HUP0302929A2 - Eljárások hidroxikarbonsavak kristályosítására - Google Patents
Eljárások hidroxikarbonsavak kristályosításáraInfo
- Publication number
- HUP0302929A2 HUP0302929A2 HU0302929A HUP0302929A HUP0302929A2 HU P0302929 A2 HUP0302929 A2 HU P0302929A2 HU 0302929 A HU0302929 A HU 0302929A HU P0302929 A HUP0302929 A HU P0302929A HU P0302929 A2 HUP0302929 A2 HU P0302929A2
- Authority
- HU
- Hungary
- Prior art keywords
- compound
- general formula
- formula
- suspension
- crystallized
- Prior art date
Links
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002425 crystallisation Methods 0.000 title abstract 2
- 230000008025 crystallization Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000000725 suspension Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salt Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya eljárás (1) általános képletű hidroxikarbonsav nagytisztaságú kristályainak jó termeléssel történő előállítása. Atalálmány szerint az (1) általános képletű vegyületet kristályosítjákoly módon, hogy egy (1) általános képletű vegyület alkálifémsója ésegy szerves oldószer elegyét megsavanyítják, és az (1) képletűvegyületet úgy kristályosítják, hogy az (1) képletű vegyület vízzelelegyedő jó oldószeres oldatát vízzel keverik, és így a szükségesszuszpenzió mennyiségű (1) általános képletű vegyület szuszpenziójátelőre elkészítik az olajképződés és kiválás megakadályozására, majd aszuszpenzió jelenlétében végzik a fő kristályosítást. Az (1) általánosképletben R jelentése CH3, CH2OH, CH2OCOR1, CO2R2, CONR3R4, OH, CH2OR1vagy CH2NR3R4; R1 jelentése 1-5 szénatomos alkilcsoport; R2 jelentésehidrogénatom vagy 1-5 szénatomos alkilcsoport, R3 és R4 jelentése egymástól függetlenül hidrogénatom vagy 1-5szénatomos alkilcsoport, a és b jelentése kettőskötés, a és b közülegyik vegyértékvonal és a másik kettőskötés vagy a és b egyarántvegyértékvonal. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000271895 | 2000-09-07 | ||
| PCT/JP2001/007762 WO2002020453A1 (fr) | 2000-09-07 | 2001-09-07 | Procedes de cristallisation d'acides hydroxycarboxyliques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302929A2 true HUP0302929A2 (hu) | 2003-12-29 |
| HUP0302929A3 HUP0302929A3 (en) | 2004-10-28 |
Family
ID=18758116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302929A HUP0302929A3 (en) | 2000-09-07 | 2001-09-07 | Methods for crystallization of hydroxycarboxylic acids |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7034180B2 (hu) |
| EP (1) | EP1323701B1 (hu) |
| JP (2) | JP4870320B2 (hu) |
| AU (1) | AU2001284469A1 (hu) |
| CZ (1) | CZ303774B6 (hu) |
| DE (1) | DE60139264D1 (hu) |
| ES (1) | ES2329974T3 (hu) |
| HU (1) | HUP0302929A3 (hu) |
| IL (2) | IL154718A0 (hu) |
| PL (1) | PL205567B1 (hu) |
| SI (1) | SI1323701T1 (hu) |
| TW (1) | TWI301483B (hu) |
| WO (1) | WO2002020453A1 (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| EP2620431A1 (en) | 2006-07-20 | 2013-07-31 | Asahi Kasei Pharma Corporation | Novel crystals of substituted phenylalkanoic acid and production process |
| JP2011016790A (ja) | 2009-06-08 | 2011-01-27 | Sumitomo Chemical Co Ltd | ピラゾリノン誘導体の精製方法 |
| CN101973904B (zh) * | 2010-09-28 | 2014-01-01 | 雅本化学股份有限公司 | 一种具有高光学纯度的n2-[1-(s)-乙氧羰基-3-苯丙基]-n6-三氟乙酰基-l-赖氨酸的制备方法 |
