HUE029958T2 - Eljárás patogén mikroba, inflammatorikus sejt vagy inflammatorikus fehérje testen kívüli eltávolítására - Google Patents

Eljárás patogén mikroba, inflammatorikus sejt vagy inflammatorikus fehérje testen kívüli eltávolítására Download PDF

Info

Publication number
HUE029958T2
HUE029958T2 HUE06835845A HUE06835845A HUE029958T2 HU E029958 T2 HUE029958 T2 HU E029958T2 HU E06835845 A HUE06835845 A HU E06835845A HU E06835845 A HUE06835845 A HU E06835845A HU E029958 T2 HUE029958 T2 HU E029958T2
Authority
HU
Hungary
Prior art keywords
heparin
inflammatory
virus
protein
cell
Prior art date
Application number
HUE06835845A
Other languages
English (en)
Inventor
Olle Larm
Thomas Bergstroem
Original Assignee
Exthera Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exthera Medical Corp filed Critical Exthera Medical Corp
Publication of HUE029958T2 publication Critical patent/HUE029958T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/20—Pathogenic agents
    • A61M2202/203—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/20—Pathogenic agents
    • A61M2202/206—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Claims (2)

  1. í< B'oparin* asovlyTackailsmUixa van pategêss srslkrsvM. is'0íí-ïïîsî:5à>>sikîj^ »ei5 vagy >óÍspiíxmorík#:1ipíp :fcW, »Iso! a heparin sailàsd hordosőns vi> ímovöhilMÍvu és ahol a hoparós kovalens végpooó köhkssel iksspsssoiva van &amp; szilárd hordozóhoz a pasogeo mikroba. »slkínsnatonkus 'sejt vapv mfiatnmsksnkus fehérje $lt^l :dkmài vagy s«lyos^äÄ:ä;;apv5 kezelés £iiárá«ába&amp;ItM^MÄ&amp;aÄs, I, Bepanu, ausdyT.ck ailhoüsa \-au pniogvss mikroba, iisOamnsalorikos xup vagy lollssruoidorib«·; léhérje iráni, alsói a hepasin sas iáid hunkvora vais knínobdsaéivo va ahoi a heparjo kovalens u-gpsxsli koolssvl iuspcsolva vasa a szilárd hmdozöbnz i. ígessypons szerinti l.vzvléxl eljárásban történd ail.alm&amp;záoa aboi a PSHogyo mnoohr s ivko )ton or so-so k 's ' i \ *\ nhd alk\ , < ·.\>y ' sbo, v<' k v ' äsen í
  2. 5, Hepar its, amelynek al'lsnitâsa vais paktgéo mikroba. issilasrsio&amp;sosikux sais vagy i;d1;s«$mnionkax fehérje {ráng ahoi a heparsü szilárd hordozóra van mxmobmzálva ás ahol a hepario kovalens végponti k<Héx«oi ikapoxoiva vais a szilárd 1ÖÄÄ««, li Igpssypil «IM MfÄ ΐΜΜ «#È S pÄgdss wskmb» baktèrkdh. d. Hep;s.no, srssielypok affisägdsa vas> sejt vagy inllarífssÉiorshox fehérje irâm, ahol a heparisi szilárd isordozora van immohilixáiY« éx aboi a hepado kovalens végposuí kbsêsxel kspvsolva vgg a sksllïd Ä#:>as>isoi. }. igpypöi saodisd; kesslesi pyárihbsxs törtért n&amp;aiusazâssa, alsói a iliklárspso a .^sfep£#r /.#»·;, ^zsyooorxxas zsropoA. Sopproax-oxr »mftuoa ÄpsÄpkdov mopro. .tvote'KÄ soi: mmémmm v«i kiválasztva. 4, iiepari«. asrseh mA: atímitása v&amp;ss p&amp;segén mikroba, IsÉsh ahol a heparin saiiátd hordozóra vass smombiliziiva ős ahoi ä : Hbpsdb pyalphis végponti kötéssel kapcsolva -rm. % ssZlP4ÄsdftZÄ%::5lv Ipoyppsys μμΜΪ. ikokhMSl jpjiÄsp ;ihÄd a&amp;xhtsa&amp;hra, alsói :;f hsddèrmm WâMïàe®twi%4<m m0 mtvvsi p, !|pppriîiÿiar!spiyssph:ikl!kàlfeb vaPipiogáss s>isísrób^ mCÍs#|S iNtlsmmsMrikps irássk ainá a heparin szösml hotxk'zora vaus smmohiisMivá is: llsdi a Wß^ β végponti köiéxxók \ sfí sok s ' o os io ni ,»?P‘i' íí« s^' s t I v^ cs <is s- Sshot louer > ts^tà s x'! 4 ipipgvíí ssslkrobss vísüs. -í, Hqxnsis.. ssrisviynvk ssksnikSxa vass pasogéss snikroha. infesmsosikoa sejs vagy iisnamroasorskax fchóijv írónk akis! a haparin asoiátd hordoaósa vass ííssiSiohiliaálva és alsói a isspanss kovái««» vé^Kmo köiéssvi kapcsolva vaa a aissnhd hosdogóisos. <>. igs-xypons SíOfissSí kazeiő»! elpisáshass khtéeks isik;^isrs.asilsr<5, ísssol a virus sa Ιό;4 tîosô« isarpvs sirup!«s vlrny ..>·<;< slpasssi isvspes sirsspias sUo<, iokoerura A virus, ekomegsloviruv «s Isassssirs issisïmfsde-s'icsancsa vims ákssi aiktsíoss csopottbói vart Hiyhlis.s-ovss. &amp; l:iep;s?sfs, ssstsciysssls aiïisniâsss vass pshapss miîyoba, ioil8«mmk>nk«s vöd vagy mllanuusnuilux ftshétiO isdlhk ahol â haparist siziiâfd isordo/sua '.ars sosíoobsissáiva é» a'a>l a hepsirns kovaion4 xvgpono kötéssel kapcsolva yss- a vxsiikrd hotdozéboz. 