WO2002020453A1 - Procedes de cristallisation d'acides hydroxycarboxyliques - Google Patents
Procedes de cristallisation d'acides hydroxycarboxyliques Download PDFInfo
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- WO2002020453A1 WO2002020453A1 PCT/JP2001/007762 JP0107762W WO0220453A1 WO 2002020453 A1 WO2002020453 A1 WO 2002020453A1 JP 0107762 W JP0107762 W JP 0107762W WO 0220453 A1 WO0220453 A1 WO 0220453A1
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- Prior art keywords
- water
- crystallization
- compound
- solvent
- crystallization method
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Definitions
- R 1 is C 1-5 alkyl
- R 2 is H, or C 1-5 alkyl
- R 3 and R 4 are independently selected from H or C 1-5 alkyl
- the compound (1) is a therapeutic agent for hyperlipidemia, particularly the following general formula (3)
- Z * is H, C1-5alkyl, or C-5alkyl substituted with one of the group consisting of phenyl, dimethylamino or acetylamino;
- R, a, and b are as defined above;
- R 5 is a group of highly functional drugs to limit cholesterol biosynthesis by inhibiting HMG-C o A reductase represented by H or CH 3) Is a very useful compound as a common intermediate.
- the method for obtaining the compound (1) is to obtain a solution by enzymatically hydrolyzing the side chain acryl group of the compound (2).
- Japanese Patent Publication No. EP 0486153A2 Japanese Patent Publication No. EP 0486153A2
- JP-A-56-122375 an example in which a solvent is extracted after hydrolysis with an aqueous solution
- a culture solution containing compound (1) is used.
- Example of obtaining an extraction solution by solvent extraction JP-A-6-71 No. 76, but all were obtained in solution.
- the conventional method for obtaining compound (1) had several problems in industrial use.
- the reaction solvent in the next step is limited to the solvent used in the deacylation or extraction or the mixed solvent containing the solvent unless the solvent replacement step is performed. Will be.
- handling such as transfer and storage was inconvenient, and there was a problem in using it as a versatile intermediate.
- high quality is generally required for pharmaceutical intermediates, but purification in the form of a solution is limited.For example, purification by ion exchange can be applied, but general-purpose equipment is inexpensive and has high purity. It is difficult to obtain goods.
- the present inventors have made intensive studies to solve these problems, and as a result, can obtain the compound (1) as good crystals which can avoid oiling and scaling and can be handled with good operability.
- the present inventors have found a feasible crystallization method and have completed the present invention. That is, the present invention provides a mixture of an alkali salt solution of the compound (1) represented by the general formula (1) and an organic solvent, wherein the solubility of the compound (1) at the end of crystallization is 3% by weight or less. This is a method of crystallizing the compound (1) in which the compound (1) is crystallized by acidification so as to be below.
- the present invention also provides a method for crystallizing the compound (1) by mixing a water-miscible solvent-rich solution of the compound (1) with water, wherein the oiling and the scaling of the compound (1) are previously determined.
- This is a method for crystallizing the compound (1), wherein a slurry having a suspension amount necessary for suppression is prepared, and then the present crystallization is performed in the presence of the slurry.
- the compound used in the present invention has the following formula (1)
- R represents CH 3 , CH 2 OH, CH 2 OCOR C0 2 R 2 , CONR 3 R 4 , OH, CHsOR 1 , or CH 2 NR 3 R 4 (where R 1 is C 1-5 alkyl; R 2 is H or C 1-5 alkyl, and R 3 and R 4 are independently selected from H or C 1-5 alkyl), and a and b are both a double bond , A or b is a single bond and the other is a double bond, or both a and b are single bonds. From the viewpoint of usefulness as an intermediate for a therapeutic agent for hyperlipidemia, R is preferably CH 3 or OH, particularly CH 3 , and both a and b are preferably double bonds.
- the solution of the above compound (1) or a salt thereof is generally prepared by a suitable means such as a deacylation reaction of the side chain acyl group portion of the compound (2), or extraction from a solution obtained by culture production or solvent replacement. Can be prepared.
