WO1999057125A3 - Hygromycin a derivatives - Google Patents

Hygromycin a derivatives Download PDF

Info

Publication number
WO1999057125A3
WO1999057125A3 PCT/IB1999/000795 IB9900795W WO9957125A3 WO 1999057125 A3 WO1999057125 A3 WO 1999057125A3 IB 9900795 W IB9900795 W IB 9900795W WO 9957125 A3 WO9957125 A3 WO 9957125A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
formula
infections
relates
hygromycin
Prior art date
Application number
PCT/IB1999/000795
Other languages
French (fr)
Other versions
WO1999057125A2 (en
Inventor
Katherine Elizabeth Brighty
Subramanian Sam Guhan
Martin Raymond Jefson
Robert Gerald Ii Linde
Ellen Lester Mccormick
Original Assignee
Pfizer Prod Inc
Katherine Elizabeth Brighty
Subramanian Sam Guhan
Martin Raymond Jefson
Robert Gerald Ii Linde
Ellen Lester Mccormick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002331297A priority Critical patent/CA2331297C/en
Priority to APAP/P/2001/002296A priority patent/AP0102296A0/en
Priority to HU0102066A priority patent/HUP0102066A3/en
Priority to BR9910206-4A priority patent/BR9910206A/en
Priority to SK1645-2000A priority patent/SK16452000A3/en
Priority to AU33419/99A priority patent/AU755806B2/en
Priority to DE69913333T priority patent/DE69913333T2/en
Priority to SI9930516T priority patent/SI1075483T1/en
Priority to US09/462,592 priority patent/US6313100B1/en
Priority to DK99914722T priority patent/DK1075483T3/en
Priority to AT99914722T priority patent/ATE255588T1/en
Priority to IL13916599A priority patent/IL139165A0/en
Priority to JP2000547094A priority patent/JP2002513796A/en
Priority to EA200001029A priority patent/EA003305B1/en
Application filed by Pfizer Prod Inc, Katherine Elizabeth Brighty, Subramanian Sam Guhan, Martin Raymond Jefson, Robert Gerald Ii Linde, Ellen Lester Mccormick filed Critical Pfizer Prod Inc
Priority to EP99914722A priority patent/EP1075483B1/en
Priority to PL99344521A priority patent/PL344521A1/en
Priority to NZ507452A priority patent/NZ507452A/en
Publication of WO1999057125A2 publication Critical patent/WO1999057125A2/en
Publication of WO1999057125A3 publication Critical patent/WO1999057125A3/en
Priority to IS5681A priority patent/IS5681A/en
Priority to NO20005552A priority patent/NO20005552L/en
Priority to HR20000747A priority patent/HRP20000747A2/en
Priority to BG105008A priority patent/BG105008A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R?1 and R2¿ are as defined herein. The compounds of formula (1) are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and the methods of treating bacterial and protozoal infections by administering the compounds of formula (1).
PCT/IB1999/000795 1998-05-04 1999-05-03 Hygromycin a derivatives WO1999057125A2 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
PL99344521A PL344521A1 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
HU0102066A HUP0102066A3 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
BR9910206-4A BR9910206A (en) 1998-05-04 1999-05-03 Hygromycin derivatives a.
SK1645-2000A SK16452000A3 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
AU33419/99A AU755806B2 (en) 1998-05-04 1999-05-03 Hygromycin A derivatives
DE69913333T DE69913333T2 (en) 1998-05-04 1999-05-03 HYGROMYCIN A DERIVATIVES
SI9930516T SI1075483T1 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
US09/462,592 US6313100B1 (en) 1998-05-04 1999-05-03 Hygromycin derivatives
DK99914722T DK1075483T3 (en) 1998-05-04 1999-05-03 Hygromycin A derivatives
AT99914722T ATE255588T1 (en) 1998-05-04 1999-05-03 HYGROMYCIN A DERIVATIVES
IL13916599A IL139165A0 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
CA002331297A CA2331297C (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
EA200001029A EA003305B1 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
JP2000547094A JP2002513796A (en) 1998-05-04 1999-05-03 Hygromycin A derivative
EP99914722A EP1075483B1 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
APAP/P/2001/002296A AP0102296A0 (en) 1998-05-04 1999-05-03 Hygromycin A derivatives.
NZ507452A NZ507452A (en) 1998-05-04 1999-05-03 Hygromycin a derivatives
IS5681A IS5681A (en) 1998-05-04 2000-10-24 Hygromycin A derivatives
NO20005552A NO20005552L (en) 1998-05-04 2000-11-03 Hygromycin A derivatives
HR20000747A HRP20000747A2 (en) 1998-05-04 2000-11-03 Hygromycin a derivatives
BG105008A BG105008A (en) 1998-05-04 2000-11-30 Hygromycin a derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8404298P 1998-05-04 1998-05-04
US60/084,042 1998-05-04

