EA200201167A1 - Производные гигромицина а для лечения бактериальных и протозойных инфекций - Google Patents
Производные гигромицина а для лечения бактериальных и протозойных инфекцийInfo
- Publication number
- EA200201167A1 EA200201167A1 EA200201167A EA200201167A EA200201167A1 EA 200201167 A1 EA200201167 A1 EA 200201167A1 EA 200201167 A EA200201167 A EA 200201167A EA 200201167 A EA200201167 A EA 200201167A EA 200201167 A1 EA200201167 A1 EA 200201167A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- infections
- formula
- bacterial
- compounds
- protosous
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000035143 Bacterial infection Diseases 0.000 abstract 2
- 206010037075 Protozoal infections Diseases 0.000 abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Данное изобретение относится к соединениям формулы (1) и их фармацевтически приемлемым солям, пролекарствам и сольватам, в которых R, R, Rи Rявляются такими, как определено в описании. Соединения формулы (1) являются антибактериальными и антипротозойными средствами, которые могут быть использованы для лечения различных бактериальных и протозойных инфекций и нарушений, связанных с такими инфекциями. Изобретение также относится к фармацевтическим композициям, содержащим соединения формулы (1), способам лечения бактериальных и протозойных инфекций путем введения соединений формулы (1).Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20902300P | 2000-06-02 | 2000-06-02 | |
| PCT/IB2001/000946 WO2001092280A1 (en) | 2000-06-02 | 2001-05-25 | Hygromycin a derivatives for the treatment of bacterial and protozoal infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200201167A1 true EA200201167A1 (ru) | 2003-06-26 |
Family
ID=22777009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200201167A EA200201167A1 (ru) | 2000-06-02 | 2001-05-25 | Производные гигромицина а для лечения бактериальных и протозойных инфекций |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6867230B2 (ru) |
| EP (1) | EP1287011A1 (ru) |
| JP (1) | JP2003535100A (ru) |
| KR (1) | KR20030010655A (ru) |
| CN (1) | CN1432019A (ru) |
| AP (1) | AP2002002669A0 (ru) |
| AR (1) | AR028667A1 (ru) |
| AU (1) | AU2001260528A1 (ru) |
| BG (1) | BG107265A (ru) |
| BR (1) | BR0111242A (ru) |
| CA (1) | CA2410643A1 (ru) |
| CZ (1) | CZ20023859A3 (ru) |
| EA (1) | EA200201167A1 (ru) |
| EC (1) | ECSP014093A (ru) |
| EE (1) | EE200200671A (ru) |
| GT (1) | GT200100099A (ru) |
| HU (1) | HUP0302263A2 (ru) |
| IL (1) | IL152984A0 (ru) |
| IS (1) | IS6618A (ru) |
| MA (1) | MA26909A1 (ru) |
| MX (1) | MXPA02011966A (ru) |
| NO (1) | NO20025704D0 (ru) |
| OA (1) | OA12277A (ru) |
| PA (1) | PA8518101A1 (ru) |
| PE (1) | PE20020334A1 (ru) |
| PL (1) | PL359179A1 (ru) |
| SK (1) | SK16612002A3 (ru) |
| SV (1) | SV2002000474A (ru) |
| TN (1) | TNSN01080A1 (ru) |
| UY (1) | UY26741A1 (ru) |
| WO (1) | WO2001092280A1 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4488350B2 (ja) | 2002-05-16 | 2010-06-23 | セプラコール インク． | 哺乳類アナンダミド輸送体を阻害するアミン、およびその使用方法 |
| WO2020041179A1 (en) * | 2018-08-20 | 2020-02-27 | Northeastern University | Hygromycin a compounds and methods of treating spirochete diseases |
| CU20180159A7 (es) * | 2018-12-28 | 2020-10-20 | Chengdu Olisynn Biotechnology Co Ltd | Derivados de oligosacáridos sintéticos como vacuna contra la bordetella pertussis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1234567A (en) * | 1915-09-14 | 1917-07-24 | Edward J Quigley | Soft collar. |
| US2004123A (en) * | 1934-02-15 | 1935-06-11 | Jr Robert B Loibl | Pest exterminator |
| EA200200779A1 (ru) * | 1998-05-04 | 2002-12-26 | Пфайзер Продактс Инк. | Способ получения композиции, содержащей гигромицин а и эпигигромицин |
| SK16442000A3 (sk) * | 1998-05-04 | 2001-07-10 | Pfizer Products Inc. | Deriváty 2''-deoxy-hygromycínu |
| CZ20011904A3 (cs) * | 1998-12-02 | 2001-10-17 | Pfizer Products Inc. | Deriváty hygromycinu jako antibakteriální činidla |
| OA12081A (en) * | 1999-10-29 | 2006-05-04 | Pfizer Prod Inc | Hygromycin derivatives. |
| US7654321B2 (en) * | 2006-12-27 | 2010-02-02 | Schlumberger Technology Corporation | Formation fluid sampling apparatus and methods |
-
2001
- 2001-05-25 EE EEP200200671A patent/EE200200671A/xx unknown
- 2001-05-25 SK SK1661-2002A patent/SK16612002A3/sk unknown
- 2001-05-25 AP APAP/P/2002/002669A patent/AP2002002669A0/en unknown
- 2001-05-25 HU HU0302263A patent/HUP0302263A2/hu unknown
- 2001-05-25 CZ CZ20023859A patent/CZ20023859A3/cs unknown
- 2001-05-25 AU AU2001260528A patent/AU2001260528A1/en not_active Abandoned
- 2001-05-25 WO PCT/IB2001/000946 patent/WO2001092280A1/en not_active Application Discontinuation
- 2001-05-25 JP JP2002500893A patent/JP2003535100A/ja not_active Withdrawn
- 2001-05-25 EP EP01934231A patent/EP1287011A1/en not_active Withdrawn
- 2001-05-25 MX MXPA02011966A patent/MXPA02011966A/es not_active Application Discontinuation
- 2001-05-25 CN CN01810623A patent/CN1432019A/zh active Pending
- 2001-05-25 CA CA002410643A patent/CA2410643A1/en not_active Abandoned
- 2001-05-25 BR BR0111242-2A patent/BR0111242A/pt not_active IP Right Cessation
- 2001-05-25 PL PL01359179A patent/PL359179A1/xx not_active Application Discontinuation
- 2001-05-25 OA OA1200200361A patent/OA12277A/en unknown
- 2001-05-25 KR KR1020027016396A patent/KR20030010655A/ko not_active Application Discontinuation
- 2001-05-25 EA EA200201167A patent/EA200201167A1/ru unknown
- 2001-05-25 IL IL15298401A patent/IL152984A0/xx unknown
- 2001-05-30 GT GT200100099A patent/GT200100099A/es unknown
- 2001-05-30 PA PA20018518101A patent/PA8518101A1/es unknown
- 2001-05-31 UY UY26741A patent/UY26741A1/es not_active Application Discontinuation
- 2001-06-01 PE PE2001000511A patent/PE20020334A1/es not_active Application Discontinuation
- 2001-06-01 TN TNTNSN01080A patent/TNSN01080A1/fr unknown
- 2001-06-01 US US09/872,731 patent/US6867230B2/en not_active Expired - Fee Related
- 2001-06-01 SV SV2001000474A patent/SV2002000474A/es not_active Application Discontinuation
- 2001-06-01 AR ARP010102642A patent/AR028667A1/es unknown
- 2001-06-01 EC EC2001004093A patent/ECSP014093A/es unknown
-
2002
- 2002-11-12 BG BG107265A patent/BG107265A/bg unknown
- 2002-11-14 IS IS6618A patent/IS6618A/is unknown
- 2002-11-27 NO NO20025704A patent/NO20025704D0/no not_active Application Discontinuation
- 2002-11-29 MA MA26928A patent/MA26909A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK16612002A3 (sk) | 2004-04-06 |
| AU2001260528A1 (en) | 2001-12-11 |
| OA12277A (en) | 2006-05-11 |
| PL359179A1 (en) | 2004-08-23 |
| AR028667A1 (es) | 2003-05-21 |
| PE20020334A1 (es) | 2002-04-30 |
| EP1287011A1 (en) | 2003-03-05 |
| SV2002000474A (es) | 2002-07-03 |
| TNSN01080A1 (fr) | 2005-11-10 |
| NO20025704L (no) | 2002-11-27 |
| AP2002002669A0 (en) | 2002-12-31 |
| CN1432019A (zh) | 2003-07-23 |
| JP2003535100A (ja) | 2003-11-25 |
| IS6618A (is) | 2002-11-14 |
| MXPA02011966A (es) | 2003-04-22 |
| US20030045528A1 (en) | 2003-03-06 |
| KR20030010655A (ko) | 2003-02-05 |
| IL152984A0 (en) | 2003-06-24 |
| CA2410643A1 (en) | 2001-12-06 |
| WO2001092280A1 (en) | 2001-12-06 |
| MA26909A1 (fr) | 2004-12-20 |
| BG107265A (bg) | 2003-07-31 |
| PA8518101A1 (es) | 2002-09-17 |
| US6867230B2 (en) | 2005-03-15 |
| ECSP014093A (es) | 2002-01-25 |
| BR0111242A (pt) | 2003-06-03 |
| UY26741A1 (es) | 2001-12-28 |
| NO20025704D0 (no) | 2002-11-27 |
| CZ20023859A3 (cs) | 2004-02-18 |
| EE200200671A (et) | 2004-08-16 |
| GT200100099A (es) | 2002-01-31 |
| HUP0302263A2 (hu) | 2003-10-28 |
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