PA8456701A1 - Composiciones parenterales de alatrofloxacino - Google Patents

Composiciones parenterales de alatrofloxacino

Info

Publication number
PA8456701A1
PA8456701A1 PA19988456701A PA8456701A PA8456701A1 PA 8456701 A1 PA8456701 A1 PA 8456701A1 PA 19988456701 A PA19988456701 A PA 19988456701A PA 8456701 A PA8456701 A PA 8456701A PA 8456701 A1 PA8456701 A1 PA 8456701A1
Authority
PA
Panama
Prior art keywords
alatrofloxacino
parenteral compositions
mesylate
purifying
procedures
Prior art date
Application number
PA19988456701A
Other languages
English (en)
Inventor
Robert Mark Guinn
John Francis Lambert
Subramanian Sam Guhan
Stanley Walter Walinsky
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8456701A1 publication Critical patent/PA8456701A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A MESILATO DE ALATROFLOXACINO ESENCIALMENTE EXENTO DE IMPUREZAS POCO POLARES, A COMPOSICIONES PARENTERALES DE MESILATO DE ALATROFLOXACINO Y A PROCEDIMIENTOS PARA PURIFICAR MESILATO DE ALATROFLOXACINO.
PA19988456701A 1997-08-01 1998-08-03 Composiciones parenterales de alatrofloxacino PA8456701A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5424697P 1997-08-01 1997-08-01

Publications (1)

Publication Number Publication Date
PA8456701A1 true PA8456701A1 (es) 2000-05-24

Family

ID=21989735

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988456701A PA8456701A1 (es) 1997-08-01 1998-08-03 Composiciones parenterales de alatrofloxacino

Country Status (40)

Country Link
US (1) US6194429B1 (es)
EP (1) EP1000086B1 (es)
JP (1) JP3463928B2 (es)
KR (1) KR20010022495A (es)
CN (1) CN1265671A (es)
AP (1) AP1031A (es)
AR (1) AR015417A1 (es)
AT (1) ATE259827T1 (es)
AU (1) AU734863B2 (es)
BG (1) BG104105A (es)
BR (1) BR9811580A (es)
CA (1) CA2296466C (es)
CO (1) CO4970688A1 (es)
DE (1) DE69821767T2 (es)
DK (1) DK1000086T3 (es)
DZ (1) DZ2576A1 (es)
EA (1) EA002120B1 (es)
ES (1) ES2214716T3 (es)
GT (1) GT199800112A (es)
HN (1) HN1998000106A (es)
HR (1) HRP980417B1 (es)
HU (1) HUP0004793A3 (es)
ID (1) ID24374A (es)
IL (1) IL134156A0 (es)
IS (1) IS5339A (es)
MA (1) MA24626A1 (es)
NO (1) NO20000485L (es)
NZ (1) NZ502249A (es)
OA (1) OA11281A (es)
PA (1) PA8456701A1 (es)
PE (1) PE103799A1 (es)
PL (1) PL338477A1 (es)
PT (1) PT1000086E (es)
SK (1) SK1012000A3 (es)
TN (1) TNSN98146A1 (es)
TW (1) TW538043B (es)
UY (1) UY25113A1 (es)
WO (1) WO1999006430A1 (es)
YU (1) YU2500A (es)
ZA (1) ZA986874B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302015B6 (cs) * 1999-10-08 2010-09-08 Affinium Pharmaceuticals, Inc. Inhibitory Fab I
EP1121933A1 (en) * 2000-02-02 2001-08-08 Pfizer Products Inc. Premixed alatrofloxacin injectable compositions
ATE420640T1 (de) * 2001-04-06 2009-01-15 Affinium Pharm Inc Fab-i-inhibitoren
DK1575951T3 (da) * 2002-12-06 2014-09-15 Debiopharm Int Sa Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
EP1608377B1 (en) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
SI1828167T1 (sl) * 2004-06-04 2014-12-31 Debiopharm International Sa Forum "Apres-Demain" Akrilamidni derivati kot anitibiotična sredstva
WO2007067416A2 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2054422B1 (en) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamide derivatives as fab i inhibitors
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
MX356695B (es) 2012-06-19 2018-06-11 Debiopharm Int Sa Profarmacos derivados de (e)-n-metil-n-((3-metilbenzofuran-2-il)me til)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il) acrilamida.
UA122204C2 (uk) * 2014-04-25 2020-10-12 Наурекс, Інк. Стабільні композиції нейроактивних пептидів
KR20180114177A (ko) 2016-02-26 2018-10-17 데비오팜 인터네셔날 에스 에이 당뇨병성 족부 감염의 치료제
CA3087898A1 (en) 2018-02-02 2019-08-08 Ripple Therapeutics Corporation Glass formulations comprising steroid dimers and uses thereof
CA3176134A1 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3713672A1 (de) 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
US5256791A (en) 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
EP0740667A1 (en) 1994-01-18 1996-11-06 Pfizer Inc. Process and intermediates for preparing naphthyridonecarboxylic acid salts
TW420610B (en) 1994-04-07 2001-02-01 Pfizer A pharmaceutical composition for treating a H. pylori infection or gastric or duodenal ulcers
US5475116A (en) 1994-04-29 1995-12-12 Pfizer Inc. Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones
CA2223404C (en) 1995-06-06 2001-01-16 Thomas A. Morris Novel crystal form of anhydrous 7-(¬1.alpha., 5.alpha., 6.alpha.|-6-amino-3-azabicyclo¬3.1.0|hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt
DK0833837T3 (da) * 1995-06-15 2002-09-02 Pfizer Fremgangsmåde til fremstilling af derivater af azabicyclonaphthydridincarboxylsyre omfattende et dipeptid
NZ310542A (en) * 1995-08-29 1999-09-29 Pfizer Polymorphs of the prodrug 6-n-(l-ala-l-ala)-trovafloxacin selected from its polymorph, its pseodomorphs and the monohydrate, preparation and pharmaceutical compositions thereof
PL325170A1 (en) 1995-08-29 1998-07-06 Pfizer Bipolar forms of throwaflocacin
GB9524466D0 (en) 1995-11-30 1996-01-31 Pfizer Ltd Process
JPH1087617A (ja) 1996-07-09 1998-04-07 Pfizer Inc キノリン系抗生物質の合成に有用な中間体の製法

Also Published As

Publication number Publication date
DZ2576A1 (fr) 2003-02-22
IL134156A0 (en) 2001-04-30
CA2296466C (en) 2003-04-15
HN1998000106A (es) 1999-01-08
BG104105A (bg) 2000-08-31
NZ502249A (en) 2001-11-30
NO20000485L (no) 2000-03-27
YU2500A (sh) 2002-09-19
KR20010022495A (ko) 2001-03-15
US6194429B1 (en) 2001-02-27
AR015417A1 (es) 2001-05-02
DK1000086T3 (da) 2004-05-17
SK1012000A3 (en) 2000-09-12
CO4970688A1 (es) 2000-11-07
AP9801310A0 (en) 1998-09-30
PE103799A1 (es) 1999-10-25
AU734863B2 (en) 2001-06-21
MA24626A1 (fr) 1999-04-01
JP2001512133A (ja) 2001-08-21
AP1031A (en) 2001-12-21
DE69821767T2 (de) 2005-01-13
EA002120B1 (ru) 2001-12-24
NO20000485D0 (no) 2000-01-31
HUP0004793A2 (hu) 2001-04-28
HUP0004793A3 (en) 2001-10-29
HRP980417B1 (en) 2002-10-31
WO1999006430A1 (en) 1999-02-11
UY25113A1 (es) 2000-12-29
ATE259827T1 (de) 2004-03-15
IS5339A (is) 2000-01-14
ZA986874B (en) 2000-01-31
DE69821767D1 (de) 2004-03-25
CA2296466A1 (en) 1999-02-11
ID24374A (id) 2000-07-13
ES2214716T3 (es) 2004-09-16
TNSN98146A1 (fr) 2005-03-15
JP3463928B2 (ja) 2003-11-05
BR9811580A (pt) 2000-08-22
GT199800112A (es) 2000-01-15
EP1000086A1 (en) 2000-05-17
CN1265671A (zh) 2000-09-06
PT1000086E (pt) 2004-05-31
OA11281A (en) 2002-11-19
PL338477A1 (en) 2000-11-06
TW538043B (en) 2003-06-21
HRP980417A2 (en) 1999-08-31
EP1000086B1 (en) 2004-02-18
AU8236898A (en) 1999-02-22
EA200000086A1 (ru) 2000-08-28

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