HUP0102066A2 - Higromicin-A-származékok - Google Patents
Higromicin-A-származékokInfo
- Publication number
- HUP0102066A2 HUP0102066A2 HU0102066A HUP0102066A HUP0102066A2 HU P0102066 A2 HUP0102066 A2 HU P0102066A2 HU 0102066 A HU0102066 A HU 0102066A HU P0102066 A HUP0102066 A HU P0102066A HU P0102066 A2 HUP0102066 A2 HU P0102066A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- general formula
- hygromycin
- derivatives
- protozoal infections
- Prior art date
Links
- YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 206010037075 Protozoal infections Diseases 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- YQYJSBFKSSDGFO-FWAVGLHBSA-N hygromycin A Chemical class O[C@H]1[C@H](O)[C@H](C(=O)C)O[C@@H]1Oc1ccc(\C=C(/C)C(=O)N[C@@H]2[C@@H]([C@H]3OCO[C@H]3[C@@H](O)[C@@H]2O)O)cc1O YQYJSBFKSSDGFO-FWAVGLHBSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A találmány tárgya higromicin-A-származékok. A találmány (1) általánosképletű vegyületekre és gyógyászatilag elfogadható sóira, prodrugjairaés szolvátjaira vonatkozik, ahol R1 és R2 jelentése a leírásbanmegadott. Az (1) általános képletű vegyületek antibakteriális ésantiprotozoális szerek, melyeket különböző bakteriális és protozoálisfertőzések és az ezekkel kapcsolatos rendellenességek kezelésére lehethasználni. A találmány kiterjed az (1) általános képletű vegyületekettartalmazó gyógyászati készítményekre és a vegyületek alkalmazásárabakteriális és protozoális fertőzések kezelésére alkalmas gyógyszerekelőállítására is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8404298P | 1998-05-04 | 1998-05-04 | |
| PCT/IB1999/000795 WO1999057125A2 (en) | 1998-05-04 | 1999-05-03 | Hygromycin a derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102066A2 true HUP0102066A2 (hu) | 2001-11-28 |
| HUP0102066A3 HUP0102066A3 (en) | 2003-07-28 |
Family
ID=22182520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102066A HUP0102066A3 (en) | 1998-05-04 | 1999-05-03 | Hygromycin a derivatives |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US6313100B1 (hu) |
| EP (1) | EP1075483B1 (hu) |
| JP (1) | JP2002513796A (hu) |
| KR (1) | KR100402560B1 (hu) |
| CN (1) | CN1299365A (hu) |
| AP (3) | AP0102296A0 (hu) |
| AR (1) | AR016251A1 (hu) |
| AT (2) | ATE255588T1 (hu) |
| AU (1) | AU755806B2 (hu) |
| BG (1) | BG105008A (hu) |
| BR (1) | BR9910206A (hu) |
| CA (1) | CA2331297C (hu) |
| DE (2) | DE69929723D1 (hu) |
| DK (1) | DK1075483T3 (hu) |
| DZ (1) | DZ2780A1 (hu) |
| EA (2) | EA200200779A1 (hu) |
| ES (1) | ES2209419T3 (hu) |
| GT (1) | GT199900064A (hu) |
| HR (1) | HRP20000747A2 (hu) |
| HU (1) | HUP0102066A3 (hu) |
| ID (1) | ID27030A (hu) |
| IL (1) | IL139165A0 (hu) |
| IS (1) | IS5681A (hu) |
| MA (1) | MA24852A1 (hu) |
| NO (1) | NO20005552L (hu) |
| NZ (1) | NZ507452A (hu) |
| OA (1) | OA11508A (hu) |
| PA (1) | PA8471801A1 (hu) |
| PE (1) | PE20000478A1 (hu) |
| PL (1) | PL344521A1 (hu) |
| PT (1) | PT1075483E (hu) |
| SK (1) | SK16452000A3 (hu) |
| TN (1) | TNSN99083A1 (hu) |
| TR (1) | TR200003250T2 (hu) |
| WO (1) | WO1999057125A2 (hu) |
| YU (1) | YU66900A (hu) |
| ZA (1) | ZA993064B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20011904A3 (cs) * | 1998-12-02 | 2001-10-17 | Pfizer Products Inc. | Deriváty hygromycinu jako antibakteriální činidla |
| GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| US6771019B1 (en) * | 1999-05-14 | 2004-08-03 | Ifire Technology, Inc. | Electroluminescent laminate with patterned phosphor structure and thick film dielectric with improved dielectric properties |
| EE200200671A (et) * | 2000-06-02 | 2004-08-16 | Pfizer Products Inc. | Hügromütsiin A derivaadid bakteriaalsete ja algloomadest põhjustatud infektsioonide ravimiseks |
