HUP9901620A2 - Itrakonazolt tartalmazó gombaellenes készítmények - Google Patents
Itrakonazolt tartalmazó gombaellenes készítményekInfo
- Publication number
- HUP9901620A2 HUP9901620A2 HU9901620A HUP9901620A HUP9901620A2 HU P9901620 A2 HUP9901620 A2 HU P9901620A2 HU 9901620 A HU9901620 A HU 9901620A HU P9901620 A HUP9901620 A HU P9901620A HU P9901620 A2 HUP9901620 A2 HU P9901620A2
- Authority
- HU
- Hungary
- Prior art keywords
- triazol
- phenyl
- day
- compositions containing
- antifungal compositions
- Prior art date
Links
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 title 1
- 239000012871 anti-fungal composition Substances 0.000 title 1
- 229960004130 itraconazole Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 230000037213 diet Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000002351 wastewater Substances 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány új, itrakőnazőltartalmú javítőtt biőlógiaihőzzáférhetőségű gyógyszerkészítményekre vőnatkőzik, amelyek gőmbásfertőzésben szenvedő emlősöknek napőnta egyszer, a nap bármelyidőpőntjában egyetlen dózisfőrmában adhatók be, az emlőstáplálkőzásától függetlenül. A találmány szerinti új készítményekitrakőnazőlt és megfelelő vízőldható pőlimert tartalmazó keverékömledékben történő extrűdálásával, és az extrűdált keverék őrlésévelelőállítőtt részecskéket tartalmaznak. Az intrakőnazől kémiai neve ()cisz -4-[4-[4-[4-[[2-(2,4-diklór-fenil)-2-(1H-1,2,4-triazől-1-il-metil)-1,3-diőxőlán-4-il]-me-tőxi]-fenil]-1-piperazinil]-fenil]-2,4-dihidrő-2-(1-metil-prőpil)- 3H-1,2,4-triazől-3-őn. ŕ
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96201430 | 1996-05-20 | ||
EP97200698 | 1997-03-07 | ||
PCT/EP1997/002507 WO1997044014A1 (en) | 1996-05-20 | 1997-05-12 | Antifungal compositions with improved bioavailability |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9901620A2 true HUP9901620A2 (hu) | 1999-10-28 |
HUP9901620A3 HUP9901620A3 (en) | 2000-03-28 |
HU227745B1 HU227745B1 (en) | 2012-02-28 |
Family
ID=26142825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9901620A HU227745B1 (en) | 1996-05-20 | 1997-05-12 | Antifungal compositions containing itraconazole |
Country Status (34)
Country | Link |
---|---|
US (4) | US6509038B2 (hu) |
EP (1) | EP0904060B1 (hu) |
JP (1) | JP3391801B2 (hu) |
KR (1) | KR19990044257A (hu) |
CN (1) | CN1165291C (hu) |
AR (1) | AR007195A1 (hu) |
AT (1) | ATE255883T1 (hu) |
AU (1) | AU722101B2 (hu) |
BG (1) | BG64368B1 (hu) |
BR (1) | BR9706897B1 (hu) |
CA (1) | CA2240161C (hu) |
CY (1) | CY2434B1 (hu) |
CZ (1) | CZ293841B6 (hu) |
DE (1) | DE69726729T2 (hu) |
DK (1) | DK0904060T3 (hu) |
EA (1) | EA001219B1 (hu) |
EE (1) | EE03902B1 (hu) |
ES (1) | ES2212810T3 (hu) |
HK (1) | HK1018002A1 (hu) |
HR (1) | HRP970270B1 (hu) |
HU (1) | HU227745B1 (hu) |
ID (1) | ID16926A (hu) |
IL (1) | IL124935A (hu) |
MX (1) | MX9805418A (hu) |
MY (1) | MY123827A (hu) |
NO (1) | NO320495B1 (hu) |
NZ (1) | NZ330739A (hu) |
PL (1) | PL188566B1 (hu) |
PT (1) | PT904060E (hu) |
SI (1) | SI0904060T1 (hu) |
SK (1) | SK284145B6 (hu) |
TR (1) | TR199801225T2 (hu) |
TW (1) | TW460282B (hu) |
WO (1) | WO1997044014A1 (hu) |
Families Citing this family (125)
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KR19990001564A (ko) * | 1997-06-16 | 1999-01-15 | 유충식 | 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제 |
KR100288890B1 (ko) * | 1997-12-31 | 2001-05-02 | 최현식 | 이트라코나졸 경구용 제제 및 그의 제조방법 |
KR100514330B1 (ko) * | 1997-12-31 | 2006-02-17 | 주식회사 중외제약 | 난용성 약물을 함유하는 코팅정 |
WO1999033467A1 (en) * | 1997-12-31 | 1999-07-08 | Choongwae Pharma Corporation | Method and composition of an oral preparation of itraconazole |
ES2157731B1 (es) * | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
DE60023465T2 (de) * | 1999-03-24 | 2006-07-20 | R.P. Scherer Technologies, Inc., Las Vegas | Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser |
KR100331529B1 (ko) * | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
WO2001034119A2 (en) | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
AU782469B2 (en) * | 1999-12-23 | 2005-08-04 | Mayne Pharma International Pty Ltd | Improved pharmaceutical compositions for poorly soluble drugs |
FR2803748A1 (fr) * | 2000-01-14 | 2001-07-20 | Ethypharm Lab Prod Ethiques | Composition d'itraconazole et procede de preparation |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
CZ20024180A3 (cs) * | 2000-06-22 | 2003-04-16 | Novartis Ag | Pevné orální farmaceutické kompozice obsahující valsartan |
DE10038571A1 (de) * | 2000-08-03 | 2002-02-14 | Knoll Ag | Zusammensetzungen und Dosierungsformen zur Anwendung in der Mundhöhle bei der Bhandlung von Mykosen |
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US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
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