7. iganyposx :wfuns ko2«ic$i uijárásbao -orhasiS alkabssarSsra ahoi a v»rus I ί-'sïSsn'Sù !s spv s-fiîfk s ''ró 0¾.os ü..' 4\ \ \i np '.ss>.thh O4ot - opo iavi sasi kîSiS'a ‘ns <k Heparin, amelynek attlnit&amp;s* van patogèfi.mikritba, k»8amn«torfct» sejt vag> HU)smmsiÄMiÄgp lâfjt Ä1 s heparin szilárd h>Kbz<tns vas mpÄliÄs pi .bol a hepan« hovbsms végponti ksMsxd kaptává \,m < v'ikV'P *'»»' y*\, : YCs'vpstsst sæermti ke-ko d'&amp;mri\n tork^o iWÂ% «M..«::. pslogé» mikroba pamalia. |Q, Heparin. aroelyoek ailmitása van paíogén mikroba, inflammaloriktis sejt vagy IjälÄüMorikm \he«p oä ,shsi ,5 lep unt -Tibiid k«*ik'\«a tan K^tn >bds>dlv ^ x ahoi a nepmm kosderx \Ogp«'iî kotr vi kapcsolva van a s/llánl hordozóhoz, y. igénypont szsrinlt kezdési eksrissibsm történd síkabispsfa, Äpl a D&amp;rsüriiäs a Pie&amp;tH!>di$tnt fahrtparum is ï'rypatutxt»ntt met állal aikok>iî csoportból v® kíyátesáSV'sí. H, Hop,üh\ utHoUoek ,ti>iitsto;, sa» natogv n snsbbxs, k-PlapaiiskaîM^ son vagy mihinsnsapvnkm Sshérié ô· i SlK> ^ '4<s ί âtü Ικ ú ✓ * a )“ ol'.hzshxs tv ». f». ms n k'<.dm‘s s_„;<o t kn. h! kapcsolva· vào « x,'«k»d VnisVöhiV. i »j xtvjvs ? 'uhü k ek'M ehm^fco» történi* bUhnv.ts*} >i·'! j inílarmnatorikus sejt ;ks iatlammarorikus Umtbcitak es. yjammaiorikns makrofägok áh&amp;i ulkoioit csoportból vsäi ki választva. 12. äkqv^in. sntehmik .tO-mUse v:m potogen mikroba, mrimtiitiátorikiis sep vngy »dkuamatonkiss lehat ie k&amp;ok ahoi a heparin szskir-i haoKoVra »mt »«mobilizálva ds abri a heparin kovalens, végponti kötési kapcsolva van a szilárd hordoxóhoz. 1. igvoypom vzcjmtí kezdési eljárásba» ííbiéoö alkalmazássá* Ä «2 «n'himrH&amp;ksriko* fehérje promiriasnsnborshm, eiiobn. 12 ik|\í' t -n, ».nb. ... míí ,.s<» vt' yov.x'ss» - \t »rimmmiímnm, w vopv >'*:imnm.s'* k ts fehértó mho. ahol SS heparin szilárd hordozóra van immobüizálva és okol sí heparin kovalens végpont UuHvei kapcsolja van a szilárd hordozóhoz, 12, igénypont sztrimi kezelési eljárásban történő alkalmazásra, ahol &amp;:ρίο?: inllummoo'rikii's eiiokin u tuioor»ckróz.U> íketor alla {Γ\!Κ*αι. lumoraekro?»» fektor hats f rNI-jl?, mi#ieiíife4 (:1.-1 ) és. mterlvokm-o (Π .-k) állal .síkoson csoportból vm* klv&amp;ía»ztva. I í ÎS s tel SS ti* }>ys o 's» î s k v , i'l,(ifîH!'\». en vss. sf st » v s v fehésk' kiüti, ahol a hónain} vbkn'd hordozóra vais Isains'PlHzsnva es; a.no; st iscparks kovalens visgpono ksstsSv.sei kisp\si:siv<s v.sü a s3'ilsssti hi)ísl:tr;thrt.í, az ι-ίο.»« tgiisyposütsk öántKiyjke .«/erinít ktízsílési císssívísíxsü sosléssà 'kt ta. sv . 3 s V, OOh' ' }|K OiC\r svci »k> mga#.·. Ix 1 lensoss. amelyijck alTäninbn van pt-ngest sssikstsha. ütOestsrisstKnikus» «t» vagy niOamnunonkts« fehérje ir.sitt, aM ;s hepami »xilätd hnnlo/őra vao »»tnobihrillva vH ahtsi a heparin kovalens végponti kötéssel Lux.solv.s vas; ss r.'hasd hofOit/olütí;. ;sí vlózó sgenyporfiok hSntsesysko s^erinis kezstkusi ssSjá:usfessí; iöiivtKi sikskttsszexi'fí ahol a viiárs! k'.srsis>ió eey sogt több öreges rosîoi kuiainis/ IP, Hv.psss'üt. asnelyitok ssikükbü v.so. patogen isnkioha, íc-ílaosínatítrikus sejt vagy mílaisntaioi-ka« !V »SS :>. íf,tstí í'listi C$ Ι)ν'\»·ίι \^}iaí’' h-'i2»'t'í.! t,'t( in nK‘"i}l/s''<* ka 3Î >'' S itopj» Iti kov.'l.Sts » SSt.pí':' : ; -»íX:: cl knpesoiva v:ísí a «ïilatô horikszöhsí.e ss;s okul) igényponiok bärnteSysks· szerinti kezdési v járás kar Uk-fesst) ítlksistTtsszsiíiv;, ahstl st síikSni hoi'sk-zo ;ts: óvt.g. s.'dhíiór. <. ssi 1 st iísí-íkís;»:;; . xisot. kriozán, s. e; eszi a étke t.»sszn«i}, kereszík«Uöii agaroz. psílipfsípllén, polietilén, psölszonon. poiiakriiisitfii, szshKon. 1 efl-sa ét< ixthü-extssoK. sUtal alkotott csoportból van kiválasztva.
HUE06835845A 2005-12-13 2006-12-13 Eljárás patogén mikroba, inflammatorikus sejt vagy inflammatorikus fehérje testen kívüli eltávolítására HUE029958T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0502750 2005-12-13

