DE69930642D1 - Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung - Google Patents

Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung

Info

Publication number
DE69930642D1
DE69930642D1 DE69930642T DE69930642T DE69930642D1 DE 69930642 D1 DE69930642 D1 DE 69930642D1 DE 69930642 T DE69930642 T DE 69930642T DE 69930642 T DE69930642 T DE 69930642T DE 69930642 D1 DE69930642 D1 DE 69930642D1
Authority
DE
Germany
Prior art keywords
microparticles
preparation
adsorbent surfaces
adsorbent
polyorthoester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69930642T
Other languages
English (en)
Other versions
DE69930642T2 (de
Inventor
Derek O'hagen
Manmohan Singh
S Ott
John Barackman
Jina Kazzaz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DE69930642D1 publication Critical patent/DE69930642D1/de
Publication of DE69930642T2 publication Critical patent/DE69930642T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
DE69930642T 1998-07-29 1999-07-29 Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung Expired - Lifetime DE69930642T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12453398A 1998-07-29 1998-07-29
US124533 1998-07-29
US28585599A 1999-04-02 1999-04-02
US285855 1999-04-02
PCT/US1999/017308 WO2000006123A1 (en) 1998-07-29 1999-07-29 Microparticles with adsorbent surfaces, methods of making same, and uses thereof

Publications (2)

Publication Number Publication Date
DE69930642D1 true DE69930642D1 (de) 2006-05-18
DE69930642T2 DE69930642T2 (de) 2006-12-28

Family

ID=26822700

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69930642T Expired - Lifetime DE69930642T2 (de) 1998-07-29 1999-07-29 Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung

Country Status (13)

