HUP0302508A2 - Piridazinon- és triazinonszármazékok, valamint alkalmazásuk gyógyászati készítmények hatóanyagaiként - Google Patents
Piridazinon- és triazinonszármazékok, valamint alkalmazásuk gyógyászati készítmények hatóanyagaikéntInfo
- Publication number
- HUP0302508A2 HUP0302508A2 HU0302508A HUP0302508A HUP0302508A2 HU P0302508 A2 HUP0302508 A2 HU P0302508A2 HU 0302508 A HU0302508 A HU 0302508A HU P0302508 A HUP0302508 A HU P0302508A HU P0302508 A2 HUP0302508 A2 HU P0302508A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally
- atom
- substituted
- independently
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- QMNWYGTWTXOQTP-UHFFFAOYSA-N 1h-triazin-6-one Chemical class O=C1C=CN=NN1 QMNWYGTWTXOQTP-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- YQYUWUKDEVZFDB-UHFFFAOYSA-N mmda Chemical compound COC1=CC(CC(C)N)=CC2=C1OCO2 YQYUWUKDEVZFDB-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 108091006082 receptor inhibitors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000005156 substituted alkylene group Chemical group 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány új piridazinon- és triazinonszármazékokra, ezek sóira éshidrátjaira, ilyen vegyületek előállítására, valamint ilyenvegyületeknek gyógyászati készítmények előállításánál valóalkalmazására vonatkozik. Közelebbről a találmány szerintipiridazinon- és triazinon-származékok mint úgynevezett nem-MMDA-receptor inhibitorok, különösen mint AMPA-receptor inhibitorokhasznosíthatók. A találmány szerinti vegyületek (I) általánosképletében A1, A2 és A3 jelentése egymástól függetlenül cikloalkil-,cikloalkenil-, nemaromás heterociklusos csoport, aromás gyűrűsszénhidrogéncsoport vagy aromás heterociklusos csoport és ezek acsoportok mindegyike helyettesített lehet; Q jelentése oxigén- vagykénatom vagy iminocsoport; Z jelentése szénatom vagy nitrogénatom; X1,X2 és X3 jelentése egymástól függetlenül egyszeres kémiai kötés, adottesetben szubsztituált alkiléncsoport, adott esetben szubsztituáltalkeniléncsoport, adott esetben szubsztituált alkiniléncsoport,oxigénatom, iminocsoport vagy -N(R4)CO-, -CON(R5)-, -N(R6)CH2-, -CH2N(R7)-, -CH2CO-, -COCH2-, -N(R8)SO0-2-, -SO0-2N(R9)-, -CH2SO0-2-, -SO0-2CH2-, -CH2O-, -OCH2-, -N(R10)CON(R11)-, -N(R12)CS-N(R13)- vagy -SO0-2- általános képletű csoport (ezekben a képletekben R4, R5, R6,R7, R8, R9, R10, R11, R12 és R13 jelentése egymástól függetlenülhidrogénatom, alkilcsoport vagy alkoxicsoport); R1 és R2 jelentéseegymástól függetlenül hidrogénatom, adott esetben szubsztituáltalkil-, alkenil- vagy alkinilcsoport, vagy R1 és R2 együtt összevannak kapcsolva úgy, hogy a CR2-ZR1 molekularész C=C jelölésű szén-szén kettőskötést képez (azzal a megkötéssel, hogy ha Z jelentésenitrogénatom, akkor R1 magányos elektronpárt jelent); R3 jelentésehidrogénatom, adott esetben szubsztituált alkil-, alkenil- vagyalkinilcsoport, vagy A1 vagy A3 jelentésén belül bármelyik atomhozkapcsolódhat ezzel az atommal együtt adott esetben szubsztituáltszénhidrogén-gyűrűt vagy adott esetben szubsztituált heterociklusosgyűrűt képezve, megkötésekkel. Ó
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000282636 | 2000-09-18 | ||
| JP2000289412 | 2000-09-22 | ||
| JP2000342614 | 2000-11-09 | ||
| GB0102824A GB0102824D0 (en) | 2001-02-05 | 2001-02-05 | Triazinone compounds process for producing the same and pharmaceuticals thereof |
| GB0102822A GB0102822D0 (en) | 2001-02-05 | 2001-02-05 | Pyridazinone compounds manufacturing methods thereof and pharmaceuticals thereof |
| PCT/JP2001/008058 WO2002022587A1 (fr) | 2000-09-18 | 2001-09-17 | Pyridazinones et triazinones ainsi que leur utilisation medicale |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0302508A2 true HUP0302508A2 (hu) | 2003-12-29 |
| HUP0302508A3 HUP0302508A3 (en) | 2007-03-28 |
