HUT43875A - Process for preparing biologically active plasminogene activator - Google Patents

Process for preparing biologically active plasminogene activator

Info

Publication number
HUT43875A
HUT43875A HU872536A HU253687A HUT43875A HU T43875 A HUT43875 A HU T43875A HU 872536 A HU872536 A HU 872536A HU 253687 A HU253687 A HU 253687A HU T43875 A HUT43875 A HU T43875A
Authority
HU
Hungary
Prior art keywords
biologically active
plasminogen activator
medium
culture
detrimental
Prior art date
Application number
HU872536A
Other languages
English (en)
Other versions
HU205171B (en
Inventor
William R Arathoon
Stuart E Builder
Anthony S Lubiniecki
Robert D Van Reis
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of HUT43875A publication Critical patent/HUT43875A/hu
Publication of HU205171B publication Critical patent/HU205171B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HU872536A 1986-06-06 1987-06-03 Process for producing biologically active plasminogen activator HU205171B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87164286A 1986-06-06 1986-06-06

Publications (2)

Publication Number Publication Date
HUT43875A true HUT43875A (en) 1987-12-28
HU205171B HU205171B (en) 1992-03-30

Family

ID=25357832

Family Applications (1)

Application Number Title Priority Date Filing Date
HU872536A HU205171B (en) 1986-06-06 1987-06-03 Process for producing biologically active plasminogen activator

Country Status (21)

Country Link
US (1) US5053334A (hu)
EP (1) EP0248675B1 (hu)
JP (1) JPS6332484A (hu)
KR (1) KR930002888B1 (hu)
AT (1) ATE75775T1 (hu)
AU (1) AU601984B2 (hu)
DD (1) DD257087A5 (hu)
DE (2) DE3778758D1 (hu)
DK (1) DK175366B1 (hu)
ES (1) ES2032444T3 (hu)
FI (1) FI91886C (hu)
FR (1) FR2599625B1 (hu)
GB (1) GB2191493B (hu)
GR (1) GR3005245T3 (hu)
HU (1) HU205171B (hu)
IE (1) IE60485B1 (hu)
IL (1) IL82746A (hu)
NO (1) NO170595C (hu)
NZ (1) NZ220547A (hu)
PT (1) PT84991B (hu)
ZA (1) ZA874054B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator
JP2576200B2 (ja) * 1988-03-09 1997-01-29 味の素株式会社 生理活性タンパク質の製造法
EP0338716A3 (en) * 1988-04-21 1990-04-11 Berlex Laboratories, Inc. Method and system for the production of non-degraded proteins from mammalian cells
DE3829244A1 (de) * 1988-08-29 1990-03-01 Boehringer Mannheim Gmbh Verfahren zur herstellung von einkettigem t-pa
EP0391080A3 (de) * 1989-03-07 1990-11-07 Roche Diagnostics GmbH Verfahren zur Herstellung von zweikettigem t-PA
GB2249099B (en) * 1990-09-26 1995-05-03 Squibb & Sons Inc Squalene synthetase
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
US6077940A (en) 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
EP1495108A2 (en) * 2002-04-08 2005-01-12 Millenium Biologix Inc. Automated tissue engineering system
KR101685246B1 (ko) 2006-07-14 2016-12-09 디피엑스 홀딩스 비.브이. 개선된 세포 배양 방법
EP3327132A3 (en) * 2007-08-09 2018-07-18 Wyeth LLC Use of perfusion to enhance production of fed-batch cell culture in bioreactors
CA2787656A1 (en) * 2010-01-22 2011-07-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
US10934519B2 (en) * 2011-07-29 2021-03-02 Global Life Sciences Solutions Usa Llc Systems, methods and control laws for cell harvesting
CN110172405A (zh) * 2012-08-20 2019-08-27 泰尔茂比司特公司 浓缩穿过细胞生长腔室循环的流体的组分
US11447745B2 (en) 2017-09-01 2022-09-20 Lonza Walkersville, Inc. End-to-end cell therapy automation
EP3898994A4 (en) 2018-12-21 2022-12-14 Lonza Walkersville, Inc. AUTOMATED VIRAL VECTOR PRODUCTION
SG11202106384YA (en) 2018-12-21 2021-07-29 Octane Biotech Inc Carousel for modular biologic production units
CA3123458A1 (en) 2018-12-28 2020-07-02 Octane Biotech Inc. Cell culture and tissue engineering systems with controlled environmental zones
CA3128387A1 (en) 2019-02-08 2020-08-13 Lonza Walkersville, Inc. Cell concentration methods and devices for use in automated bioreactors
JP2024525479A (ja) 2021-07-02 2024-07-12 コンバンジョ・インコーポレイテッド 細胞性フィブロネクチン組成物を作製及び使用するためのプロセス

