HUE029454T2 - Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto - Google Patents
Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto Download PDFInfo
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- HUE029454T2 HUE029454T2 HUE10830777A HUE10830777A HUE029454T2 HU E029454 T2 HUE029454 T2 HU E029454T2 HU E10830777 A HUE10830777 A HU E10830777A HU E10830777 A HUE10830777 A HU E10830777A HU E029454 T2 HUE029454 T2 HU E029454T2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
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- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプramのチエツク方法 |
| KR101580938B1 (ko) | 2007-06-01 | 2015-12-30 | 유니버시티 오브 매릴랜드, 발티모어 | 면역글로불린 불변영역 Fc 수용체 결합제 |
| US20120263701A1 (en) | 2009-08-24 | 2012-10-18 | Volker Schellenberger | Coagulation factor vii compositions and methods of making and using same |
| RU2579977C2 (ru) | 2009-11-13 | 2016-04-10 | Грифольс Терапьютикс Инк. | СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ |
| MX368531B (es) | 2010-07-28 | 2019-10-07 | Gliknik Inc | Proteinas de fusion de fragmentos de proteinas humanas naturales para crear composiciones de fc de inmunoglobulinas multimerizadas ordenadamente. |
| WO2013098676A1 (en) | 2011-12-30 | 2013-07-04 | Grifols, S.A. | Method for purifying factor viii |
| PL2802668T3 (pl) | 2012-01-12 | 2019-03-29 | Bioverativ Therapeutics Inc. | Sposoby zmniejszania immunogenności wobec czynnika krzepnięcia viii u pacjentów poddawanych leczeniu czynnikiem krzepnięcia viii |
| CN104271150A (zh) * | 2012-01-12 | 2015-01-07 | 比奥根艾迪克Ma公司 | 嵌合因子viii多肽及其用途 |
| NZ628014A (en) | 2012-02-15 | 2016-09-30 | Biogen Ma Inc | Recombinant factor viii proteins |
| MX369862B (es) | 2012-02-15 | 2019-11-25 | Bioverativ Therapeutics Inc | Composiciones del factor viii y metodos para hacerlas y usarlas. |
| CN104411716B (zh) * | 2012-04-24 | 2018-09-07 | 诺和诺德股份有限公司 | 适用于治疗血友病的化合物 |
| RS59876B1 (sr) * | 2012-07-11 | 2020-03-31 | Bioverativ Therapeutics Inc | Kompleks faktora viii sa xten i proteinom fon vilebrandovog faktora, i njihova primena |
| CN104718223A (zh) | 2012-08-20 | 2015-06-17 | 格利克尼克股份有限公司 | 具有抗原结合和多价FCγ受体结合活性的分子 |
| WO2014066663A1 (en) * | 2012-10-24 | 2014-05-01 | Platelet Targeted Therapeutics, Llc | Platelet targeted treatment |
| GB201304973D0 (en) * | 2013-03-19 | 2013-05-01 | Profactor Pharma Ltd | Recombinant protein |
| ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
| WO2014198699A2 (en) * | 2013-06-12 | 2014-12-18 | Novo Nordisk A/S | Compounds suitable for treatment of haemophilia |
| KR102714760B1 (ko) * | 2013-06-28 | 2024-10-11 | 바이오버라티브 테라퓨틱스 인크. | Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도 |
| EP3013359A4 (en) * | 2013-06-28 | 2017-01-25 | Biogen MA Inc. | Thrombin cleavable linker |
| WO2015021423A2 (en) * | 2013-08-08 | 2015-02-12 | Biogen Idec Ma Inc. | Purification of chimeric fviii molecules |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| PT4176894T (pt) * | 2014-01-10 | 2024-05-21 | Bioverativ Therapeutics Inc | Proteínas quiméricas de fator viii e utilizações destas |
| US10626164B2 (en) * | 2014-07-25 | 2020-04-21 | Csl Limited | Purification of VWF |
| US9701933B2 (en) * | 2014-09-19 | 2017-07-11 | Sarfaraz K. Niazi | Harvesting and purification or perfusion yielder (HAPPY) device |
| DK3265483T3 (da) * | 2015-03-06 | 2020-03-02 | CSL Behring Lengnau AG | Modificeret von Willebrand-faktor med forbedret halveringstid |
| EP4089109A3 (en) | 2015-05-22 | 2023-03-01 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
| EP3297656B1 (en) | 2015-05-22 | 2020-01-08 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| ES2846024T7 (es) | 2015-07-24 | 2023-06-22 | Gliknik Inc | Proteínas de fusión de fragmentos de proteína humana para crear composiciones de Fc de inmunoglobulina multimerizada de forma ordenada con unión al complemento aumentada |
| CA2994547A1 (en) | 2015-08-03 | 2017-02-09 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