| HU228961B1 HU228961B1 (en) | 2013-07-29 |
Family
ID=27516005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302508A HU228961B1 (en) | 2000-09-18 | 2001-09-17 | Triazinones and their use as active ingredients of pharmaceutical compositions |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20030225081A1 (hu) |
| EP (1) | EP1319659B1 (hu) |
| JP (2) | JP4233868B2 (hu) |
| KR (1) | KR100770327B1 (hu) |
| CN (1) | CN100473647C (hu) |
| AT (1) | ATE425148T1 (hu) |
| AU (2) | AU9022901A (hu) |
| CA (2) | CA2742411A1 (hu) |
| DE (1) | DE60137948D1 (hu) |
| HU (1) | HU228961B1 (hu) |
| IL (2) | IL154709A0 (hu) |
| MX (1) | MXPA03002324A (hu) |
| NO (1) | NO327813B1 (hu) |
| NZ (1) | NZ524745A (hu) |
| TW (1) | TWI262915B (hu) |
| WO (1) | WO2002022587A1 (hu) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861428B2 (en) * | 2001-09-26 | 2005-03-01 | Kowa Co., Ltd. | Water-soluble phenylpyridazine compounds and compositions containing the same |
| PL368340A1 (en) * | 2001-09-26 | 2005-03-21 | Kowa Co, Ltd. | Water-soluble phenylpyridazine derivatives and drugs containing the same |
| US7309701B2 (en) | 2002-11-19 | 2007-12-18 | Sanofi-Aventis Deutschland Gmbh | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
| FR2847253B1 (fr) * | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
| US7462613B2 (en) | 2002-11-19 | 2008-12-09 | Sanofi-Aventis Deutschland Gmbh | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
| AU2006232517A1 (en) * | 2005-04-04 | 2006-10-12 | Eisai R&D Management Co., Ltd. | Dihydropyridine compounds and compositions for headaches |
| RS53599B1 (en) | 2005-05-10 | 2015-02-27 | Intermune, Inc. | PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS |
| EP1953147A1 (en) * | 2005-11-21 | 2008-08-06 | Japan Tobacco, Inc. | Heterocyclic compound and medicinal application thereof |
| DE602006020330D1 (de) * | 2005-12-07 | 2011-04-07 | Sumitomo Chemical Co | Pyridazinverbindung und deren verwendung |
| KR20090114371A (ko) * | 2007-01-29 | 2009-11-03 | 코와 가부시키가이샤 | 다발성 경화증 치료제 |
| JP2010520154A (ja) * | 2007-03-05 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経変性疾患のためのａｍｐａレセプターアンタゴニストおよびｎｍｄａレセプターアンタゴニスト |
| WO2008139984A1 (en) * | 2007-04-26 | 2008-11-20 | Eisai R & D Management Co., Ltd. | Cinnamide compounds for dementia |
| CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| UA103918C2 (en) | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP2951157A1 (en) | 2013-02-04 | 2015-12-09 | Merck Patent GmbH | Positive allosteric modulators of mglur3 |
| US8877766B2 (en) * | 2013-02-15 | 2014-11-04 | Peter F. Kador | Neuroprotective multifunctional antioxidants and their monofunctional analogs |
| KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
| WO2016051799A1 (ja) * | 2014-10-01 | 2016-04-07 | 学校法人同志社 | ２－アミノヒドロキノン誘導体及びタウ凝集阻害剤 |
| CN106146404B (zh) * | 2015-04-15 | 2020-03-20 | 江苏恩华药业股份有限公司 | 哒嗪酮类衍生物及其应用 |
| CA3002930A1 (en) | 2015-11-13 | 2017-05-18 | Eisai R&D Management Co., Ltd. | Pyranodipyridine compound |
| PE20190509A1 (es) * | 2016-05-25 | 2019-04-10 | Bayer Pharma AG | 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas |
| JOP20190193A1 (ar) | 2017-02-09 | 2019-08-08 | Bayer Pharma AG | ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان |
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| US3014034A (en) * | 1959-01-22 | 1961-12-19 | Ciba Pharm Prod Inc | 1, 3-diaryl, 5-amino-pyridazinones |
| US3018034A (en) * | 1959-11-17 | 1962-01-23 | Gen Applied Science Lab Inc | Propulsion device for vertical takeoff aircraft |
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| DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0478195B1 (en) * | 1990-09-21 | 1999-05-26 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones as fungicides |