Publications (1)

Publication Number Publication Date
HUE029958T2 true HUE029958T2 (hu) 2017-04-28

Family

ID=38163194

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE06835845A HUE029958T2 (hu) 2005-12-13 2006-12-13 Eljárás patogén mikroba, inflammatorikus sejt vagy inflammatorikus fehérje testen kívüli eltávolítására

Country Status (14)

Country Link
US (5) US9173989B2 (hu)
EP (1) EP1960016B1 (hu)
JP (3) JP5715325B2 (hu)
KR (2) KR101397386B1 (hu)
CN (2) CN101370536A (hu)
AU (1) AU2006325531B2 (hu)
BR (1) BRPI0619820A2 (hu)
CA (1) CA2630823C (hu)
DK (1) DK1960016T3 (hu)
ES (1) ES2608399T3 (hu)
HU (1) HUE029958T2 (hu)
MX (2) MX2008007716A (hu)
RU (1) RU2432187C2 (hu)
WO (1) WO2007069983A1 (hu)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0619820A2 (pt) 2005-12-13 2011-10-18 Exthera Ab método de remoção extracorpórea de um micróbio patogênico, uma célula inflamatória ou uma proteìna inflamatória do sangue
WO2008157570A2 (en) * 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
JP5692738B2 (ja) * 2009-07-28 2015-04-01 国立大学法人 鹿児島大学 ウイルスの濃縮方法および磁性体組成物
US8758286B2 (en) * 2009-12-01 2014-06-24 Exthera Medical Corporation Method for removing cytokines from blood with surface immobilized polysaccharides
AU2014277852B2 (en) * 2009-12-01 2016-08-25 Exthera Medical Corporation Method for removing cytokines from blood with surface immobilized polysaccharides
JP5774607B2 (ja) * 2010-02-09 2015-09-09 エクステラ・メディカル・コーポレーション 体外治療による毒性因子の除去
WO2011133099A1 (en) * 2010-04-21 2011-10-27 Exthera Medical Llc Method for removal of mrsa from blood
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
US20140054227A1 (en) * 2011-03-04 2014-02-27 Dic Corporation Sugar-immobilized polymer substrate for removing virus and method for removing virus
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
RU2500434C1 (ru) * 2012-11-28 2013-12-10 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" Способ лечения сепсиса при заболеваниях органов брюшной полости и забрюшинного пространства
EP3013445B1 (en) 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
JP6806563B2 (ja) 2013-11-08 2021-01-06 エクステラ・メディカル・コーポレーション 吸着媒体を使用する感染症の診断法
BR112016024569B1 (pt) 2014-04-24 2023-01-03 Exthera Medical Corporation Método ex vivo para remover bactérias de uma amostra retirada de um indivíduo que é suspeito de estar infectado com a mesma
AU2015321601B2 (en) 2014-09-22 2020-04-23 Exthera Medical Corporation Wearable hemoperfusion device
RU2572019C1 (ru) * 2014-11-12 2015-12-27 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения сепсиса при заболеваниях органов брюшной полости осложненных печеночной недостаточностью
WO2016094827A1 (en) * 2014-12-12 2016-06-16 Velo3D, Inc. Feedback control systems for three-dimensional printing
JP2016146809A (ja) * 2015-02-13 2016-08-18 国立大学法人広島大学 ウイルス分離デバイス
TWI580782B (zh) * 2015-08-11 2017-05-01 財團法人工業技術研究院 去除陰電性低密度脂蛋白之生化反應材料與裝置以及體外處理血液或血漿以去除其中陰電性低密度脂蛋白的方法
US20170044516A1 (en) 2015-08-11 2017-02-16 Industrial Technology Research Institute Biochemistry reactive material and device for eliminating electronegative low-density lipoprotein (ldl) and method for treating blood or plasma ex vivo to eliminate electronegative low-density lipoprotein therein
EP3422943A4 (en) 2016-03-02 2019-10-16 ExThera Medical Corporation METHOD OF TREATING DRUG ENTRIES
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
CN109843347B (zh) * 2016-11-29 2021-06-15 富士胶片株式会社 血液成分选择吸附滤材及血液过滤器
JP6231236B1 (ja) * 2017-03-30 2017-11-15 株式会社日立製作所 摩擦攪拌接合装置及び摩擦攪拌接合制御装置並びに摩擦攪拌接合方法
JP2022550403A (ja) 2019-09-30 2022-12-01 ヘモチューン アーゲー 体液の体外処理のためのアセンブリ
EP3981505A1 (en) 2020-10-12 2022-04-13 Gambro Lundia AB Membrane with immobilized anticoagulant and process for producing same
CN114042441B (zh) * 2021-12-09 2024-05-03 云南师范大学 在血液灌流树脂微球表面修饰并固载肝素的方法及其制备的吸附剂