| CN102168034B (zh) * | 2010-11-29 | 2012-12-05 | 中国科学院南海海洋研究所 | 一种海洋链霉菌以及利用该菌制备替达霉素a和b的方法 |
| JP2016069333A (ja) * | 2014-09-30 | 2016-05-09 | 公益財団法人微生物化学研究会 | 新規化合物、その製造方法、及びその用途、並びに、新規微生物 |
| CN104480039B (zh) * | 2014-11-25 | 2017-09-12 | 辽宁大学 | 抗生素产生菌及其应用 |
| WO2020041179A1 (en) * | 2018-08-20 | 2020-02-27 | Northeastern University | Hygromycin a compounds and methods of treating spirochete diseases |
| TWI771766B (zh) | 2019-10-04 | 2022-07-21 | 美商輝瑞股份有限公司 | 二醯基甘油醯基轉移酶２ 抑制劑 |
| JP2022058085A (ja) | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0213692B1 (en) | 1985-06-27 | 1990-09-26 | Takeda Chemical Industries, Ltd. | Use of hygromycin and epihygromycin in the treatment of swine dysentery |
| GB8605245D0 (en) | 1986-03-04 | 1986-04-09 | Fujisawa Pharmaceutical Co | Prophylactic & therapeutic agent |
-
1999
- 1999-05-03 EA EA200200779A patent/EA200200779A1/ru unknown
- 1999-05-03 EP EP99914722A patent/EP1075483B1/en not_active Expired - Lifetime
- 1999-05-03 DK DK99914722T patent/DK1075483T3/da active
- 1999-05-03 TR TR2000/03250T patent/TR200003250T2/xx unknown
- 1999-05-03 GT GT199900064A patent/GT199900064A/es unknown
- 1999-05-03 PT PT99914722T patent/PT1075483E/pt unknown
- 1999-05-03 DZ DZ990080A patent/DZ2780A1/xx active
- 1999-05-03 AP APAP/P/2001/002296A patent/AP0102296A0/en unknown
- 1999-05-03 SK SK1645-2000A patent/SK16452000A3/sk unknown
- 1999-05-03 AU AU33419/99A patent/AU755806B2/en not_active Ceased
- 1999-05-03 KR KR10-2000-7012266A patent/KR100402560B1/ko not_active IP Right Cessation
- 1999-05-03 ID IDW20002255A patent/ID27030A/id unknown
- 1999-05-03 ZA ZA9903064A patent/ZA993064B/xx unknown
- 1999-05-03 TN TNTNSN99083A patent/TNSN99083A1/fr unknown
- 1999-05-03 WO PCT/IB1999/000795 patent/WO1999057125A2/en active Search and Examination
- 1999-05-03 BR BR9910206-4A patent/BR9910206A/pt not_active IP Right Cessation
- 1999-05-03 DE DE69929723T patent/DE69929723D1/de not_active Expired - Lifetime
- 1999-05-03 CN CN99805807A patent/CN1299365A/zh active Pending
- 1999-05-03 DE DE69913333T patent/DE69913333T2/de not_active Expired - Fee Related
- 1999-05-03 US US09/462,592 patent/US6313100B1/en not_active Expired - Fee Related
- 1999-05-03 PE PE1999000362A patent/PE20000478A1/es not_active Application Discontinuation
- 1999-05-03 JP JP2000547094A patent/JP2002513796A/ja active Pending
- 1999-05-03 YU YU66900A patent/YU66900A/sh unknown
- 1999-05-03 AT AT99914722T patent/ATE255588T1/de not_active IP Right Cessation
- 1999-05-03 PL PL99344521A patent/PL344521A1/xx not_active Application Discontinuation
- 1999-05-03 MA MA25565A patent/MA24852A1/fr unknown
- 1999-05-03 CA CA002331297A patent/CA2331297C/en not_active Expired - Fee Related
- 1999-05-03 EA EA200001029A patent/EA003305B1/ru not_active IP Right Cessation
- 1999-05-03 NZ NZ507452A patent/NZ507452A/xx unknown
- 1999-05-03 IL IL13916599A patent/IL139165A0/xx unknown
- 1999-05-03 AR ARP990102059A patent/AR016251A1/es not_active Application Discontinuation
- 1999-05-03 HU HU0102066A patent/HUP0102066A3/hu unknown
- 1999-05-03 ES ES99914722T patent/ES2209419T3/es not_active Expired - Lifetime
- 1999-05-03 AT AT03020745T patent/ATE317448T1/de not_active IP Right Cessation
- 1999-05-04 AP AP2001002296A patent/AP2001002296A0/xx unknown
- 1999-05-04 PA PA19998471801A patent/PA8471801A1/es unknown
- 1999-05-04 AP APAP/P/1999/001527A patent/AP1266A/en active
-
2000
- 2000-10-24 IS IS5681A patent/IS5681A/is unknown
- 2000-10-27 OA OA1200000299A patent/OA11508A/en unknown
- 2000-11-03 HR HR20000747A patent/HRP20000747A2/hr not_active Application Discontinuation
- 2000-11-03 NO NO20005552A patent/NO20005552L/no not_active Application Discontinuation
- 2000-11-30 BG BG105008A patent/BG105008A/xx unknown
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