HU906469D0 - Process for producing a new 5h-2,3-benzodiazepine derivative - Google Patents

Process for producing a new 5h-2,3-benzodiazepine derivative

Info

Publication number
HU906469D0
HU906469D0 HU906469A HU646990A HU906469D0 HU 906469 D0 HU906469 D0 HU 906469D0 HU 906469 A HU906469 A HU 906469A HU 646990 A HU646990 A HU 646990A HU 906469 D0 HU906469 D0 HU 906469D0
Authority
HU
Hungary
Prior art keywords
producing
new
benzodiazepine derivative
benzodiazepine
derivative
Prior art date
Application number
HU906469A
Other languages
English (en)
Other versions
HU207055B (en
HUT59381A (en
Inventor
Ferenc Andrasi
Peter Botka
Dr Horvath Katal Goldschmidtne
Tamas Hamori
Gyula Horvath
Jenoe Koeroesi
Imre Moravcsik
Dr Patfalusi Marta Ruszne
Laszlone Tomori
Gabor Zolyomi
Original Assignee
Gyogyszerkutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet
Priority to HU906469A priority Critical patent/HU207055B/hu
Publication of HU906469D0 publication Critical patent/HU906469D0/hu
Priority to IL9963791A priority patent/IL99637A/en
Priority to KR1019910018098A priority patent/KR920008011A/ko
Priority to NO91914056A priority patent/NO914056L/no
Priority to CS913141A priority patent/CZ282249B6/cs
Priority to DK174891A priority patent/DK174891A/da
Priority to SU915010047A priority patent/RU2058982C1/ru
Priority to NL9101741A priority patent/NL9101741A/nl
Priority to AU85922/91A priority patent/AU648111B2/en
Priority to ZA918273A priority patent/ZA918273B/xx
Priority to JP3298535A priority patent/JPH04282374A/ja
Priority to YU166991A priority patent/YU47859B/sh
Priority to CN91109753A priority patent/CN1033582C/zh
Priority to GR910100426A priority patent/GR1001068B/el
Priority to FI914918A priority patent/FI914918A/fi
Priority to CH3051/91A priority patent/CH682400A5/de
Priority to CA002053622A priority patent/CA2053622A1/en
Priority to FR9112807A priority patent/FR2668148B1/fr
Priority to AT0207191A priority patent/AT399506B/de
Priority to SE9103022A priority patent/SE506380C2/sv
Priority to ITMI912745A priority patent/IT1256279B/it
Priority to ES9102303A priority patent/ES2036137B1/es
Priority to BE9100952A priority patent/BE1004995A3/fr
Priority to BG095336A priority patent/BG95336A/bg
Priority to PL91292091A priority patent/PL167108B1/pl
Priority to US07/776,771 priority patent/US5204343A/en
Priority to GB9122090A priority patent/GB2248838B/en
Priority to DE4134402A priority patent/DE4134402A1/de
Publication of HUT59381A publication Critical patent/HUT59381A/hu
Publication of HU207055B publication Critical patent/HU207055B/hu
Priority to HU9500268P priority patent/HU211693A9/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU906469A 1990-10-17 1990-10-17 Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same HU207055B (en)

Priority Applications (29)