- the compound (1) obtained as a culture product is acidified with isopropyl acetate at pH 4-4.5. After extracting as a mold, back-extracting with aqueous sodium carbonate solution of pH 1.5 to obtain an aqueous solution of the sodium salt of compound (1), and further adjusting the pH of this aqueous solution to pH 4 with phosphoric acid, Extraction with isopropyl to obtain a solution of compound (1) in isopropyl acetate.
- compound (2) is deacylated with lithium hydroxide, then acidified with phosphoric acid, and ethyl acetate.
- a solution is obtained by extraction at -122375).
- a crystallization method of the compound (1) a crystallization method by oxidizing an alkali salt solution of the compound (1) will be described.
- the alkali salt of the compound (1) used in the present crystallization method is not particularly limited, and is preferably an alkali metal salt or an amine salt, specifically, a lithium salt, a sodium salt, a potassium salt, an ammonium salt, a pyridium salt. And trimethylamine salts, triethylamine salts and the like.
- the solubility of compound (1) at the end of crystallization was 3% under the condition that an organic solvent coexisted with an alkali salt solution of compound (1).
- Crystallization is performed by acidification so as to be / 0 or less. In order to suitably carry out crystallization, it is important to coexist an organic solvent during acidification.
- solubility can be measured by an absolute calibration curve method using a standard product using high performance liquid chromatography.
- the measurement conditions at this time are shown below.
- the organic solvent to coexist is not particularly limited, hydrocarbons, ethers, S. ethers, ketones, halogenated hydrocarbons, nitriles, alcohols can be used suitably, among others C n H 2n + saturated hydrocarbons C. 5 to 12 represented by 2 or C n H 2n, an unsaturated hydrocarbon of C 5 to 12 represented by C n H 2n or C n H 2n, 2, C 6 ⁇ 12
- Aromatic hydrocarbons, C4-10 ethers, C3-10 esters, C3-10 ketones, C1-8 halogenated hydrocarbons, C2-6 double trinoles, C1-8 alcohols are more preferred, and C6-12 aromatic hydrocarbons are more preferred.
- pentane as saturated hydrocarbons C.
- Examples of 10 esters include ethyl acetate, isopropyl acetate, and butyl acetate.
- Examples of C3 to 10 ketones include acetone, methylethyl ketone, methyl isobutyl ketone, cyclohexanone, and C1 to C8.
- Halogenated hydrocarbons Dichloromethane, 1,2-dichloroethane, etc .; C2-6 nitriles, such as acetonitrile; C1-8 alcohols, methanol, ethanol, 1-propanol, 2-propanol, 1 -Butanol / t, t-ptanol / l, 1-hexanol / 2-hexanol, and the like.
- pentane normal hexane, isohexane, normal heptane, octane, methinolecyclohexane, benzene, toluene, xylene, t-peptinole methynoleether, ethynole acetate, acetone, methyl isopti / leketone, dichloromethane, acetonitrile, 2-propanol, more preferably benzene, toluene and xylene.
- the amount of the organic solvent to coexist depends on the type of the coexisting organic solvent and the concentration of the compound (1). 10 is preferable, and more preferably 0.2 to 4. Specifically, when a hydrocarbon such as hexane or an aromatic hydrocarbon such as toluene is used as the coexisting solvent, the weight ratio to the alkali salt solution of the compound (1) is 0.1. To 10 are preferred, and more preferably 0.2 to 4.
- the compound (alcohol of D) is used.
- the weight ratio to the potassium salt solution is preferably from 0.05 to 2, more preferably from 0.1 to 0.5.
- an alkali salt solution of compound (1) is oxidized in the presence of the above-mentioned organic solvent, but from the viewpoint of operability and the like, acidification is usually carried out by adding an acid to the alkali solution.
- acids to be added include inorganic acids such as sulfuric acid, hydrochloric acid, phosphoric acid, and perchloric acid; carboxylic acids such as formic acid, trifluoroacetic acid, and trichloroacetic acid; and sulfonic acids such as p-toluenesulfonic acid and methanesulfonic acid.
- the addition time of the acid can be about 5 minutes to 10 hours, but in order to obtain crystals having a large particle size and good operability such as filtration, it is usually 10 minutes or more, preferably 3 minutes or more. Requires at least 0 minutes.
