0341215A2 (en) 1989-11-08
IE891451L (en) 1989-11-04
JPH0824565B2 (ja) 1996-03-13
FI103129B (fi) 1999-04-30
NO180593B (no) 1997-02-03
DE68923123T2 (de) 1995-11-30
ATE124086T1 (de) 1995-07-15
IL90170A0 (en) 1989-12-15
DE68923123D1 (de) 1995-07-27
EP0341215A3 (en) 1992-01-15
FI892114A (fi) 1989-11-05
NZ228955A (en) 1991-06-25
NO180593C (no) 1997-05-14
DK175701B1 (da) 2005-01-24

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Legal Events

Date Code Title Description
DGB9 Succession in title of applicant

Owner name: UCP GEN-PHARMA AG., CH

Owner name: NOVARTIS AG., CH