HUP0004251A2 - Eljárás brómmetil-bifenil-származékok előállítására - Google Patents

Eljárás brómmetil-bifenil-származékok előállítására

Info

Publication number
HUP0004251A2
HUP0004251A2 HU0004251A HUP0004251A HUP0004251A2 HU P0004251 A2 HUP0004251 A2 HU P0004251A2 HU 0004251 A HU0004251 A HU 0004251A HU P0004251 A HUP0004251 A HU P0004251A HU P0004251 A2 HUP0004251 A2 HU P0004251A2
Authority
HU
Hungary
Prior art keywords
general formula
group
bromomethyl
preparing
biphenyl derivatives
Prior art date
Application number
HU0004251A
Other languages
English (en)
Inventor
Michel Biard
Bertrand Castro
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HUP0004251A2 publication Critical patent/HUP0004251A2/hu
Publication of HUP0004251A3 publication Critical patent/HUP0004251A3/hu
Publication of HU228640B1 publication Critical patent/HU228640B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány az (I) általános képletű - ahol R jelentése cianocsoport,-COOR1 vagy -CONR2R3 általános képletű csoport vagy (III) általánosképletű csoport, ahol R4 halogénatom vagy védőcsoport - 4'-bróm-metil-bifenil-származékok egy előállítási eljárására vonatkozik, melyrejellemző, hogy a bróm, N-bróm-acetamid, N-bróm-ftálimid, N-bróm-maleinimid, N-bróm-szulfonamid, N-bróm-szukcinimid, 1,3-dibróm-5,5-dimetil-hidantoin és egy alkálifém-bromát/bróm-hidrogénsav rendszerközül választott brómozószert és egy (II) általános képletűbifenilszármazékot - ahol R jelentése a fentivel azonos - reagáltatnakkétfázisú rendszerben fénybesugárzás közben, és így a kívántvegyületet kapják. Ó
HU0004251A 1997-11-17 1998-11-09 Method for preparing bromomethyl-biphenyl derivatives HU228640B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9714376A FR2771090B1 (fr) 1997-11-17 1997-11-17 Procede de preparation de derives de bromomethyl-biphenyle
PCT/FR1998/002383 WO1999025681A1 (fr) 1997-11-17 1998-11-09 Procede de preparation de derives de bromomethyl-biphenyle

Publications (3)

Publication Number Publication Date
HUP0004251A2 true HUP0004251A2 (hu) 2001-04-28
HUP0004251A3 HUP0004251A3 (en) 2003-05-28
HU228640B1 HU228640B1 (en) 2013-04-29

Family

ID=9513439

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004251A HU228640B1 (en) 1997-11-17 1998-11-09 Method for preparing bromomethyl-biphenyl derivatives

Country Status (15)