Country Link
EP (1) EP1100468B1 (de)
JP (2) JP4601168B2 (de)
AT (1) ATE321535T1 (de)
AU (1) AU763975B2 (de)
CA (1) CA2338646C (de)
CY (1) CY1107326T1 (de)
DE (1) DE69930642T2 (de)
DK (1) DK1100468T3 (de)
ES (1) ES2260923T3 (de)
HK (1) HK1035862A1 (de)
NZ (1) NZ509853A (de)
PT (1) PT1100468E (de)
WO (1) WO2000006123A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206749B1 (en) 1999-02-26 2012-06-26 Novartis Vaccines And Diagnostics, Inc. Microemulsions with adsorbed macromolecules and microparticles
US7713739B1 (en) 2000-11-17 2010-05-11 Novartis Vaccines And Diagnostics, Inc. Microparticle-based transfection and activation of dendritic cells
EP1333806A2 (de) * 2000-06-29 2003-08-13 Bernina Biosystems GmbH Bdellosomen
BR0114304A (pt) * 2000-09-28 2003-07-29 Chiron Corp Composições de micropartìculas e métodos para a manufatura das mesmas
CN100354297C (zh) * 2001-10-03 2007-12-12 希龙公司 辅助的脑膜炎球菌组合物
AR045702A1 (es) * 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
US7838015B2 (en) * 2001-10-03 2010-11-23 Novartis Vaccines And Diagnostics, Inc. Adjuvanted meningococcus compositions
JP4646516B2 (ja) 2002-02-20 2011-03-09 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 吸着したポリペプチド含有分子を有する微粒子
US20060110736A1 (en) 2002-10-07 2006-05-25 John Donnelly Hiv vaccine formulations
US8034378B2 (en) 2002-12-27 2011-10-11 Novartis Vaccines And Diagnostics, Inc Immunogenic compositions containing phospholipid
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
DE602004022286D1 (de) 2003-06-02 2009-09-10 Novartis Vaccines & Diagnostic Immunogene zusammensetzungen auf basis von biologisch abbaubaren mikroteilchen enthaltend ein diphtherie- und ein tetanustoxoid
FR2859909B1 (fr) 2003-09-22 2007-09-07 Biomerieux Sa Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
US7899527B2 (en) * 2004-05-13 2011-03-01 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system during at least one predetermined menstrual cycle phase
CN101072585A (zh) 2004-11-01 2007-11-14 诺华疫苗和诊断公司 产生免疫应答的组合方法
CA2588089C (en) 2004-11-15 2015-06-23 Novartis Vaccines And Diagnostics Inc. Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant
ES2564241T3 (es) 2005-12-02 2016-03-21 Glaxosmithkline Biologicals Sa Nanopartículas para su uso en composiciones inmunogénicas
EP1991204A2 (de) 2006-02-24 2008-11-19 Novartis AG Mikropartikel mit biologisch abbaubarem polymer und kationischem polysaccharid zur verwendung für immunogene zusammensetzungen
ES2664753T3 (es) 2007-12-07 2018-04-23 Glaxosmithkline Biologicals Sa Composiciones de inducción de respuestas inmunes
ES2498091T3 (es) 2008-04-28 2014-09-24 Novartis Ag Procedimiento para producir nanopartículas
MX350667B (es) 2009-05-27 2017-09-12 Selecta Biosciences Inc Nanoportadores que poseen componentes con diferentes tasas de liberacion.
ES2658863T3 (es) 2009-06-10 2018-03-12 Glaxosmithkline Biologicals Sa Vacunas que contienen benzonaftiridina
WO2012082165A1 (en) * 2010-01-24 2012-06-21 Novartis Ag Irradiated biodegradable polymer microparticles
WO2011150240A1 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Nanocarrier compositions with uncoupled adjuvant
WO2011149564A1 (en) 2010-05-28 2011-12-01 Tetris Online, Inc. Interactive hybrid asynchronous computer game infrastructure
US9192661B2 (en) 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
EP2640190A4 (de) 2010-11-05 2016-05-11 Selecta Biosciences Inc Modifizierte nikotinische verbindungen und zugehörige verfahren
WO2013006837A1 (en) 2011-07-06 2013-01-10 Novartis Ag Cationic oil-in-water emulsions
EP3424495A1 (de) 2011-07-06 2019-01-09 GlaxoSmithKline Biologicals S.A. Öl-in-wasser-emulsionen mit nukleinsäuren
KR20140050698A (ko) 2011-07-29 2014-04-29 셀렉타 바이오사이언시즈, 인크. 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체
EP2968510B1 (de) 2013-03-14 2019-10-09 President and Fellows of Harvard College Zusammensetzungen von nanopartikeln
WO2023186757A1 (en) 2022-03-30 2023-10-05 Evonik Operations Gmbh Formulations composed of cationic lipids and poly(lactic-co-glycolic acid) for the delivery of polynucleotides into cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69630514D1 (de) * 1995-01-05 2003-12-04 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
GB9514285D0 (en) * 1995-07-13 1995-09-13 Univ Nottingham Polymeric lamellar substrate particles for drug delivery
US5759583A (en) * 1995-08-30 1998-06-02 Syntex (U.S.A.) Inc. Sustained release poly (lactic/glycolic) matrices
ATE235890T1 (de) * 1997-01-30 2003-04-15 Chiron Corp Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr

Also Published As

Publication number Publication date
EP1100468B1 (de) 2006-03-29
HK1035862A1 (en) 2001-12-14
JP2010168392A (ja) 2010-08-05
CA2338646C (en) 2008-10-07
JP4601168B2 (ja) 2010-12-22
DE69930642T2 (de) 2006-12-28
NZ509853A (en) 2003-08-29
AU5245299A (en) 2000-02-21
CY1107326T1 (el) 2012-11-21
ATE321535T1 (de) 2006-04-15
JP2002521425A (ja) 2002-07-16
EP1100468A1 (de) 2001-05-23
DK1100468T3 (da) 2006-07-31
AU763975B2 (en) 2003-08-07
WO2000006123A1 (en) 2000-02-10
ES2260923T3 (es) 2006-11-01
PT1100468E (pt) 2006-07-31
CA2338646A1 (en) 2000-02-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US