HUP0102839A2 - Lanreotide-szomatosztatin analóg alkalmazása gyógyszerkészítmények előállítására és az azt tartalmazó gyógyszerkészítmények - Google Patents
Lanreotide-szomatosztatin analóg alkalmazása gyógyszerkészítmények előállítására és az azt tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0102839A2 HUP0102839A2 HU0102839A HUP0102839A HUP0102839A2 HU P0102839 A2 HUP0102839 A2 HU P0102839A2 HU 0102839 A HU0102839 A HU 0102839A HU P0102839 A HUP0102839 A HU P0102839A HU P0102839 A2 HUP0102839 A2 HU P0102839A2
- Authority
- HU
- Hungary
- Prior art keywords
- hypertension
- syndrome
- cys
- pancreatic
- lanreotide
- Prior art date
Links
- PUDHBTGHUJUUFI-SCTWWAJVSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2r)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-p Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1 PUDHBTGHUJUUFI-SCTWWAJVSA-N 0.000 title 1
- 229960002437 lanreotide Drugs 0.000 title 1
- 108010021336 lanreotide Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
- 229940075620 somatostatin analogue Drugs 0.000 title 1
- 206010020772 Hypertension Diseases 0.000 abstract 2
- 201000000052 gastrinoma Diseases 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 206010003445 Ascites Diseases 0.000 abstract 1
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 208000014311 Cushing syndrome Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 abstract 1
- 201000002980 Hyperparathyroidism Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 206010033635 Pancreatic pseudocyst Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010039710 Scleroderma Diseases 0.000 abstract 1
- 206010041101 Small intestinal obstruction Diseases 0.000 abstract 1
- 201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
- 206010042953 Systemic sclerosis Diseases 0.000 abstract 1
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 abstract 1
- 208000009311 VIPoma Diseases 0.000 abstract 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 150000001945 cysteines Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010060865 duodenogastric reflux Diseases 0.000 abstract 1
- 208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 abstract 1
- 201000008980 hyperinsulinism Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 206010027191 meningioma Diseases 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 208000007232 portal hypertension Diseases 0.000 abstract 1
- 230000000291 postprandial effect Effects 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
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- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
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- Cardiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgya H-b-D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys- Thr-NH2 - aképletben a két cisztein diszulfidkötéssel kapcsolódik - vagy valamelygyógyszerészetileg elfogadható sója alkalmazása az alábbi betegségekvagy állapotok kezelésére alkalmas gyógyszerkészítményekelőállítására: szisztémás sclerosis, hasnyálmirigy pszeudociszták,hasnyálmirigy hasvízkór, VIPoma, nesidoblastosis, hyperinsulinémia,gastrinoma, Zollinger-Ellison szindróma, hyperszekréciós hasmenés,scleroderma, irritálható bél szindróma, felső gastrointestinálisvérzés, postprandialis venae portae hypertensio, portalishypertensioval összefüggő komplikációk, vékonybél elzáródás, duodeno-gyomor reflux, Cushing-féle szindróma, gonadotropinoma,hyperparathyroidismus, diabeteszes neuropathya, maculás degeneráció,rosszindulatú hypercalcemia, Paget-féle betegség, meningioma, rákoscachexia, psoriasis, hypertensio és pánik rohamok. A találmány tárgyamég a fenti vegyületet tartalmazó gyógyszerkészítmény. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12652598A | 1998-07-30 | 1998-07-30 | |
US9469398P | 1998-07-30 | 1998-07-30 | |
PCT/US1999/017294 WO2000006185A2 (en) | 1998-07-30 | 1999-07-29 | Methods of using lanreotide, a somatostatin analogue |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0102839A2 true HUP0102839A2 (hu) | 2002-01-28 |
HUP0102839A3 HUP0102839A3 (en) | 2002-02-28 |
Family
ID=26789150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102839A HUP0102839A3 (en) | 1998-07-30 | 1999-07-29 | Methods of using lanreotide, a somatostatin analogue and pharmaceutical compositions comprising thereof |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1100532A2 (hu) |
JP (1) | JP2002521456A (hu) |
KR (1) | KR20010071071A (hu) |
CN (1) | CN1334742A (hu) |
