PT90436A - Metodo aperfeicoado para a producao de polipeptideos - Google Patents

Metodo aperfeicoado para a producao de polipeptideos

Info

Publication number
PT90436A
PT90436A PT90436A PT9043689A PT90436A PT 90436 A PT90436 A PT 90436A PT 90436 A PT90436 A PT 90436A PT 9043689 A PT9043689 A PT 9043689A PT 90436 A PT90436 A PT 90436A
Authority
PT
Portugal
Prior art keywords
production
polipeptidees
approached
yeast strains
transformed
Prior art date
Application number
PT90436A
Other languages
English (en)
Other versions
PT90436B (pt
Inventor
Jutta Heim
Kenji Takabayashi
Hansjorg Treicher
Dieter Heinrich Wolf
Original Assignee
Ciba Geigy Ag
Ucp Gen Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888810524A external-priority patent/GB8810524D0/en
Priority claimed from GB888812627A external-priority patent/GB8812627D0/en
Priority claimed from GB898907110A external-priority patent/GB8907110D0/en
Application filed by Ciba Geigy Ag, Ucp Gen Pharma Ag filed Critical Ciba Geigy Ag
Publication of PT90436A publication Critical patent/PT90436A/pt
Publication of PT90436B publication Critical patent/PT90436B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
PT90436A 1988-05-04 1989-05-02 Metodo para a producao de uma estirpe de levedura e metodo para a priducao de uma proteina heterologa para levedura PT90436B (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888810524A GB8810524D0 (en) 1988-05-04 1988-05-04 Improvements in production of polypeptides
GB888812627A GB8812627D0 (en) 1988-05-27 1988-05-27 Improvements in production of polypeptides
GB898907110A GB8907110D0 (en) 1988-05-04 1989-03-29 Improvements in the production of polypeptides

Publications (2)

Publication Number Publication Date
PT90436A true PT90436A (pt) 1989-11-30
PT90436B PT90436B (pt) 1994-11-30

Family

ID=27263890

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90436A PT90436B (pt) 1988-05-04 1989-05-02 Metodo para a producao de uma estirpe de levedura e metodo para a priducao de uma proteina heterologa para levedura

Country Status (16)