- the temperature during the above acidification is particularly limited as long as compound (1) is stable and the solubility of compound (1) in the entire solution at the end of crystallization is 3% by weight or less.
- the temperature is preferably 70 ° C or less at pH 6 or less. Under an acidic condition of H5 or less, the temperature is more preferably 0 to 60 ° C.
- the alkali salt solution of the compound (1) used in the present crystallization method may be a force that is a reaction solution obtained by a deacylation reaction of the compound ( ⁇ 2) represented by the general formula (2), or may be a reaction solution.
- Post-treatment such as concentration or solvent replacement, or adjustment of pH to about 8, may be used.
- the solvent used for the reaction is not particularly limited as long as it is a solvent stable in the deacylation reaction. Usually, alcohols, ethers, water or a mixed solvent thereof can be preferably used.
- alcohols such as ethanol, 2-propanol and t-butanol, ethers such as 1,4-dioxane, water and the like can be generally preferably used, and among them, 2-propanol and t-butanol / re. Secondary and tertiary alcohols are preferred.
- the solvent used in the crystallization and the solvent used in the deacylation reaction need not be the same, and after the deacylation reaction, the reaction solvent was replaced with a solvent suitable for crystallization.
- a thing may be used.
- alcohols such as 2-propanol
- potassium hydroxide is used as the alkali
- the operation of concentrating and adding water after the reaction is performed once or more than once to obtain water. It can be substituted and preferably used as an aqueous solution of a potassium salt of compound (1).
- it can be used after neutralizing excess potassium hydroxide to adjust to an appropriate pH (for example, pH 8) if necessary.
- impurities and coloring components produced as a by-product in the deacylation reaction are removed by using an adsorbent (preferably activated carbon) or the like when performing the present crystallization method.
- an adsorbent preferably activated carbon
- This crystallization method can be used as a method for isolating and purifying compound (1) from a reaction solution, and can also be used as a method for recrystallizing compound (1).
- a crystallization method by mixing a water-miscible rich solvent solution of the above compound (1) with water will be described.
- Examples of the water-miscible good solvent for use in the present method is not particularly limited, saturated alcohols C 1 to 6, represented by C n H 2n + 2 O, represented by C n H 2n + 2 0 2 C 1-8 saturated dionoles, C n H 2n +2 ⁇ 3 represented by C 1-8 saturated triols, C n H 2n O represented by C 3-5 ketones, ethers, Nitriles can be suitably used, and among them, the above-mentioned alcohols, ketones, and nitriles are preferable.
- methanol, ethanol, 1-propanol, 2-propanol, butanol, 2-butanol, 2-methylpropanol, t-butanol, 2-methynolebutanol, 1,2-ethanediol, 1,3-propanedi Aonole, 1,5-pentanediol, acetone, methylethyl ketone, tetrahydrofuran, 1,4-dioxane, 1,2-dimethyloxetane, acetonitrile, and the like are preferable, and methanol, ethanol, 1-propanol, and 2 are more preferable.
- the water-miscible solvent solution of the compound (1) may be mixed with water by adding water to the water-miscible solvent solution of the compound (1).
- the miscible rich solvent solution may be added to water, but from the viewpoint of the quality and particle size of the obtained crystals, a method of adding water to the water miscible rich solvent solution of the compound (1) is more preferable. .
- a slurry having a suspension amount necessary to suppress oiling, scaling, and difficulty in stirring during crystallization is prepared in advance, and the present crystallization is performed in the presence of the slurry. It is characterized by the following.
- the slurry prepared in advance may be prepared by performing preliminary crystallization, or crystals of the compound (1) may be added.
- the amount of suspension required to suppress oiling, scaling, and stirring difficulties during crystallization is usually 1 weight based on the total amount of compound (1) at the end of this crystallization. /.
- the content is preferably 5 to 20% by weight, and the water-miscible solvent solution of the compound (1) is added to water. In this case, 1 to 5% by weight is preferable.
- the suspension amount indicates the weight ratio of the crystals precipitated in the slurry to the total amount of the compound (1).
- the upper limit of the amount of suspension is not particularly limited, but is usually preferably 30% by weight or less, more preferably 20% by weight or less based on the total amount of compound (1) in consideration of economy and the like.
- Preliminary crystallization for preparing a slurry in advance will be described.
- water is added to the solution of the compound (1) in a water-miscible solvent
- the mixture of the water-miscible solvent and water is adjusted to a composition in which a part of the compound (1) is precipitated, nucleated, and preliminarily crystallized. It is preferred to perform the analysis.
- a water-miscible solvent-rich solution of the compound (1) is added to water, it is preferable to add a part of the water-miscible solvent-rich solution to nucleate the mixture and perform preliminary crystallization.
- a preferable mixed composition for achieving the above suspension amount cannot be uniformly defined depending on the crystallization concentration or the kind of the solvent to be used.
- the weight ratio of the water-miscible rich solvent to water is determined by the compound (1
- 0.1 to 20 is preferable, 0.1 to 10 is more preferable, and 0.3 to 8 is further preferable.
- a water-miscible solvent-rich solution of compound (1) is added to water, 1 or less is preferable.
- 0.5 or less is more preferable.
- the lower limit in this case is usually 0.001.
- the weight ratio of the water-miscible rich solvent to water to achieve the above-mentioned suspension amount is determined by the compound (1)
- water is added to the water-miscible rich solvent solution of the above, it is preferably 0.1 to 6 and more preferably 0.2 to 5; and the water-miscible rich solvent solution of the compound (1) is added to water.
- it is preferably 0.5 or less, more preferably 0.001 to 0.2.
- water-miscible rich solvent solution of the compound (1) when water is added to the water-miscible rich solvent solution of the compound (1), it is preferably from 0.3 to 20, and more preferably. Is from 0.3 to 15. When a solution of the compound (1) in a water-miscible solvent is added to water, it is preferably 1 or less, more preferably from 0.001 to 0.5.
- the method of adding water to the water-miscible solvent solution of compound (1) water is continuously or dividedly added, and the water-miscible solution of compound (1) is added to water. In such a method, it is preferable to continuously or partly add a part of the water-miscible rich solvent solution.
- the above-mentioned continuous or divided addition time is, for example, generally 10 minutes or more, but for good nucleation and crystal growth, it is usually 30 minutes or more, preferably about 1 hour. .
- the addition time is slightly shorter than in the method of adding water to a water-miscible solvent-rich solution of compound (1).
- stirring is difficult and scaling and the like are suppressed.
- the temperature during pre-crystallization is preferably 70 ° C or less. in order to exert the maximum, more preferably 0 to 50 D C, in order to obtain a stable particle size larger crystals, more preferably 0 to 40 ° C.
- the retention time in the preliminary crystallization is not particularly limited, but usually, about 30 minutes or more after addition of a predetermined amount of water or the water-miscible solvent-rich compound (1) is sufficient.
- a method of adding a crystal of compound (1) can also be adopted.
- compound (1) mixed with water
- a crystal of the compound (1) in the method of adding water to a water-miscible rich solvent solution of the compound (1), it is usually preferable to add a crystal of the compound (1) to a mixture obtained by adding a predetermined amount of water.
- the solvent composition of the above that is, the weight ratio of the water-miscible rich solvent to water cannot be uniformly defined depending on the crystallization concentration or the kind of the solvent used, but is preferably 0.1 to 20 and more preferably 0.1 to 20. It is 3-10.
- the crystallization is carried out by adding a predetermined amount of water to the slurry.
- the compound (a) the compound (a)
- the ratio of the water-miscible rich solvent to water is finally adjusted to a predetermined ratio, so that 80% by weight or more of the total amount of the compound (1) is obtained.
- the crystals of the compound (1) of good quality can be obtained at a high recovery rate.
- the ratio of the water-miscible rich solvent to water at the end of this crystallization depends on the combination of the water-miscible rich solvent and water used and the concentration of the compound (1) used in the water-miscible rich solvent solution. From the viewpoint of productivity and the like, the weight ratio of the water-miscible rich solvent to water is preferably from 0.01 to 2, more preferably from 0.05 to 1.
- the weight ratio of the water-miscible rich solvent to water is preferably from 0.01 to 1, more preferably from 0.1 to 1. It is 0.5 to 0.7.
