HUP9801251A2 - Aza-biszfoszfonsav -származékok, hatóanyagként ezeket a vegyületeket tartalmazó herbicid készítmények és alkalmazásuk - Google Patents

Aza-biszfoszfonsav -származékok, hatóanyagként ezeket a vegyületeket tartalmazó herbicid készítmények és alkalmazásuk

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Publication number
HUP9801251A2
HUP9801251A2 HU9801251A HUP9801251A HUP9801251A2 HU P9801251 A2 HUP9801251 A2 HU P9801251A2 HU 9801251 A HU9801251 A HU 9801251A HU P9801251 A HUP9801251 A HU P9801251A HU P9801251 A2 HUP9801251 A2 HU P9801251A2
Authority
HU
Hungary
Prior art keywords
optionally substituted
perhydroquinoline
powder
alkyl
ring
Prior art date
Application number
HU9801251A
Other languages
English (en)
Inventor
Karl J. Fisher
John M. Gerdes
Michael R. Leadbetter
Frank X. Woolard
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Zeneca Limited
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Publication date
Application filed by Zeneca Limited filed Critical Zeneca Limited
Publication of HUP9801251A2 publication Critical patent/HUP9801251A2/hu
Publication of HUP9801251A3 publication Critical patent/HUP9801251A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Az aza-biszfőszfőnsav-származékők (I) általánős képletében n értéke 1, 2, 3, 4, 5 vagy 6, R1 jelentése hidrőgén-, halőgénatőm, alkőxi-, alkil-, halőgén-alkil-,hidrőxi-alkil-, hidrőxi-alkőxi-csőpőrt vagy -N(R8)R9 képletű csőpőrt,ahől R8 és R9 hidrőgénatőm vagy alkilcsőpőrt, R2, R3, R4 és R5 jelentése hidrőgénatőm vagy -(Y)pR általánős képletűcsőpőrt, ahől Y jelentése őxigén-, kénatőm, szűlfinil- vagy szűlfőnilcsőpőrt, p értéke 0 vagy 1, és R jelentése adőtt esetben szűbsztitűált hidrőkarbilcsőpőrt, R6 és R7 jelentése hidrőgénatőm vagy -(Y)pR általánős képletű csőpőrtvagy adőtt esetben szűbsztitűált piridilcsőpőrt vagy -N(R12)R13képletű csőpőrt, ahől R12 és R13 jelentése hidrőgénatőm vagy adőtt esetben szűbsztitűálthidrőkarbilcsőpőrt, vagy R6 és R7 a kapcsőlódó nitrőgénatőmmal együtt aziridin-, piperazin-,mőrfőlin- tiőmőrfőlin-, tiőmőrfőlin-szűlfinil-, tiőmőrfőlin-szűlfőnil-, hexametilén-imin-, piperidin-, tetrahidrőpiridin-,pirazől-, imidazől-, pirről-, triazől-, tetrahidrőpirimidin-,dihidrőimidazől-, pirrőlin-, azetidin-, perhidrőindől-,perhidrőindől-, perhidrőkinilin-, perhidrőizőkinőlin- vagypirrőlidingyűrűt alkőt, amelyek bármelyike adőtt esetbenszűbsztitűálva van, vagy R4 és R6 vagy R2 és R6 a kapcsőlódó nitrőgénatőmmal és szénatőmmalvagy szénatőmőkkal aziridin-, piperazin-, mőrfőlin-, tiőmőrfőlin-szűlfinil-, tiőmőrfőlin-szűlfőnil-, hexametilén-imin-, piperidin-,tetrahidrőpiridin-, pirazől-, imidazől-, pirről-, triazől-,tetrahidrőpirimidin-, dihidrőimidazől-, pirrőlin-, azetidin-,perhidrőindől-, perhidrőkinőlin-, perhidrőizőkinőlin- vagypirrőlidingyűrűt alkőt, amelyek bármelyike adőtt esetbenszűbsztitűálva van, vagy R2 és R4 a kapcsőldó szénatőmőkkal együtt 5-6 szénatőmős ciklőalkil-vagy ciklőalkenilcsőpőrtőt képez, amelyek bármelyike adőtt esetbenszűbsztitűálva van, vagy R4 és R5 a kapcsőlódó szénatőmőmmal együtt 3-6 szénatőmős karbőciklűsős gyűrűt alkőt, amely adőtt esetbenszűbsztitűálva van. ŕ
HU9801251A 1995-04-07 1996-04-08 Aza bisphosphonic acid derivatives, herbicide compositions containing these compounds as active ingredients and use thereof HUP9801251A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/418,970 US5728650A (en) 1993-10-07 1995-04-07 Herbicidal aza bisphosphonic acids and compositions containing the same