| CZ26507U1 (cs) | 2013-10-03 | 2014-02-24 | Hedviga Group, A.S. | Zařízení pro úpravu a regulaci plynů pro spalovací zařízení |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA81703B (en) | 1980-02-04 | 1982-09-29 | Merck & Co Inc | New antihypercholesterolemic compounds,intermediates and processes |
| AU548996B2 (en) | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
| JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
| CA2053000C (en) | 1990-10-15 | 1995-08-29 | Michael J. Conder | Biosynthetic production of 6(r)-[2-(8(s)-hydroxy-2(s), 6(r)-dimethyl-1,2,6,7,8,8a(r)-hexahydronaphthyl)-ethyl]-4 (r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one triol acid by enzymatic hydrolysis of lovastatin acid using an enzyme derived from__lonostachys compactiuscula |
| US5250435A (en) | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
| HUT75342A (en) | 1994-01-27 | 1997-05-28 | Schering Ag | New leukotriene b4 derivatives, methods of preparing them and their use as drugs |
| EP0725054A1 (de) | 1995-01-24 | 1996-08-07 | Hüls Aktiengesellschaft | Verfahren zur Herstellung von Terephthalsäure und ihrer Isomeren |
-
2001
- 2001-09-07 JP JP2002525079A patent/JP4870320B2/ja not_active Expired - Fee Related
- 2001-09-07 IL IL15471801A patent/IL154718A0/xx active IP Right Grant
- 2001-09-07 ES ES01963496T patent/ES2329974T3/es not_active Expired - Lifetime
- 2001-09-07 AU AU2001284469A patent/AU2001284469A1/en not_active Abandoned
- 2001-09-07 CZ CZ20030677A patent/CZ303774B6/cs not_active IP Right Cessation
- 2001-09-07 SI SI200130943T patent/SI1323701T1/sl unknown
- 2001-09-07 PL PL361205A patent/PL205567B1/pl unknown
- 2001-09-07 HU HU0302929A patent/HUP0302929A3/hu unknown
- 2001-09-07 WO PCT/JP2001/007762 patent/WO2002020453A1/ja active Application Filing
- 2001-09-07 DE DE60139264T patent/DE60139264D1/de not_active Expired - Lifetime
- 2001-09-07 TW TW090122172A patent/TWI301483B/zh not_active IP Right Cessation
- 2001-09-07 EP EP01963496A patent/EP1323701B1/en not_active Expired - Lifetime
- 2001-09-07 US US10/362,460 patent/US7034180B2/en not_active Expired - Fee Related
-
2003
- 2003-03-03 IL IL154718A patent/IL154718A/en not_active IP Right Cessation
-
2006
- 2006-02-23 US US11/276,306 patent/US7323592B2/en not_active Expired - Fee Related
-
2011
- 2011-08-30 JP JP2011187565A patent/JP5357226B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001284469A1 (en) | 2002-03-22 |
| PL361205A1 (en) | 2004-09-20 |
| CZ303774B6 (cs) | 2013-05-02 |
| US20060149098A1 (en) | 2006-07-06 |
| WO2002020453A1 (fr) | 2002-03-14 |
| EP1323701B1 (en) | 2009-07-15 |
| DE60139264D1 (de) | 2009-08-27 |
| TWI301483B (hu) | 2008-10-01 |
| HUP0302929A3 (en) | 2004-10-28 |
| IL154718A0 (en) | 2003-10-31 |
| JP2012025757A (ja) | 2012-02-09 |
| US7323592B2 (en) | 2008-01-29 |
| US7034180B2 (en) | 2006-04-25 |
| JP5357226B2 (ja) | 2013-12-04 |
| ES2329974T3 (es) | 2009-12-03 |
| IL154718A (en) | 2009-02-11 |
| EP1323701A4 (en) | 2005-11-23 |
| PL205567B1 (pl) | 2010-05-31 |
| JP4870320B2 (ja) | 2012-02-08 |
| EP1323701A1 (en) | 2003-07-02 |
| US20050075508A1 (en) | 2005-04-07 |
| SI1323701T1 (sl) | 2009-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: KANEKA CORPORATION, JP Free format text: FORMER OWNER(S): KANEKA CORPORATION, JP |
|
| FD9A | Lapse of provisional protection due to non-payment of fees |