DE69612874D1 - Arylethensulfonamid-derivate und diese enthaltende medikamente - Google Patents
Arylethensulfonamid-derivate und diese enthaltende medikamenteInfo
- Publication number
- DE69612874D1 DE69612874D1 DE69612874T DE69612874T DE69612874D1 DE 69612874 D1 DE69612874 D1 DE 69612874D1 DE 69612874 T DE69612874 T DE 69612874T DE 69612874 T DE69612874 T DE 69612874T DE 69612874 D1 DE69612874 D1 DE 69612874D1
- Authority
- DE
- Germany
- Prior art keywords
- optionally substituted
- halogens
- carboxy
- drugs
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33211195 | 1995-12-20 | ||
PCT/JP1996/003701 WO1997022595A1 (fr) | 1995-12-20 | 1996-12-19 | Derives arylethenesulfonamide et composition de medicaments renfermant ces derives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69612874D1 true DE69612874D1 (de) | 2001-06-21 |
DE69612874T2 DE69612874T2 (de) | 2001-10-04 |
Family
ID=18251283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69612874T Expired - Lifetime DE69612874T2 (de) | 1995-12-20 | 1996-12-19 | Arylethensulfonamid-derivate und diese enthaltende medikamente |
Country Status (14)
Country | Link |
---|---|
US (1) | US6083955A (de) |
EP (1) | EP0882719B1 (de) |
JP (1) | JP3087968B2 (de) |
KR (1) | KR100456650B1 (de) |
CN (1) | CN1102580C (de) |
AT (1) | ATE201202T1 (de) |
AU (1) | AU703386B2 (de) |
BR (1) | BR9612061A (de) |
DE (1) | DE69612874T2 (de) |
ES (1) | ES2156305T3 (de) |
HU (1) | HUP0000474A3 (de) |
RU (1) | RU2172735C2 (de) |
TW (1) | TW414792B (de) |
WO (1) | WO1997022595A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
EE04156B1 (et) | 1997-04-28 | 2003-10-15 | Texas Biotechnology Corporation | Sulfoonamiidid endoteliini vahendatud haiguste ravimiseks |
TWI284642B (en) | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
CA2315614C (en) | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
HUP0204168A2 (hu) * | 1999-12-22 | 2003-04-28 | Actelion Pharmaceuticals Ltd. | Butin-diol-származékok, ilyeneket tartalmazó gyógyszerkészítmény és előállítása |
AU2464301A (en) | 1999-12-31 | 2001-07-16 | Encysive Pharmaceuticals Inc. | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
GB0003234D0 (en) * | 2000-02-11 | 2000-04-05 | Pfizer Ltd | Method of treatment |
DE60032517T2 (de) * | 2000-02-16 | 2007-10-04 | Astellas Pharma Inc. | Heilmittel gegen durch endothelin verursachte erkrankungen |
US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
MY140724A (en) * | 2000-07-21 | 2010-01-15 | Actelion Pharmaceuticals Ltd | Novel arylethene-sulfonamides |
US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
GB0023074D0 (en) * | 2000-09-20 | 2000-11-01 | Pfizer Ltd | Pyridazines |
ES2333409T3 (es) | 2000-09-25 | 2010-02-22 | Actelion Pharmaceuticals Ltd. | Arilalcano-sulfonamidas dotadas de actividad antagonistas de la endotelina. |
US8168616B1 (en) | 2000-11-17 | 2012-05-01 | Novartis Ag | Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension |
EP1345920B1 (de) | 2000-12-18 | 2006-04-12 | Actelion Pharmaceuticals Ltd. | Neue sulfamiden und deren verwendung als endothelin-antagonisten |
CA2434833A1 (en) * | 2001-02-09 | 2002-08-22 | Hironori Harada | Pharmaceutical composition for treating chronic heart failure |
WO2002080924A1 (fr) * | 2001-04-03 | 2002-10-17 | Yamanouchi Pharmaceutical Co., Ltd. | Nouvelle utilisation du derive sulfonamide arylethene |
WO2002083650A1 (en) * | 2001-04-11 | 2002-10-24 | Actelion Pharmaceuticals Ltd | Novel sulfonylamino-pyrimidines |
EP1393731A1 (de) * | 2001-04-13 | 2004-03-03 | Yamanouchi Pharmaceutical Co. Ltd. | Neuartige verwendung eines arylethensulfonamid-derivats |
JPWO2003010152A1 (ja) * | 2001-07-27 | 2004-11-18 | 山之内製薬株式会社 | アリールエテンスルホンアミド誘導体の新規結晶及びその製造法 |