- the weight ratio of the water-miscible rich solvent to water is preferably from 0.01 to 3, more preferably from 0.05 to 5. Is one.
- the addition of water or a water-miscible solvent-rich solution of compound (1) in the present crystallization is preferably performed over 10 minutes or more. Preferably, the treatment is carried out for one hour or more.
- the method of adding a water-miscible solvent solution of compound (1) to water has a slightly shorter addition time than the method of adding water to a water-miscible solvent solution of compound (1). Also, there is a tendency that difficulty in stirring and scaling are suppressed.
- the temperature at the time of the main crystallization is preferably 70 ° C. or lower, more preferably 60 ° C. or lower at the start of the main crystallization, and still more preferably 30 ° C. or lower.
- the retention time in this crystallization is not particularly limited, but 30 minutes or more after addition of water or a water-miscible rich solvent solution of compound (1) is sufficient.
- a predetermined amount of total water is gradually added to the total amount of the water-miscible solvent solution of the compound (1) without preliminarily crystallization under the above-mentioned conditions.
- the ratio of the water-miscible rich solvent to water at the end of the main crystallization is adjusted to the above-mentioned preferred ratio by gradually adding the entire amount of the water-miscible rich solvent solution of 1) to a predetermined amount of water over a long period of time.
- the method can be considered to be one in which the preliminary crystallization and the main crystallization are performed continuously, and the same effect as through the preliminary crystallization can be expected.
- the obtained crystals are further cooled before being separated, and the internal temperature is set to 30 ° C or less. More preferably, the temperature is reduced to 0 to 25 ° C. to sufficiently precipitate crystals. This cooling operation can further increase the crystal recovery rate.
- the solution of the compound (1) in the water-miscible rich solvent used in the present crystallization method is obtained by dissolving the isolated compound (1) in the corresponding water-miscible rich solvent.
- a solution obtained by neutralizing the reaction solution obtained by the deacylation reaction of the compound (2) represented by 2) and filtering out and removing precipitated salts and the like may be used.
- a 55% sulfuric acid aqueous solution is used after the deacylation reaction.
- the solution is acidified to pH 3 and the salts such as potassium sulfate that precipitates out are removed by filtration, and the compound (1) in which the concentration has been adjusted can be used as a water-miscible rich solvent solution.
- impurities or coloring components contained in the water-miscible solvent-rich solution were previously subjected to an adsorbent (preferably activated carbon) before carrying out the present crystallization method. ) Is preferably removed.
- Crystals obtained by these crystallization methods are separated by a common solid-liquid separation operation such as centrifugation, pressure filtration, or vacuum filtration, and preferably after washing with a medium having a solvent composition at the end of crystallization. If necessary, drying can be performed by drying under normal pressure, drying under reduced pressure (vacuum drying), or the like.
- R is CH 3 , a and b are double bonds, 6 (R)-[2—
- 2-propanol is distilled off by pressure reduction and the same volume as 2-propanol Of ion-exchanged water twice, and 6% by weight of 7- [1,2,6,7,8,8a (R) 1-hexahydro 2 (S), 6 (R) -dimethyl
- An alkaline aqueous solution of potassium salt of 8 (S) -hydroxyl 1 (s) -naphthinole] -3 (R), 5 (R) -dihydroxyheptanoic acid (hereinafter abbreviated as TOA) was obtained.
- the precipitated TOA crystals were filtered off with a Nutsche filter under reduced pressure, and the crystals were washed with a small amount of a 30% aqueous solution of 2-propanol (2-propanol to water at the end of the main crystallization). The weight ratio is 0.43).
- the obtained crystals were dried under vacuum at 40 ° C overnight and analyzed by high performance liquid chromatography. The purity of the obtained crystals was 98.8% and the recovery was 81%.
- the precipitated TOA crystals were collected by filtration with a Nutsche filter under reduced pressure, and the crystals were washed with a small amount of 40% acetone aqueous solution (weight of acetone relative to water at the end of the main crystallization). The ratio is 0.66).
- the obtained crystals were dried under vacuum at 40 ° C overnight, and analyzed by high performance liquid chromatography. The purity of the obtained crystals was 99.0%, and the recovery was 84%.
