ES2104952T3 - Derivados de nitroanilina y su uso como agentes antitumorales. - Google Patents
Derivados de nitroanilina y su uso como agentes antitumorales.Info
- Publication number
- ES2104952T3 ES2104952T3 ES92923932T ES92923932T ES2104952T3 ES 2104952 T3 ES2104952 T3 ES 2104952T3 ES 92923932 T ES92923932 T ES 92923932T ES 92923932 T ES92923932 T ES 92923932T ES 2104952 T3 ES2104952 T3 ES 2104952T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- substituted
- date
- available benzene
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/48—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SUMINISTRA DERIVADOS DE LA NITROANILINA REPRESENTADOS POR LA FORMULA GENERAL (I) EN DONDE EL GRUPO NITRO ESTA SUSTITUIDO EN CUALQUIERA DE LAS POSICIONES 2-6 DISPONIBLES DE BENCENO; EN DONDE R Y A REPRESENTAN SEPARADAMENTE LOS GRUPOS NO2, CN, COOR1, CONR1R2, CSNR1R2 O SO2NR1R2 Y A ESTA SUSTITUIDA EN CUALQUIERA DE LAS POSICIONES 2-6 DISPONIBLES DE BENCENO; EN DONDE B REPRESENTA N(CH2CH2HALOGENO)2 O N(CH2CH2OSO2R3)2 SUSTITUIDO EN CUALQUIERA DE LAS POSICIONES DISPONIBLES DEL BENCENO; Y EN DONDE R1, R2 Y R3 REPRESENTAN SEPARADAMENTE, H O ALQUIL INFERIOR OPCIONALMENTE SUSTITUIDO CON HIDROXIL, ETER, CARBOXIDO O AMINO, INCLUYENDO ESTRUCTURAS CICLICAS O R1 Y R2 JUNTO CON EL NITROGENO FORMAN UNA ESTRUCTURA HETEROCICLICA, ASIMISMO SE PRESENTAN LAS PREPARACIONES FARMACEUTICAS QUE LOS CONTIENEN. ESTOS COMPUESTOS TIENEN ACTIVIDAD COMO CITOTOXINAS SELECTIVAS A LA HIPOXIA, PRODROGAS ACTIVADAS DE FORMA REDUCTIVA PARA LAS CITOTOXINAS, RADIOSENSIBILIZADORES DE CELULAS HIPOXICAS, Y COMO AGENTES ANTICANCERIGENOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ240785A NZ240785A (en) | 1991-11-28 | 1991-11-28 | Substituted nitro aniline derivatives and medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2104952T3 true ES2104952T3 (es) | 1997-10-16 |
Family
ID=19923816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92923932T Expired - Lifetime ES2104952T3 (es) | 1991-11-28 | 1992-11-27 | Derivados de nitroanilina y su uso como agentes antitumorales. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5571845A (es) |
EP (1) | EP0616609B1 (es) |
JP (1) | JP2987205B2 (es) |
AT (1) | ATE154591T1 (es) |
AU (1) | AU666342B2 (es) |
CA (1) | CA2124315C (es) |
DE (1) | DE69220505T2 (es) |
DK (1) | DK0616609T3 (es) |
ES (1) | ES2104952T3 (es) |
GR (1) | GR3024610T3 (es) |
NZ (1) | NZ240785A (es) |
WO (1) | WO1993011099A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9323008D0 (en) * | 1993-11-05 | 1994-01-05 | Connors Thomas | Improvements relating to cancer therapy |
GB9516943D0 (en) * | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
GB9517001D0 (en) * | 1995-08-18 | 1995-10-18 | Denny William | Enediyne compounds |
US6130237A (en) * | 1996-09-12 | 2000-10-10 | Cancer Research Campaign Technology Limited | Condensed N-aclyindoles as antitumor agents |
GB9805866D0 (en) * | 1998-03-20 | 1998-05-13 | Zeneca Ltd | Anti-tumour agents |
GB9805868D0 (en) * | 1998-03-20 | 1998-05-13 | Zeneca Ltd | Anti-tumour agents |
US6433199B1 (en) | 1998-05-22 | 2002-08-13 | Shionogi Bioresearch Corporation | Quinone derivatives |
US5969133A (en) * | 1998-05-22 | 1999-10-19 | Shiongi Bioresearch Corp. | Bioreductive cytotoxic agents |
