EA200200779A1 - Способ получения композиции, содержащей гигромицин а и эпигигромицин - Google Patents
Способ получения композиции, содержащей гигромицин а и эпигигромицинInfo
- Publication number
- EA200200779A1 EA200200779A1 EA200200779A EA200200779A EA200200779A1 EA 200200779 A1 EA200200779 A1 EA 200200779A1 EA 200200779 A EA200200779 A EA 200200779A EA 200200779 A EA200200779 A EA 200200779A EA 200200779 A1 EA200200779 A1 EA 200200779A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- epigigromycin
- composition containing
- obtaining
- containing hygromycin
- hygromycin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Предложен способ получения композиции, содержащей гигромицин А и эпигигромицин, где отношение гигромицина А к эпигигромицину составляет, по меньшей мере, 10:1, путем ферментации Streptomyces hygroscopicus в средах, имеющих значение рН, меньшее чем 6,9, при температуре в пределах от 25 до 35°С.Отчет о международном поиске был опубликован 1999.12.29.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8404298P | 1998-05-04 | 1998-05-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200200779A1 true EA200200779A1 (ru) | 2002-12-26 |
Family
ID=22182520
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200779A EA200200779A1 (ru) | 1998-05-04 | 1999-05-03 | Способ получения композиции, содержащей гигромицин а и эпигигромицин |
EA200001029A EA003305B1 (ru) | 1998-05-04 | 1999-05-03 | Производные гигромицина |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200001029A EA003305B1 (ru) | 1998-05-04 | 1999-05-03 | Производные гигромицина |
Country Status (37)
Country | Link |
---|---|
US (1) | US6313100B1 (ru) |
EP (1) | EP1075483B1 (ru) |
JP (1) | JP2002513796A (ru) |
KR (1) | KR100402560B1 (ru) |
CN (1) | CN1299365A (ru) |
AP (3) | AP0102296A0 (ru) |
AR (1) | AR016251A1 (ru) |
AT (2) | ATE317448T1 (ru) |
AU (1) | AU755806B2 (ru) |
BG (1) | BG105008A (ru) |
BR (1) | BR9910206A (ru) |
CA (1) | CA2331297C (ru) |
DE (2) | DE69913333T2 (ru) |
DK (1) | DK1075483T3 (ru) |
DZ (1) | DZ2780A1 (ru) |
EA (2) | EA200200779A1 (ru) |
ES (1) | ES2209419T3 (ru) |
GT (1) | GT199900064A (ru) |
HR (1) | HRP20000747A2 (ru) |
HU (1) | HUP0102066A3 (ru) |
ID (1) | ID27030A (ru) |
IL (1) | IL139165A0 (ru) |
IS (1) | IS5681A (ru) |
MA (1) | MA24852A1 (ru) |
NO (1) | NO20005552L (ru) |
NZ (1) | NZ507452A (ru) |
OA (1) | OA11508A (ru) |
PA (1) | PA8471801A1 (ru) |
PE (1) | PE20000478A1 (ru) |
PL (1) | PL344521A1 (ru) |
PT (1) | PT1075483E (ru) |
SK (1) | SK16452000A3 (ru) |
TN (1) | TNSN99083A1 (ru) |
TR (1) | TR200003250T2 (ru) |
WO (1) | WO1999057125A2 (ru) |
YU (1) | YU66900A (ru) |
ZA (1) | ZA993064B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ID28848A (id) | 1998-12-02 | 2001-07-05 | Pfizer Prod Inc | Turunan-turunan higromisin a |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
US6771019B1 (en) * | 1999-05-14 | 2004-08-03 | Ifire Technology, Inc. | Electroluminescent laminate with patterned phosphor structure and thick film dielectric with improved dielectric properties |
EA200201167A1 (ru) * | 2000-06-02 | 2003-06-26 | Пфайзер Продактс Инк. | Производные гигромицина а для лечения бактериальных и протозойных инфекций |
CN102168034B (zh) * | 2010-11-29 | 2012-12-05 | 中国科学院南海海洋研究所 | 一种海洋链霉菌以及利用该菌制备替达霉素a和b的方法 |
JP2016069333A (ja) * | 2014-09-30 | 2016-05-09 | 公益財団法人微生物化学研究会 | 新規化合物、その製造方法、及びその用途、並びに、新規微生物 |
CN104480039B (zh) * | 2014-11-25 | 2017-09-12 | 辽宁大学 | 抗生素产生菌及其应用 |
WO2020041179A1 (en) * | 2018-08-20 | 2020-02-27 | Northeastern University | Hygromycin a compounds and methods of treating spirochete diseases |