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3782382A (en) 1972-02-03 1974-01-01 K N Enterprises Inc Means for blood administration and the like
US4103685A (en) 1976-01-05 1978-08-01 Lupien Paul J Method and apparatus for extravascular treatment of blood
JPS54127493U (hu) 1978-02-25 1979-09-05
JPS6040926B2 (ja) 1979-07-24 1985-09-13 三菱重工業株式会社 マンドレルバ−の自動サポ−ト装置
US4430496A (en) 1980-01-17 1984-02-07 Varian Associates, Inc. Strong anion exchange composition and methods
US4415665A (en) 1980-12-12 1983-11-15 Pharmacia Fine Chemicals Ab Method of covalently binding biologically active organic substances to polymeric substances
JPS5853757A (ja) 1981-09-25 1983-03-30 Denki Kagaku Kogyo Kk 免疫アフイニテイクロマトグラフイ−用吸着体及びその製法
SE8200751L (sv) 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
JPS58146354A (ja) 1982-02-26 1983-08-31 日機装株式会社 体液浄化器の製造法
US4820302A (en) 1982-04-22 1989-04-11 Sterling Drug Inc. Bio compatible and blood compatible materials and methods
CA1221307A (en) 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
DE3609021A1 (de) 1985-03-25 1986-09-25 Bio-Rad Laboratories, Inc., Richmond, Calif. Chromatographisches trennmedium fuer die schnelle analyse von kleinen proben
DE3519011A1 (de) 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
CA1327963C (en) 1987-09-08 1994-03-22 Ryuichi Yokohari Autoantibody adsorbent and apparatus for removing autoantibodies using the same
EP0321703B1 (en) 1987-11-20 1993-04-28 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Absorbent for serum amyloid protein
US4955870A (en) 1988-08-23 1990-09-11 Ridderheim Kristen A Hypodermic syringe with retractable needle
AU6441490A (en) 1989-09-18 1991-04-18 Cuno Incorporated Filter media and use for pyrogen removal
JPH0489500A (ja) 1990-07-31 1992-03-23 Kirin Brewery Co Ltd アフィニティクロマトグラフィーによる物質の精製法および精製装置
SE469256B (sv) 1991-02-18 1993-06-14 Medscand Ab Rengoeringsprodukt
CA2083168C (en) 1991-03-26 1999-03-23 Kaneji Asakawa Adsorbent for cellular fibronectin and a method for fractional purification of fibronectin
US5211850A (en) 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
DE4217917A1 (de) 1992-05-30 1993-12-02 Job Prof Dr Med Harenberg Immobilisation von chemisch kovalent gebundenem Heparin an Polymere mit Arylresten im Polymer
JPH0640926A (ja) 1992-07-24 1994-02-15 Chemo Sero Therapeut Res Inst Ｃ型肝炎ウイルスの除去方法
DE4331358A1 (de) 1992-10-12 1994-04-14 Braun Melsungen Ag Verfahren zur quantitativen selektiven Entfernung oder präparativen Gewinnung von Tumor-Nekrose-Faktor (TNF) oder/und Lipopolysacchariden (LPS) aus wäßrigen Flüssigkeiten
US5344455A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5437861A (en) * 1993-03-16 1995-08-01 Applied Immune Sciences, Inc. Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome
JP2643823B2 (ja) 1993-03-25 1997-08-20 有限会社 エンゼル総合研究所 吸着材料及びその製造方法
NO931809L (no) 1993-05-19 1994-11-21 Norsk Hydro As Hemofilter
US5447859A (en) * 1993-07-16 1995-09-05 Viagene Method for the purification or removal of retroviruses using sulfated cellulose
US5753227A (en) 1993-07-23 1998-05-19 Strahilevitz; Meir Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases
CN1130386A (zh) * 1993-08-19 1996-09-04 美国3M公司 肝素官能亲合性载体
JPH07178161A (ja) 1993-12-24 1995-07-18 Terumo Corp 医療器具
DE69621597T2 (de) 1995-02-16 2003-01-16 Kanegafuchi Chemical Ind Adsorbens für tumornekrosefaktor alpha, methode zur entfernung durch adsorption und adsorptionsvorrichtung unter verwendung des adsorbens
SE9501056D0 (sv) 1995-03-23 1995-03-23 Probi Ab Epithelial adherent lactobacilli
US6312907B1 (en) 1995-04-24 2001-11-06 The Texas A & M University System DbpA compositions and methods of use
US6544727B1 (en) 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
WO1996040857A1 (en) 1995-06-07 1996-12-19 Cerus Corporation Methods and devices for the removal of psoralens from blood products
CA2229986C (en) 1995-06-20 2014-10-21 Johannes Schumacher Process and device for determining the activity of enzymes in liquids, or the concentration and/or activity of inhibitors in liquids
