HUP0100406A2 - Egy vagy több hatóanyag azonnali és tartós felszabadulását biztosító tabletta - Google Patents

Egy vagy több hatóanyag azonnali és tartós felszabadulását biztosító tabletta

Info

Publication number
HUP0100406A2
HUP0100406A2 HU0100406A HUP0100406A HUP0100406A2 HU P0100406 A2 HUP0100406 A2 HU P0100406A2 HU 0100406 A HU0100406 A HU 0100406A HU P0100406 A HUP0100406 A HU P0100406A HU P0100406 A2 HUP0100406 A2 HU P0100406A2
Authority
HU
Hungary
Prior art keywords
tablet
layer
instant
active ingredient
active substances
Prior art date
Application number
HU0100406A
Other languages
English (en)
Inventor
Laurence Orlando
Olivier Saslawski
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0100406A2 publication Critical patent/HUP0100406A2/hu
Publication of HU226069B1 publication Critical patent/HU226069B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A találmány tárgya többrétegű tabletta, amely a hatóanyagok azonnali,majd tartós felszabadulását biztosítja, és amely legalább két egymásonelhelyezkedő réteget tartalmaz, azzal jellemezve, hogy az alábbiakattartalmazza: - egy első külső réteg, ami adalékanyagok és egy elsőhatóanyag keverékéből áll, ahol az említett első réteg lehetővé tesziaz említett első hatóanyag azonnali felszabadulását; - egy második réteg, ami érintkezik az említett első réteggel, ésegy biológiailag nem lebontható inert porózus polimer mátrixból áll,amiben egy második hatóanyag van diszpergálva. A találmány tárgyátképezi a fenti tabletta előállítására szolgáló eljárás is. Ó
HU0100406A 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances HU226069B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9716402A FR2772615B1 (fr) 1997-12-23 1997-12-23 Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
PCT/EP1998/008100 WO1999033448A1 (en) 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances

Publications (2)

Publication Number Publication Date
HUP0100406A2 true HUP0100406A2 (hu) 2001-08-28
HU226069B1 HU226069B1 (en) 2008-04-28

Family

ID=9515042

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100406A HU226069B1 (en) 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances

Country Status (24)

Country Link
US (1) US6372255B1 (hu)
EP (1) EP1041972B1 (hu)
JP (1) JP4451563B2 (hu)
KR (1) KR100574207B1 (hu)
CN (1) CN1163220C (hu)
AR (1) AR017897A1 (hu)
AT (1) ATE223207T1 (hu)
AU (1) AU743195B2 (hu)
BR (1) BR9814345A (hu)
CA (1) CA2316277C (hu)
CZ (1) CZ291884B6 (hu)
DE (1) DE69807747T2 (hu)
DK (1) DK1041972T3 (hu)
ES (1) ES2182397T3 (hu)
FR (1) FR2772615B1 (hu)
HU (1) HU226069B1 (hu)
ID (1) ID26313A (hu)
NO (1) NO20003289L (hu)
PT (1) PT1041972E (hu)
RU (1) RU2212885C2 (hu)
SK (1) SK283236B6 (hu)
UA (1) UA55503C2 (hu)
WO (1) WO1999033448A1 (hu)
ZA (1) ZA9811799B (hu)

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UA55503C2 (uk) 2003-04-15
BR9814345A (pt) 2000-10-03
WO1999033448A1 (en) 1999-07-08
CN1283110A (zh) 2001-02-07
CZ291884B6 (cs) 2003-06-18
FR2772615B1 (fr) 2002-06-14
ES2182397T3 (es) 2003-03-01
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CN1163220C (zh) 2004-08-25
HU226069B1 (en) 2008-04-28
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DK1041972T3 (da) 2003-01-06
ID26313A (id) 2000-12-14
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US6372255B1 (en) 2002-04-16
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CA2316277A1 (en) 1999-07-08
FR2772615A1 (fr) 1999-06-25
AR017897A1 (es) 2001-10-24
EP1041972B1 (en) 2002-09-04
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ZA9811799B (en) 1999-06-22
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AU2160699A (en) 1999-07-19
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RU2212885C2 (ru) 2003-09-27

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