HUE033019T2 - Tirozin kináz inhibitorok - Google Patents
Tirozin kináz inhibitorok Download PDFInfo
- Publication number
- HUE033019T2 HUE033019T2 HUE12722662A HUE12722662A HUE033019T2 HU E033019 T2 HUE033019 T2 HU E033019T2 HU E12722662 A HUE12722662 A HU E12722662A HU E12722662 A HUE12722662 A HU E12722662A HU E033019 T2 HUE033019 T2 HU E033019T2
- Authority
- HU
- Hungary
- Prior art keywords
- pyrimidin
- amino
- pyrazolo
- mmol
- methyl
- Prior art date
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- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title description 12
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title description 6
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- UFOVYHGILLJGLP-UHFFFAOYSA-N vitilevuamide Chemical compound N1C(=O)C(NC(=O)CCC(O)=O)CSCC(C(NC(C(=O)NC(=C)C(=O)NC(CC(C)CC)C(=O)NC(C(=O)N(C)C(C(O)COC)C(=O)NC(CO)C(=O)OC2C)C(C)C)C(C)CC)=O)NC(=O)C3CCCN3C(=O)C(CC=3C=CC=CC=3)NC(=O)C2NC(=O)C(CC(C)CC)NC(=O)C(C)NC(=O)C1CC1=CC=CC=C1 UFOVYHGILLJGLP-UHFFFAOYSA-N 0.000 description 1
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- 229950009233 zinostatin stimalamer Drugs 0.000 description 1
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Oncology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (5)
- kináz sNHisrroROK SZABADALMI sGÉ^YPOMTOK i vagy arm#;i!d? §í;oL ZMVkmugm -fa vagyCRL slxá R:? IM-xMHv Momgén vagy aM.; jsiaaMsssvsmui gyüms kágív;.Rs 8S:R? ps8nl8ss íígpiíssiol ^ggsásaaLMamgám; mask msfoah $#>, fcifu^wfk á^siii vagy daacmvopon; 4'€W8·· léisslége 4aMéíkRR8vk 4^1^^0¾¾ vágy mmdágyik gyáfá gpcioáSLásá ssyásáláv#i«gy vágy fáLá sávgaáfsigeássM egymasIM függ&ftgől álHlL. Mámái-· vagy ixHogövcscvaxi kösd kivékmíva. és a kamosA ás saüilöálfeáogsrmi as gmkkay-VR'SO:?·.CSöpagökbas p -CfCDMCHR1' vvajmithov psaaskomsk: Ss mMsen agyas R' jeiaaSva agymávtAlMggyíiasö! sMísgém vagy glkíRspprL és R·· gkerkavá á||··» Lajosík-A: imbvkamk aikk sAlaaiLíL, eAmaAkmRRkR aagy cvlosMángaiMáry· NíRRA ονορ-ον mas; Rv -h R* kvamas vgya-asm! Liggkkxm! károg ám. aihll·- vagy óiklíjsllíitsssps>ít|. vagy 3Z-!agu tabfek mono-ciklusos ho^ocilyias vegyüli. amdy taksÉM egy vagy N;, •érötj^n^isa« szuhszötuéH-igy· -vas/ ks5& fíUi ^í 5ss^li:HiMr€sáEK:;:slfeíl·· v^y ^μοί^δ^^ί· ^öxíÜ? kivásasybm. 