Publications (2)

Publication Number Publication Date
WO1999057125A2 WO1999057125A2 (en) 1999-11-11
WO1999057125A3 true WO1999057125A3 (en) 1999-12-29

Family

ID=22182520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000795 WO1999057125A2 (en) 1998-05-04 1999-05-03 Hygromycin a derivatives

Country Status (37)

Country Link
US (1) US6313100B1 (en)
EP (1) EP1075483B1 (en)
JP (1) JP2002513796A (en)
KR (1) KR100402560B1 (en)
CN (1) CN1299365A (en)
AP (3) AP0102296A0 (en)
AR (1) AR016251A1 (en)
AT (2) ATE317448T1 (en)
AU (1) AU755806B2 (en)
BG (1) BG105008A (en)
BR (1) BR9910206A (en)
CA (1) CA2331297C (en)
DE (2) DE69913333T2 (en)
DK (1) DK1075483T3 (en)
DZ (1) DZ2780A1 (en)
EA (2) EA003305B1 (en)
ES (1) ES2209419T3 (en)
GT (1) GT199900064A (en)
HR (1) HRP20000747A2 (en)
HU (1) HUP0102066A3 (en)
ID (1) ID27030A (en)
IL (1) IL139165A0 (en)
IS (1) IS5681A (en)
MA (1) MA24852A1 (en)
NO (1) NO20005552L (en)
NZ (1) NZ507452A (en)
OA (1) OA11508A (en)
PA (1) PA8471801A1 (en)
PE (1) PE20000478A1 (en)
PL (1) PL344521A1 (en)
PT (1) PT1075483E (en)
SK (1) SK16452000A3 (en)
TN (1) TNSN99083A1 (en)
TR (1) TR200003250T2 (en)
WO (1) WO1999057125A2 (en)
YU (1) YU66900A (en)
ZA (1) ZA993064B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1135400A1 (en) * 1998-12-02 2001-09-26 Pfizer Products Inc. Hygromycin a derivatives as antibacterial agents
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
US6771019B1 (en) * 1999-05-14 2004-08-03 Ifire Technology, Inc. Electroluminescent laminate with patterned phosphor structure and thick film dielectric with improved dielectric properties
CA2410643A1 (en) 2000-06-02 2001-12-06 Pfizer Products Inc. Hygromycin a derivatives for the treatment of bacterial and protozoal infections
CN102168034B (en) * 2010-11-29 2012-12-05 中国科学院南海海洋研究所 Marine streptomyces and method for preparing tirandamycin A and B by utilizing strain
JP2016069333A (en) * 2014-09-30 2016-05-09 公益財団法人微生物化学研究会 Novel compounds, methods of making and uses thereof and novel microorganisms
CN104480039B (en) * 2014-11-25 2017-09-12 辽宁大学 Antibiotics generated bacterium and its application
EP3840743A4 (en) * 2018-08-20 2022-08-17 Northeastern University Hygromycin a compounds and methods of treating spirochete diseases
TWI771766B (en) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 Diacylglycerol acyltransferase 2 inhibitor
JP2022058085A (en) 2020-02-24 2022-04-11 ファイザー・インク Combination of inhibitors of diacylglycerol acyltransferase 2 and inhibitors of acetyl-coa carboxylase