Application Number Priority Date Filing Date Title
HU906469A HU207055B (en) 1990-10-17 1990-10-17 Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
IL9963791A IL99637A (en) 1990-10-17 1991-10-02 1-) 3-Chlorophenyl (-4-hydroxymethyl-7,8-dimethoxy-H-2,35-benzodiazepine, and its acidic additive salts preparation and pharmaceutical preparations containing it
KR1019910018098A KR920008011A (ko) 1990-10-17 1991-10-15 5h-벤조디아제핀 유도체 및 이 유도체를 함유하는 제약조성물과 이 들의 제조방법
NO91914056A NO914056L (no) 1990-10-17 1991-10-16 Fremgangsmaate for fremstilling av 5h-benzodiazepinderivat
CS913141A CZ282249B6 (cs) 1990-10-17 1991-10-16 Nový derivát 5H-benzodiazepinu, způsob jeho pří pravy a farmaceutický prostředek, který ho obsa huje
DK174891A DK174891A (da) 1990-10-17 1991-10-16 Benzodiazepinderivater
SU915010047A RU2058982C1 (ru) 1990-10-17 1991-10-16 1-(3-хлорфенил)-4-оксиметил-7,8-диметокси-5н-2,3-бензо-диазепин или его терапевтически приемлемая соль присоединения кислоты
DE4134402A DE4134402A1 (de) 1990-10-17 1991-10-17 1(3'-(chlor)-phenyl)-4-(hydroxymethyl)-7,8- di-(methoxy)-5h-2,3-benzodiazepin und seine saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel und ihre verwendung sowie zwischenprodukte zur herstellung der ersteren
FI914918A FI914918A (fi) 1990-10-17 1991-10-17 Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart 5h-ben sodiazepinderivat.
AT0207191A AT399506B (de) 1990-10-17 1991-10-17 Ein neues 5h-2,3-benzodiazepin-derivat, seine säureadditionssalze und diese enthaltende arzneimittelpräparate sowie verfahren zu deren herstellung
ZA918273A ZA918273B (en) 1990-10-17 1991-10-17 A new 5H-benzodiazepine derivative pharmaceutical compositions containing same and process for preparing them
JP3298535A JPH04282374A (ja) 1990-10-17 1991-10-17 新規５ｈ−ベンゾジアゼピン誘導体、それを含有してなる製剤組成物、およびそれらの製造方法
YU166991A YU47859B (sh) 1990-10-17 1991-10-17 Novi 5h-benzodiazepin derivat farmaceutski preparati koji sadrže isti i postupak za njihovo dobivanje
CN91109753A CN1033582C (zh) 1990-10-17 1991-10-17 一种制备新的5h-苯并二氮杂䓬衍生物的方法
GR910100426A GR1001068B (el) 1990-10-17 1991-10-17 Νέον παράγωγον 5Η-βενζοδιαζεπίνης, φαρμακευτικαί συν?έσεις περιέχουσαι τούτο, και μέ?οδος δια την παρασκευήν αυτών.
NL9101741A NL9101741A (nl) 1990-10-17 1991-10-17 Nieuw 5h-benzodiazepinederivaat, farmaceutische samenstellingen welke deze bevatten en werkwijze voor de bereiding ervan.
CH3051/91A CH682400A5 (de) 1990-10-17 1991-10-17 1-(3-Chlorphenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benzodiazepin, seine Säureadditionssalze und diese enthaltende Arzneimittelpräparate sowie Verfahren zu deren Herstellung.
CA002053622A CA2053622A1 (en) 1990-10-17 1991-10-17 5-h benzodiazepine derivative, pharmaceutical compositions containing same and process for preparing them
FR9112807A FR2668148B1 (fr) 1990-10-17 1991-10-17 Nouveau derive de 5h-benzodiazepine, compositions pharmaceutiques le contenant et procede pour les preparer.
AU85922/91A AU648111B2 (en) 1990-10-17 1991-10-17 A new 5H-benzodiazepine derivative, pharmaceutical compositions containing same and process for preparing them
SE9103022A SE506380C2 (sv) 1990-10-17 1991-10-17 Ett nytt 5-H-bensodiazepinderivat, farmaceutiska kompositione r innehållande detsamma, förfarande för framställning av detta samt användning därav
ITMI912745A IT1256279B (it) 1990-10-17 1991-10-17 Derivati 5h-benzodiazepinici, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione.
ES9102303A ES2036137B1 (es) 1990-10-17 1991-10-17 Procedimiento para la preparacion de la nueva 1-(3-clorofenil)-4-hidroximetil-7,8-dimetoxi-5h-2,3-benzodiacepina y de sus sales de adicion acida.
BE9100952A BE1004995A3 (fr) 1990-10-17 1991-10-17 Nouveau derive de 5h-benzodiazepine, compositions pharmaceutiques le contenant et procede pour les preparer.
BG095336A BG95336A (bg) 1990-10-17 1991-10-17 5н-2,3-бензодиазепинови производни,съдържащи ги фармацевтични състави и метод за тяхното получаване
PL91292091A PL167108B1 (pl) 1990-10-17 1991-10-17 Sposób wytwarzania nowej pochodnej 5H-2,3-benzodiazepiny PL PL
US07/776,771 US5204343A (en) 1990-10-17 1991-10-17 5h-benzodiazepin derivative
GB9122090A GB2248838B (en) 1990-10-17 1991-10-17 A new 5H-benzodiazepine derivative,pharmaceutical compositions containing same and process for preparing them
HU9500268P HU211693A9 (hu) 1990-10-17 1995-06-20 Új 5H-benzodiazepin-származék, ilyen hatóanyagot tartalmazó gyógyászati készítmények és eljárás a hatóanyag és a készítmények előállítására