1, : A : yegp# si 1 -es igleypk as^ak ;|p|piMsMteg eifeplbati #$|· fg icipteee altkkkaib4tköki;: sasiisXiuá!! :ál, dksasikk·. «salíiék^^ oabgcvv4sml K'! ^ ^ jelentése ílgyskgstek föggeMtt® ntdsmgén·. aiki'· vagy : dkkjit^assgofl), vagy 3-β-ísgO tevfe» l^gigiiligSox vegyeséi agllyispiniek így :yg0y::|öglj ^éüogifeüi.· H, Ckvagy I kegsl szssbeslitPU agy vagy kaki spSsItitüggssi bsifXk likll ^Égjy í^jérésögöíi^^dskií :^y^;sssívsy ^5«; pm-Kme: I; a ,.ρρΡ „m 1 -4' ^é^ygsatikbárraeiyjys sérsbi vagy ei>k gyogyszsrésaekisg elfogadna* sqa. ahcss: f iáigiliik stlbólak szenek gyyrCIs képks!:tip 4. 4, vsfpéti? Pnfe vagy azok gyógyszes'eszettleg ssfogabbato pa ébol -Z-EWG- sdesaésea^ely op< -oneksan am.bumsmls vgvmsHto: íaggspam p* ?agy k>eb v. 1' vs. uy a*vA ^ va v V' a ' t*sa^ d„*c\v a" r> sotsntése gski;.. cRkaaíkk- txdogíkéssvRRsR? csoport taho! R·' la ^ ^argé^e en)«*v.m 'v-ggeH-asa fpr^fgk vagy sfkifeso^p#^^^#· NPBí bsgplP yy.p«í>M& Sikk·, dkloslssk mesoxlaskie vagy adósaik» ososxsn es R' ímemgse aikticeopoéj vagy he^rodkio-aramoC^iMtos;. amp-ogmosdíssafi szubsztstuén egymastéi kggaprkk agy vagy kettő csoport*: atklt- vagy hld^x;osopoftfe& v;s9>
- 3-Pagű tabdb monoasklpo^ heterocf*ie$os vágyóiéi amely tsrfassnaz egy vagy több t*?eroapaot N. v mgy a kozió kkáissztva ss opmoaáitean szeoextstoaii egy vagy kstfö sa\;bszt!loeo»§e; ddamm avas- vagy «a^'-v^xt kmd ksvaSaaatva: psetefáltor* wmmm^ : ^réliláW Evssgy4sip^iá4:; v®9>' *'tóí! ^!'!ί ^0 ^"* '' -E-E^G- psssMsssgrady ^>w«ai ásaSí^'^ egya-jvid ^sy^aaOs agy v;.;gy dab mbsMmmé m*, wiM tatauM. $* ftpriffa* 3fc^:#n% urnává* NRR' caoprtltf {&$ R i»*1#· M”*** 8lK:l'· ü:iíSo8ik!K hidrosisikü- vagy alkjaiké csoport és R' jdenfesa h-dfogéfs} vagy hdfcíotfkío-'srdnoesopam ameiy a? aidysspaPbp;? ssuBaafeM tena*·*** ff|p8eA$(j? vagy h*M csoparüas 3;M- á|pldfp;*SP^ |*IM w ,$mm -üích^íHHí. h^shpíhöh% ^{ρ#νμοη&%· -:<p$pHSNp$í& ^iciepíe '> > S s' ' N~ f M O v\ ' ^ '»' N »*<· '^'s "*S - ‘ Rs ielanfee »C(CH s)íNH? vagy -CiCHs^moifoka^P | tok bSrm&iyíN^ :^^rí^|;;:::^#g y? 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- 17, VagyiM m MS igúaypofek báraPyAs szaSai vagy aaőt gyágyasarAssafeg afegadéaté adja-gyügyaMkénitssIlbö faiaaZaaíásbá® íi; Vagyist vagy sapgk gysgyszersslsieg alíúgádúalö 80f8 M 1-AS ippyapaiak báaml^kt szarná gyulladásos o®«aoíegedést agSospaua ®aslssiagedáx vagy rákos vbaggatágádéákáZAiásiúaá áAáaS falbbszolÉsra; prgfeiaSsfv