HU229445B1 - Compound with growth hormone releasing properties - Google Patents
Compound with growth hormone releasing propertiesInfo
- Publication number
- HU229445B1 HU229445B1 HU0203844A HUP0203844A HU229445B1 HU 229445 B1 HU229445 B1 HU 229445B1 HU 0203844 A HU0203844 A HU 0203844A HU P0203844 A HUP0203844 A HU P0203844A HU 229445 B1 HU229445 B1 HU 229445B1
- Authority
- HU
- Hungary
- Prior art keywords
- growth hormone
- compound
- hormone releasing
- releasing properties
- trimethylhydrazinocarbonyl
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 230000003578 releasing effect Effects 0.000 title 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Dermatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901618 | 1999-11-10 | ||
| US16710199P | 1999-11-23 | 1999-11-23 | |
| PCT/DK2000/000624 WO2001034593A1 (en) | 1999-11-10 | 2000-11-10 | Compound with growth hormone releasing properties |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0203844A2 HUP0203844A2 (hu) | 2003-03-28 |
| HUP0203844A3 HUP0203844A3 (en) | 2004-07-28 |
| HU229445B1 true HU229445B1 (en) | 2013-12-30 |
Family
ID=26065963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0203844A HU229445B1 (en) | 1999-11-10 | 2000-11-10 | Compound with growth hormone releasing properties |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6576648B2 (https=) |
| EP (1) | EP1230236B1 (https=) |
| JP (2) | JP2003527338A (https=) |
| KR (1) | KR100907637B1 (https=) |
| CN (1) | CN1198818C (https=) |
| AT (1) | ATE280168T1 (https=) |
| AU (1) | AU782260B2 (https=) |
| BR (1) | BR0015407A (https=) |
| CA (1) | CA2387095C (https=) |
| CZ (1) | CZ301078B6 (https=) |
| DE (1) | DE60015173T2 (https=) |
| DK (1) | DK1230236T3 (https=) |
| ES (1) | ES2231279T3 (https=) |
| HU (1) | HU229445B1 (https=) |
| IL (1) | IL149049A0 (https=) |
| MX (1) | MXPA02004656A (https=) |
| NO (1) | NO323910B1 (https=) |
| PL (1) | PL199989B1 (https=) |
| PT (1) | PT1230236E (https=) |
| RU (1) | RU2272034C2 (https=) |
| UA (1) | UA73530C2 (https=) |
| WO (1) | WO2001034593A1 (https=) |
| ZA (1) | ZA200202757B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070010151A (ko) * | 2004-03-30 | 2007-01-22 | 사파이어 세라퓨틱스, 인크. | 성장 호르몬 분비촉진제를 이용하여 c-반응성 단백질을감소시키는 방법 |
| US20130281701A1 (en) | 2004-06-29 | 2013-10-24 | Helsinn Therapeutics (U.S.), Inc. | Crystal forms of anamorelin |
| AU2005272074B2 (en) * | 2004-06-29 | 2011-11-24 | Albany Molecular Research, Inc. | Crystal forms of (3r)-1-(2-methylalanyl-d-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide |
| CN1976921B (zh) * | 2004-06-29 | 2013-08-21 | 蓝宝石治疗公司 | (3r)-1-(2-甲基丙氨酰-d-色氨酰)-3-(苯甲基)-3-哌啶羧酸1,2,2-三甲基酰肼的晶形 |
| KR101380200B1 (ko) | 2004-08-12 | 2014-04-01 | 헬신 세라퓨틱스 (유.에스.) 인크. | 성장 호르몬 분비촉진제를 이용하여 위장관계의 운동성을촉진하는 방법 |
| US8039456B2 (en) | 2004-08-12 | 2011-10-18 | Helsinn Therapeutics (U.S.), Inc. | Method of stimulating the motility of the gastrointestinal system using ipamorelin |
| CN101595107A (zh) * | 2006-06-30 | 2009-12-02 | 先灵公司 | 能提高p53活性的有取代哌啶及其用途 |
| WO2008100448A2 (en) | 2007-02-13 | 2008-08-21 | Helsinn Therapeutics (U.S.), Inc. | Method of treating cell proliferative disorders using growth hormone secretagogues |
| TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
| US8664267B2 (en) * | 2007-04-12 | 2014-03-04 | Academic Pharmaceuticals Incorporated | Parenteral solution containing amiodarone in NNDMA (N,N,-Dimethylacetamide) |
| ES2464342T3 (es) | 2008-02-08 | 2014-06-02 | Zeria Pharmaceutical Co., Ltd. | Derivado de 3,8-diaminotetrahidroquinolina |
| UA105657C2 (uk) * | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Поліпшені способи лікування мігрені на основі анамореліну |
| JO3353B1 (ar) * | 2012-04-20 | 2019-03-13 | Ono Pharmaceutical Co | شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي |
| WO2014065341A1 (ja) | 2012-10-24 | 2014-05-01 | 第一三共株式会社 | 筋萎縮性側索硬化症治療剤 |
| WO2017067438A1 (zh) * | 2015-10-20 | 2017-04-27 | 江苏恒瑞医药股份有限公司 | 一种阿拉莫林的结晶形式及其制备方法 |
| CN106187865A (zh) * | 2016-07-08 | 2016-12-07 | 武汉工程大学 | (r)‑1‑叔丁氧羰基‑3‑苄基‑3‑甲酸哌啶的合成及手性拆分方法 |
| CN108129357B (zh) * | 2016-12-01 | 2021-12-21 | 上海医药工业研究院 | 阿拉莫林中间体的制备方法 |