DE69722491T2 (de) 1996-03-18 2004-05-19 Kaneka Corp. Adsorbens und Verfahren zur Entfernung von Chemokinen des CC-Subtyps aus Körperflüssigkeiten
RU2089283C1 (ru) 1996-03-23 1997-09-10 Научно-исследовательская фирма "Ультрасан" Био-, гемосовместимые сорбенты на основе сверхсшитых полимеров стирола с модифицированной поверхностью, способ их получения (варианты) и способ получения матрицы сорбента
SE507028C2 (sv) 1996-08-06 1998-03-16 Medicarb Ab Ny medicinsk användning
WO1998029727A2 (en) 1996-12-31 1998-07-09 Stephon, Robert, L. Microsphere-enhanced immunoassay for the detection of veterinary diseases
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
TW514537B (en) 1997-03-25 2002-12-21 Kanegafuchi Chemical Ind Adsorbent for removing hepatitis c virus and adsorption apparatus
US6465170B2 (en) 1997-06-13 2002-10-15 Baxter Aktiengesellschaft Method for depleting viral and molecular pathogens in a biological material
US6197568B1 (en) * 1997-07-29 2001-03-06 The Regents Of The University Of Michigan Method and compositions for isolation, diagnosis and treatment of polyanion-binding microorganisms
US20020197249A1 (en) 2001-04-10 2002-12-26 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood products
US20020197250A1 (en) 2001-04-10 2002-12-26 Renal Tech International Biocompatible devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood
US20020159995A1 (en) 1997-07-30 2002-10-31 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing
US6053894A (en) 1997-08-04 2000-04-25 Shadd, Jr.; Daniel L. Hypodermic syringe
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6136424A (en) 1998-02-06 2000-10-24 Renal Tech International, Llc Method of and material for purification of physiological liquids of organism, and method of producing the material
GB9804632D0 (en) * 1998-03-05 1998-04-29 Cantab Pharma Res Virus preparations and methods
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
JP2000086688A (ja) * 1998-09-04 2000-03-28 Ngk Insulators Ltd パルボウイルス吸着糖鎖リガンドおよびこれを利用したパルボウイルス除去装置
NO984143L (no) 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
AU5670299A (en) 1998-10-19 2000-05-08 Cbd Technologies Ltd. Methods of concentrating microorganisms using affinity separation
US6461517B1 (en) 1998-12-22 2002-10-08 Toray Industries, Inc. Bacterial-derived component removal material
ES2372580T3 (es) 1998-12-24 2012-01-24 Toray Industries, Inc. Columna para purificar sangre.
JP2000217575A (ja) 1999-02-01 2000-08-08 Masashi Funayama 生理活性物質、ヒト血球分化細胞およびヒト細胞の吸着体。
DE19916352A1 (de) * 1999-04-12 2000-10-19 Braun Melsungen Ag Entfernung von hüllehaltigen Viren aus Blut, Plasma oder Serum
US6531159B1 (en) 1999-04-28 2003-03-11 Toray Industries, Inc. Materials eliminating cannabinoids and columns for the elimination of cannabinoids with the use of the same
WO2001018060A1 (fr) 1999-09-08 2001-03-15 Toray Industries, Inc. Materiaux de circulation extracorporelle, adsorbants de facteurs de complication diabetique, reservoirs servant a eliminer des facteurs de complication diabetique et procede d'elimination de facteurs de complication diabetique
SE515295C2 (sv) * 1999-11-23 2001-07-09 Medicarb Ab Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat
JP2001178817A (ja) 1999-12-24 2001-07-03 Terumo Corp 人工腎臓用装置およびこれを用いた品質評価装置ならびに流体回路
US7067060B2 (en) 2000-01-11 2006-06-27 Nephros, Inc. Ionic enhanced dialysis/diafiltration system
JP2001190273A (ja) 2000-01-14 2001-07-17 Jsr Corp ウイルス濃縮用粒子、該粒子を使用するウイルス濃縮方法およびウイルス検出方法
GB0001450D0 (en) 2000-01-21 2000-03-08 Genpoint As Cell isolation method
EP1264181B1 (en) 2000-03-06 2007-06-06 Dade Behring Marburg GmbH Carriers coated with polysaccharides, their preparation and use
EP1192963A4 (en) 2000-04-05 2004-08-25 Toray Industries ADSORBENTS FOR PROTEINS OF THE HIGH MOBILITY PROTEIN AND PILLAR GROUP FOR CLEANING BODY LIQUIDS
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
DE10045434B4 (de) 2000-09-14 2005-07-14 Fresenius Hemocare Gmbh Adsorbens mit unterschiedlich modifizierten Oberflächenbereichen, Verfahren zu dessen Herstellung und Verwendung davon
JP4283430B2 (ja) 2000-09-26 2009-06-24 株式会社カネカ エンテロトキシンの吸着材、吸着除去方法および吸着器
