HUP9904180A3 - Thio acid derived monocyclic n-heteroaromatics and pharmaceutical compositions containing them - Google Patents
Thio acid derived monocyclic n-heteroaromatics and pharmaceutical compositions containing themInfo
- Publication number
- HUP9904180A3 HUP9904180A3 HU9904180A HUP9904180A HUP9904180A3 HU P9904180 A3 HUP9904180 A3 HU P9904180A3 HU 9904180 A HU9904180 A HU 9904180A HU P9904180 A HUP9904180 A HU P9904180A HU P9904180 A3 HUP9904180 A3 HU P9904180A3
- Authority
- HU
- Hungary
- Prior art keywords
- heteroaromatics
- pharmaceutical compositions
- compositions containing
- acid derived
- thio acid
- Prior art date
Links
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 125000002950 monocyclic group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/731,128 US6004985A (en) | 1996-10-09 | 1996-10-09 | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| PCT/EP1997/005231 WO1998015547A1 (en) | 1996-10-09 | 1997-09-24 | Thio acid derived monocyclic n-heterocyclics as anticoagulants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9904180A2 HUP9904180A2 (hu) | 2000-09-28 |
| HUP9904180A3 true HUP9904180A3 (en) | 2000-11-28 |
Family
ID=24938188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904180A HUP9904180A3 (en) | 1996-10-09 | 1997-09-24 | Thio acid derived monocyclic n-heteroaromatics and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US6004985A (hu) |
| EP (1) | EP0934310B1 (hu) |
| JP (1) | JP3768244B2 (hu) |
| KR (1) | KR20000048966A (hu) |
| CN (1) | CN1111159C (hu) |
| AT (1) | ATE288908T1 (hu) |
| AU (1) | AU730060B2 (hu) |
| CA (1) | CA2268172A1 (hu) |
| CZ (1) | CZ122799A3 (hu) |
| DE (1) | DE69732490T2 (hu) |
| DK (1) | DK0934310T3 (hu) |
| ES (1) | ES2236828T3 (hu) |
| HK (1) | HK1020958A1 (hu) |
| HU (1) | HUP9904180A3 (hu) |
| IL (1) | IL129056A0 (hu) |
| NO (1) | NO991594L (hu) |
| NZ (1) | NZ334758A (hu) |
| PL (1) | PL332602A1 (hu) |
| PT (1) | PT934310E (hu) |
| SK (1) | SK46499A3 (hu) |
| WO (1) | WO1998015547A1 (hu) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2214685C (en) | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
| US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| PT929547E (pt) | 1996-09-12 | 2003-03-31 | Schering Ag | Derivados da benzamidina substituidos por derivados de aminoacidos ciclicos e de hidroxiacidos ciclicos e seu uso como anticoagulantes |
| US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| US6235974B1 (en) | 1996-12-05 | 2001-05-22 | Cornell Research Foundation, Inc. | Hypersensitive response induced resistance in plants by seed treatment with a hypersensitive response elicitor |
| US6277814B1 (en) | 1997-01-27 | 2001-08-21 | Cornell Research Foundation, Inc. | Enhancement of growth in plants |
| US6998515B1 (en) | 1997-01-27 | 2006-02-14 | Cornell Research Foundation, Inc. | Use of a nucleic acid encoding a hypersensitive response elicitor polypeptide to enhance growth in plants |
| US6228644B1 (en) | 1997-08-06 | 2001-05-08 | Cornell Research Foundation, Inc. | Hypersensitive response elicitor from Erwinia amylovora, its use, and encoding gene |
| US6172184B1 (en) | 1997-08-06 | 2001-01-09 | Cornell Research Foundation, Inc. | Hypersensitive response elicitor from Pseudomonas syringae and its use |
| US6262018B1 (en) | 1997-08-06 | 2001-07-17 | Cornell Research Foundation, Inc. | Hypersensitive response elicitor from Erwinia amylovora and its use |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| PL341044A1 (en) | 1997-12-19 | 2001-03-26 | Schering Ag | Derivatives of orthoantranilic amide as anticoagulants |
| US6713651B1 (en) * | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6858707B1 (en) | 1998-10-05 | 2005-02-22 | Eden Bioscience Corporation | Hypersensitive response elicitor fragments which are active but do not elicit a hypersensitive response |
| US6960705B2 (en) | 1998-10-05 | 2005-11-01 | Eden Bioscience Corporation | Nucleic acid encoding a hypersensitive response elicitor from Xanthomonas campestris |