| CN108239141A (zh) * | 2016-12-23 | 2018-07-03 | 江苏先声药业有限公司 | 一种阿拉莫林的制备方法 |
| BR112022002767A2 (pt) * | 2019-08-30 | 2022-05-10 | Helsinn Healthcare Sa | Métodos de fabricação de um comprimido de cloridrato de anamorelina, comprimidos e método para melhorar um ou mais sintomas de caquexia de câncer |
| CN114805305B (zh) * | 2022-04-20 | 2024-04-26 | 成都诺和晟泰生物科技有限公司 | 一种化合物及其应用 |
| CN119792264B (zh) * | 2025-03-14 | 2025-06-10 | 华中科技大学同济医学院附属同济医院 | 丁酰肼在制备预防或治疗copd的药物中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4839344A (en) | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
| DE68922602T2 (de) | 1988-01-28 | 1995-12-07 | Polygen Holding Corp | Polypeptide mit hormonwachstumsbefreiender wirkung. |
| JPH03504245A (ja) | 1988-05-11 | 1991-09-19 | ポリゲン ホールディング コーポレイション | 成長ホルモン放出活性を有するポリペプチド化合物類 |
| IT1240643B (it) | 1990-05-11 | 1993-12-17 | Mediolanum Farmaceutici Spa | Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano |
| IL98910A0 (en) | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
| US5663146A (en) | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| US5492916A (en) * | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| PL322706A1 (en) * | 1993-11-09 | 1998-02-16 | Merck & Co Inc | Piperidines, pyrolidines and hexahydro-1h-azepins enhancing growth hormone liberation |
| CA2176140A1 (en) | 1993-11-24 | 1995-06-01 | Meng Hsin Chen | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
| US5721250A (en) * | 1993-12-23 | 1998-02-24 | Merck & Co. Inc. | Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| WO1998003473A1 (en) * | 1996-07-22 | 1998-01-29 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| IL137007A0 (en) * | 1998-01-16 | 2001-06-14 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| PT1077941E (pt) * | 1998-05-11 | 2010-07-01 | Novo Nordisk As | Compostos com propriedades de libertaão da hormona de crescimento |
| US6303620B1 (en) * | 1998-05-11 | 2001-10-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US20010020012A1 (en) * | 2000-02-01 | 2001-09-06 | Andersen Maibritt Bansholm | Use of compounds for the regulation of food intake |
-
2000
- 2000-10-11 UA UA2002053785A patent/UA73530C2/uk unknown
- 2000-11-10 WO PCT/DK2000/000624 patent/WO2001034593A1/en not_active Ceased
- 2000-11-10 ES ES00974349T patent/ES2231279T3/es not_active Expired - Lifetime
- 2000-11-10 CA CA2387095A patent/CA2387095C/en not_active Expired - Lifetime
- 2000-11-10 JP JP2001536540A patent/JP2003527338A/ja active Pending
- 2000-11-10 BR BR0015407-5A patent/BR0015407A/pt not_active Application Discontinuation
- 2000-11-10 PL PL356993A patent/PL199989B1/pl unknown
- 2000-11-10 AT AT00974349T patent/ATE280168T1/de active
- 2000-11-10 PT PT00974349T patent/PT1230236E/pt unknown
- 2000-11-10 HU HU0203844A patent/HU229445B1/hu unknown
- 2000-11-10 DE DE60015173T patent/DE60015173T2/de not_active Expired - Lifetime
- 2000-11-10 CN CNB008151458A patent/CN1198818C/zh not_active Expired - Lifetime
- 2000-11-10 IL IL14904900A patent/IL149049A0/xx active IP Right Grant
- 2000-11-10 EP EP00974349A patent/EP1230236B1/en not_active Expired - Lifetime
- 2000-11-10 CZ CZ20021587A patent/CZ301078B6/cs not_active IP Right Cessation
- 2000-11-10 KR KR1020027005836A patent/KR100907637B1/ko not_active Expired - Lifetime
- 2000-11-10 RU RU2002115406/04A patent/RU2272034C2/ru active
- 2000-11-10 DK DK00974349T patent/DK1230236T3/da active
- 2000-11-10 AU AU12694/01A patent/AU782260B2/en not_active Expired
- 2000-11-10 MX MXPA02004656A patent/MXPA02004656A/es active IP Right Grant
-
2001
- 2001-03-26 US US09/817,840 patent/US6576648B2/en not_active Expired - Lifetime
-
2002
- 2002-04-09 ZA ZA200202757A patent/ZA200202757B/xx unknown
- 2002-05-08 NO NO20022200A patent/NO323910B1/no not_active IP Right Cessation
-
2008
- 2008-09-04 JP JP2008227447A patent/JP5053960B2/ja not_active Expired - Lifetime
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| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: HELSINN HEALTHCARE SA, CH Free format text: FORMER OWNER(S): NOVO NORDISK A/S, DK |