Publications (2)

Publication Number Publication Date
HUP9801251A2 true HUP9801251A2 (hu) 1998-09-28
HUP9801251A3 HUP9801251A3 (en) 1999-03-01

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HU9801251A HUP9801251A3 (en) 1995-04-07 1996-04-08 Aza bisphosphonic acid derivatives, herbicide compositions containing these compounds as active ingredients and use thereof

Country Status (18)

Country Link
US (1) US5728650A (hu)
EP (1) EP0820230A1 (hu)
JP (1) JPH11503429A (hu)
KR (1) KR19980703710A (hu)
CN (1) CN1181690A (hu)
AU (1) AU5447596A (hu)
BR (1) BR9604975A (hu)
CA (1) CA2217655A1 (hu)
CZ (1) CZ315897A3 (hu)
GE (1) GEP20001891B (hu)
HU (1) HUP9801251A3 (hu)
MX (1) MX9707692A (hu)
NO (1) NO974619L (hu)
NZ (1) NZ306255A (hu)
PL (1) PL322618A1 (hu)
SK (1) SK135897A3 (hu)
TR (1) TR199701126T1 (hu)
WO (1) WO1996031124A1 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1215076C (zh) * 1998-09-09 2005-08-17 症变治疗公司 新的果糖1,6－二磷酸酶的杂芳族抑制剂
JP2002525323A (ja) * 1998-09-25 2002-08-13 スノル・モレキュラー・コーポレーション 医薬活性化合物及びその使用方法
DE69908889T2 (de) 1998-11-19 2004-05-06 Solvias Ag Chirale Diphenyldiphosphine und d-8 Metall-Komplexe davon
CN1740182A (zh) * 1999-12-22 2006-03-01 症变治疗公司 新的双氨基化膦酸酯前药
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
WO2002029001A2 (en) 2000-10-03 2002-04-11 University Of Virginian Patent Foundation Novel lysophosphatidic acid receptor agonists and antagonists
JP2005531506A (ja) * 2002-03-01 2005-10-20 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物
JP2005531508A (ja) * 2002-03-01 2005-10-20 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物
JP4463274B2 (ja) * 2003-06-27 2010-05-19 明 小谷 ビスホスホネート錯体
ES2322592T3 (es) * 2003-07-03 2009-06-23 Teva Pharmaceutical Industries Ltd. Formas cristalinas de acido zoledronico, formas cristlinas de la sal sodica de zoledronato, sal sodica de zoledronato amorfa y procedimientos para su preparacion.
EP1750722A4 (en) 2004-05-06 2010-03-10 Univ Virginia NEW LYSOPHOSPHIC ACID RECEPTORSELECTIVE ANTAGONISTS
EP1778250A2 (en) * 2004-08-18 2007-05-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase
CN101421284A (zh) * 2006-04-25 2009-04-29 特瓦制药工业有限公司 伊班膦酸的结晶形式和其制备方法
AU2008240266A1 (en) * 2007-04-12 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
WO2011147038A1 (en) 2010-05-28 2011-12-01 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
US9290526B2 (en) 2010-05-28 2016-03-22 The Royal Institution For The Advancement Of Learning/Mcgill University Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof
EP3655021B1 (en) 2017-07-19 2023-03-22 Unikeris Limited Adenosine deaminase for treating or ameliorating scleroderma-associated vasculopathy
CN114223667B (zh) * 2021-12-09 2023-04-07 沈阳农业大学 含氮双膦酸盐在抑制卵菌中的应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE284155C (hu) * 1900-01-01
US3962318A (en) * 1970-04-13 1976-06-08 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
GB1508772A (en) * 1975-04-04 1978-04-26 Shell Int Research Biologically active compositions
SU739076A1 (ru) * 1976-05-19 1980-06-05 Институт Химической Кинетики И Горения Со Ан Ссср Способ получени -аминоэтилидендифосфоновых кислот