US8178304B2 (en) 2000-10-06 2012-05-15 Smith Terry J Diagnostic methods relating to Graves' disease and other autoimmune disorders
US8153121B2 (en) 2000-10-06 2012-04-10 Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center Diagnosis and therapy of antibody-mediated inflammatory autoimmune disorders
US6509104B2 (en) * 2000-12-05 2003-01-21 Michigan Biotechnology Institute Antithrombogenic polymer coating
WO2002053251A1 (en) 2000-12-29 2002-07-11 Upfront Chromatography A/S Extracorporeal capturing of specific bio-macromolecular entities from extracellular body fluids
CN1220531C (zh) 2001-01-30 2005-09-28 钟渊化学工业株式会社 能够直接进行血液灌流的体液处理器
DE10117043A1 (de) 2001-04-05 2002-11-07 Gerhard Puetz Verfahren zur Eliminierung von potentiell toxischen und/oder schädlichen Stoffen
US20020197252A1 (en) 2001-04-10 2002-12-26 Renal Tech International Selective adsorption devices and systems
US6773412B2 (en) 2001-04-13 2004-08-10 Chf Solutions, Inc. User interface for blood treatment device
KR20040050912A (ko) 2001-10-10 2004-06-17 가부시키가이샤 노리타케 캄파니 리미티드 생물학적 유해 물질을 선택적으로 불활성화 하는 광촉매재료 및 그 이용
JP2003128502A (ja) 2001-10-18 2003-05-08 Noritake Co Ltd 有害物質の処理材およびその製造方法
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US20030148017A1 (en) 2001-12-07 2003-08-07 Olli Tuominen Copolymer coating for a hydrophobic membrane
JP2005519744A (ja) 2002-03-14 2005-07-07 バクスター・インターナショナル・インコーポレイテッド 化合物除去器
EP1507557A4 (en) 2002-04-23 2006-06-14 Meir Strahilevitz METHODS AND DEVICES FOR TARGETING A SITE IN A MAMMAL AND DETERMINING CHEMICAL SPECIES FROM A MAMMAL
US20050249724A1 (en) 2002-07-11 2005-11-10 Upfront Chromatography A/S Extracorporeal stablised expanded bed adsorption method for the treatment of sepsis
DE60326864D1 (de) 2002-07-24 2009-05-07 Bio Rad Laboratories Proteininteraktionsdifferenzabbildung
US20040182783A1 (en) 2003-03-17 2004-09-23 Walker Kimberly A. Filter and concentrator device for treatment of blood
US7207964B2 (en) 2003-03-17 2007-04-24 Hemavation, Llc Apparatus and method for down-regulating immune system mediators in blood
DE602004020999D1 (de) 2003-08-15 2009-06-18 Univ South Florida Materialien und verfahren zum einfangen von krankheitserregern und zur abtrennung von aurintricarbonsäure aus einer probe
US7399400B2 (en) 2003-09-30 2008-07-15 Nano-Proprietary, Inc. Nanobiosensor and carbon nanotube thin film transistors
CA2546222A1 (en) 2003-11-19 2005-06-09 Chiron Corporation Methods and reagents for treating, preventing and diagnosing bunyavirus infection
EP1790365B1 (en) 2004-07-23 2015-11-18 Kaneka Corporation Direct hemoperfusion adsorber packed with adsorbent having water-insoluble microparticles removed therefrom, and method of obtaining direct hemoperfusion adsorber packed with adsorbent having water-insoluble microparticles removed therefrom
WO2006025371A1 (ja) 2004-08-30 2006-03-09 Kaneka Corporation 顆粒球吸着材
US8445293B2 (en) 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
GB0509433D0 (en) 2005-05-09 2005-06-15 Uni For Milj Og Biovitenskap Method
AU2006261953B2 (en) 2005-06-24 2012-02-23 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US20100239673A1 (en) 2005-08-01 2010-09-23 Linhardt Robert J Blood compatible nanomaterials and methods of making and using the same
AU2006316039B2 (en) 2005-11-21 2011-08-18 Ge Healthcare Bio-Sciences Ab A method of chromatography using semi-synthetic heparin ligands
BRPI0619820A2 (pt) 2005-12-13 2011-10-18 Exthera Ab método de remoção extracorpórea de um micróbio patogênico, uma célula inflamatória ou uma proteìna inflamatória do sangue
CA3122671A1 (en) 2005-12-21 2008-05-15 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
US8211048B2 (en) 2006-02-22 2012-07-03 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US7763097B2 (en) 2006-06-08 2010-07-27 University of Pittsburgh—of the Commonwealth System of Higher Education Devices, systems and methods for reducing the concentration of a chemical entity in fluids
WO2007145328A1 (ja) 2006-06-16 2007-12-21 Terumo Kabushiki Kaisha 血液処理フィルターおよび血液処理回路
FR2902670B1 (fr) 2006-06-22 2009-04-24 Gambro Lundia Ab Utilisation d'une suspension pour traiter un support a usage medical, support a usage medical, echangeur et dispositif d'adsorption comprenant le support