gygPdPgs bibaágááá Izaléf gyyúadas, ágat; Időit ssklzrMI gplabas, ^gssriMtea'iö^ gyulladás, llaialkoo ladl·® qyMadds. Sklgrarov/lodró®*. ysISsIlSvsfyoSzáíaséS (SM}; Beckfafépkéí, IdlápáÚaS f&sl&pyspéáis gurágsii Porkeaibayadm áyssIAsfila gravis {súlyos lzössgyáa§áség}< rnúlsg aúlitáskspssy aylbimráos námóiikoS: abégSiá, Wpaaa^gra&gldaiaiéyis, plkkélysbaár, axzursa. vgáiagdélgyíiilááás, yidkárfya'gyulaéás, szú® Mxopső ParMobk a gyufái# {yvsü, bdígyüilsdés, bvvrét #8ό&&|§ :$n$ép&::ii#t (Maiak! geassliszi, vkcéonv «saiabkitás iyásaas}, börpir (rossoes), hagassdés pszabáslxos láaói. dlkuz assy 8-spas iimfbiM bzkyiáds iaidaiá, krönikgs ii®ix>cHáv k®io®a. krgaikua MMckás ibuMavs, B-s^kppksfpl!és ieukú-ola. te-ib glasbzpllis ii#®s / VVsldaosv'o® axakroglobollaám-s Idő· marginális sboa JI®fS®a.; plpsagsad ayyalomb, piasg?Piiö®a; ayirgkcsa®áú kivbk:®drgld|ks sorsa B-ssps ΙΙόΙΙδύΡ rzj?rP;Rösömíí ??sákgrnáris;pSíis B-xajiev Siaifösáa,:kpbeúysoiíes 1ΜΙ0®ρ:. mPiasknals flúysaaaj aagy S-asitas lirráóms, MMvaáoolaas nagy Bspies litnlbmia, alsSPIégas felysaékgyöfem Máma, Stirkiggikaföraa (iéúkamla Ssjgy: ^íbfiSÉt IZalail gy#sb|s vagy bárgyuiiadás kskeiáúlbún idésé Makzoblásra; IS:. Vegyülik a 18-as IgérlygM Mans basznáiálns, sasi a vegydla-o! vagy sónak gyógyvverésznllleg alfogsPbatő eoiát agy vagy loOb ?#®ο SsagPkígadés éúaal vagy gyoiiasasssokkasla Visföaayaggai kodlbidáps agagopk aú. 20 Falyaasat képia! agars'# vsgyiak vgagy gyégysrsgksaakssg s!ísp#;#o sé saékaásárs·(ki) shöi: 42 ]abi#S8 -!# csapost R! jeisaiasa íli-o?: Ra^a^Sé njéíégérr; P:5 éa FF paalssa sgyraésiéypgiékaaé; íüdíí>g^ fear; -24:vVG- |e#nté%e vagy ssaéégy# győri; apsiaaáksaa saaPsafeáií agyvagy tóbb ssvdss kiásássá! ssyg^sioHOgggOsiiOraiFil' larsaé vagy éasagéaasögaf! kasé! #váias2im; és a karOssi és sMior# ogagoáyggyCsaíbén #sa -CaCNpCHR· osopasnoa vsaiisaksaK és R.:: jsieuisss askik ikioakgkk ssyssduuak aikll·. ai!éa!#k öRipaRkéa-RR^ vagy oPoaRsénUaskkanr NW* @0po0 (agai Pkés FP jakklsa égyraéstéi léggsOöáüFéis'ögéa*, sk# vagy esklöaRisösspsítL vagy OéMagé .#|í|§8';í^R^^íi^<>§-:^|eísöcigiy's$g. vagykag araaly lanaSnaéa agy vagy tagé géigröpkakt:#;. 0 vagy S kgap tívéksiks és opkPPékaan sagésgtikált agy vagy kaiig sggssaikaanssk kéraxk: a!