| US6624139B1 (en) | 1998-11-05 | 2003-09-23 | Eden Bioscience Corporation | Hypersensitive response elicitor-induced stress resistance |
| US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
| US6127376A (en) | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
| CA2320730A1 (en) | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
| US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
| WO2003037346A1 (en) * | 2001-10-31 | 2003-05-08 | Cell Therapeutics, Inc. | 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| TW200409629A (en) | 2002-06-27 | 2004-06-16 | Bristol Myers Squibb Co | 2,4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors |
| CN1678321A (zh) | 2002-07-29 | 2005-10-05 | 里格尔药品股份有限公司 | 用2,4－嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
| US7419984B2 (en) * | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
| KR20040042071A (ko) * | 2002-11-12 | 2004-05-20 | 박영민 | 인터넷 홈페이지를 활용한 경조사 자동알림 및 게시판 자동등록 방법 |
| HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
| US6875781B2 (en) * | 2003-04-04 | 2005-04-05 | Cell Therapeutics, Inc. | Pyridines and uses thereof |
| US7122542B2 (en) * | 2003-07-30 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| DK1814878T3 (da) * | 2004-11-24 | 2012-05-07 | Rigel Pharmaceuticals Inc | Spiro-2, 4-pyrimidindiamin-forbindelser og anvendelser deraf |
| DK1856135T3 (da) | 2005-01-19 | 2010-04-12 | Rigel Pharmaceuticals Inc | Prodrugs af 2,4-pyrimidindiamin-forbindelser og deres anvendelser |
| US20060270694A1 (en) * | 2005-05-03 | 2006-11-30 | Rigel Pharmaceuticals, Inc. | JAK kinase inhibitors and their uses |
| US20070015834A1 (en) * | 2005-07-18 | 2007-01-18 | Moshe Flashner-Barak | Formulations of fenofibrate containing PEG/Poloxamer |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| ES2546502T3 (es) * | 2008-04-16 | 2015-09-24 | Portola Pharmaceuticals, Inc. | 2,6-Diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o JAK quinasas |
| MX2010012703A (es) | 2008-05-21 | 2010-12-21 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| MX363551B (es) | 2011-11-23 | 2019-03-27 | Portola Pharmaceuticals Inc Star | Compuestos derivados de pirazina como inhibidores de cinasa. |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| US10676436B2 (en) * | 2018-07-05 | 2020-06-09 | Landos Biopharma, Inc. | NLRX1 ligands |
| US10487057B1 (en) * | 2018-07-05 | 2019-11-26 | Landos Biopharma, Inc. | NLRX1 ligands |
| CN113527193B (zh) * | 2020-04-18 | 2022-06-10 | 中国科学院精密测量科学与技术创新研究院 | 一种用于核磁氟谱检测的探针及其在检测巯基类化合物中的应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US518735A (en) * | 1894-04-24 | doolittle | ||
| GB824908A (en) * | 1958-06-03 | 1959-12-09 | May & Baker Ltd | Improvements in or relating to triazine derivatives |
| JPS5922697B2 (ja) * | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−（メタ−アミジノフエノキシ）−化合物 |
| DE69112898T2 (de) * | 1990-05-02 | 1996-06-13 | Mita Industrial Co Ltd | Meta-Phenylendiaminverbindung und elektrophotoempfindliches Material, das diese Verbindung verwendet. |
| AU8868991A (en) * | 1990-11-15 | 1992-06-11 | Pentapharm Ag | Meta-substituted phenyl alanine derivatives |
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
| EP0518818A3 (en) * | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| JP3194953B2 (ja) * | 1992-02-14 | 2001-08-06 | コルバス・インターナショナル、インコーポレイテッド | 血栓症抑制剤 |
| DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| TW234077B (hu) * | 1992-07-17 | 1994-11-11 | Shell Internat Res Schappej B V | |
| AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| JPH08504769A (ja) * | 1992-12-15 | 1996-05-21 | コルバス・インターナショナル、インコーポレイテッド | 因子Ｘａの新規インヒビター |
| US5332822A (en) * | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
| DE69419141D1 (de) * | 1993-02-12 | 1999-07-22 | Corvas Int Inc | Inhibitoren gegen thrombose |
| US5633381A (en) * | 1994-07-05 | 1997-05-27 | Berlex Laboratories, Inc. | (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US5691364A (en) * | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| CA2214685C (en) * | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
