HUP0300267A2 - Eljárás aszimmetrikus 4,6-bisz(ariloxi)pirimidin-származékok előállítására - Google Patents
Eljárás aszimmetrikus 4,6-bisz(ariloxi)pirimidin-származékok előállításáraInfo
- Publication number
- HUP0300267A2 HUP0300267A2 HU0300267A HUP0300267A HUP0300267A2 HU P0300267 A2 HUP0300267 A2 HU P0300267A2 HU 0300267 A HU0300267 A HU 0300267A HU P0300267 A HUP0300267 A HU P0300267A HU P0300267 A2 HUP0300267 A2 HU P0300267A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- formula
- atom
- optionally substituted
- aryloxy
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000004104 aryloxy group Chemical group 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- QVCUKHQDEZNNOC-UHFFFAOYSA-N 1,2-diazabicyclo[2.2.2]octane Chemical compound C1CC2CCN1NC2 QVCUKHQDEZNNOC-UHFFFAOYSA-N 0.000 abstract 2
- -1 3-methyl-5-methoxy-2-oxo-1,3,4- triazolinyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Liquid Crystal Substances (AREA)
Abstract
A találmány szerinti eljárás ismert, (I) általános képletű 4,6-bisz-(ariloxi)pirimidin-származékok - ahol a képletben Ar1 jelentése adottesetben szubsztituált aril- vagy heterociklusos csoport, X jelentésehidrogén-, fluor-, klór- vagy brómatom, L1, L2, L3, L4 és L5 jelentéseegymástól függetlenül hidrogén-, halogénatom, ciano-, nitro-, alkil-karbonil-, formil-, alkoxi-karbonil-, amino-karbonil-, alkil-amino-karbonil-, dialkil-amino-karbonil-csoport, halogénatommal adottesetben szubsztituált alkil-, alkoxi-, alkil-tio-, alkil-szulfinil-vagy alkil-szulfonil-csoport, L5 jelenthet még 3-metil-5-metoxi-2-oxo-1,3,4-triazolinil-csoportot vagy az egyes szimbólumok egymástólbizonyos módon függő értelmezésével egy (q) képletű csoportot,amelyben X1 és X2 jelentése hidrogén- vagy fluoratom, Z jelentése nitrogénatom vagy =CH-csoport, Y jelentése oxigénatomés W jelentése metoxi- vagy metil-amino-csoport, vagy Y és W együtt=N-O-CH2-CH2-W1- képletű csoport, ahol W1 oxigén-, kénatomot vagy -NH-csoportot jelent; azzal a megkötéssel, hogy Ar1 adott esetbenszubsztituált fenilcsoport jelentése esetén eltér az Ar1fenilcsoporttól - előállítási eljárására vonatkozik diaza-biciklo[2,2,2]-oktán (DABCO) alkalmazásával. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10014607A DE10014607A1 (de) | 2000-03-24 | 2000-03-24 | Verfahren zur Herstellung von unsymmetrischen 4,6-Bis(aryloxy pyrimidin-Derivaten |
| PCT/EP2001/002731 WO2001072719A1 (de) | 2000-03-24 | 2001-03-12 | Verfahren zur herstellung von unsymmetrischen 4,6-bis(aryloxy)pyrimidin-derivaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0300267A2 true HUP0300267A2 (hu) | 2003-06-28 |
| HUP0300267A3 HUP0300267A3 (en) | 2005-11-28 |
Family
ID=7636165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300267A HUP0300267A3 (en) | 2000-03-24 | 2001-03-12 | Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6734304B2 (hu) |
| EP (1) | EP1268446B1 (hu) |
| JP (1) | JP5008242B2 (hu) |
| KR (1) | KR100758615B1 (hu) |
| CN (1) | CN1280278C (hu) |
| AR (1) | AR034693A1 (hu) |
| AT (1) | ATE483691T1 (hu) |
| AU (1) | AU2001242454A1 (hu) |
| BR (1) | BR0109442B1 (hu) |
