HUP0004793A2 - Eljárás alatrofloxacin-mezilát tisztítására és alkalmazására, a vegyületet tartalmazó parenterális készítmények - Google Patents

Eljárás alatrofloxacin-mezilát tisztítására és alkalmazására, a vegyületet tartalmazó parenterális készítmények

Info

Publication number
HUP0004793A2
HUP0004793A2 HU0004793A HUP0004793A HUP0004793A2 HU P0004793 A2 HUP0004793 A2 HU P0004793A2 HU 0004793 A HU0004793 A HU 0004793A HU P0004793 A HUP0004793 A HU P0004793A HU P0004793 A2 HUP0004793 A2 HU P0004793A2
Authority
HU
Hungary
Prior art keywords
compounds
purifying
mesylate
alatrofloxacin mesylate
processes
Prior art date
Application number
HU0004793A
Other languages
English (en)
Inventor
Subramanian Sam Guhan
Robert Mark Guinn
John Francis Lambert
Stanley Walter Walinsky
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0004793A2 publication Critical patent/HUP0004793A2/hu
Publication of HUP0004793A3 publication Critical patent/HUP0004793A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgya kevésbé poláros szennyező anyagoktól lényegébenmentes alatrofloxacin-mezilát - mely egy naftiridon típusúantibiotikum -, hatóanyagként ezen altrofloxacin-mezilátot tartalmazóparenterális gyógyszerkészítmények, valamint eljárások alatrofloxacin-mezilát tisztítására. Az (I) képletű vegyület tisztítása során nyersreakcióterméket - mely az (I) képletű vegyületet és kevésbé polárosszennyező anyagokat tartalmaz - hidrofób gyantával kezelnek. Atalálmány tárgyát képezik továbbá a (II) és (III) képletű vegyületek,e vegyületek bármelyikét tartalmazó antibakteriálisgyógyszerkészítmények, valamint antibakteriális fertőzések kezeléséreszolgáló eljárások a (II), illetve a (III) képletű vegyületfelhasználásával. Ó
HU0004793A 1997-08-01 1998-07-23 Processes for purifying and using alatrofloxacin mesylate and parenteral compositions containing these compounds HUP0004793A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5424697P 1997-08-01 1997-08-01
PCT/IB1998/001122 WO1999006430A1 (en) 1997-08-01 1998-07-23 Alatrofloxacin parenteral compositions

Publications (2)

Publication Number Publication Date
HUP0004793A2 true HUP0004793A2 (hu) 2001-04-28
HUP0004793A3 HUP0004793A3 (en) 2001-10-29

Family

ID=21989735

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004793A HUP0004793A3 (en) 1997-08-01 1998-07-23 Processes for purifying and using alatrofloxacin mesylate and parenteral compositions containing these compounds

Country Status (40)

Country Link
US (1) US6194429B1 (hu)
EP (1) EP1000086B1 (hu)
JP (1) JP3463928B2 (hu)
KR (1) KR20010022495A (hu)
CN (1) CN1265671A (hu)
AP (1) AP1031A (hu)
AR (1) AR015417A1 (hu)
AT (1) ATE259827T1 (hu)
AU (1) AU734863B2 (hu)
BG (1) BG104105A (hu)
BR (1) BR9811580A (hu)
CA (1) CA2296466C (hu)
CO (1) CO4970688A1 (hu)
DE (1) DE69821767T2 (hu)
DK (1) DK1000086T3 (hu)
DZ (1) DZ2576A1 (hu)
EA (1) EA002120B1 (hu)
ES (1) ES2214716T3 (hu)
GT (1) GT199800112A (hu)
HN (1) HN1998000106A (hu)
HR (1) HRP980417B1 (hu)
HU (1) HUP0004793A3 (hu)
ID (1) ID24374A (hu)
IL (1) IL134156A0 (hu)
IS (1) IS5339A (hu)
MA (1) MA24626A1 (hu)
NO (1) NO20000485L (hu)
NZ (1) NZ502249A (hu)
OA (1) OA11281A (hu)
PA (1) PA8456701A1 (hu)
PE (1) PE103799A1 (hu)
PL (1) PL338477A1 (hu)
PT (1) PT1000086E (hu)
SK (1) SK1012000A3 (hu)
TN (1) TNSN98146A1 (hu)
TW (1) TW538043B (hu)
UY (1) UY25113A1 (hu)
WO (1) WO1999006430A1 (hu)
YU (1) YU2500A (hu)
ZA (1) ZA986874B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1226138B1 (en) * 1999-10-08 2004-12-29 Affinium Pharmaceuticals, Inc. Fab i inhibitors
EP1121933A1 (en) * 2000-02-02 2001-08-08 Pfizer Products Inc. Premixed alatrofloxacin injectable compositions
DK1560584T3 (da) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
DK1575951T3 (da) 2002-12-06 2014-09-15 Debiopharm Int Sa Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
EP1608377B1 (en) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
CA2632476A1 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉインヒビターとしてのアクリルアミド誘導体
WO2008098374A1 (en) * 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
ES2731474T3 (es) 2012-06-19 2019-11-15 Debiopharm Int Sa Derivados de profármaco de (E)-N-metil-N-((3-metilbenzofuran-2-il)metil)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)acrilamida
KR20160144499A (ko) * 2014-04-25 2016-12-16 노렉스, 인크. 신경활성 펩타이드의 안정한 조성물
EP3419628B1 (en) 2016-02-26 2020-10-14 Debiopharm International SA Medicament for treatment of diabetic foot infections
AU2019214347B2 (en) 2018-02-02 2023-09-28 Ripple Therapeutics Corporation Glass formulations comprising steroid dimers and uses thereof
CA3176134A1 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3713672A1 (de) 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
US5256791A (en) 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
NZ276478A (en) 1994-01-18 1998-05-27 Pfizer Azabicyclohexyl-substd. naphthyridine carboxylic acid derivatives and their manufacture; intermediates
TW420610B (en) 1994-04-07 2001-02-01 Pfizer A pharmaceutical composition for treating a H. pylori infection or gastric or duodenal ulcers
US5475116A (en) 1994-04-29 1995-12-12 Pfizer Inc. Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones
JP3145715B2 (ja) 1995-06-06 2001-03-12 ファイザー・インコーポレーテッド 無水７−（［１α，５α，６α］−６−アミノ−３−アザビシクロ［３．１．０］ヘキサ−３−イル）−６−フルオロ−１−（２，４−ジフルオロフェニル）−１，４−ジヒドロ−４−オキソ−１，８−ナフチリディン−３−カルボン酸メタンスルホン酸塩の新規な結晶形態
DE69622715T2 (de) * 1995-06-15 2002-11-14 Pfizer Inc., New York Verfahren zur herstellung von derivaten der ein peptid enthaltenden azabizylo-naphtyridin-carbonsäure
KR100343909B1 (ko) 1995-08-29 2003-04-10 화이자 인코포레이티드 트로바플록사신의쯔비터이온형태
JPH11509188A (ja) * 1995-08-29 1999-08-17 ファイザー・インコーポレーテッド プロドラッグ６−ｎ−（ｌ−ａｌａ−ｌ−ａｌａ）トロバフロキサシンの多形体
GB9524466D0 (en) 1995-11-30 1996-01-31 Pfizer Ltd Process
JPH1087617A (ja) 1996-07-09 1998-04-07 Pfizer Inc キノリン系抗生物質の合成に有用な中間体の製法

Also Published As

Publication number Publication date
IL134156A0 (en) 2001-04-30
PE103799A1 (es) 1999-10-25
PT1000086E (pt) 2004-05-31
HN1998000106A (es) 1999-01-08
DE69821767T2 (de) 2005-01-13
EP1000086A1 (en) 2000-05-17
ATE259827T1 (de) 2004-03-15
AU734863B2 (en) 2001-06-21
PA8456701A1 (es) 2000-05-24
SK1012000A3 (en) 2000-09-12
AP1031A (en) 2001-12-21
CA2296466A1 (en) 1999-02-11
GT199800112A (es) 2000-01-15
CN1265671A (zh) 2000-09-06
DK1000086T3 (da) 2004-05-17
TW538043B (en) 2003-06-21
NO20000485D0 (no) 2000-01-31
CA2296466C (en) 2003-04-15
DZ2576A1 (fr) 2003-02-22
IS5339A (is) 2000-01-14
ZA986874B (en) 2000-01-31
KR20010022495A (ko) 2001-03-15
BG104105A (bg) 2000-08-31
NO20000485L (no) 2000-03-27
NZ502249A (en) 2001-11-30
AR015417A1 (es) 2001-05-02
DE69821767D1 (de) 2004-03-25
EA002120B1 (ru) 2001-12-24
BR9811580A (pt) 2000-08-22
OA11281A (en) 2002-11-19
TNSN98146A1 (fr) 2005-03-15
YU2500A (sh) 2002-09-19
AP9801310A0 (en) 1998-09-30
ES2214716T3 (es) 2004-09-16
AU8236898A (en) 1999-02-22
US6194429B1 (en) 2001-02-27
EA200000086A1 (ru) 2000-08-28
UY25113A1 (es) 2000-12-29
EP1000086B1 (en) 2004-02-18
PL338477A1 (en) 2000-11-06
HUP0004793A3 (en) 2001-10-29
WO1999006430A1 (en) 1999-02-11
ID24374A (id) 2000-07-13
MA24626A1 (fr) 1999-04-01
JP3463928B2 (ja) 2003-11-05
HRP980417B1 (en) 2002-10-31
JP2001512133A (ja) 2001-08-21
CO4970688A1 (es) 2000-11-07
HRP980417A2 (en) 1999-08-31

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