#F vagy flgaresspöil ággal kívéissklvs;. a fgiyafaRvViégaOsa Isgiép: |a) as jég képié! ssavak vagyuk?! íaégákaiaagi::íA-> aéok XtoisíVösa ·Ν· ονοοοό: R^iéíéniásaííapr; R'· ialóálésa fsbrogéa; R® és R? léisPlásé agyotsGéíbggelispli bkac#é gpsr; -X-EWG- joipotPsí;: vagy apói rmodon gyáré opoípsÉitaa: sgsbsisbrii agy vagy tssfe$yvijSaii|pao vsaoi #)§».: S^os' vagy éidésskaggatt köaöi k) vaigsglvai •s§y ;R$H0 i képiöt-ste# pfé$fiá#!> ahol R* jeísntése #$·, -§pb|?iiii|!| Síkit-, Cikiöslkit-. olkipalkiiér!-NRtR* y#y csoport fából R« és Rv jéláaléss sgyiaéslgi fbggaifeaöl bidragérn, alkli- vagy clkloslklicsöpoftv vagy IMXtagö: rí kod éiOéoöikiavca hotsrooitysor vágyaiét, ameiy iartáinioy agy vágy tana Χδΐοορρ?οηΐθ! M, © vagy I kogpi kivMassars és ogdiogaksao sgiÉsgékiéil agy vagy kábé séuaséSiyéasséi isaroX··, aikii-vagy tgorcaopprtkagbi NyRasgRa; vagy íb) ·«: !S| képiét yvarial vagyöiai rosgéltstssái:oa· a hoi at Rt Rt Rr és R5 az oiéob oisléattsk szartól oiágOaisiozéliák; és •itkWG'· imantésavagy shöl misésa gyéré apoiöaássan 8zobs.niu;sk agya\ssro; föggalaoöl egy vagy lóba: skobvaivsaasai #;)·, hrdaosk vagy iialpg#nespport: kégli! kiváigagfva, és R^GsCfCNiGOX kégiat szabóit vagyufege!, aés! X iaváiö ssopori és W ag Oiébp aotkeisk szalot magosiarogoé; it agciopáiissa agy, -s fant- is) vagyfb) taslsbon kapóé vagyöisi savaéOisiés séjapsk stéPiiáaa; f# opeiaoáésan agy, a teli la) vagy la) lopásban kapóé vagyéipi sssbgb téglának ak|Üilssa;pfafaféitao:. soo;Jsiapfes a Rövoikazék azgaaé győrit képiéi; fapa Vagy '£€WG> j8&í:é$fc:és R* \rnm* #, cá&ék* dk!o«:M;e:vh;R<R* söpöri <&no; R- és R4· Jeí&»e %§®semtf :^8Q¥ Sl^es^it; Sídéi sáíéákkéiP hdrpxR CaK~ msHlso sgyasü· ^:6η&έ$« m* dxtoskksk ;vdsox;a^;- vagy ms**M csoport és R' fmtim mi «**»<**0 mf 'v i\. o oi' %. \.''as· ' ',„ να'?; a t'íí ' » > i ^ aN< MRáp ν%ξ$ϊΜ smesy fófta&rta* egy v^y *»» h«t§f§ete^( R: öáíigy s k&É Éviá^á# va$?km szui^m^x^ m&m\ mw- vagy’korcsoport k<kk kviéSEtm gk A (ll^e* koptét sjs-sos kőim vagyis!Pl áhö!;· R4 okolás Mdrogéfi és R'%ka!«se to. srosi? s feigyiPu 2- pos^öaOsfs tatamsto, a tshtgyg&oes so :soéns!§é|s vso «s 1. posdkbaR «folyik a prasos-ps-éospio gvűrPPös csatunk R'- as R? etetése egymást függni hiceogéa vagy Puor és •#»©vjsteo$é$6:adói s *0 ebében a ssteseotoia (Ry ptoitao Shot R· és R? seisnfeso kdr&gén: 21: A;< aiéPb· sssrkexoü kópsto reto^ köztes vegyük:
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