NZ521851A (en) * | 2002-10-08 | 2005-02-25 | Auckland Uniservices Ltd | Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy |
AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
AU2004209644A1 (en) * | 2003-02-03 | 2004-08-19 | Palo Alto Institute Of Molecular Medicine | Cell-killing molecules and methods of use thereof |
US7629332B2 (en) | 2003-10-31 | 2009-12-08 | Auckland Uniservices Limited | Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents |
NZ529249A (en) * | 2003-10-31 | 2006-04-28 | Auckland Uniservices Ltd | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic |
NZ549659A (en) * | 2006-09-04 | 2008-12-24 | Auckland Uniservices Ltd | Processes of preparing asymmetric dinitrobenzamide mustard compounds, intermediate compounds useful therein and products obtained therefrom |
WO2010044685A1 (en) * | 2008-10-17 | 2010-04-22 | Auckland Uniservices Limited | Nitrophenyl mustard alcohols, their corresponding phosphates and their use as targeted cytotoxic agents |
WO2010044686A1 (en) * | 2008-10-17 | 2010-04-22 | Auckland Uniservices Limited | Akr1c3 as a biomarker, methods of selecting and treating patients based upon an akr1c3 profile and compounds for use therein |
US10202408B2 (en) | 2012-08-23 | 2019-02-12 | Health Innovation Ventures B.V. | Prodrugs and methods of use thereof |
DK2888227T3 (da) * | 2012-08-23 | 2020-11-02 | Convert Pharmaceuticals SA | Nye prodrugs og anvendelsesmetoder for dem |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0270292A3 (en) * | 1986-12-03 | 1988-07-13 | Merck & Co. Inc. | Radiation sensitizers |
GB8804068D0 (en) * | 1988-02-22 | 1988-03-23 | Roberts J R | Improvements relating to control of neoplastic tissue growth |
-
1991
- 1991-11-28 NZ NZ240785A patent/NZ240785A/en not_active IP Right Cessation
-
1992
- 1992-11-27 DE DE69220505T patent/DE69220505T2/de not_active Expired - Lifetime
- 1992-11-27 CA CA002124315A patent/CA2124315C/en not_active Expired - Fee Related
- 1992-11-27 ES ES92923932T patent/ES2104952T3/es not_active Expired - Lifetime
- 1992-11-27 AU AU29526/92A patent/AU666342B2/en not_active Ceased
- 1992-11-27 WO PCT/GB1992/002199 patent/WO1993011099A1/en active IP Right Grant
- 1992-11-27 AT AT92923932T patent/ATE154591T1/de not_active IP Right Cessation
- 1992-11-27 EP EP92923932A patent/EP0616609B1/en not_active Expired - Lifetime
- 1992-11-27 US US08/244,449 patent/US5571845A/en not_active Expired - Lifetime
- 1992-11-27 JP JP5509940A patent/JP2987205B2/ja not_active Expired - Fee Related
- 1992-11-27 DK DK92923932.5T patent/DK0616609T3/da active
-
1997
- 1997-09-03 GR GR970402251T patent/GR3024610T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69220505T2 (de) | 1998-02-05 |
ATE154591T1 (de) | 1997-07-15 |
AU666342B2 (en) | 1996-02-08 |
DE69220505D1 (de) | 1997-07-24 |
JPH07503946A (ja) | 1995-04-27 |
EP0616609A1 (en) | 1994-09-28 |
DK0616609T3 (da) | 1998-01-26 |
AU2952692A (en) | 1993-06-28 |
EP0616609B1 (en) | 1997-06-18 |
CA2124315A1 (en) | 1993-06-10 |
US5571845A (en) | 1996-11-05 |
NZ240785A (en) | 1995-08-28 |
JP2987205B2 (ja) | 1999-12-06 |
WO1993011099A1 (en) | 1993-06-10 |
CA2124315C (en) | 2002-07-02 |
GR3024610T3 (en) | 1997-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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