| WO2017117630A1 (en) * | 2016-01-07 | 2017-07-13 | Csl Limited | Mutated von willebrand factor |
| KR20180094114A (ko) | 2016-01-07 | 2018-08-22 | 체에스엘 베링 리컴비넌트 퍼실리티 아게 | 돌연변이된 절단된 폰 빌레브란트 인자 |
| CA3026420A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| WO2017222337A1 (ko) | 2016-06-24 | 2017-12-28 | 재단법인 목암생명과학연구소 | Fviii 및 vwf 인자를 포함하는 키메라 단백질 및 그 용도 |
| TW201828975A (zh) * | 2016-11-11 | 2018-08-16 | 瑞士商Csl貝林重組技能公司 | 用於治療血友病之截短型類血友病因子(von Willebrand factor)多肽類 |
| AU2017358865A1 (en) | 2016-11-11 | 2019-05-09 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
| US12257288B2 (en) | 2016-12-02 | 2025-03-25 | Bioverativ Therapeutics Inc. | Methods of inducing immune tolerance to clotting factors |
| WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| IL266988B2 (en) | 2016-12-09 | 2024-11-01 | Gliknik Inc | Methods of treating inflammatory disorders with multivalent fc compounds |
| JP2020503855A (ja) | 2016-12-09 | 2020-02-06 | グリックニック インコーポレイテッド | 多量体化ストラドマーgl−2045の製造最適化 |
| AU2018256453B2 (en) | 2017-04-20 | 2024-02-08 | The University Of Chicago | Methods and compositions for treating cancer with ECM-affinity peptides linked to immunotherapeutic antibodies |
| GB201707139D0 (en) * | 2017-05-04 | 2017-06-21 | Imp Innovations Ltd | Polypeptides |
| EP3641800B1 (en) | 2017-06-22 | 2023-10-04 | CSL Behring Lengnau AG | Modulation of fviii immunogenicity by truncated vwf |
| US20190091298A1 (en) * | 2017-07-07 | 2019-03-28 | Baxalta Incorporated | Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant vwf |
| WO2019084691A1 (en) * | 2017-11-01 | 2019-05-09 | Queen's University At Kingston | Von willebrand factor proteins for treating bleeding disorders |
| BR112020018196A2 (pt) | 2018-03-05 | 2020-12-29 | The University Of Chicago | Métodos e composições para tratar câncer com peptídeos de afinidade com ecm ligados a citocinas |
| SG11202010767SA (en) | 2018-05-18 | 2020-11-27 | Bioverativ Therapeutics Inc | Methods of treating hemophilia a |
| US10654911B1 (en) * | 2019-04-02 | 2020-05-19 | Beijing Neoletix Biological Technology Co., Ltd. | Vector co-expressing truncated von Willebrand factor and factor VIII |
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| US20220348637A1 (en) | 2019-11-11 | 2022-11-03 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
| CN120225678A (zh) * | 2022-11-14 | 2025-06-27 | 赛尔吉恩技术株式会社 | 产生血液第viii凝血因子修饰体的离体基因治疗用细胞 |
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- 2010-11-12 JP JP2012539007A patent/JP5876416B2/ja active Active
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- 2010-11-12 WO PCT/US2010/056496 patent/WO2011060242A2/en not_active Ceased
- 2010-11-12 ES ES10830777.8T patent/ES2600879T3/es active Active
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- 2010-11-12 CN CN201080051549.3A patent/CN102648212B/zh active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2780542A1 (en) | 2011-05-19 |
| US20120289468A1 (en) | 2012-11-15 |
| WO2011060242A3 (en) | 2011-10-13 |
| PT2499165T (pt) | 2016-10-28 |
| RU2012122402A (ru) | 2013-12-20 |
| CA2780542C (en) | 2020-03-24 |
| ES2600879T3 (es) | 2017-02-13 |
| AU2010319425B2 (en) | 2015-07-02 |
| NZ600278A (en) | 2014-04-30 |
| IL219679A (en) | 2016-11-30 |
| MX2012005527A (es) | 2012-08-08 |
| AU2010319425A1 (en) | 2012-06-14 |
| WO2011060242A2 (en) | 2011-05-19 |
| CN102648212B (zh) | 2014-12-03 |
| JP5876416B2 (ja) | 2016-03-02 |
| EP2499165B1 (en) | 2016-09-14 |
| ZA201203795B (en) | 2014-10-29 |
| EP2499165A2 (en) | 2012-09-19 |
| PL2499165T3 (pl) | 2017-04-28 |
| IL219679A0 (en) | 2012-07-31 |
| CN102648212A (zh) | 2012-08-22 |
| BR112012011740A2 (pt) | 2018-03-27 |
| US8759293B2 (en) | 2014-06-24 |
| KR20120113214A (ko) | 2012-10-12 |
| JP2013510581A (ja) | 2013-03-28 |
| EP2499165A4 (en) | 2013-09-11 |
| KR101808751B1 (ko) | 2017-12-13 |
| CL2012001258A1 (es) | 2012-09-14 |
| HK1170244A1 (zh) | 2013-02-22 |
| RU2579977C2 (ru) | 2016-04-10 |
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