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU906469A HU207055B (en) 1990-10-17 1990-10-17 Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same

Publications (3)

Publication Number Publication Date
HU906469D0 true HU906469D0 (en) 1991-04-29
HUT59381A HUT59381A (en) 1992-05-28
HU207055B HU207055B (en) 1993-03-01

Family

ID=10971685

Family Applications (1)

Application Number Title Priority Date Filing Date
HU906469A HU207055B (en) 1990-10-17 1990-10-17 Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same

Country Status (28)

Country Link
US (1) US5204343A (hu)
JP (1) JPH04282374A (hu)
KR (1) KR920008011A (hu)
CN (1) CN1033582C (hu)
AT (1) AT399506B (hu)
AU (1) AU648111B2 (hu)
BE (1) BE1004995A3 (hu)
BG (1) BG95336A (hu)
CA (1) CA2053622A1 (hu)
CH (1) CH682400A5 (hu)
CZ (1) CZ282249B6 (hu)
DE (1) DE4134402A1 (hu)
DK (1) DK174891A (hu)
ES (1) ES2036137B1 (hu)
FI (1) FI914918A (hu)
FR (1) FR2668148B1 (hu)
GB (1) GB2248838B (hu)
GR (1) GR1001068B (hu)
HU (1) HU207055B (hu)
IL (1) IL99637A (hu)
IT (1) IT1256279B (hu)
NL (1) NL9101741A (hu)
NO (1) NO914056L (hu)
PL (1) PL167108B1 (hu)
RU (1) RU2058982C1 (hu)
SE (1) SE506380C2 (hu)
YU (1) YU47859B (hu)
ZA (1) ZA918273B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9701284A3 (en) * 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
AU2003303312A1 (en) * 2002-12-03 2004-08-30 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2257274A1 (en) * 1974-01-16 1975-08-08 Synthelabo Substd. 1,2-diazepin-7-one analgesic and psychotropic agents - prepd by cyclizing a delta keto acid and a substd hydrazine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
GR1001068B (el) 1993-04-28
ITMI912745A0 (it) 1991-10-17
BE1004995A3 (fr) 1993-03-16
NL9101741A (nl) 1992-05-18
IL99637A (en) 1996-06-18
ATA207191A (de) 1994-10-15
CN1033582C (zh) 1996-12-18
DK174891A (da) 1992-04-18
NO914056L (no) 1992-04-21
PL167108B1 (pl) 1995-07-31
FR2668148B1 (fr) 1993-07-30
BG95336A (bg) 1993-12-24
ITMI912745A1 (it) 1993-04-17
YU166991A (sh) 1994-06-10
CA2053622A1 (en) 1992-04-18
DE4134402A1 (de) 1992-05-14
RU2058982C1 (ru) 1996-04-27
IL99637A0 (en) 1992-08-18
FI914918A0 (fi) 1991-10-17
CH682400A5 (de) 1993-09-15
HU207055B (en) 1993-03-01
GR910100426A (en) 1992-09-25
CN1060838A (zh) 1992-05-06
DK174891D0 (da) 1991-10-16
JPH04282374A (ja) 1992-10-07
HUT59381A (en) 1992-05-28
NO914056D0 (no) 1991-10-16
SE9103022L (sv) 1992-04-18
ZA918273B (en) 1994-10-04
FI914918A (fi) 1992-04-18
PL292091A1 (en) 1992-06-26
AU648111B2 (en) 1994-04-14
ES2036137A1 (es) 1993-05-01
GB2248838B (en) 1994-04-06
US5204343A (en) 1993-04-20
SE9103022D0 (sv) 1991-10-17
SE506380C2 (sv) 1997-12-08
YU47859B (sh) 1996-02-19
AT399506B (de) 1995-05-26
AU8592291A (en) 1992-04-30
KR920008011A (ko) 1992-05-27
IT1256279B (it) 1995-11-29
GB2248838A (en) 1992-04-22
GB9122090D0 (en) 1991-11-27
CS314191A3 (en) 1992-05-13
ES2036137B1 (es) 1994-03-01
CZ282249B6 (cs) 1997-06-11
FR2668148A1 (fr) 1992-04-24

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Legal Events

Date Code Title Description
HPC4 Succession in title of patentee

Owner name: EGIS GYOGYSZERGYAR RT., HU

HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYRT., HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU; GYOGYSZERKUTATO INTEZET KOEZOES VALLALAT, HU

MM4A Lapse of definitive patent protection due to non-payment of fees