AR (1) | AR023633A1 (hu) |
AU (2) | AU770193B2 (hu) |
BR (1) | BR9912609A (hu) |
CA (1) | CA2335654A1 (hu) |
CZ (1) | CZ2001157A3 (hu) |
HU (1) | HUP0102839A3 (hu) |
IL (2) | IL140837A0 (hu) |
MX (1) | MXPA01000969A (hu) |
NO (1) | NO324123B1 (hu) |
NZ (1) | NZ509348A (hu) |
PL (1) | PL346361A1 (hu) |
WO (1) | WO2000006185A2 (hu) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1040837A3 (en) * | 1999-02-26 | 2002-01-02 | Erasmus Universiteit Rotterdam | Medicaments for the treatment of a choroidal neovascularization (CNV) related disorder |
WO2002009739A1 (en) * | 2000-07-27 | 2002-02-07 | Novartis Ag | Treatment of ocular disorders with somatostatin analogues |
US6316414B1 (en) | 2000-07-31 | 2001-11-13 | Dabur Research Foundation | Somatostatin analogs for the treatment of cancer |
ES2284859T3 (es) | 2001-03-06 | 2007-11-16 | Il Consorzio Ferrara Richerche | Procedimiento para modular la proliferacion de celulas de carcinoma medular tiroideo. |
GB0109461D0 (en) * | 2001-04-18 | 2001-06-06 | Univ London | New Gene |
EP1485117A4 (en) | 2002-01-22 | 2006-03-22 | Univ New York | METHOD FOR THERAPEUTIC TREATMENT OF BENIGN PROSTATE HYPERTROPHY (BPH) |
KR101642363B1 (ko) | 2008-06-12 | 2016-07-25 | 입센 바이오이노베이션 리미티드 | 신경내분비계 질환의 억제 |
CN102083451A (zh) | 2008-06-12 | 2011-06-01 | 赛恩泰新公司 | 癌症的抑制 |
GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
CN101935252B (zh) * | 2010-07-29 | 2013-01-30 | 广东省农业科学院科技情报研究所 | 一种园林植物生长延缓剂及其制备方法 |
US9333234B2 (en) * | 2012-04-12 | 2016-05-10 | Novartis Ag | Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors |
CN105168115A (zh) * | 2015-09-02 | 2015-12-23 | 中国药科大学 | 生长抑素类似物多肽药物的口服给药途径 |
WO2017212390A1 (en) * | 2016-06-06 | 2017-12-14 | Emcure Pharmaceuticals Ltd, | Process for lanreotide acetate preparation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4853371A (en) * | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
DK0457888T3 (da) * | 1989-12-08 | 1996-08-12 | Univ Tulane | Octapeptidanaloger af somatostatin med threonin i 6-stillingen |
AU3215597A (en) * | 1996-08-30 | 1998-03-19 | Biomeasure Incorporated | Method of inhibiting fibrosis with a somatostatin agonist |
AU4133997A (en) * | 1996-09-12 | 1998-04-02 | Yarom Cohen | Pharmaceutical composition for the treatment of syndrome x of reaven |
PT980253E (pt) * | 1997-05-13 | 2004-08-31 | Conseils De Rec Appl Scient S | Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x |
-
1999
- 1999-07-29 CN CN99808953A patent/CN1334742A/zh active Pending
- 1999-07-29 IL IL14083799A patent/IL140837A0/xx unknown
- 1999-07-29 CA CA002335654A patent/CA2335654A1/en not_active Abandoned
- 1999-07-29 KR KR1020017001277A patent/KR20010071071A/ko not_active Application Discontinuation
- 1999-07-29 PL PL99346361A patent/PL346361A1/xx unknown
- 1999-07-29 AR ARP990103765A patent/AR023633A1/es unknown
- 1999-07-29 MX MXPA01000969A patent/MXPA01000969A/es unknown
- 1999-07-29 BR BR9912609-5A patent/BR9912609A/pt not_active IP Right Cessation
- 1999-07-29 NZ NZ509348A patent/NZ509348A/xx unknown
- 1999-07-29 EP EP99937658A patent/EP1100532A2/en not_active Withdrawn
- 1999-07-29 AU AU52447/99A patent/AU770193B2/en not_active Ceased
- 1999-07-29 HU HU0102839A patent/HUP0102839A3/hu unknown
- 1999-07-29 JP JP2000562039A patent/JP2002521456A/ja active Pending
- 1999-07-29 WO PCT/US1999/017294 patent/WO2000006185A2/en not_active Application Discontinuation
- 1999-07-29 CZ CZ2001157A patent/CZ2001157A3/cs unknown
-
2001
- 2001-01-29 NO NO20010481A patent/NO324123B1/no not_active IP Right Cessation
-
2004
- 2004-04-29 AU AU2004201783A patent/AU2004201783A1/en not_active Abandoned
-
2007
- 2007-02-15 IL IL181349A patent/IL181349A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2335654A1 (en) | 2000-02-10 |
MXPA01000969A (es) | 2003-04-07 |
WO2000006185A3 (en) | 2000-08-03 |
JP2002521456A (ja) | 2002-07-16 |
CN1334742A (zh) | 2002-02-06 |
AR023633A1 (es) | 2002-09-04 |
AU770193B2 (en) | 2004-02-12 |
IL140837A0 (en) | 2002-02-10 |
WO2000006185A2 (en) | 2000-02-10 |
KR20010071071A (ko) | 2001-07-28 |
AU5244799A (en) | 2000-02-21 |
NO324123B1 (no) | 2007-08-27 |
AU2004201783A1 (en) | 2004-05-27 |
CZ2001157A3 (cs) | 2002-02-13 |
NZ509348A (en) | 2004-02-27 |
BR9912609A (pt) | 2001-05-02 |
NO20010481L (no) | 2001-03-21 |
IL181349A0 (en) | 2007-07-04 |
HUP0102839A3 (en) | 2002-02-28 |
PL346361A1 (en) | 2002-02-11 |
EP1100532A2 (en) | 2001-05-23 |
NO20010481D0 (no) | 2001-01-29 |
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