Country Link
US (1) US6214999B1 (hu)
EP (1) EP1032557B1 (hu)
JP (1) JP4546642B2 (hu)
AT (1) ATE249424T1 (hu)
AU (1) AU1160899A (hu)
BR (1) BR9814651B1 (hu)
CA (1) CA2310324C (hu)
DE (1) DE69818091T2 (hu)
DK (1) DK1032557T5 (hu)
ES (1) ES2207004T3 (hu)
FR (1) FR2771090B1 (hu)
HU (1) HU228640B1 (hu)
NO (1) NO327836B1 (hu)
PT (1) PT1032557E (hu)
WO (1) WO1999025681A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60225486T2 (de) * 2002-06-12 2009-04-02 Sumitomo Chemical Co., Ltd. Verfahren zur herstellung von 4'-brommethyl-2-cyanobiphenyl
US7641181B2 (en) * 2003-01-24 2010-01-05 Liquid Spring Technologies, Inc. Distributed power suspension system
WO2004103947A1 (ja) * 2003-05-20 2004-12-02 Sumitomo Chemical Company, Limited ブロモメチル置換芳香族カルボン酸エステル化合物の製造方法
US7528258B2 (en) * 2004-09-02 2009-05-05 Teva Pharmaceutical Industries Ltd Preparation of olmesartan medoxomil
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
US20060074117A1 (en) * 2004-09-02 2006-04-06 Lilach Hedvati Purification of olmesartan medoxomil
JP2008503595A (ja) * 2004-10-15 2008-02-07 テバ ファーマシューティカル インダストリーズ リミティド テルミサルタンの調製方法
JP2007525504A (ja) * 2004-12-30 2007-09-06 テバ ファーマシューティカル インダストリーズ リミティド ２．５よりも高いｐＨでオルメサルタンメドキソミルを調製するための方法
WO2006073519A1 (en) * 2005-01-03 2006-07-13 Teva Pharmaceutical Industries Ltd. Olmesartan medoxomil with reduced levels of impurities
US20060258727A1 (en) * 2005-01-03 2006-11-16 Lilach Hedvati Olmesartan medoxomil with reduced levels of impurities
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
HUP0900788A2 (en) * 2009-12-16 2011-11-28 Sanofi Aventis Process for producing 4-bromomethyl-biphenyl derivatives
CN105399627A (zh) * 2015-10-22 2016-03-16 威特(湖南)药业有限公司 4’-溴甲基联苯-2-羧酸酯的合成方法
AU2017239816B9 (en) * 2016-03-31 2020-09-24 Fujifilm Corporation Method for producing 5-(bromomethyl)-1-benzothiophene
CN108164434A (zh) * 2017-12-27 2018-06-15 安徽太主科技发展有限公司 一种低成本4′-溴甲基-2-氰基联苯的制备方法
CN113816874B (zh) * 2021-10-30 2024-01-26 大连双硼医药化工有限公司 一种合成4-氰基-2-氟苄醇的工艺方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8806584D0 (en) * 1988-03-19 1988-04-20 Interox Chemicals Ltd Bromination
JPH06298683A (ja) * 1993-04-15 1994-10-25 Sankyo Co Ltd 光反応による４−（２−置換）フェニルベンジルブロミド類の製造法
JPH0859515A (ja) * 1994-08-12 1996-03-05 Sanko Kagaku Kogyo Kk モノブロモメチル化芳香族化合物の製造方法
JP2928982B2 (ja) * 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
IT1291551B1 (it) * 1997-04-11 1999-01-11 Luso Farmaco Inst Processo per la preparazione di composti 4-bromometil bifenilici

Also Published As

Publication number Publication date
NO327836B1 (no) 2009-10-05
DE69818091D1 (de) 2003-10-16
EP1032557B1 (fr) 2003-09-10
PT1032557E (pt) 2004-02-27
EP1032557A1 (fr) 2000-09-06
DK1032557T5 (da) 2004-03-08
AU1160899A (en) 1999-06-07
BR9814651A (pt) 2000-10-03
CA2310324C (en) 2010-01-26
DK1032557T3 (da) 2004-01-19
HUP0004251A3 (en) 2003-05-28
JP2001523658A (ja) 2001-11-27
DE69818091T2 (de) 2004-07-01
FR2771090B1 (fr) 2000-02-04
NO20002530L (no) 2000-07-17
ES2207004T3 (es) 2004-05-16
WO1999025681A1 (fr) 1999-05-27
BR9814651B1 (pt) 2010-12-14
US6214999B1 (en) 2001-04-10
HU228640B1 (en) 2013-04-29
FR2771090A1 (fr) 1999-05-21
JP4546642B2 (ja) 2010-09-15
CA2310324A1 (en) 1999-05-27
NO20002530D0 (no) 2000-05-16
ATE249424T1 (de) 2003-09-15

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Legal Events

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HC9A Change of name, address

Owner name: SANOFI, FR

Free format text: FORMER OWNER(S): SANOFI-SYNTHELABO, FR; SANOFI-AVENTIS, FR