| DE (2) | DE10014607A1 (hu) |
| DK (1) | DK1268446T3 (hu) |
| ES (1) | ES2353271T3 (hu) |
| HU (1) | HUP0300267A3 (hu) |
| IL (1) | IL151678A (hu) |
| MX (1) | MXPA02009286A (hu) |
| TW (1) | TWI296621B (hu) |
| WO (1) | WO2001072719A1 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005122771A1 (de) * | 2004-06-17 | 2005-12-29 | Basf Aktiengesellschaft | Verwendung von (e)-5-(4-chlorbenzyliden)-2,2-dimethyl-1-(1h-1,2,4-triazol-1-ylmethyl)cyclopentanol zur bekämpfung des rostbefalls an sojapflanzen |
| GB0508422D0 (en) | 2005-04-26 | 2005-06-01 | Syngenta Ltd | Chemical process |
| JP5061565B2 (ja) * | 2006-04-24 | 2012-10-31 | 住友化学株式会社 | ピリミジン化合物の新規製造方法 |
| US7847111B2 (en) * | 2006-06-19 | 2010-12-07 | Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III |
| GB0619942D0 (en) * | 2006-10-09 | 2006-11-15 | Syngenta Ltd | Chemical process |
| GB0619941D0 (en) | 2006-10-09 | 2006-11-15 | Syngenta Ltd | Chemical process |
| JP2015083541A (ja) * | 2012-02-03 | 2015-04-30 | アグロカネショウ株式会社 | 対称性４，６−ビス（アリールオキシ）ピリミジン化合物の製造方法 |
| TWI621614B (zh) | 2013-05-28 | 2018-04-21 | 科麥農股份有限公司 | 4,6-雙(芳氧基)嘧啶衍生物的製備方法 |
| US9193698B2 (en) * | 2013-07-08 | 2015-11-24 | Advinus Therapeutics, Ltd. | Process for preparing fluoxastrobin |
| US10087152B2 (en) | 2015-05-29 | 2018-10-02 | Arysta Lifescience Corporation | Process for preparing (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime |
| WO2017060917A1 (en) | 2015-10-06 | 2017-04-13 | Gsp Crop Science Pvt. Ltd, | Process for the preparation of azoxystrobin |
| CN105536873B (zh) * | 2016-02-05 | 2017-11-28 | 帕潘纳(北京)科技有限公司 | 一种复合催化剂及其应用 |
| CN110294716B (zh) | 2018-03-23 | 2021-05-07 | 帕潘纳(北京)科技有限公司 | 一种嘧菌酯及其中间体的制备方法 |
| TWI705961B (zh) * | 2018-11-28 | 2020-10-01 | 興農股份有限公司 | 亞托敏的製備方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2038435C (en) * | 1990-03-19 | 1997-10-14 | Sherrol Lee Baysdon | Process for preparation of fluoromethyl-substituted piperidine carbodithioates |
| IL106324A (en) | 1992-07-17 | 1998-09-24 | Shell Int Research | Transformed pyrimidine compounds, their preparation and use as pesticides |
| ZW8594A1 (en) | 1993-08-11 | 1994-10-12 | Bayer Ag | Substituted azadioxacycbalkenes |
| DE4327596A1 (de) * | 1993-08-17 | 1995-02-23 | Bayer Ag | 3-Methoxy-2-phenyl-acrylsäuremethylester |
| GB9404375D0 (en) | 1994-03-07 | 1994-04-20 | Zeneca Ltd | Fungicides |
| DE19531299A1 (de) | 1995-08-25 | 1997-02-27 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidinen |
| EP0863886B1 (de) | 1995-10-18 | 2002-01-09 | Bayer Ag | Fluormethoxyacrylsäurederivate und ihre verwendung als schädlingsbekämpfungsmittel |
| DE19602095A1 (de) | 1996-01-22 | 1997-07-24 | Bayer Ag | Halogenpyrimidine |
| SG63694A1 (en) * | 1996-03-07 | 1999-03-30 | American Cyanamid Co | Process for the preparation of unsymmetrical 4,6-bis (aryloxy) pyrimidine compounds |
| US5977363A (en) | 1996-03-07 | 1999-11-02 | American Cyanamid Company | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds |
| DE19642533A1 (de) | 1996-10-15 | 1998-04-16 | Bayer Ag | Verfahren zur Herstellung von 4,6-Dichlorpyrimidin |
