HUP0004297A2 - Nyújtott felszabadulású készítmények és eljárás előállításukra - Google Patents
Nyújtott felszabadulású készítmények és eljárás előállításukraInfo
- Publication number
- HUP0004297A2 HUP0004297A2 HU0004297A HUP0004297A HUP0004297A2 HU P0004297 A2 HUP0004297 A2 HU P0004297A2 HU 0004297 A HU0004297 A HU 0004297A HU P0004297 A HUP0004297 A HU P0004297A HU P0004297 A2 HUP0004297 A2 HU P0004297A2
- Authority
- HU
- Hungary
- Prior art keywords
- microcapsules
- mixture
- implants
- active substances
- sustained
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 5
- 239000003094 microcapsule Substances 0.000 abstract 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- 229920001577 copolymer Polymers 0.000 abstract 3
- 239000007943 implant Substances 0.000 abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Abstract
A találmány tárgya készítmény mikrokapszulák vagy implantátumokformájában, amely biológiailag lebomlani képes polimer vagy kopolimerexcipienst vagy ilyen excipiensek keverékét és egy hatóanyagot vagyhatóanyagok keverékét tartalmazza és amely mikrokapszulákból vagyimplantátumokból a hatóanyag vagy a hatóanyag keveréke hosszantartóan3 hónapig vagy még hosszabb ideig terjedő idő alatt szabadul fellényegében egyfázisú felszabadulási profil szerint és amelykészítményben: - mikrokapszulák esetén az excipiensben lévő kopolimerviszkozitása 0,9 dl/g és 1,6 dl/g (CHCl3-ban meghatározva) és amikrokapszulák előállítási eljárásánál nincs mikrokapszulaösszeolvadás, vagy - implantátumok esetén a polimerek vagy kopolimerekviszkozitása 0,5 dl/g és 1,6 dl/g közötti érték (CHCl3-banmeghatározva). A találmány vonatkozik továbbá a találmány szerintikészítményekben felhasználásra kerülő nagy fajlagos felületűhatóanyagok, előnyösen peptidek vagy proteinek előállítására, valamintmagára az így nyert nagy fajlagos felületű anyagra is. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9704837A FR2762318B1 (fr) | 1997-04-18 | 1997-04-18 | Compositions presentant une liberation prolongee et leur procede de preparation |
FR9803666A FR2776516B1 (fr) | 1998-03-25 | 1998-03-25 | Compositions presentant une liberation prolongee et leur procede de preparation |
PCT/FR1998/000773 WO1998047489A1 (fr) | 1997-04-18 | 1998-04-17 | Compositions presentant une liberation prolongee et leur procede de preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0004297A2 true HUP0004297A2 (hu) | 2001-08-28 |
Family
ID=26233477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0004297A HUP0004297A2 (hu) | 1997-04-18 | 1998-04-17 | Nyújtott felszabadulású készítmények és eljárás előállításukra |
Country Status (23)
Country | Link |
---|---|
US (2) | US6217893B1 (hu) |
EP (1) | EP0980240B1 (hu) |
JP (1) | JP4557312B2 (hu) |
CN (2) | CN1313082C (hu) |
AR (2) | AR012448A1 (hu) |
AT (1) | ATE389388T1 (hu) |
AU (1) | AU741964B2 (hu) |
BR (1) | BR9808933A (hu) |
CA (1) | CA2286575C (hu) |
CZ (1) | CZ297078B6 (hu) |
DE (1) | DE69839264T2 (hu) |
DK (1) | DK0980240T3 (hu) |
ES (1) | ES2303353T3 (hu) |
HK (1) | HK1027983A1 (hu) |
HU (1) | HUP0004297A2 (hu) |
IL (1) | IL132217A (hu) |
MY (1) | MY118835A (hu) |
NO (2) | NO327999B1 (hu) |
PL (1) | PL196771B1 (hu) |
PT (1) | PT980240E (hu) |
RU (1) | RU2198678C2 (hu) |
TW (1) | TW577759B (hu) |
WO (1) | WO1998047489A1 (hu) |
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CZ288147B6 (en) * | 1995-06-07 | 2001-05-16 | Alkermes Inc | Preparation for prolonged release of human growth hormone |
JPH11509862A (ja) | 1996-01-24 | 1999-08-31 | アメリカ合衆国 | 新規「バーストフリー」持続放出型ポリ(ラクチド/グリコリド)微小球 |
AR012448A1 (es) * | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
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1998
- 1998-04-16 AR ARP980101756A patent/AR012448A1/es not_active Application Discontinuation
- 1998-04-16 TW TW087105802A patent/TW577759B/zh not_active IP Right Cessation
- 1998-04-16 MY MYPI98001698A patent/MY118835A/en unknown
- 1998-04-17 RU RU99124209/14A patent/RU2198678C2/ru not_active IP Right Cessation
- 1998-04-17 HU HU0004297A patent/HUP0004297A2/hu unknown
- 1998-04-17 BR BR9808933-1A patent/BR9808933A/pt not_active Application Discontinuation
- 1998-04-17 DK DK98921551T patent/DK0980240T3/da active
- 1998-04-17 AU AU74363/98A patent/AU741964B2/en not_active Ceased
- 1998-04-17 EP EP98921551A patent/EP0980240B1/fr not_active Revoked
- 1998-04-17 US US09/403,058 patent/US6217893B1/en not_active Expired - Lifetime
- 1998-04-17 CZ CZ0362699A patent/CZ297078B6/cs not_active IP Right Cessation
- 1998-04-17 ES ES98921551T patent/ES2303353T3/es not_active Expired - Lifetime
- 1998-04-17 AT AT98921551T patent/ATE389388T1/de active
- 1998-04-17 WO PCT/FR1998/000773 patent/WO1998047489A1/fr active IP Right Grant
- 1998-04-17 CN CNB031545998A patent/CN1313082C/zh not_active Expired - Fee Related
- 1998-04-17 PL PL336296A patent/PL196771B1/pl unknown
- 1998-04-17 CA CA2286575A patent/CA2286575C/fr not_active Expired - Fee Related
- 1998-04-17 IL IL13221798A patent/IL132217A/en not_active IP Right Cessation
- 1998-04-17 JP JP54515098A patent/JP4557312B2/ja not_active Expired - Fee Related
- 1998-04-17 PT PT98921551T patent/PT980240E/pt unknown
- 1998-04-17 DE DE69839264T patent/DE69839264T2/de not_active Expired - Lifetime
- 1998-04-17 CN CNB988052202A patent/CN1144584C/zh not_active Expired - Fee Related
-
1999
- 1999-10-15 NO NO19995063A patent/NO327999B1/no not_active IP Right Cessation
-
2000
- 2000-11-06 US US09/707,372 patent/US6475507B1/en not_active Expired - Lifetime
- 2000-11-23 HK HK00107498A patent/HK1027983A1/xx not_active IP Right Cessation
-
2007
- 2007-07-05 AR ARP070102999A patent/AR061828A2/es not_active Application Discontinuation
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2008
- 2008-02-14 NO NO20080803A patent/NO20080803L/no not_active Application Discontinuation
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