Country Link
EP (1) EP0341215B1 (pt)
JP (1) JPH0824565B2 (pt)
AT (1) ATE124086T1 (pt)
AU (1) AU614121B2 (pt)
CA (1) CA1340016C (pt)
DE (1) DE68923123T2 (pt)
DK (1) DK175701B1 (pt)
ES (1) ES2072918T3 (pt)
FI (1) FI103129B1 (pt)
HU (1) HU218731B (pt)
IE (1) IE66044B1 (pt)
IL (1) IL90170A (pt)
MX (1) MX169508B (pt)
NO (1) NO180593C (pt)
NZ (1) NZ228955A (pt)
PT (1) PT90436B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
FR2645174B1 (fr) * 1989-03-31 1994-01-07 Transgene Sa Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
US5879926A (en) * 1989-03-31 1999-03-09 Transgene S.A. Yeast strains for the production of mature heterologous proteins, especially hirudin
FR2645175B1 (fr) * 1989-03-31 1994-02-18 Transgene Sa Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
US5663141A (en) * 1989-12-01 1997-09-02 Basf Aktiengesellschaft Hirudin/polyalkylene glycol conjugates and hirudin muteins
US5580734A (en) * 1990-07-13 1996-12-03 Transkaryotic Therapies, Inc. Method of producing a physical map contigous DNA sequences
MY106504A (en) * 1990-07-13 1995-06-30 Transkaryotic Therapies Inc Library screening method.
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
WO1992004363A1 (en) * 1990-09-04 1992-03-19 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of insulin-like growth factor-1 in methylotrophic yeast cells
CA2255396A1 (en) 1990-11-08 1992-05-09 Nippon Mining Company Limited Hirudin analog, method of manufacturing thereof and anti-coagulant composition, and secretion vector, transformed microorganisms containing said vector and manufacturing method ofproducts which is produced from said microorganism
SG84484A1 (en) * 1991-02-25 2001-11-20 Ciba Geigy Ag Improved yeast vectors
JPH06506117A (ja) * 1991-04-01 1994-07-14 メルク　エンド　カンパニー　インコーポレーテッド ピキア（Ｐｉｃｈｉａ）蛋白質分解活性に影響する遺伝子およびその使用
HU214698B (hu) * 1992-04-09 1998-06-29 Gyógyszerkutató Intézet Kft. Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
EP0592358B1 (en) * 1992-09-04 2000-10-11 Novartis AG Process for the production of protease inhibitors
TW282490B (pt) * 1992-12-15 1996-08-01 Ciba Geigy Ag
HUT72926A (en) * 1993-08-04 1996-06-28 Ciba Geigy Ag High molecular weight desulphatohirudin
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
WO1996024678A1 (en) * 1995-02-09 1996-08-15 Novartis Ag Process for the production of proteins
CN1225550C (zh) * 1995-03-20 2005-11-02 诺沃奇梅兹有限公司 表达降低水平的金属蛋白酶的宿主细胞和在蛋白质产生中使用该宿主细胞的方法
DE19529997C1 (de) * 1995-08-16 1997-04-10 Hoechst Ag Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
AU7112796A (en) * 1995-09-27 1997-04-17 Chiron Corporation Method of making a protease deficient host
EP0787569B1 (en) 1996-01-31 2002-10-02 Sumitomo Bakelite Company Limited Method of producing epoxy resin-encapsulated semiconductor device
FR2768743B1 (fr) * 1997-09-23 2001-09-14 Bio Merieux Procede de lyse de micro-organisme
GB2338236B (en) 1998-06-13 2003-04-09 Aea Technology Plc Microbiological cell processing
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
CN102639559B (zh) 2009-11-25 2015-04-29 诺沃—诺迪斯克有限公司 用于制备多肽的方法
EP3696274A4 (en) 2017-10-10 2021-07-28 Ajinomoto Co., Inc. PROTEIN MANUFACTURING PROCESS
KR20230023751A (ko) 2020-06-11 2023-02-17 아지노모토 가부시키가이샤 단백질의 제조법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
JPS62224284A (ja) * 1986-03-25 1987-10-02 Agency Of Ind Science & Technol 微生物
GB8809860D0 (en) * 1988-04-26 1988-06-02 Ciba Geigy Ag Process for production of polypeptides
GB8817160D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Novel proteins
GB8817161D0 (en) * 1988-07-19 1988-08-24 Ciba Geigy Ag Modified proteins

Also Published As

Publication number Publication date
EP0341215A2 (en) 1989-11-08
DE68923123D1 (de) 1995-07-27
MX169508B (es) 1993-07-08
NZ228955A (en) 1991-06-25
EP0341215A3 (en) 1992-01-15
NO180593C (no) 1997-05-14
EP0341215B1 (en) 1995-06-21
DK217589A (da) 1989-11-05
ES2072918T3 (es) 1995-08-01
HUT54210A (en) 1991-01-28
IL90170A (en) 1995-12-31
DK175701B1 (da) 2005-01-24
AU3382889A (en) 1989-11-09
FI892114A0 (fi) 1989-05-03
IE66044B1 (en) 1995-12-13
IL90170A0 (en) 1989-12-15
FI103129B (fi) 1999-04-30
IE891451L (en) 1989-11-04
NO891837D0 (no) 1989-05-03
DE68923123T2 (de) 1995-11-30
NO180593B (no) 1997-02-03
JPH02104279A (ja) 1990-04-17
NO891837L (no) 1989-11-06
FI103129B1 (fi) 1999-04-30
DK217589D0 (da) 1989-05-03
PT90436B (pt) 1994-11-30
CA1340016C (en) 1998-08-25
JPH0824565B2 (ja) 1996-03-13
FI892114A (fi) 1989-11-05
ATE124086T1 (de) 1995-07-15
AU614121B2 (en) 1991-08-22
HU218731B (hu) 2000-11-28

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940524

PC3A Transfer or assignment

Free format text: 970410 NOVARTIS AG CH

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090524