HUP0000474A2 - Aril-etén-szulfonamid-származékok és e vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Aril-etén-szulfonamid-származékok és e vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0000474A2 HUP0000474A2 HU0000474A HUP0000474A HUP0000474A2 HU P0000474 A2 HUP0000474 A2 HU P0000474A2 HU 0000474 A HU0000474 A HU 0000474A HU P0000474 A HUP0000474 A HU P0000474A HU P0000474 A2 HUP0000474 A2 HU P0000474A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- short
- chain
- substituted
- optionally
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003431 oxalo group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 102000010180 Endothelin receptor Human genes 0.000 abstract 1
- 108050001739 Endothelin receptor Proteins 0.000 abstract 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
A találmány tárgya új (I) általános képletű aril-etén-szulfonamid-származékok, amelyek nagy affinitást mutatnak az endotelinreceptorokiránt, ezek gyógyászatilag elfogadható sói, a hatóanyagokat tartalmazógyógyászati készítmények, különösen endotelinreceptor-antagonisták. Az(I) általános képletben Ar jelentése adott esetben szubsztituált aril-vagy adott esetben szubsztituált 5-6 tagú heteroarilcsoport, Xjelentése oxigén- vagy kénatom, vagy -NH-csoport, Y jelentése oxigén-vagy kénatom, R1 jelentése hidrogénatom vagy adott esetben halogén-szubsztituált rövid szénláncú alkil-, cikloalkilcsoport, adott esetbenszubsztituált aril- vagy adott esetben szubsztituált 5 vagy 6 tagúheteroarilcsoport, R2 jelentése rövid szénláncú alkil-, rövidszénláncú alkenil- vagy rövid szénláncú alkinilcsoport, melyekmindegyike szubsztituálva lehet egy-három hidroxil-, rövid szénláncúalkoxi-, cikloalkilcsoporttal, halogénatommal, karboxil- vagy rövidszénláncú alkoxi-karbonil-csoporttal, R3 jelentése adott esetben egy-négyszer adott esetben halogén-szubsztituált rövid szénláncú alkil-,rövid szénláncú alkoxicsoporttal, halogénatommal, rövid szénláncúalkil-tio-, rövid szénláncú alkil-szulfinil-, rövid szénláncú alkán-szulfonil-, karboxil-, rövid szénláncú alkoxi-karbonil- vagykarbamoilcsoporttal szubsztituált fenilcsoport, és R4 és R5 azonosvagy különböző, és jelentésük hidrogénatom vagy rövid szénláncúalkilcsoport. A találmány szerinti gyógyszerkészítmények példáulkülönböző eredetű magas vérnyomás, vesebetegségek, ischémiás zavarokkezelésére alkalmasak. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33211195 | 1995-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000474A2 true HUP0000474A2 (hu) | 2000-12-28 |
| HUP0000474A3 HUP0000474A3 (en) | 2001-06-28 |
Family
ID=18251283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000474A HUP0000474A3 (en) | 1995-12-20 | 1996-12-19 | Arylethenesulfonamide derivatives and drug composition containing the same |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6083955A (hu) |
| EP (1) | EP0882719B1 (hu) |
| JP (1) | JP3087968B2 (hu) |
| KR (1) | KR100456650B1 (hu) |
| CN (1) | CN1102580C (hu) |
| AT (1) | ATE201202T1 (hu) |
| AU (1) | AU703386B2 (hu) |
| BR (1) | BR9612061A (hu) |
| DE (1) | DE69612874T2 (hu) |
| ES (1) | ES2156305T3 (hu) |
| HU (1) | HUP0000474A3 (hu) |
| RU (1) | RU2172735C2 (hu) |
| TW (1) | TW414792B (hu) |
| WO (1) | WO1997022595A1 (hu) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| HU227183B1 (en) | 1997-04-28 | 2010-09-28 | Encysive Pharmaceuticals Inc | Sulfonamide derivatives and pharmaceutical compositions containing them for the treatment of endothelin-mediated disorders |
| US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
| CA2315614C (en) | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
| CN1407973A (zh) * | 1999-12-22 | 2003-04-02 | 埃科特莱茵药品有限公司 | 丁炔二醇衍生物 |
| CA2395684C (en) | 1999-12-31 | 2012-01-03 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| GB0003234D0 (en) * | 2000-02-11 | 2000-04-05 | Pfizer Ltd | Method of treatment |
| JP3832229B2 (ja) * | 2000-02-16 | 2006-10-11 | アステラス製薬株式会社 | フェニルエテンスルホンアミド誘導体含有医薬 |
| US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
| MY140724A (en) | 2000-07-21 | 2010-01-15 | Actelion Pharmaceuticals Ltd | Novel arylethene-sulfonamides |
| GB0023074D0 (en) * | 2000-09-20 | 2000-11-01 | Pfizer Ltd | Pyridazines |
| US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
| BR0114082A (pt) * | 2000-09-25 | 2003-07-22 | Actelion Pharmaceuticals Ltd | Compostos, composições farmacêuticas, uso de um ou mais compostos, e, processo para a fabricação de composições farmacêuticas |
| US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