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213692A2 (en) * 1985-06-27 1987-03-11 Takeda Chemical Industries, Ltd. Use of hygromycin and epihygromycin in the treatment of swine dysentery
EP0236110A2 (en) * 1986-03-04 1987-09-09 Fujisawa Pharmaceutical Co., Ltd. Animal growth promoting agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0213692A2 (en) * 1985-06-27 1987-03-11 Takeda Chemical Industries, Ltd. Use of hygromycin and epihygromycin in the treatment of swine dysentery
EP0236110A2 (en) * 1986-03-04 1987-09-09 Fujisawa Pharmaceutical Co., Ltd. Animal growth promoting agents

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 80, no. 17, 29 April 1974, Columbus, Ohio, US; abstract no. 94225, POLATOVSKAYA, O. G. ET AL: "Effect of age and amount of inoculation material on the rate of biosynthesis of Hygromycin V" XP002120212 *
HAYASHI, SHIGERU F. ET AL: "Structure-activity relationships of hygromycin A and its analogs: protein synthesis inhibition activity in a cell free system", J. ANTIBIOT. (1997), 50(6), 514-521, XP002120210 *
HECKER S. J. ET AL.: "Application of hygromycin A structure activity relationships to the antibiotic A201A", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 2, 1993, pages 295 - 298, XP002120209 *
HECKER S. J. ET AL.: "Semisynthetic modification of hygromycin A. I. Synthesis and antibacterial activity of vinyl methyl and amide analogs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 6, 1992, pages 533 - 536, XP002120208 *
TR., LENINGRAD. NAUCH.-ISSLED. INST. ANTIBIOT. (1972), NO. 9, 82-3 *
WAKISAKA, YOSHIHARU ET AL: "Hygromycin and epihygromycin from a bacterium, Corynebacterium equi No. 2841", J. ANTIBIOT. (1980), 33(7), 695-704, XP002120211 *

Also Published As

Publication number Publication date
TR200003250T2 (en) 2001-01-22
BG105008A (en) 2001-09-28
ZA993064B (en) 2000-12-06
NZ507452A (en) 2003-04-29
HUP0102066A3 (en) 2003-07-28
AP9901527A0 (en) 1999-06-30
TNSN99083A1 (en) 2005-11-10
WO1999057125A2 (en) 1999-11-11
AR016251A1 (en) 2001-06-20
SK16452000A3 (en) 2001-09-11
DZ2780A1 (en) 2005-04-23
ES2209419T3 (en) 2004-06-16
BR9910206A (en) 2001-01-30
PT1075483E (en) 2004-03-31
PL344521A1 (en) 2001-11-05
IL139165A0 (en) 2001-11-25
NO20005552L (en) 2001-01-02
PE20000478A1 (en) 2000-05-31
AP0102296A0 (en) 2000-11-04
KR100402560B1 (en) 2003-10-17
DE69913333T2 (en) 2004-10-07
OA11508A (en) 2004-02-09
ATE255588T1 (en) 2003-12-15
CA2331297A1 (en) 1999-11-11
CA2331297C (en) 2004-12-28
EP1075483A2 (en) 2001-02-14
ATE317448T1 (en) 2006-02-15
CN1299365A (en) 2001-06-13
ID27030A (en) 2001-02-22
AU3341999A (en) 1999-11-23
AP1266A (en) 2004-03-29
GT199900064A (en) 2000-10-24
KR20010043303A (en) 2001-05-25
NO20005552D0 (en) 2000-11-03
US6313100B1 (en) 2001-11-06
EP1075483B1 (en) 2003-12-03
AP2001002296A0 (en) 2001-12-31
IS5681A (en) 2000-10-24
MA24852A1 (en) 1999-12-31
HUP0102066A2 (en) 2001-11-28
DE69929723D1 (en) 2006-04-20
DK1075483T3 (en) 2004-03-15
EA003305B1 (en) 2003-04-24
YU66900A (en) 2003-12-31
AU755806B2 (en) 2002-12-19
PA8471801A1 (en) 2000-09-29
DE69913333D1 (en) 2004-01-15
HRP20000747A2 (en) 2001-06-30
JP2002513796A (en) 2002-05-14
EA200001029A1 (en) 2001-04-23
EA200200779A1 (en) 2002-12-26

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