HUP9802913A2 - Bioadhezív, szilárd gyógyszer-adagolási forma - Google Patents
Bioadhezív, szilárd gyógyszer-adagolási formaInfo
- Publication number
- HUP9802913A2 HUP9802913A2 HU9802913A HUP9802913A HUP9802913A2 HU P9802913 A2 HUP9802913 A2 HU P9802913A2 HU 9802913 A HU9802913 A HU 9802913A HU P9802913 A HUP9802913 A HU P9802913A HU P9802913 A2 HUP9802913 A2 HU P9802913A2
- Authority
- HU
- Hungary
- Prior art keywords
- weight
- vaginal
- rectal
- locally
- active ingredient
- Prior art date
Links
- 239000000227 bioadhesive Substances 0.000 title abstract 2
- 239000007909 solid dosage form Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 244000025254 Cannabis sativa Species 0.000 abstract 1
- 229920000881 Modified starch Polymers 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000005178 buccal mucosa Anatomy 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000004575 stone Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 210000001215 vagina Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány biőadhezív (biőlógiai körülmények között tapadó)készítményekre és ezekből előállítőtt szilárd gyógyszer-adagőlásifőrmákra vőnatkőzik, amelyek szabályőzőtt és tartós felszabadűlástbiztősítanak egy lőkálisan (helyileg) ható kőmpőnens számára, vagy egyszisztémás hatóanyag számára, és őrális, nazális (őrrnyálkahártyán átvégzett), rektális (végbélen át végzett), valamint vaginális (hüvelyenát végzett) adagőlásra alkalmasak. A találmány egyik előnyös kivitelifőrmája szerint a biőadhezív gyógyászati készítmény egy hatóanyaggyógyászati szempőntból hatásős mennyiségét, 80-98,8 tömeg%prezselatinizált keményítőt és 1-10 tömeg% hidrőfil mátrixképzőpőlimert tartalmaz, tővábbá kiegészítőleg jellemző módőnsíkősítószerként 0,2-5 tömeg% alkálifém-(16-22 szénatőmős alkil)-fűmarátőt is tartalmaz. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95203649 | 1995-12-27 | ||
PCT/EP1996/005884 WO1997024109A1 (en) | 1995-12-27 | 1996-12-20 | Bioadhesive solid dosage form |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP9802913A2 true HUP9802913A2 (hu) | 1999-06-28 |
HUP9802913A3 HUP9802913A3 (en) | 2000-06-28 |
HU228350B1 HU228350B1 (hu) | 2013-03-28 |
Family
ID=8221021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802913A HU228350B1 (hu) | 1995-12-27 | 1996-12-20 | Bioadhezív, szilárd gyógyszeradagolási forma |
Country Status (27)
Country | Link |
---|---|
US (1) | US6303147B1 (hu) |
EP (1) | EP0869772B1 (hu) |
JP (1) | JP4317264B2 (hu) |
KR (1) | KR100459029B1 (hu) |
CN (1) | CN1146401C (hu) |
AT (1) | ATE206304T1 (hu) |
AU (1) | AU713849B2 (hu) |
BR (1) | BR9612291A (hu) |
CA (1) | CA2232152C (hu) |
CY (1) | CY2269B1 (hu) |
CZ (1) | CZ298690B6 (hu) |
DE (1) | DE69615704T2 (hu) |
DK (1) | DK0869772T3 (hu) |
EA (1) | EA000818B1 (hu) |
ES (1) | ES2164940T3 (hu) |
HK (1) | HK1015680A1 (hu) |
HU (1) | HU228350B1 (hu) |
IL (1) | IL123636A (hu) |
NO (1) | NO320015B1 (hu) |
NZ (1) | NZ325844A (hu) |
PL (1) | PL186278B1 (hu) |
PT (1) | PT869772E (hu) |
SI (1) | SI0869772T1 (hu) |
SK (1) | SK283370B6 (hu) |
TR (1) | TR199800894T2 (hu) |
WO (1) | WO1997024109A1 (hu) |
ZA (1) | ZA9610886B (hu) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080213378A1 (en) * | 1998-10-01 | 2008-09-04 | Elan Pharma International, Ltd. | Nanoparticulate statin formulations and novel statin combinations |
EP2266542A3 (en) * | 1998-10-01 | 2013-07-31 | Elan Pharma International Limited | Controlled release nanoparticulate compositions |
US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
ATE313319T1 (de) | 1999-03-31 | 2006-01-15 | Janssen Pharmaceutica Nv | Vorgelatinierte stärke in einer formulierung mit gesteuerter freigabe |
US7503493B2 (en) * | 1999-10-25 | 2009-03-17 | Silverbrook Research Pty Ltd | Method and system for digitizing freehand graphics with user-selected properties |