| GB9206266D0 (en) * | 1992-03-23 | 1992-05-06 | Merck Sharp & Dohme | Therapeutic agents |
| US5356902A (en) * | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| IL115889A0 (en) * | 1994-11-14 | 1996-01-31 | Rohm & Haas | Pyridazinones and their use as fungicides |
| DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| IL123340A0 (en) * | 1997-02-20 | 1998-09-24 | Sumitomo Chemical Co | Pyridazin-3-one derivatives and their use |
| TWI241295B (en) * | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| JP2000119257A (ja) * | 1998-08-14 | 2000-04-25 | Nippon Nohyaku Co Ltd | ピリダジノン誘導体 |
| KR100657189B1 (ko) * | 1998-08-14 | 2006-12-14 | 니혼노야쿠가부시키가이샤 | 피리다지논 유도체 및 이를 함유하는 의약 조성물 |
| JP2000247959A (ja) * | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−３−オン誘導体及びこれを含有する医薬 |
| KR100344790B1 (ko) * | 1999-10-07 | 2002-07-19 | 엘지전자주식회사 | 마이크로 기계구조를 이용한 주파수 가변 초고주파 필터 |
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2001
- 2001-09-17 HU HU0302508A patent/HU228961B1/hu not_active IP Right Cessation
- 2001-09-17 AT AT01970120T patent/ATE425148T1/de not_active IP Right Cessation
- 2001-09-17 CA CA2742411A patent/CA2742411A1/en not_active Abandoned
- 2001-09-17 CN CNB018158803A patent/CN100473647C/zh not_active Expired - Fee Related
- 2001-09-17 EP EP01970120A patent/EP1319659B1/en not_active Expired - Lifetime
- 2001-09-17 US US10/380,783 patent/US20030225081A1/en not_active Abandoned
- 2001-09-17 KR KR1020037003807A patent/KR100770327B1/ko not_active IP Right Cessation
- 2001-09-17 MX MXPA03002324A patent/MXPA03002324A/es active IP Right Grant
- 2001-09-17 CA CA2422589A patent/CA2422589C/en not_active Expired - Fee Related
- 2001-09-17 AU AU9022901A patent/AU9022901A/xx active Pending
- 2001-09-17 IL IL15470901A patent/IL154709A0/xx active IP Right Grant
- 2001-09-17 WO PCT/JP2001/008058 patent/WO2002022587A1/ja active Application Filing
- 2001-09-17 DE DE60137948T patent/DE60137948D1/de not_active Expired - Lifetime
- 2001-09-17 NZ NZ524745A patent/NZ524745A/en not_active IP Right Cessation
- 2001-09-17 JP JP2002526840A patent/JP4233868B2/ja not_active Expired - Fee Related
- 2001-09-17 AU AU2001290229A patent/AU2001290229B2/en not_active Ceased
- 2001-09-19 TW TW090123425A patent/TWI262915B/zh not_active IP Right Cessation
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2003
- 2003-03-03 IL IL154709A patent/IL154709A/en not_active IP Right Cessation
- 2003-03-17 NO NO20031232A patent/NO327813B1/no not_active IP Right Cessation
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2006
- 2006-04-21 US US11/408,078 patent/US20060189622A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2002022587A1 (fr) | 2002-03-21 |
| IL154709A0 (en) | 2003-10-31 |
| CN100473647C (zh) | 2009-04-01 |
| KR100770327B1 (ko) | 2007-10-25 |
| HUP0302508A3 (en) | 2007-03-28 |
| AU9022901A (en) | 2002-03-26 |
| CA2422589C (en) | 2011-08-09 |
| EP1319659B1 (en) | 2009-03-11 |
| DE60137948D1 (de) | 2009-04-23 |
| NZ524745A (en) | 2006-01-27 |
| CA2742411A1 (en) | 2002-03-21 |
| JP4233868B2 (ja) | 2009-03-04 |
| EP1319659A1 (en) | 2003-06-18 |
| JPWO2002022587A1 (ja) | 2004-01-22 |
| KR20030030007A (ko) | 2003-04-16 |
| MXPA03002324A (es) | 2003-06-06 |
| US20030225081A1 (en) | 2003-12-04 |
| NO327813B1 (no) | 2009-09-28 |
| NO20031232L (no) | 2003-05-19 |
| HU228961B1 (en) | 2013-07-29 |
| EP1319659A4 (en) | 2005-08-10 |
| US20060189622A1 (en) | 2006-08-24 |
| NO20031232D0 (no) | 2003-03-17 |
| CN1458924A (zh) | 2003-11-26 |
| AU2001290229B2 (en) | 2006-12-07 |
| CA2422589A1 (en) | 2003-03-17 |
| JP2009007356A (ja) | 2009-01-15 |
| IL154709A (en) | 2007-09-20 |
| JP4906790B2 (ja) | 2012-03-28 |
| ATE425148T1 (de) | 2009-03-15 |
| TWI262915B (en) | 2006-10-01 |
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