HUE038285T2 - Módosított antitest, antitest-konjugátum és eljárás ezek elõállítására - Google Patents

Módosított antitest, antitest-konjugátum és eljárás ezek elõállítására

Info

Publication number
HUE038285T2
HUE038285T2 HUE13786322A HUE13786322A HUE038285T2 HU E038285 T2 HUE038285 T2 HU E038285T2 HU E13786322 A HUE13786322 A HU E13786322A HU E13786322 A HUE13786322 A HU E13786322A HU E038285 T2 HUE038285 T2 HU E038285T2
Authority
HU
Hungary
Prior art keywords
antibody
conjugate
preparation
modified
modified antibody
Prior art date
Application number
HUE13786322A
Other languages
English (en)
Hungarian (hu)
Inventor
Delft Floris Louis Van
Geel Remon Van
Maria Antonia Wijdeven
Original Assignee
Synaffix Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50544942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE038285(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synaffix Bv filed Critical Synaffix Bv
Publication of HUE038285T2 publication Critical patent/HUE038285T2/hu

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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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