HUP0003280A1 - Apolipoprotein A-1 agonista peptidek, ezeket hatóanyagként tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents

Apolipoprotein A-1 agonista peptidek, ezeket hatóanyagként tartalmazó gyógyászati készítmények és alkalmazásuk

Info

Publication number
HUP0003280A1
HUP0003280A1 HU0003280A HUP0003280A HUP0003280A1 HU P0003280 A1 HUP0003280 A1 HU P0003280A1 HU 0003280 A HU0003280 A HU 0003280A HU P0003280 A HUP0003280 A HU P0003280A HU P0003280 A1 HUP0003280 A1 HU P0003280A1
Authority
HU
Hungary
Prior art keywords
peptides
apolipoprotein
pharmaceutical compositions
agonist activity
diseases
Prior art date
Application number
HU0003280A
Other languages
English (en)
Inventor
Klaus Buttner
Isabelle Cornut
Jean-Louis Dasseux
Gunther Metz
Renate Sekul
Original Assignee
Klaus Buttner
Isabelle Cornut
Jean-Louis Dasseux
Gunther Metz
Renate Sekul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klaus Buttner, Isabelle Cornut, Jean-Louis Dasseux, Gunther Metz, Renate Sekul filed Critical Klaus Buttner
Publication of HUP0003280A1 publication Critical patent/HUP0003280A1/hu
Publication of HUP0003280A3 publication Critical patent/HUP0003280A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgyát a humán apolipoprotein A-I (ApoA-I) szerkezeti ésfarmakológiai tulajdonságait utánzó peptid vagy peptidanalóg-agonistapeptidek, ezeket tartalmazó gyógyáaszti készítmények képezik, amelyekalkalmasak a diszlipoproteinémiához kapcsolódó betegségek -beleértve ahiperkoleszterolémiát, a keringési betegségeket, az atheroszklerózist,a resztenózist, valamint más megbetegedéseket, mint például azaszeptikus sokkot - kezelésére. Apeptidek szerkezetére jellemző, hogy14-22 aminosav-maradékot tartalmaz, ami amfipatikus a-hélixet képezlipidek jelenlétében, vagy 1-8aminosavmaradék kivágásával a fenti 14-22tagú peptid vagy peptidanalóg deléciós formája. Ó
HU0003280A 1997-09-29 1998-09-28 Peptides having apolipoprotein a-1 agonist activity, pharmaceutical compositions comprising thereof and their use to treat dyslipidemic disorders HUP0003280A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/940,093 US6037323A (en) 1997-09-29 1997-09-29 Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders

Publications (2)

Publication Number Publication Date
HUP0003280A1 true HUP0003280A1 (hu) 2001-01-29
HUP0003280A3 HUP0003280A3 (en) 2005-06-28

Family

ID=25474213

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003280A HUP0003280A3 (en) 1997-09-29 1998-09-28 Peptides having apolipoprotein a-1 agonist activity, pharmaceutical compositions comprising thereof and their use to treat dyslipidemic disorders

Country Status (19)

Country Link
US (5) US6037323A (hu)
EP (1) EP1019010B1 (hu)
JP (1) JP2003525840A (hu)
KR (1) KR100650974B1 (hu)
CN (1) CN1345245A (hu)
AT (1) ATE363287T1 (hu)
AU (1) AU747823B2 (hu)
CA (1) CA2304931A1 (hu)
DE (1) DE69837855T2 (hu)
ES (1) ES2288768T3 (hu)
HK (1) HK1044898A1 (hu)
HU (1) HUP0003280A3 (hu)
IL (1) IL135321A0 (hu)
NO (1) NO20001600L (hu)
NZ (1) NZ503719A (hu)
PL (1) PL200744B1 (hu)
RU (1) RU2219941C2 (hu)
UA (1) UA71554C2 (hu)
WO (1) WO1999016408A2 (hu)

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HK1044898A1 (zh) 2002-11-08
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US20030008827A1 (en) 2003-01-09
EP1019010B1 (en) 2007-05-30
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US6265377B1 (en) 2001-07-24
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CN1345245A (zh) 2002-04-17
DE69837855T2 (de) 2008-02-07
KR100650974B1 (ko) 2006-11-29
US20040198662A1 (en) 2004-10-07
NZ503719A (en) 2002-09-27
EP1019010A4 (en) 2003-07-23
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US20080058270A1 (en) 2008-03-06
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