US20040156872A1 (en) * | 2000-05-18 | 2004-08-12 | Elan Pharma International Ltd. | Novel nimesulide compositions |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US8980334B2 (en) | 2001-02-28 | 2015-03-17 | Axiomedic Ltd. | Double-layered absorbable solid compositions for the topical treatment of oral mucosal disorders |
EP2324821A1 (en) * | 2001-02-28 | 2011-05-25 | Axiomedic Ltd. | Oral care compositions |
FR2827517B1 (fr) * | 2001-07-23 | 2003-10-24 | Bioalliance Pharma | Systemes therapeutiques bioadhesifs a liberation prolongee |
US20030124196A1 (en) * | 2001-08-22 | 2003-07-03 | Susan Weinbach | Pulsatile release compositions and methods for enhanced intestinal drug absorption |
US20030083286A1 (en) * | 2001-08-22 | 2003-05-01 | Ching-Leou Teng | Bioadhesive compositions and methods for enhanced intestinal drug absorption |
US7709026B2 (en) * | 2001-10-29 | 2010-05-04 | Columbia Laboratories, Inc. | Low concentration of peroxide for treating or preventing vaginal infections |
US7846478B2 (en) | 2002-01-31 | 2010-12-07 | Henkel Ag & Co. Kgaa | Bioadhesive composition |
DK1471887T3 (da) | 2002-02-04 | 2010-06-07 | Elan Pharma Int Ltd | Nanopartikelkompositioner der har lysozym som overfladestabiliseringsmiddel |
AU2003261167A1 (en) * | 2002-07-16 | 2004-02-02 | Elan Pharma International, Ltd | Liquid dosage compositions of stable nanoparticulate active agents |
MY142204A (en) | 2002-07-25 | 2010-10-29 | Pharmacia Corp | Pramipexole once-daily dosage form |
GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
WO2005032554A1 (en) | 2003-10-03 | 2005-04-14 | Astron Research Pvt. Ltd | A novel transmucosal delivery system |
EP1734931A2 (en) * | 2004-03-24 | 2006-12-27 | Actavis Group | Formulations of ramipril |
US9925139B2 (en) * | 2004-04-22 | 2018-03-27 | Acucort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
TWI338583B (en) * | 2004-05-20 | 2011-03-11 | Otsuka Pharma Co Ltd | Solid pharmaceutical formulation |
GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
CN101843597A (zh) | 2004-08-13 | 2010-09-29 | 贝林格尔·英格海姆国际有限公司 | 包含普拉克索或其可药用盐的延长释放小球制剂、其制备方法及其用途 |
US20070048369A1 (en) * | 2005-08-26 | 2007-03-01 | National Starch And Chemical Investment Holding Corporation | Mucosal delivery tablet |
GB0518129D0 (en) * | 2005-09-06 | 2005-10-12 | Arrow Int Ltd | Ramipril formulation |
US20070098782A1 (en) * | 2005-10-28 | 2007-05-03 | Selamine Limited | Ramipril Formulation |
GB2431579A (en) * | 2005-10-28 | 2007-05-02 | Arrow Int Ltd | Ramipril formulations |
US8349120B2 (en) * | 2006-03-07 | 2013-01-08 | Ora Health Corporation | Multi-layer patch made on a sheet and enclosed in a blister |
EP1837020A1 (en) | 2006-03-24 | 2007-09-26 | Bioalliance Pharma | Mucosal bioadhesive slow release carrier for delivering active principles |
US20070248655A1 (en) * | 2006-04-21 | 2007-10-25 | Haley Jeffrey T | Lenticular shaped protective mouth sore discs |
EP2037895A4 (en) * | 2006-05-23 | 2009-12-02 | Orahealth Corp | XYLITOL-PASTILLAS AND METHOD OF USE |
US20070293587A1 (en) * | 2006-05-23 | 2007-12-20 | Haley Jeffrey T | Combating sinus, throat, and blood infections with xylitol delivered in the mouth |
GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
RU2444364C2 (ru) * | 2006-07-12 | 2012-03-10 | Контроллд Терапьютикс (Скотлэнд) Лтд. | Полимер для доставки лекарств с гидрохлоридной солью клиндамицина |
GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
GB0624087D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril combination salt |
EP2942053A1 (en) | 2007-07-06 | 2015-11-11 | Lupin Limited | Pharmaceutical compositions for gastrointestinal drug delivery |
US20120027855A1 (en) | 2007-07-06 | 2012-02-02 | Lupin Limited | Pharmaceutical compositions for gastrointestinal drug delivery |
US8974825B2 (en) * | 2007-07-06 | 2015-03-10 | Lupin Limited | Pharmaceutical compositions for gastrointestinal drug delivery |
