EA200200779A1 - Способ получения композиции, содержащей гигромицин а и эпигигромицин - Google Patents

Способ получения композиции, содержащей гигромицин а и эпигигромицин

Info

Publication number
EA200200779A1
EA200200779A1 EA200200779A EA200200779A EA200200779A1 EA 200200779 A1 EA200200779 A1 EA 200200779A1 EA 200200779 A EA200200779 A EA 200200779A EA 200200779 A EA200200779 A EA 200200779A EA 200200779 A1 EA200200779 A1 EA 200200779A1
Authority
EA
Eurasian Patent Office
Prior art keywords
epigigromycin
composition containing
obtaining
containing hygromycin
hygromycin
Prior art date
Application number
EA200200779A
Other languages
English (en)
Inventor
Кэтрин Элизабет Брайти
Субраманян Сэм Гухан
Мартин Раймонд Джефсон
Роберт Джеральд II Линде
Эллен Лестер Маккормик
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200200779A1 publication Critical patent/EA200200779A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Предложен способ получения композиции, содержащей гигромицин А и эпигигромицин, где отношение гигромицина А к эпигигромицину составляет, по меньшей мере, 10:1, путем ферментации Streptomyces hygroscopicus в средах, имеющих значение рН, меньшее чем 6,9, при температуре в пределах от 25 до 35°С.Отчет о международном поиске был опубликован 1999.12.29.
EA200200779A 1998-05-04 1999-05-03 Способ получения композиции, содержащей гигромицин а и эпигигромицин EA200200779A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8404298P 1998-05-04 1998-05-04

Publications (1)

Publication Number Publication Date
EA200200779A1 true EA200200779A1 (ru) 2002-12-26

Family

ID=22182520

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200200779A EA200200779A1 (ru) 1998-05-04 1999-05-03 Способ получения композиции, содержащей гигромицин а и эпигигромицин
EA200001029A EA003305B1 (ru) 1998-05-04 1999-05-03 Производные гигромицина

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200001029A EA003305B1 (ru) 1998-05-04 1999-05-03 Производные гигромицина

Country Status (37)

Country Link
US (1) US6313100B1 (ru)
EP (1) EP1075483B1 (ru)
JP (1) JP2002513796A (ru)
KR (1) KR100402560B1 (ru)
CN (1) CN1299365A (ru)
AP (3) AP0102296A0 (ru)
AR (1) AR016251A1 (ru)
AT (2) ATE317448T1 (ru)
AU (1) AU755806B2 (ru)
BG (1) BG105008A (ru)
BR (1) BR9910206A (ru)
CA (1) CA2331297C (ru)
DE (2) DE69913333T2 (ru)
DK (1) DK1075483T3 (ru)
DZ (1) DZ2780A1 (ru)
EA (2) EA200200779A1 (ru)
ES (1) ES2209419T3 (ru)
GT (1) GT199900064A (ru)
HR (1) HRP20000747A2 (ru)
HU (1) HUP0102066A3 (ru)
ID (1) ID27030A (ru)
IL (1) IL139165A0 (ru)
IS (1) IS5681A (ru)
MA (1) MA24852A1 (ru)
NO (1) NO20005552L (ru)
NZ (1) NZ507452A (ru)
OA (1) OA11508A (ru)
PA (1) PA8471801A1 (ru)
PE (1) PE20000478A1 (ru)
PL (1) PL344521A1 (ru)
PT (1) PT1075483E (ru)
SK (1) SK16452000A3 (ru)
TN (1) TNSN99083A1 (ru)
TR (1) TR200003250T2 (ru)
WO (1) WO1999057125A2 (ru)
YU (1) YU66900A (ru)
ZA (1) ZA993064B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID28848A (id) 1998-12-02 2001-07-05 Pfizer Prod Inc Turunan-turunan higromisin a
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
US6771019B1 (en) * 1999-05-14 2004-08-03 Ifire Technology, Inc. Electroluminescent laminate with patterned phosphor structure and thick film dielectric with improved dielectric properties
EA200201167A1 (ru) * 2000-06-02 2003-06-26 Пфайзер Продактс Инк. Производные гигромицина а для лечения бактериальных и протозойных инфекций
CN102168034B (zh) * 2010-11-29 2012-12-05 中国科学院南海海洋研究所 一种海洋链霉菌以及利用该菌制备替达霉素a和b的方法
JP2016069333A (ja) * 2014-09-30 2016-05-09 公益財団法人微生物化学研究会 新規化合物、その製造方法、及びその用途、並びに、新規微生物
CN104480039B (zh) * 2014-11-25 2017-09-12 辽宁大学 抗生素产生菌及其应用
WO2020041179A1 (en) * 2018-08-20 2020-02-27 Northeastern University Hygromycin a compounds and methods of treating spirochete diseases
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3674513D1 (de) * 1985-06-27 1990-10-31 Takeda Chemical Industries Ltd Verwendung von hygromycin und epihygromycin zur behandlung von dysentrie bei schweinen.
GB8605245D0 (en) * 1986-03-04 1986-04-09 Fujisawa Pharmaceutical Co Prophylactic & therapeutic agent

Also Published As

Publication number Publication date
TNSN99083A1 (fr) 2005-11-10
WO1999057125A3 (en) 1999-12-29
AP0102296A0 (en) 2000-11-04
IL139165A0 (en) 2001-11-25
EP1075483A2 (en) 2001-02-14
AP9901527A0 (en) 1999-06-30
EP1075483B1 (en) 2003-12-03
KR100402560B1 (ko) 2003-10-17
EA200001029A1 (ru) 2001-04-23
PT1075483E (pt) 2004-03-31
AU755806B2 (en) 2002-12-19
DZ2780A1 (fr) 2005-04-23
ID27030A (id) 2001-02-22
CN1299365A (zh) 2001-06-13
CA2331297C (en) 2004-12-28
KR20010043303A (ko) 2001-05-25
EA003305B1 (ru) 2003-04-24
HUP0102066A2 (hu) 2001-11-28
GT199900064A (es) 2000-10-24
HUP0102066A3 (en) 2003-07-28
JP2002513796A (ja) 2002-05-14
CA2331297A1 (en) 1999-11-11
ES2209419T3 (es) 2004-06-16
BR9910206A (pt) 2001-01-30
AP1266A (en) 2004-03-29
IS5681A (is) 2000-10-24
MA24852A1 (fr) 1999-12-31
AU3341999A (en) 1999-11-23
BG105008A (en) 2001-09-28
DE69913333D1 (de) 2004-01-15
AP2001002296A0 (en) 2001-12-31
DE69913333T2 (de) 2004-10-07
DE69929723D1 (de) 2006-04-20
SK16452000A3 (sk) 2001-09-11
AR016251A1 (es) 2001-06-20
WO1999057125A2 (en) 1999-11-11
ATE255588T1 (de) 2003-12-15
PL344521A1 (en) 2001-11-05
YU66900A (sh) 2003-12-31
PA8471801A1 (es) 2000-09-29
HRP20000747A2 (en) 2001-06-30
DK1075483T3 (da) 2004-03-15
NZ507452A (en) 2003-04-29
OA11508A (en) 2004-02-09
NO20005552D0 (no) 2000-11-03
ATE317448T1 (de) 2006-02-15
US6313100B1 (en) 2001-11-06
NO20005552L (no) 2001-01-02
PE20000478A1 (es) 2000-05-31
TR200003250T2 (tr) 2001-01-22
ZA993064B (en) 2000-12-06

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