TWI771766B (zh) | 2019-10-04 | 2022-07-21 | 美商輝瑞股份有限公司 | 二醯基甘油醯基轉移酶2 抑制劑 |
JP2022058085A (ja) | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ2阻害剤とアセチル-CoAカルボキシラーゼ阻害剤との組合せ |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3674513D1 (de) * | 1985-06-27 | 1990-10-31 | Takeda Chemical Industries Ltd | Verwendung von hygromycin und epihygromycin zur behandlung von dysentrie bei schweinen. |
GB8605245D0 (en) * | 1986-03-04 | 1986-04-09 | Fujisawa Pharmaceutical Co | Prophylactic & therapeutic agent |
-
1999
- 1999-05-03 EA EA200200779A patent/EA200200779A1/ru unknown
- 1999-05-03 EA EA200001029A patent/EA003305B1/ru not_active IP Right Cessation
- 1999-05-03 BR BR9910206-4A patent/BR9910206A/pt not_active IP Right Cessation
- 1999-05-03 CA CA002331297A patent/CA2331297C/en not_active Expired - Fee Related
- 1999-05-03 PT PT99914722T patent/PT1075483E/pt unknown
- 1999-05-03 MA MA25565A patent/MA24852A1/fr unknown
- 1999-05-03 TN TNTNSN99083A patent/TNSN99083A1/fr unknown
- 1999-05-03 WO PCT/IB1999/000795 patent/WO1999057125A2/en active Search and Examination
- 1999-05-03 ZA ZA9903064A patent/ZA993064B/xx unknown
- 1999-05-03 DE DE69913333T patent/DE69913333T2/de not_active Expired - Fee Related
- 1999-05-03 ID IDW20002255A patent/ID27030A/id unknown
- 1999-05-03 IL IL13916599A patent/IL139165A0/xx unknown
- 1999-05-03 AP APAP/P/2001/002296A patent/AP0102296A0/en unknown
- 1999-05-03 PE PE1999000362A patent/PE20000478A1/es not_active Application Discontinuation
- 1999-05-03 DE DE69929723T patent/DE69929723D1/de not_active Expired - Lifetime
- 1999-05-03 CN CN99805807A patent/CN1299365A/zh active Pending
- 1999-05-03 NZ NZ507452A patent/NZ507452A/xx unknown
- 1999-05-03 JP JP2000547094A patent/JP2002513796A/ja active Pending
- 1999-05-03 AU AU33419/99A patent/AU755806B2/en not_active Ceased
- 1999-05-03 EP EP99914722A patent/EP1075483B1/en not_active Expired - Lifetime
- 1999-05-03 AR ARP990102059A patent/AR016251A1/es not_active Application Discontinuation
- 1999-05-03 GT GT199900064A patent/GT199900064A/es unknown
- 1999-05-03 TR TR2000/03250T patent/TR200003250T2/xx unknown
- 1999-05-03 SK SK1645-2000A patent/SK16452000A3/sk unknown
- 1999-05-03 US US09/462,592 patent/US6313100B1/en not_active Expired - Fee Related
- 1999-05-03 YU YU66900A patent/YU66900A/sh unknown
- 1999-05-03 AT AT03020745T patent/ATE317448T1/de not_active IP Right Cessation
- 1999-05-03 DK DK99914722T patent/DK1075483T3/da active
- 1999-05-03 KR KR10-2000-7012266A patent/KR100402560B1/ko not_active IP Right Cessation
- 1999-05-03 AT AT99914722T patent/ATE255588T1/de not_active IP Right Cessation
- 1999-05-03 HU HU0102066A patent/HUP0102066A3/hu unknown
- 1999-05-03 PL PL99344521A patent/PL344521A1/xx not_active Application Discontinuation
- 1999-05-03 DZ DZ990080A patent/DZ2780A1/xx active
- 1999-05-03 ES ES99914722T patent/ES2209419T3/es not_active Expired - Lifetime
- 1999-05-04 AP APAP/P/1999/001527A patent/AP1266A/en active
- 1999-05-04 AP AP2001002296A patent/AP2001002296A0/xx unknown
- 1999-05-04 PA PA19998471801A patent/PA8471801A1/es unknown
-
2000
- 2000-10-24 IS IS5681A patent/IS5681A/is unknown
- 2000-10-27 OA OA1200000299A patent/OA11508A/en unknown
- 2000-11-03 NO NO20005552A patent/NO20005552L/no not_active Application Discontinuation
- 2000-11-03 HR HR20000747A patent/HRP20000747A2/hr not_active Application Discontinuation
- 2000-11-30 BG BG105008A patent/BG105008A/xx unknown
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