- the compound (1) of good quality can be obtained by a simple operation as a crystal
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Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL361205A PL205567B1 (pl) | 2000-09-07 | 2001-09-07 | Sposoby krystalizacji kwasów hydroksykarboksylowych |
JP2002525079A JP4870320B2 (ja) | 2000-09-07 | 2001-09-07 | ヒドロキシカルボン酸の結晶化法 |
IL15471801A IL154718A0 (en) | 2000-09-07 | 2001-09-07 | Methods for crystallization of hydroxycarboxylic acids |
HU0302929A HUP0302929A3 (en) | 2000-09-07 | 2001-09-07 | Methods for crystallization of hydroxycarboxylic acids |
DE60139264T DE60139264D1 (de) | 2000-09-07 | 2001-09-07 | Verfahren zur kristallisation von hydroxycarbonsäuren |
EP01963496A EP1323701B1 (en) | 2000-09-07 | 2001-09-07 | Methods for crystallization of hydroxycarboxylic acids |
SI200130943T SI1323701T1 (sl) | 2000-09-07 | 2001-09-07 | Postopki za kristalizacijo hidroksikarboksilnih kislin |
AU2001284469A AU2001284469A1 (en) | 2000-09-07 | 2001-09-07 | Methods for crystallization of hydroxycarboxylic acids |
US10/362,460 US7034180B2 (en) | 2000-09-07 | 2001-09-07 | Method for crystallization of hydroxycarboxylic acids |
IL154718A IL154718A (en) | 2000-09-07 | 2003-03-03 | Methods for the formation of hydroxycarboxylic acids |
US11/276,306 US7323592B2 (en) | 2000-09-07 | 2006-02-23 | Methods for crystallization of hydroxycarboxylic acids |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2000-271895 | 2000-09-07 | ||
JP2000271895 | 2000-09-07 |
Related Child Applications (2)
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US10362460 A-371-Of-International | 2001-09-07 | ||
US11/276,306 Division US7323592B2 (en) | 2000-09-07 | 2006-02-23 | Methods for crystallization of hydroxycarboxylic acids |
Publications (1)
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WO2002020453A1 true WO2002020453A1 (fr) | 2002-03-14 |
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PCT/JP2001/007762 WO2002020453A1 (fr) | 2000-09-07 | 2001-09-07 | Procedes de cristallisation d'acides hydroxycarboxyliques |
Country Status (13)
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US (2) | US7034180B2 (ja) |
EP (1) | EP1323701B1 (ja) |
JP (2) | JP4870320B2 (ja) |
AU (1) | AU2001284469A1 (ja) |
CZ (1) | CZ303774B6 (ja) |
DE (1) | DE60139264D1 (ja) |
ES (1) | ES2329974T3 (ja) |
HU (1) | HUP0302929A3 (ja) |
IL (2) | IL154718A0 (ja) |
PL (1) | PL205567B1 (ja) |
SI (1) | SI1323701T1 (ja) |
TW (1) | TWI301483B (ja) |
WO (1) | WO2002020453A1 (ja) |
Cited By (1)
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JP2006523210A (ja) * | 2003-03-17 | 2006-10-12 | ファーミオン・コーポレーション | 5−アザシチジンの結晶形iの分離方法 |
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US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
KR101322116B1 (ko) | 2006-07-20 | 2013-10-25 | 아사히 가세이 파마 가부시키가이샤 | 치환 페닐알칸산의 신규 결정 및 제조 방법 |
JP2011016790A (ja) | 2009-06-08 | 2011-01-27 | Sumitomo Chemical Co Ltd | ピラゾリノン誘導体の精製方法 |
CN101973904B (zh) * | 2010-09-28 | 2014-01-01 | 雅本化学股份有限公司 | 一种具有高光学纯度的n2-[1-(s)-乙氧羰基-3-苯丙基]-n6-三氟乙酰基-l-赖氨酸的制备方法 |
CZ26507U1 (cs) | 2013-10-03 | 2014-02-24 | Hedviga Group, A.S. | Zařízení pro úpravu a regulaci plynů pro spalovací zařízení |
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2001
