HUP0401924A2 - Kannabinoid-receptor ligandok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Kannabinoid-receptor ligandok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401924A2 HUP0401924A2 HU0401924A HUP0401924A HUP0401924A2 HU P0401924 A2 HUP0401924 A2 HU P0401924A2 HU 0401924 A HU0401924 A HU 0401924A HU P0401924 A HUP0401924 A HU P0401924A HU P0401924 A2 HUP0401924 A2 HU P0401924A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- haloalkyl
- cycloalkyl
- heteroaryl
- halogen
- Prior art date
Links
- 102000018208 Cannabinoid Receptor Human genes 0.000 title 1
- 108050007331 Cannabinoid receptor Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 2
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
A találmány tárgyát az (I) általános képletű vegyületek vagy ezekgyógyászatilag elfogadható sói vagy szolvátjai képezik, amelyekgyulladáscsökkentő és immunmodulátor aktivitással rendelkeznek,továbbá ezeket a vegyületeket tartalmazó gyógyszerkészítmények. Az (I)általános képletben L1 jelentése egy kovalens kötés, -CH2-, -C(O)-, -C(O)O-, S(O2)-, -S(O)-, -S-, -O-, -NH- vagy -N(R7)-; L2 jelentése -CH2-, -C(H) (alkil)-, -C(alkil)2-, -C(O)-, -SO-, -S(O2) -, -C(=NR7) -,-C(=N-CN) - vagy -C (=N-OR7); L3 jelentése egy kovalens kötés, -C(O)-vagy -S(O2)-; R1 jelentése H, halogén, alkil, haloalkil, cikloalkil,cikloalkil-alkil, heterociklil-alkil, -NHR7, -N(R7)2, -C(O)R7, -C(O)OR7, -S(O2)R7, -Si(alkil)n(aril)3-n, adott esetben 1-5 csoporttalszubsztituált aril- vagy heteroaril, R2 jelentése H, -OH; halogén, -N(R7)2-, -CF3, alkoxi, alkil, haloalkil, cikloalkil vagy cikloalkil-alkil; R3 és R4 jelentése egymástól függetlenül H vagy alkil, vagy R3és R4 együtt egy karbonilcsoportot, azaz C(=O) képez; R5 jelentése Hvagy alkil; R6 jelentése H, alkil, haloalkil, cikloalkil, NHR7,N(R7)2, adott esetben szubsztituált aril vagy heteroaril; R7 jelentéseH, alkil, haloalkil, cikloalkil, heterociklil-alkil, adott esetbenszubsztituált aril vagy heteroaril; A jelentése fenil, naftil,piridil, tienil, tiazolil, indolil, kinolil, izokinolil, pirazinil,piridazinil, furanil, pirrolil, pirimidil, kinazolinil, kinoxalinil,ftalazinil, benzofuranil vagy benzotienil; X jelentése egymástólfüggetlenül H, halogén, alkil, cikloalkil, haloalkil, hidroxi, alkoxi,alkoxi-karbonil, haloalkoxi, -N(R7)2, -N(R7) (C(O)R7), -N(R7)(C(O)OR7), -NO2 vagy -CN közül kerül kiválasztásra, n jelentése 0-3. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33291101P | 2001-11-14 | 2001-11-14 | |
PCT/US2002/036185 WO2003042174A1 (en) | 2001-11-14 | 2002-11-12 | Cannabinoid receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0401924A2 true HUP0401924A2 (hu) | 2005-01-28 |
HUP0401924A3 HUP0401924A3 (en) | 2009-07-28 |
Family
ID=23300394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401924A HUP0401924A3 (en) | 2001-11-14 | 2002-11-12 | Cannabinoid receptor ligands, their use and pharmaceutical compositions containing them |
Country Status (20)
Country | Link |
---|---|
US (2) | US7071213B2 (hu) |
EP (1) | EP1444203A1 (hu) |
JP (2) | JP2005509032A (hu) |
KR (1) | KR20050044417A (hu) |
CN (2) | CN100567266C (hu) |
AR (1) | AR037352A1 (hu) |
BR (1) | BR0214164A (hu) |
CA (1) | CA2466440A1 (hu) |
EC (1) | ECSP045104A (hu) |
HU (1) | HUP0401924A3 (hu) |
IL (1) | IL161439A0 (hu) |
MX (1) | MXPA04004674A (hu) |
NO (1) | NO20042435L (hu) |
NZ (1) | NZ532291A (hu) |
PE (1) | PE20030720A1 (hu) |
PL (1) | PL369952A1 (hu) |
RU (1) | RU2004117907A (hu) |
TW (1) | TW200302088A (hu) |
WO (1) | WO2003042174A1 (hu) |
ZA (1) | ZA200403685B (hu) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7067539B2 (en) | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
US7868204B2 (en) * | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
EP1429765A2 (en) * | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
HUP0401924A3 (en) | 2001-11-14 | 2009-07-28 | Schering Corp | Cannabinoid receptor ligands, their use and pharmaceutical compositions containing them |
EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
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ZA200403685B (en) | 2005-05-23 |
IL161439A0 (en) | 2004-09-27 |
EP1444203A1 (en) | 2004-08-11 |
PL369952A1 (en) | 2005-05-02 |
WO2003042174A1 (en) | 2003-05-22 |
AR037352A1 (es) | 2004-11-03 |
BR0214164A (pt) | 2004-09-28 |
CN100567266C (zh) | 2009-12-09 |
US7645774B2 (en) | 2010-01-12 |
US7071213B2 (en) | 2006-07-04 |
US20040010013A1 (en) | 2004-01-15 |
KR20050044417A (ko) | 2005-05-12 |
US20050282861A1 (en) | 2005-12-22 |
JP2005509032A (ja) | 2005-04-07 |
CN1585749A (zh) | 2005-02-23 |
NO20042435L (no) | 2004-06-11 |
HUP0401924A3 (en) | 2009-07-28 |
JP2010018635A (ja) | 2010-01-28 |
CA2466440A1 (en) | 2003-05-22 |
ECSP045104A (es) | 2004-06-28 |
TW200302088A (en) | 2003-08-01 |
MXPA04004674A (es) | 2004-08-12 |
PE20030720A1 (es) | 2003-08-29 |
NZ532291A (en) | 2005-11-25 |
CN101684091A (zh) | 2010-03-31 |
RU2004117907A (ru) | 2006-01-10 |
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