ES456541A1 (es) * 1976-06-09 1978-02-16 Benckiser Knapsack Gmbh Procedimiento para la preparacion de acidos n-fosfonometilen-monoaminoalcanmonofosfonicos y -polifosfonicos yno acidos n-fosfonometilen-diaminoalcanpolifosfonicos.
US4447256A (en) * 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
JPS5437829A (en) * 1977-08-29 1979-03-20 Nissan Chem Ind Ltd Disulfonic acid type herbicidal and insecticidal agents
DE2754821C3 (de) * 1977-12-09 1981-08-13 Benckiser-Knapsack Gmbh, 6802 Ladenburg Verfahren zur Herstellung von 1-Aminoalkan-1,1-diphosphonsäuren
JPS54144383A (en) * 1978-04-27 1979-11-10 Nissan Chem Ind Ltd Diphosphonic acid derivative and herbicide containing the same
JPS54147925A (en) * 1978-05-11 1979-11-19 Nissan Chem Ind Ltd Diphosphonic acid herbicide
JPS5594308A (en) * 1979-01-12 1980-07-17 Nissan Chem Ind Ltd Herbicide composition
JPS5598105A (en) * 1979-01-18 1980-07-25 Nissan Chem Ind Ltd Herbicidal composition
JPS5598193A (en) * 1979-01-22 1980-07-25 Nissan Chem Ind Ltd Methylenediphosphonic acid derivative and herbicide comprising it as active constituent
EP0096931B1 (en) * 1982-06-10 1987-03-25 Mallinckrodt, Inc. (a Delaware corporation) Radiographic imaging agents
US4504462A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
DE3623397A1 (de) * 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
DE3804686A1 (de) * 1988-02-15 1989-08-24 Henkel Kgaa Arzneimittel mit einer kombination von cytostatika bzw. hormontherapeutika und phosphonoderivaten
DD284155A5 (de) * 1988-04-05 1990-11-07 Karl-Marx-Universitaet,Buero F. Neuerer U. Schutzrechte,Dd Mittel zur chemotherapie von virosen der samenpflanzen
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
EP0491374B1 (en) * 1990-12-19 1996-01-31 Takeda Chemical Industries, Ltd. Bisphosphonic acid derivatives, their production and use
JPH05163150A (ja) * 1991-05-13 1993-06-29 E R Squibb & Sons Inc アテローム性動脈硬化症の抑制・治療剤
JPH05194563A (ja) * 1991-07-12 1993-08-03 Hoechst Ag 置換アミノエタン−１，１−ビスホスホン酸およびアミノエタン−１，１−アルキルホスフィノホスホン酸
NZ253524A (en) * 1992-05-29 1997-01-29 Procter & Gamble Pharma Sulphur-containing phosphonate derivatives and medicaments (for treating abnormal calcium and phosphate metabolism)
KR950701927A (ko) * 1992-05-29 1995-05-17 제이코버스 코넬리스 레이서 비정상 칼슘 및 인산염 대사를 치료하기 위한 4급 질소 함유 포스포네이트 화합물(quaternary nitrogen-containing phosphonate compounds, for treating abnormal calcium and phosphate metabolism)
WO1994020508A1 (en) * 1993-03-08 1994-09-15 Eisai Co., Ltd. Phosphonic acid derivatives
TW401276B (en) * 1993-10-07 2000-08-11 Zeneca Ltd Novel compounds and a method of controlling growth of plants

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PL322618A1 (en) 1998-02-02
AU5447596A (en) 1996-10-23
US5728650A (en) 1998-03-17
MX9707692A (es) 1997-12-31
JPH11503429A (ja) 1999-03-26
BR9604975A (pt) 1998-06-09
SK135897A3 (en) 1998-02-04
TR199701126T1 (xx) 1998-01-21
NZ306255A (en) 1999-08-30
KR19980703710A (ko) 1998-12-05
GEP20001891B (en) 2000-01-05
CZ315897A3 (cs) 1998-01-14
NO974619D0 (no) 1997-10-06
CN1181690A (zh) 1998-05-13
WO1996031124A1 (en) 1996-10-10
NO974619L (no) 1997-10-06
CA2217655A1 (en) 1996-10-10
HUP9801251A3 (en) 1999-03-01
EP0820230A1 (en) 1998-01-28

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