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
MX2009004460A (es) 2006-10-26 2009-07-09 Abbott Lab Inmunoensayo de analitos en muestras que contienen anticuerpos anti-analito endogenos.
GB0702183D0 (en) 2007-02-05 2007-03-14 Iti Scotland Ltd Pathogen binding
WO2008128251A1 (en) 2007-04-17 2008-10-23 The Children's Hospital Of Philadelphia Humanized viral vectors and methods of use thereof
CN101715317A (zh) 2007-04-19 2010-05-26 C.G.M.3有限公司 监控血液分析物水平的设备系统和方法
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
WO2008157570A2 (en) 2007-06-18 2008-12-24 Exthera Ab Device and method for restoration of the condition of blood
JP4226050B1 (ja) 2007-09-12 2009-02-18 株式会社Ｒｅｉメディカル 体液浄化処理用吸着カラム
AU2008321357A1 (en) 2007-11-16 2009-05-22 Smith & Nephew, Inc. Annular ring implant
US20110183398A1 (en) 2007-12-31 2011-07-28 3M Innovative Properties Microorganism-capturing compositions and methods
EP2087916A1 (en) 2008-02-11 2009-08-12 ICinnovation BV Electrosorption device for the purification of blood and other fluids
CN101632686A (zh) 2008-04-04 2010-01-27 马斯特里赫特大学 糖胺聚糖用于修复糖萼的用途
ES2821448T3 (es) 2008-06-23 2021-04-26 Temasek Polytechnic Sorbente para un dispositivo de diálisis
WO2010029317A2 (en) 2008-09-10 2010-03-18 Ibd Column Therapies International Ab Treating inflammatory conditions
US8310415B2 (en) 2008-09-30 2012-11-13 Animas Corporation Medical devices using bistable displays
US8454547B2 (en) 2009-02-25 2013-06-04 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
US8801922B2 (en) 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
US20120219561A1 (en) 2009-07-31 2012-08-30 Ingeneron, Inc. Prophylaxis Against Cancer Metastasis
US8758286B2 (en) 2009-12-01 2014-06-24 Exthera Medical Corporation Method for removing cytokines from blood with surface immobilized polysaccharides
JP5774607B2 (ja) 2010-02-09 2015-09-09 エクステラ・メディカル・コーポレーション 体外治療による毒性因子の除去
WO2011133287A1 (en) 2010-04-19 2011-10-27 The Trustees Of Columbia University In The City Of New York Portable blood filtration devices, systems, and methods
US20130288370A1 (en) 2010-10-15 2013-10-31 Cytopherx, Inc. Cytopheresis cartridges and use thereof
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
US8569000B2 (en) 2011-03-02 2013-10-29 Guangzhou Kingmed Center for Clinical Laboratory Immunoassays using antibodies specific to carbamazepine
US20130131423A1 (en) 2011-04-12 2013-05-23 Tianxin Wang Methods to detect and treat diseases
ES2800316T3 (es) 2011-06-13 2020-12-29 Tla Targeted Immunotherapies Ab Tratamiento del cáncer
WO2013012924A2 (en) 2011-07-18 2013-01-24 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
EP2556849A1 (en) 2011-08-08 2013-02-13 Gambro Lundia AB Separation material
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
WO2014085713A1 (en) 2012-11-30 2014-06-05 The Methodist Hospital Research Institute Methods and compositions for detecting tuberculosis
GB201302774D0 (en) 2013-02-18 2013-04-03 Sphere Medical Ltd Analyte extraction apparatus and method
EP3013445B1 (en) 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
JP2016531874A (ja) 2013-09-26 2016-10-13 ファーマケア，インク． オートタキシン阻害剤化合物
JP6806563B2 (ja) 2013-11-08 2021-01-06 エクステラ・メディカル・コーポレーション 吸着媒体を使用する感染症の診断法
JP6040926B2 (ja) 2013-12-16 2016-12-07 株式会社オートネットワーク技術研究所 基板内蔵コネクタ
BR112016024569B1 (pt) 2014-04-24 2023-01-03 Exthera Medical Corporation Método ex vivo para remover bactérias de uma amostra retirada de um indivíduo que é suspeito de estar infectado com a mesma
AU2015321601B2 (en) 2014-09-22 2020-04-23 Exthera Medical Corporation Wearable hemoperfusion device
EP3422943A4 (en) 2016-03-02 2019-10-16 ExThera Medical Corporation METHOD OF TREATING DRUG ENTRIES
US10711831B2 (en) 2017-03-02 2020-07-14 Raytheon Company Flexural pivot
WO2019137381A1 (en) 2018-01-10 2019-07-18 Xw Laboratories, Inc. Prodrugs of ketamine, compositions and uses thereof
US20200023001A1 (en) 2018-07-20 2020-01-23 Northeastern University GlycoFix (Structurally And Functionally Repaired Endothelial Glycocalyx)