- 2001-09-07 DE DE60139264T patent/DE60139264D1/de not_active Expired - Lifetime
- 2001-09-07 IL IL15471801A patent/IL154718A0/xx active IP Right Grant
- 2001-09-07 US US10/362,460 patent/US7034180B2/en not_active Expired - Fee Related
- 2001-09-07 ES ES01963496T patent/ES2329974T3/es not_active Expired - Lifetime
- 2001-09-07 CZ CZ20030677A patent/CZ303774B6/cs not_active IP Right Cessation
- 2001-09-07 HU HU0302929A patent/HUP0302929A3/hu unknown
- 2001-09-07 PL PL361205A patent/PL205567B1/pl unknown
- 2001-09-07 SI SI200130943T patent/SI1323701T1/sl unknown
- 2001-09-07 AU AU2001284469A patent/AU2001284469A1/en not_active Abandoned
- 2001-09-07 WO PCT/JP2001/007762 patent/WO2002020453A1/ja active Application Filing
- 2001-09-07 TW TW090122172A patent/TWI301483B/zh not_active IP Right Cessation
- 2001-09-07 JP JP2002525079A patent/JP4870320B2/ja not_active Expired - Fee Related
- 2001-09-07 EP EP01963496A patent/EP1323701B1/en not_active Expired - Lifetime
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2003
- 2003-03-03 IL IL154718A patent/IL154718A/en not_active IP Right Cessation
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2006
- 2006-02-23 US US11/276,306 patent/US7323592B2/en not_active Expired - Fee Related
-
2011
- 2011-08-30 JP JP2011187565A patent/JP5357226B2/ja not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0033538A2 (en) * | 1980-02-04 | 1981-08-12 | Merck & Co. Inc. | 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same |
JPS56122375A (en) | 1980-02-04 | 1981-09-25 | Merck & Co Inc | Novel antihypercholesteremic compound* its intermediate and its manufacture |
JPS56142236A (en) * | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
JPS56150037A (en) * | 1980-04-22 | 1981-11-20 | Sankyo Co Ltd | Hydronaphthalene compound |
EP0486153A2 (en) | 1990-10-15 | 1992-05-20 | Merck & Co. Inc. | Enzymatic hydrolysis of lovastatin acid using an enzyme derived from Clonostachys compactiuscula |
JPH067176A (ja) | 1991-06-04 | 1994-01-18 | Merck & Co Inc | アスペルギルス・テレウスの変異株によるトリオール酸(i)の新規発酵 |
Non-Patent Citations (1)
Title |
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See also references of EP1323701A4 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006523210A (ja) * | 2003-03-17 | 2006-10-12 | ファーミオン・コーポレーション | 5−アザシチジンの結晶形iの分離方法 |
JP4792550B2 (ja) * | 2003-03-17 | 2011-10-12 | セルジーン・インターナショナル・ソシエテ・ア・レスポンサビリテ・リミテ | 5−アザシチジンの結晶形iの分離方法 |
Also Published As
Publication number | Publication date |
---|---|
US20050075508A1 (en) | 2005-04-07 |
JP2012025757A (ja) | 2012-02-09 |
JP5357226B2 (ja) | 2013-12-04 |
US20060149098A1 (en) | 2006-07-06 |
IL154718A0 (en) | 2003-10-31 |
EP1323701B1 (en) | 2009-07-15 |
DE60139264D1 (de) | 2009-08-27 |
CZ303774B6 (cs) | 2013-05-02 |
PL361205A1 (en) | 2004-09-20 |
EP1323701A1 (en) | 2003-07-02 |
HUP0302929A2 (hu) | 2003-12-29 |
EP1323701A4 (en) | 2005-11-23 |
JP4870320B2 (ja) | 2012-02-08 |
AU2001284469A1 (en) | 2002-03-22 |
PL205567B1 (pl) | 2010-05-31 |
IL154718A (en) | 2009-02-11 |
US7323592B2 (en) | 2008-01-29 |
HUP0302929A3 (en) | 2004-10-28 |
US7034180B2 (en) | 2006-04-25 |
SI1323701T1 (sl) | 2009-12-31 |
ES2329974T3 (es) | 2009-12-03 |
TWI301483B (ja) | 2008-10-01 |
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