PE20030720A1 - Ligandos de los receptores de los cannabinoides - Google Patents

Ligandos de los receptores de los cannabinoides

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Publication number
PE20030720A1
PE20030720A1 PE2002001100A PE2002001100A PE20030720A1 PE 20030720 A1 PE20030720 A1 PE 20030720A1 PE 2002001100 A PE2002001100 A PE 2002001100A PE 2002001100 A PE2002001100 A PE 2002001100A PE 20030720 A1 PE20030720 A1 PE 20030720A1
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PE
Peru
Prior art keywords
alkyl
covalent link
haloalkyl
cycloalkyl
cannabinoid receptors
Prior art date
Application number
PE2002001100A
Other languages
English (en)
Inventor
Neng-Yang Shih
Joseph A Kozlowski
Richard J Friary
Bandarpalle B Shankar
Michael K C Wong
Lei Chen
Youheng Shu
Guowei Zhou
Ling Tong
Brian J Lavey
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20030720A1 publication Critical patent/PE20030720A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

SE REFIERE A LIGANDOS DE LOS RECEPTORES DE CANNABINOIDES DE FORMULA I DONDE L1 ES UN ENLACE COVALENTE, -CH2-, -C(O), -C(O)O-, SO2, -S-, ENTRE OTROS; L2 ES -CH2-, -C(H)(ALQUIL)-, -C(ALQUIL)2-, -C(O)-, -SO-, ENTRE OTROS; L3 ES UN ENLACE COVALENTE, -C(O)-, -S(O2)-; R1 ES H, HALOGENO, ALQUILO, HALOALQUILO, CICLOALQUILO, CICLOALQUILALQUILO, HETEROCICLILALQUILO, -CHR7-, ENTRE OTROS; CON LA CONDICION DE QUE CUANDO R1 ES HALO, L1 ES UN ENLACE COVALENTE, CUANDO R1 ES -NHR7, L1 ES UN ENLACE COVALENTE, -CH2-, -C(O)-, SO2, -SO-, ENTRE OTROS; R2 ES H, OH, HALO, -CF3, ALCOXI, ALQUILO, ENTRE OTROS; R3 Y R4 SON H, ALQUILO; R3 Y R4 TOMADOS CONJUNTAMENTE FORMAN UN GRUPO CARBONILO ES DECIR C(=O); R5 ES H, ALQUILO; R6 ES H, ALQUILO, HALOALQUILO, CICLOALQUILO, NHR7, N(R7)2, ARILO, HETEROARILO, ENTRE OTROS; R7 ES H, ALQUILO, HALOALQUILO, CICLOALQUILO, HETEROCICLILALQUILO, ENTRE OTROS; A ES FENILO, NAFTILO, PIRIDILO, TIENILO, TIAZOLILO, INDOLILO, QUINOLILO, ISOQUINOLILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS PRESENTAN UNA ACTIVIDAD ANTIINFLAMATORIA E INMUNOMODULADORA
PE2002001100A 2001-11-14 2002-11-13 Ligandos de los receptores de los cannabinoides PE20030720A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33291101P 2001-11-14 2001-11-14

Publications (1)

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PE20030720A1 true PE20030720A1 (es) 2003-08-29

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ID=23300394

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Application Number Title Priority Date Filing Date
PE2002001100A PE20030720A1 (es) 2001-11-14 2002-11-13 Ligandos de los receptores de los cannabinoides

Country Status (20)

Country Link
US (2) US7071213B2 (es)
EP (1) EP1444203A1 (es)
JP (2) JP2005509032A (es)
KR (1) KR20050044417A (es)
CN (2) CN100567266C (es)
AR (1) AR037352A1 (es)
BR (1) BR0214164A (es)
CA (1) CA2466440A1 (es)
EC (1) ECSP045104A (es)
HU (1) HUP0401924A3 (es)
IL (1) IL161439A0 (es)
MX (1) MXPA04004674A (es)
NO (1) NO20042435L (es)
NZ (1) NZ532291A (es)
PE (1) PE20030720A1 (es)
PL (1) PL369952A1 (es)
RU (1) RU2004117907A (es)
TW (1) TW200302088A (es)
WO (1) WO2003042174A1 (es)
ZA (1) ZA200403685B (es)

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AR037352A1 (es) 2004-11-03
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US7645774B2 (en) 2010-01-12
US7071213B2 (en) 2006-07-04
US20040010013A1 (en) 2004-01-15
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