| DE19646407A1 (de) | 1996-11-11 | 1998-05-14 | Bayer Ag | Halogenpyrimidine |
| WO1998023155A1 (en) | 1996-11-26 | 1998-06-04 | E.I. Du Pont De Nemours And Company | Arthropodicidal and fungicidal cyclic amides |
| DE19710609A1 (de) | 1997-03-14 | 1998-09-17 | Bayer Ag | Substituierte Aminosalicylsäureamide |
| DE19723195A1 (de) | 1997-06-03 | 1998-12-10 | Bayer Ag | Fluormethoximinoverbindungen |
| EP1003742A1 (de) | 1997-08-14 | 2000-05-31 | Bayer Aktiengesellschaft | Methoximinomethyloxadiazine als pestizide |
| US5849910A (en) * | 1997-09-05 | 1998-12-15 | American Cyanamid Company | Process for the preparation of unsymmetrical 4,6-bis aryloxy-pyrimidine compounds |
| DE19819828A1 (de) | 1998-05-04 | 1999-11-11 | Bayer Ag | Methoximinomethyloxathiazine |
-
2000
- 2000-03-24 DE DE10014607A patent/DE10014607A1/de not_active Withdrawn
-
2001
- 2001-03-12 DE DE50115655T patent/DE50115655D1/de not_active Expired - Lifetime
- 2001-03-12 KR KR1020027011334A patent/KR100758615B1/ko active IP Right Grant
- 2001-03-12 WO PCT/EP2001/002731 patent/WO2001072719A1/de active Application Filing
- 2001-03-12 BR BRPI0109442-4A patent/BR0109442B1/pt not_active IP Right Cessation
- 2001-03-12 DK DK01915326.1T patent/DK1268446T3/da active
- 2001-03-12 IL IL15167801A patent/IL151678A/xx active IP Right Grant
- 2001-03-12 HU HU0300267A patent/HUP0300267A3/hu unknown
- 2001-03-12 JP JP2001570632A patent/JP5008242B2/ja not_active Expired - Lifetime
- 2001-03-12 AU AU2001242454A patent/AU2001242454A1/en not_active Abandoned
- 2001-03-12 CN CNB018070019A patent/CN1280278C/zh not_active Expired - Lifetime
- 2001-03-12 AT AT01915326T patent/ATE483691T1/de active
- 2001-03-12 US US10/221,889 patent/US6734304B2/en not_active Expired - Lifetime
- 2001-03-12 EP EP01915326A patent/EP1268446B1/de not_active Expired - Lifetime
- 2001-03-12 MX MXPA02009286A patent/MXPA02009286A/es active IP Right Grant
- 2001-03-12 ES ES01915326T patent/ES2353271T3/es not_active Expired - Lifetime
- 2001-03-19 TW TW090106292A patent/TWI296621B/zh not_active IP Right Cessation
- 2001-03-20 AR ARP010101298A patent/AR034693A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1268446A1 (de) | 2003-01-02 |
| IL151678A0 (en) | 2003-04-10 |
| HUP0300267A3 (en) | 2005-11-28 |
| AR034693A1 (es) | 2004-03-17 |
| US20030092723A1 (en) | 2003-05-15 |
| EP1268446B1 (de) | 2010-10-06 |
| JP2003528862A (ja) | 2003-09-30 |
| CN1419549A (zh) | 2003-05-21 |
| DE10014607A1 (de) | 2001-09-27 |
| ES2353271T3 (es) | 2011-02-28 |
| MXPA02009286A (es) | 2003-05-23 |
| DE50115655D1 (de) | 2010-11-18 |
| BR0109442B1 (pt) | 2013-02-19 |
| WO2001072719A1 (de) | 2001-10-04 |
| TWI296621B (en) | 2008-05-11 |
| JP5008242B2 (ja) | 2012-08-22 |
| DK1268446T3 (da) | 2011-01-31 |
| AU2001242454A1 (en) | 2001-10-08 |
| KR100758615B1 (ko) | 2007-09-13 |
| ATE483691T1 (de) | 2010-10-15 |
| US6734304B2 (en) | 2004-05-11 |
| KR20030011779A (ko) | 2003-02-11 |
| IL151678A (en) | 2005-08-31 |
| BR0109442A (pt) | 2002-12-10 |
| CN1280278C (zh) | 2006-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |