DE60027877D1 - Verfahren zur schnellen herstellung von crystallen mit wünschenswerter morphologie - Google Patents

Verfahren zur schnellen herstellung von crystallen mit wünschenswerter morphologie

Info

Publication number
DE60027877D1
DE60027877D1 DE60027877T DE60027877T DE60027877D1 DE 60027877 D1 DE60027877 D1 DE 60027877D1 DE 60027877 T DE60027877 T DE 60027877T DE 60027877 T DE60027877 T DE 60027877T DE 60027877 D1 DE60027877 D1 DE 60027877D1
Authority
DE
Germany
Prior art keywords
desirable
crystalles
crystallization
morphology
desirable morphology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60027877T
Other languages
English (en)
Other versions
DE60027877T2 (de
Inventor
Hong Heng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Danisco US Inc
Original Assignee
Genencor International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor International Inc filed Critical Genencor International Inc
Publication of DE60027877D1 publication Critical patent/DE60027877D1/de
Application granted granted Critical
Publication of DE60027877T2 publication Critical patent/DE60027877T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/816—Enzyme separation or purification by solubility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Metallurgy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Silicon Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
DE60027877T 1999-03-05 2000-03-03 Verfahren zur schnellen herstellung von crystallen mit wünschenswerter morphologie Expired - Lifetime DE60027877T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12314799P 1999-03-05 1999-03-05
US123147P 1999-03-05
PCT/US2000/005564 WO2000052150A1 (en) 1999-03-05 2000-03-03 Method for rapidly obtaining crystals with desirable morphologies

Publications (2)

Publication Number Publication Date
DE60027877D1 true DE60027877D1 (de) 2006-06-14
DE60027877T2 DE60027877T2 (de) 2006-12-28

Family

ID=22406974

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027877T Expired - Lifetime DE60027877T2 (de) 1999-03-05 2000-03-03 Verfahren zur schnellen herstellung von crystallen mit wünschenswerter morphologie

Country Status (12)

Country Link
US (2) US6403350B1 (de)
EP (1) EP1159410B1 (de)
JP (1) JP2002537804A (de)
CN (1) CN1342198A (de)
AT (1) ATE325868T1 (de)
AU (1) AU3393800A (de)
CA (1) CA2361507C (de)
DE (1) DE60027877T2 (de)
DK (1) DK1159410T3 (de)
MX (1) MXPA01008715A (de)
NZ (1) NZ513163A (de)
WO (1) WO2000052150A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1345968A2 (de) 2000-12-28 2003-09-24 Altus Biologics Inc. Kristalle ganzer antikörper und fragmente davon und verfahren zu ihrer herstellung und verwendung
CA2451185A1 (en) 2001-06-21 2003-01-03 Altus Biologics, Inc. Spherical protein particles and methods of making and using them
EP1664398A4 (de) * 2003-09-03 2009-08-26 Shmuel Bukshpan Verfahren und vorrichtung zur schnellen kristallisation von biomolekülen
US20080300790A1 (en) * 2007-05-29 2008-12-04 James Kirunda Kakaire Environmental data delivery - edd
US9138659B2 (en) 2010-08-23 2015-09-22 Massachusetts Institute Of Technology Compositions, methods, and systems relating to controlled crystallization and/or nucleation of molecular species
US9822467B2 (en) 2011-11-15 2017-11-21 Massachusetts Institute Of Technology Methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species
CN103642772B (zh) * 2013-12-09 2017-02-15 中国水产科学研究院黄海水产研究所 一种海洋低温碱性脂肪酶Bohai Sea‑9145晶体及其制备方法
WO2016201040A1 (en) 2015-06-09 2016-12-15 Danisco Us Inc. Water-triggered enzyme suspension
EP3983425A1 (de) 2019-06-13 2022-04-20 Basf Se Verfahren zur rückgewinnung eines proteins aus fermentationsbrühe mithilfe eines divalenten kations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659667A (en) * 1985-02-26 1987-04-21 Miles Laboratories, Inc. Process to recover crystalline enzymes and crystalline enzymes produced thereby
EP0404817B1 (de) * 1988-03-18 1994-11-30 Genencor International, Inc. Verfahren zur kristallisation von subtilisin
ES2060360T3 (es) * 1989-12-21 1994-11-16 Novo Nordisk As Metodo para la cristalizacion de enzimas.
US5441734A (en) 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
US6190898B1 (en) 1995-10-23 2001-02-20 Genencor International, Inc. Crystalline cellulase and method for producing same
US6207437B1 (en) 1996-03-11 2001-03-27 Genencor International, Inc. Crystalline protease and method for producing same

Also Published As

Publication number Publication date
CA2361507A1 (en) 2000-09-08
JP2002537804A (ja) 2002-11-12
EP1159410A1 (de) 2001-12-05
US6403350B1 (en) 2002-06-11
NZ513163A (en) 2004-02-27
US6593118B2 (en) 2003-07-15
ATE325868T1 (de) 2006-06-15
DK1159410T3 (da) 2006-09-18
EP1159410B1 (de) 2006-05-10
DE60027877T2 (de) 2006-12-28
MXPA01008715A (es) 2002-07-30
US20020177206A1 (en) 2002-11-28
WO2000052150A1 (en) 2000-09-08
CN1342198A (zh) 2002-03-27
CA2361507C (en) 2014-05-06
AU3393800A (en) 2000-09-21

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