EP2163240A1 (en) * | 2008-09-12 | 2010-03-17 | Universita' Degli Studi Di Genova | A method for the production of bioadhesive compact matrices |
KR20140114269A (ko) | 2010-12-20 | 2014-09-26 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 표적화된 과가수분해효소 |
JO3256B1 (ar) * | 2013-03-06 | 2018-09-16 | Novartis Ag | صياغات من مركبات عضوية |
CN105193768A (zh) * | 2015-08-27 | 2015-12-30 | 武汉武药科技有限公司 | 一种曲安奈德口腔粘贴片及其制备工艺 |
RS64644B9 (sr) * | 2016-07-15 | 2024-02-29 | H2 Water Tech Ltd | Kompozicije za proizvodnju vode obogaćene vodonikom |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3554764A (en) * | 1967-12-21 | 1971-01-12 | Gen Foods Corp | Freeze-thaw resistant flour and starch thickener blend |
DE3739690A1 (de) * | 1987-11-24 | 1989-06-08 | Hoechst Ag | Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen |
EP0451433B1 (en) * | 1990-04-12 | 1996-10-23 | Janssen Pharmaceutica N.V. | Composition of a bioadhesive sustained delivery carrier for drug administration |
US5330761A (en) * | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
US5370878A (en) | 1993-09-30 | 1994-12-06 | Hallmark Pharmaceuticals, Inc. | Method for preparing a direct compression granulated acetaminophen composition |
TW355683B (en) | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
ES2082723B1 (es) * | 1994-07-20 | 1996-10-01 | Lilly Sa | Formulacion farmaceutica de fluoxetina en forma dispersable. |
US5656283A (en) | 1995-06-08 | 1997-08-12 | Ortho Pharmaceutical Corporation | In-situ lyophilization of vaginal suppository in unit dose applicator and resultant product |
-
1996
- 1996-12-20 SK SK887-98A patent/SK283370B6/sk not_active IP Right Cessation
- 1996-12-20 HU HU9802913A patent/HU228350B1/hu unknown
- 1996-12-20 SI SI9630387T patent/SI0869772T1/xx unknown
- 1996-12-20 AU AU13085/97A patent/AU713849B2/en not_active Expired
- 1996-12-20 CN CNB961978783A patent/CN1146401C/zh not_active Expired - Lifetime
- 1996-12-20 BR BR9612291A patent/BR9612291A/pt not_active IP Right Cessation
- 1996-12-20 EA EA199800350A patent/EA000818B1/ru not_active IP Right Cessation
- 1996-12-20 KR KR1019980703055A patent/KR100459029B1/ko not_active IP Right Cessation
- 1996-12-20 ES ES96944692T patent/ES2164940T3/es not_active Expired - Lifetime
- 1996-12-20 US US09/091,685 patent/US6303147B1/en not_active Expired - Lifetime
- 1996-12-20 JP JP52403297A patent/JP4317264B2/ja not_active Expired - Lifetime
- 1996-12-20 WO PCT/EP1996/005884 patent/WO1997024109A1/en active IP Right Grant
- 1996-12-20 IL IL12363696A patent/IL123636A/en not_active IP Right Cessation
- 1996-12-20 CZ CZ0199298A patent/CZ298690B6/cs not_active IP Right Cessation
- 1996-12-20 CA CA002232152A patent/CA2232152C/en not_active Expired - Lifetime
- 1996-12-20 DE DE69615704T patent/DE69615704T2/de not_active Expired - Lifetime
- 1996-12-20 PT PT96944692T patent/PT869772E/pt unknown
- 1996-12-20 AT AT96944692T patent/ATE206304T1/de active
- 1996-12-20 EP EP96944692A patent/EP0869772B1/en not_active Expired - Lifetime
- 1996-12-20 TR TR1998/00894T patent/TR199800894T2/xx unknown
- 1996-12-20 PL PL96326196A patent/PL186278B1/pl unknown
- 1996-12-20 NZ NZ325844A patent/NZ325844A/xx not_active IP Right Cessation
- 1996-12-20 DK DK96944692T patent/DK0869772T3/da active
- 1996-12-23 ZA ZA9610886A patent/ZA9610886B/xx unknown
-
1998
- 1998-03-09 NO NO19981027A patent/NO320015B1/no not_active IP Right Cessation
-
1999
- 1999-02-20 HK HK99100697A patent/HK1015680A1/xx not_active IP Right Cessation
-
2002
- 2002-04-25 CY CY0200020A patent/CY2269B1/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB9A | Succession in title |
Owner name: TIBOTEC PHARMACEUTICALS LTD., IE Free format text: FORMER OWNER(S): JANSSEN PHARMACEUTICA N.V., BE |
|
GB9A | Succession in title |
Owner name: JANSSEN SCIENCES IRELAND UC, IE Free format text: FORMER OWNER(S): JANSSEN PHARMACEUTICA N.V., BE; TIBOTEC PHARMACEUTICALS LTD., IE |