| US5663381A (en) * | 1995-04-21 | 1997-09-02 | Hexal Pharmaceuticals, Inc. | Process for preparing form 1 ranitidine hydrochloride |
| US5612363A (en) * | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
| US5849759A (en) * | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| US5753635A (en) * | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
| US5693641A (en) * | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| PT929547E (pt) * | 1996-09-12 | 2003-03-31 | Schering Ag | Derivados da benzamidina substituidos por derivados de aminoacidos ciclicos e de hidroxiacidos ciclicos e seu uso como anticoagulantes |
| US6008234A (en) | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| PL341044A1 (en) | 1997-12-19 | 2001-03-26 | Schering Ag | Derivatives of orthoantranilic amide as anticoagulants |
-
1996
- 1996-10-09 US US08/731,128 patent/US6004985A/en not_active Expired - Fee Related
-
1997
- 1997-09-24 AU AU46240/97A patent/AU730060B2/en not_active Ceased
- 1997-09-24 PL PL97332602A patent/PL332602A1/xx unknown
- 1997-09-24 DK DK97944891T patent/DK0934310T3/da active
- 1997-09-24 KR KR1019990703014A patent/KR20000048966A/ko not_active Application Discontinuation
- 1997-09-24 SK SK464-99A patent/SK46499A3/sk unknown
- 1997-09-24 ES ES97944891T patent/ES2236828T3/es not_active Expired - Lifetime
- 1997-09-24 DE DE69732490T patent/DE69732490T2/de not_active Expired - Fee Related
- 1997-09-24 WO PCT/EP1997/005231 patent/WO1998015547A1/en not_active Application Discontinuation
- 1997-09-24 HU HU9904180A patent/HUP9904180A3/hu unknown
- 1997-09-24 JP JP51712798A patent/JP3768244B2/ja not_active Expired - Fee Related
- 1997-09-24 CA CA002268172A patent/CA2268172A1/en not_active Abandoned
- 1997-09-24 CZ CZ991227A patent/CZ122799A3/cs unknown
- 1997-09-24 AT AT97944891T patent/ATE288908T1/de not_active IP Right Cessation
- 1997-09-24 NZ NZ334758A patent/NZ334758A/xx unknown
- 1997-09-24 IL IL12905697A patent/IL129056A0/xx unknown
- 1997-09-24 PT PT97944891T patent/PT934310E/pt unknown
- 1997-09-24 CN CN97198655A patent/CN1111159C/zh not_active Expired - Fee Related
- 1997-09-24 EP EP97944891A patent/EP0934310B1/en not_active Expired - Lifetime
-
1999
- 1999-03-31 NO NO991594A patent/NO991594L/no not_active Application Discontinuation
- 1999-05-19 US US09/315,120 patent/US6166014A/en not_active Expired - Fee Related
- 1999-05-19 US US09/314,619 patent/US6034084A/en not_active Expired - Fee Related
- 1999-05-21 US US09/315,790 patent/US6150382A/en not_active Expired - Fee Related
- 1999-12-30 HK HK99106206A patent/HK1020958A1/xx not_active IP Right Cessation
-
2000
- 2000-01-11 US US09/481,987 patent/US6221886B1/en not_active Expired - Fee Related
- 2000-01-11 US US09/481,761 patent/US6162807A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT934310E (pt) | 2005-06-30 |
| CN1233247A (zh) | 1999-10-27 |
| NZ334758A (en) | 2000-11-24 |
| CA2268172A1 (en) | 1998-04-16 |
| EP0934310A1 (en) | 1999-08-11 |
| US6004985A (en) | 1999-12-21 |
| US6166014A (en) | 2000-12-26 |
| NO991594D0 (no) | 1999-03-31 |
| HUP9904180A2 (hu) | 2000-09-28 |
| US6150382A (en) | 2000-11-21 |
| EP0934310B1 (en) | 2005-02-09 |
| NO991594L (no) | 1999-06-08 |
| HK1020958A1 (en) | 2004-03-19 |
| SK46499A3 (en) | 2000-04-10 |
| JP3768244B2 (ja) | 2006-04-19 |
| WO1998015547A1 (en) | 1998-04-16 |
| CN1111159C (zh) | 2003-06-11 |
| US6162807A (en) | 2000-12-19 |
| CZ122799A3 (cs) | 1999-09-15 |
| US6221886B1 (en) | 2001-04-24 |
| DE69732490T2 (de) | 2006-04-27 |
| PL332602A1 (en) | 1999-09-27 |
| DE69732490D1 (en) | 2005-03-17 |
| AU4624097A (en) | 1998-05-05 |
| ES2236828T3 (es) | 2005-07-16 |
| US6034084A (en) | 2000-03-07 |
| ATE288908T1 (de) | 2005-02-15 |
| DK0934310T3 (da) | 2005-05-30 |
| AU730060B2 (en) | 2001-02-22 |
| JP2001501632A (ja) | 2001-02-06 |
| KR20000048966A (ko) | 2000-07-25 |
| IL129056A0 (en) | 2000-02-17 |
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