Also Published As

Publication number Publication date
BRPI0619820A2 (pt) 2011-10-18
US9173989B2 (en) 2015-11-03
CN101370536A (zh) 2009-02-18
RU2008128416A (ru) 2010-01-20
US9764077B2 (en) 2017-09-19
US10188783B2 (en) 2019-01-29
EP1960016A4 (en) 2013-04-24
JP2016027047A (ja) 2016-02-18
KR20080077405A (ko) 2008-08-22
DK1960016T3 (en) 2017-01-09
JP5868356B2 (ja) 2016-02-24
MX2008007716A (es) 2008-09-26
AU2006325531A1 (en) 2007-06-21
EP1960016B1 (en) 2016-10-05
MX344592B (es) 2016-12-20
KR20140021725A (ko) 2014-02-20
CA2630823C (en) 2015-02-10
KR101397386B1 (ko) 2014-05-26
AU2006325531B2 (en) 2012-04-19
US20090136586A1 (en) 2009-05-28
JP5715325B2 (ja) 2015-05-07
WO2007069983A1 (en) 2007-06-21
EP1960016A1 (en) 2008-08-27
RU2432187C2 (ru) 2011-10-27
US11065378B2 (en) 2021-07-20
US10688239B2 (en) 2020-06-23
US20200297913A1 (en) 2020-09-24
CA2630823A1 (en) 2007-06-21
JP2009521413A (ja) 2009-06-04
US20160022898A1 (en) 2016-01-28
US20170340803A1 (en) 2017-11-30
CN103203048A (zh) 2013-07-17
ES2608399T3 (es) 2017-04-10
JP2014005284A (ja) 2014-01-16
US20190143027A1 (en) 2019-05-16

Similar Documents

Publication Publication Date Title
US11065378B2 (en) Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood
JP6031069B2 (ja) 血液の病態を回復させるための装置及び方法
US9669150B2 (en) Device and method for restoration of the condition of blood
JP5774607B2 (ja) 体外治療による毒性因子の除去
JPS59149901A (ja) ヘパリンの精製および分別方法
JP2003135594A (ja) 体液浄化カラム
JPS6388129A (ja) 血液凝固第９因子吸着体およびそれを用いた血液凝固第９因子の精製法
JPH0431735B2 (hu)