| IL155805A0 (en) | 2000-12-18 | 2003-12-23 | Actelion Pharmaceuticals Ltd | Novel sulfamides and their use as endothelin receptor antagonists |
| CA2434833A1 (en) * | 2001-02-09 | 2002-08-22 | Hironori Harada | Pharmaceutical composition for treating chronic heart failure |
| CN1499971A (zh) * | 2001-04-03 | 2004-05-26 | ֮����ҩ��ʽ���� | 芳基乙烯磺酰胺衍生物的新用途 |
| WO2002083650A1 (en) * | 2001-04-11 | 2002-10-24 | Actelion Pharmaceuticals Ltd | Novel sulfonylamino-pyrimidines |
| KR20030087074A (ko) * | 2001-04-13 | 2003-11-12 | 야마노우치세이야쿠 가부시키가이샤 | 아릴에텐술폰아미드 유도체의 신규 용도 |
| EP1413578A4 (en) * | 2001-07-27 | 2004-10-20 | Yamanouchi Pharma Co Ltd | NEW CRYSTAL OF AN ARYLETHEN SULPHONAMIDE DERIVATIVE AND METHOD FOR THE PRODUCTION THEREOF |
| IL162534A0 (en) * | 2002-01-02 | 2005-11-20 | Actelion Pharmaceuticals Ltd | Novel alkansulfonamides as endotheline antagonists |
| ATE423103T1 (de) | 2002-12-02 | 2009-03-15 | Actelion Pharmaceuticals Ltd | Pyrimidin-sulfonamide und ihre verwendung als endothelin-rezeptor-antagonisten |
| GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
| US20080161321A1 (en) | 2004-03-17 | 2008-07-03 | David Louis Feldman | Use of Renin Inhibitors in Therapy |
| TW200628467A (en) | 2004-11-11 | 2006-08-16 | Actelion Pharmaceuticals Ltd | Novel sulfamides |
| MY151003A (en) | 2005-09-12 | 2014-03-31 | Actelion Pharmaceuticals Ltd | Stable pharmaceutical composition comprising a pyrimidine-sulfamide |
| AR062501A1 (es) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
| MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
| EP2294056A1 (en) * | 2008-05-23 | 2011-03-16 | Synthon B.V. | Bosentan salts |
| IT1393136B1 (it) * | 2009-03-11 | 2012-04-11 | Sifa Vitor S R L | Procedimento per la preparazione del bosentan |
| US20100256371A1 (en) * | 2009-04-02 | 2010-10-07 | Glenmark | Processes for the preparation of bosentan and its intermediates thereof |
| TW201136582A (en) | 2010-03-16 | 2011-11-01 | Novartis Ag | Improved pharmaceutical compositions of aliskiren and methods of delivery |
| CN112898208B (zh) * | 2021-01-29 | 2023-06-20 | 中国医科大学 | 苯基嘧啶胺类抗肿瘤化合物及其制备方法和应用 |
| CN112778215B (zh) * | 2021-01-29 | 2023-06-20 | 中国医科大学 | 2-甲氧基苯氧基嘧啶类抗肿瘤化合物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5222003A (en) * | 1975-08-13 | 1977-02-19 | Hitachi Ltd | Process for removing hydrogen sulfide from hot gas |
| US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| TW270116B (hu) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| TW287160B (hu) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
| JPH07332111A (ja) * | 1994-06-07 | 1995-12-22 | Nippon Muki Co Ltd | 吸気フィルタ装置 |
-
1996
- 1996-12-19 AU AU11710/97A patent/AU703386B2/en not_active Ceased
- 1996-12-19 DE DE69612874T patent/DE69612874T2/de not_active Expired - Lifetime
- 1996-12-19 RU RU98114081/04A patent/RU2172735C2/ru not_active IP Right Cessation
- 1996-12-19 WO PCT/JP1996/003701 patent/WO1997022595A1/ja active IP Right Grant
- 1996-12-19 CN CN96199036A patent/CN1102580C/zh not_active Expired - Fee Related
- 1996-12-19 US US09/091,524 patent/US6083955A/en not_active Expired - Fee Related
- 1996-12-19 TW TW085115694A patent/TW414792B/zh not_active IP Right Cessation
- 1996-12-19 HU HU0000474A patent/HUP0000474A3/hu active IP Right Revival
- 1996-12-19 ES ES96942574T patent/ES2156305T3/es not_active Expired - Lifetime
- 1996-12-19 KR KR10-1998-0704531A patent/KR100456650B1/ko not_active IP Right Cessation
- 1996-12-19 JP JP09522664A patent/JP3087968B2/ja not_active Expired - Fee Related
- 1996-12-19 AT AT96942574T patent/ATE201202T1/de not_active IP Right Cessation
- 1996-12-19 EP EP96942574A patent/EP0882719B1/en not_active Expired - Lifetime
- 1996-12-19 BR BR9612061A patent/BR9612061A/pt active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| EP0882719A4 (en) | 1999-04-28 |
| HUP0000474A3 (en) | 2001-06-28 |
| KR100456650B1 (ko) | 2005-06-20 |
| WO1997022595A1 (fr) | 1997-06-26 |
| TW414792B (en) | 2000-12-11 |
| ATE201202T1 (de) | 2001-06-15 |
| RU2172735C2 (ru) | 2001-08-27 |
| KR20000064423A (ko) | 2000-11-06 |
| CN1102580C (zh) | 2003-03-05 |
| DE69612874T2 (de) | 2001-10-04 |
| BR9612061A (pt) | 1999-02-23 |
| EP0882719A1 (en) | 1998-12-09 |
| AU703386B2 (en) | 1999-03-25 |
| DE69612874D1 (de) | 2001-06-21 |
| US6083955A (en) | 2000-07-04 |
| JP3087968B2 (ja) | 2000-09-18 |
| ES2156305T3 (es) | 2001-06-16 |
| AU1171097A (en) | 1997-07-14 |
| EP0882719B1 (en) | 2001-05-16 |
| CN1204326A (zh) | 1999-01-06 |
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