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
JPS5329985A (en) * 1976-08-27 1978-03-20 Kanegafuchi Chem Ind Co Ltd High concentration culturing of yeast
JPS5571496A (en) * 1978-11-24 1980-05-29 Asahi Chem Ind Co Ltd Preparation of living substance
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
IE56716B1 (en) * 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
JPS59121172U (ja) * 1983-02-04 1984-08-15 ミネソタ・マイニング・アンド・マニユフアクチユアリング・コンパニ− ケーブル電線被覆の剥離部分のカバー装置
US4546083A (en) * 1983-04-22 1985-10-08 Stolle Research & Development Corporation Method and device for cell culture growth
EP0143081B1 (en) * 1983-11-21 1989-08-23 Ciba-Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4888115A (en) * 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
US4757005A (en) * 1984-04-19 1988-07-12 Miles Inc. Method and cell line for obtaining plasminogen activators
JPH0740942B2 (ja) * 1985-03-22 1995-05-10 カイロン コ−ポレイシヨン 哺乳動物細胞におけるｔＰＡの発現
AU593264B2 (en) * 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
WO1987001389A1 (en) * 1985-09-06 1987-03-12 Codon Methods for the recovery of tissue plasminogen activator
JPH07110232B2 (ja) * 1985-10-14 1995-11-29 株式会社日立製作所 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator

Also Published As

Publication number Publication date
JPS6332484A (ja) 1988-02-12
PT84991B (pt) 1990-03-08
ZA874054B (en) 1989-02-22
DK175366B1 (da) 2004-09-13
DD257087A5 (de) 1988-06-01
HU205171B (en) 1992-03-30
NO170595C (no) 1992-11-04
FI91886C (fi) 1994-08-25
IE871504L (en) 1987-12-06
IL82746A0 (en) 1987-12-20
GB8713267D0 (en) 1987-07-08
DE3778758D1 (de) 1992-06-11
AU7387287A (en) 1987-12-10
EP0248675A1 (en) 1987-12-09
DE3718939A1 (de) 1987-12-17
KR930002888B1 (ko) 1993-04-12
FR2599625A1 (fr) 1987-12-11
NZ220547A (en) 1990-01-29
KR880000590A (ko) 1988-03-28
DE3718939C2 (de) 1998-09-17
IL82746A (en) 1994-10-07
NO872395L (no) 1987-12-07
GB2191493A (en) 1987-12-16
ES2032444T3 (es) 1993-02-16
NO872395D0 (no) 1987-06-05
NO170595B (no) 1992-07-27
FI872526A (fi) 1987-12-07
FI91886B (fi) 1994-05-13
FR2599625B1 (fr) 1992-03-13
AU601984B2 (en) 1990-09-27
FI872526A0 (fi) 1987-06-05
GR3005245T3 (hu) 1993-05-24
DK288187A (da) 1987-12-07
JPH0574346B2 (hu) 1993-10-18
PT84991A (en) 1987-07-01
DK288187D0 (da) 1987-06-04
ATE75775T1 (de) 1992-05-15
IE60485B1 (en) 1994-07-27
GB2191493B (en) 1991-02-27
EP0248675B1 (en) 1992-05-06
US5053334A (en) 1991-10-01

Similar Documents

Publication Publication Date Title
GB2191493B (en) Process for producing biologically active plasminogen activator
ATE37764T1 (de) Verfahren zur vermehrung von pflanzlichen gewebekulturen.
DK163932C (da) Fremgangsmåde til fremstilling af et pattedyrprotein, som er heterologt for en gærorganisme, som produkt af gærudtrykkelse -forarbejdning og -sekretion samt gærorganisme-cellekultur, dyrkningsmedium af cellekulturen og gærudtrykkelsesmedium
NZ219347A (en) Apparatus and method for mist cultivation of cells
JPS57105191A (en) Production of human urogastrone
EP0474790A4 (en) Media for cell growth and method for making them
MY114220A (en) Process and apparatus for amino acid fermentation
DE3485444D1 (de) Hybrid-dns-synthese von insulin.
DE3687699D1 (de) Verfahren und vorrichtung zum kultivieren von zellen.
DE3666458D1 (en) Method and device for the _i(in vitro) culture of plant cells and organs, as well as for the micropropagation and regeneration of complete plants
EP0338716A3 (en) Method and system for the production of non-degraded proteins from mammalian cells
HUT35715A (en) Process for the promition of regenerating plants from tissue culture
ES449890A1 (es) Procedimiento para el tratamiento de proteina de celula sim-ple.
EP0249772A3 (en) Method and composition for plant tissue and cell culture
ATE22702T1 (de) Herstellung von glucosedehydrogenase.
EP0101273A3 (en) Production of biological products using resting cells
GB2162198B (en) Process for producing dense nutrient medium for culturing microorganisms and macroorganism cell cultures
JPS645486A (en) Cell culture method and apparatus therefor
EP0276154A3 (en) Method and apparatus for cell culture
ES432537A1 (es) Un metodo de producir biopolimeros.
SU1692145A1 (ru) Способ получения клеточной культуры
ATE115183T1 (de) Zellzüchtungsverfahren.
JPS5542564A (en) Production of antitumorigenic substance
GB2250741A (en) A process for preparing alkaloids
JPS6475096A (en) Removal method for tetramethylammonium compound