DE60224223T2 (de) * | 2002-01-02 | 2008-12-04 | Actelion Pharmaceuticals Ltd. | Neue alkylsulfonamide als endothelinantagonisten |
ES2320649T3 (es) | 2002-12-02 | 2009-05-27 | Actelion Pharmaceuticals Ltd. | Pirimidin-sulfamidas y su uso como antagonistas de receptores de endotelina. |
GB0327839D0 (en) | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
EP1729749A2 (de) | 2004-03-17 | 2006-12-13 | Novartis AG | Verwendung von renininhibitoren in therapie |
TW200628467A (en) | 2004-11-11 | 2006-08-16 | Actelion Pharmaceuticals Ltd | Novel sulfamides |
US20080233188A1 (en) | 2005-09-12 | 2008-09-25 | Actelion Pharmaceuticals Ltd. | Stable Pharmaceutical Compositions Comprising a Pyrimidine - Sulfamide |
AR062501A1 (es) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
WO2009141167A1 (en) * | 2008-05-23 | 2009-11-26 | Synthon B.V. | Bosentan salts |
IT1393136B1 (it) * | 2009-03-11 | 2012-04-11 | Sifa Vitor S R L | Procedimento per la preparazione del bosentan |
US20100256371A1 (en) * | 2009-04-02 | 2010-10-07 | Glenmark | Processes for the preparation of bosentan and its intermediates thereof |
WO2011116115A1 (en) | 2010-03-16 | 2011-09-22 | Novartis Ag | Aliskiren composition comprising a medium chain fatty acid, their process of manufacturing |
CN112778215B (zh) * | 2021-01-29 | 2023-06-20 | 中国医科大学 | 2-甲氧基苯氧基嘧啶类抗肿瘤化合物及其制备方法和应用 |
CN112898208B (zh) * | 2021-01-29 | 2023-06-20 | 中国医科大学 | 苯基嘧啶胺类抗肿瘤化合物及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5222003A (en) * | 1975-08-13 | 1977-02-19 | Hitachi Ltd | Process for removing hydrogen sulfide from hot gas |
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
TW270116B (de) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
TW287160B (de) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
JPH07332111A (ja) * | 1994-06-07 | 1995-12-22 | Nippon Muki Co Ltd | 吸気フィルタ装置 |
-
1996
- 1996-12-19 RU RU98114081/04A patent/RU2172735C2/ru not_active IP Right Cessation
- 1996-12-19 CN CN96199036A patent/CN1102580C/zh not_active Expired - Fee Related
- 1996-12-19 WO PCT/JP1996/003701 patent/WO1997022595A1/ja active IP Right Grant
- 1996-12-19 AU AU11710/97A patent/AU703386B2/en not_active Ceased
- 1996-12-19 KR KR10-1998-0704531A patent/KR100456650B1/ko not_active IP Right Cessation
- 1996-12-19 BR BR9612061A patent/BR9612061A/pt active Search and Examination
- 1996-12-19 EP EP96942574A patent/EP0882719B1/de not_active Expired - Lifetime
- 1996-12-19 DE DE69612874T patent/DE69612874T2/de not_active Expired - Lifetime
- 1996-12-19 ES ES96942574T patent/ES2156305T3/es not_active Expired - Lifetime
- 1996-12-19 TW TW085115694A patent/TW414792B/zh not_active IP Right Cessation
- 1996-12-19 US US09/091,524 patent/US6083955A/en not_active Expired - Fee Related
- 1996-12-19 HU HU0000474A patent/HUP0000474A3/hu active IP Right Revival
- 1996-12-19 AT AT96942574T patent/ATE201202T1/de not_active IP Right Cessation
- 1996-12-19 JP JP09522664A patent/JP3087968B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3087968B2 (ja) | 2000-09-18 |
AU1171097A (en) | 1997-07-14 |
CN1102580C (zh) | 2003-03-05 |
HUP0000474A3 (en) | 2001-06-28 |
ES2156305T3 (es) | 2001-06-16 |
RU2172735C2 (ru) | 2001-08-27 |
KR20000064423A (ko) | 2000-11-06 |
EP0882719B1 (de) | 2001-05-16 |
WO1997022595A1 (fr) | 1997-06-26 |
KR100456650B1 (ko) | 2005-06-20 |
AU703386B2 (en) | 1999-03-25 |
HUP0000474A2 (hu) | 2000-12-28 |
US6083955A (en) | 2000-07-04 |
BR9612061A (pt) | 1999-02-23 |
EP0882719A1 (de) | 1998-12-09 |
DE69612874T2 (de) | 2001-10-04 |
EP0882719A4 (de) | 1999-04-28 |
CN1204326A (zh) | 1999-01-06 |
TW414792B (en) | 2000-12-11 |
ATE201202T1 (de) | 2001-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP |