HU220606B1 - (1,2,4-Oxadiazolil-fenoxi-alkil)-izoxazol-származékok, eljárás ezek előállítására és az ezeket tartalmazó vírusellenes készítmények - Google Patents

(1,2,4-Oxadiazolil-fenoxi-alkil)-izoxazol-származékok, eljárás ezek előállítására és az ezeket tartalmazó vírusellenes készítmények Download PDF

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Publication number
HU220606B1
HU220606B1 HU9301084A HU9301084A HU220606B1 HU 220606 B1 HU220606 B1 HU 220606B1 HU 9301084 A HU9301084 A HU 9301084A HU 9301084 A HU9301084 A HU 9301084A HU 220606 B1 HU220606 B1 HU 220606B1
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HU
Hungary
Prior art keywords
alkyl
formula
alkoxy
compound
hydroxy
Prior art date
Application number
HU9301084A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT65574A (en
HU9301084D0 (en
Inventor
Guy Dominic Diana
Theodore John Nitz
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of HU9301084D0 publication Critical patent/HU9301084D0/hu
Publication of HUT65574A publication Critical patent/HUT65574A/hu
Publication of HU220606B1 publication Critical patent/HU220606B1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9301084A 1992-04-15 1993-04-14 (1,2,4-Oxadiazolil-fenoxi-alkil)-izoxazol-származékok, eljárás ezek előállítására és az ezeket tartalmazó vírusellenes készítmények HU220606B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (3)

Publication Number Publication Date
HU9301084D0 HU9301084D0 (en) 1993-06-28
HUT65574A HUT65574A (en) 1994-07-28
HU220606B1 true HU220606B1 (hu) 2002-03-28

Family

ID=25353269

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9301084A HU220606B1 (hu) 1992-04-15 1993-04-14 (1,2,4-Oxadiazolil-fenoxi-alkil)-izoxazol-származékok, eljárás ezek előállítására és az ezeket tartalmazó vírusellenes készítmények
HU95P/P00642P HU211320A9 (en) 1992-04-15 1995-06-30 1,2,4-oxadiazolyc-phenoxyalkylisoxazoles and their use as antiviral agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU95P/P00642P HU211320A9 (en) 1992-04-15 1995-06-30 1,2,4-oxadiazolyc-phenoxyalkylisoxazoles and their use as antiviral agents

Country Status (26)

Country Link
US (3) US5349068A (enExample)
EP (1) EP0566199B1 (enExample)
JP (1) JP3103845B2 (enExample)
KR (1) KR100314158B1 (enExample)
AT (1) ATE189958T1 (enExample)
AU (1) AU666528B2 (enExample)
CA (1) CA2094012C (enExample)
CZ (1) CZ285845B6 (enExample)
DE (1) DE69327913T2 (enExample)
DK (1) DK0566199T3 (enExample)
ES (1) ES2143487T3 (enExample)
FI (1) FI112229B (enExample)
GR (1) GR3033486T3 (enExample)
HU (2) HU220606B1 (enExample)
IL (1) IL105372A (enExample)
MX (1) MX9302169A (enExample)
MY (1) MY110191A (enExample)
NO (1) NO302700B1 (enExample)
NZ (1) NZ247411A (enExample)
PH (1) PH30454A (enExample)
PT (1) PT566199E (enExample)
RU (1) RU2114112C1 (enExample)
SG (1) SG50663A1 (enExample)
SK (1) SK279786B6 (enExample)
TW (1) TW239140B (enExample)
UA (1) UA35557C2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6528652B1 (en) 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
US7041685B2 (en) * 2001-06-08 2006-05-09 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
US7129359B2 (en) 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
CA2459376A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
CA2459375A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
EP2193792B1 (en) 2001-12-07 2011-08-31 Ana Maria Sandino Neomycin for increasing the survival of aquatic animals exposed to IPNV
US20060167109A1 (en) * 2002-02-14 2006-07-27 Pevear Daniel C Methods of reducing rhinovirus contagion and related compositions
JP2006516250A (ja) * 2002-12-18 2006-06-29 サイトビア インコーポレイティッド カスパーゼ活性化剤およびアポトーシス誘導物質としての３，５−二置換−［１，２，４］−オキサジアゾールおよびそれらの誘導体ならびにそれらの使用
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
WO2006017505A2 (en) * 2004-08-04 2006-02-16 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
CA2641616A1 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
AR059359A1 (es) * 2006-02-09 2008-03-26 Schering Corp Formulaciones farmaceuticas que contienen pleconaril
JP2009526063A (ja) * 2006-02-09 2009-07-16 シェーリング コーポレイション 医薬製剤
ES2550152T3 (es) 2006-12-13 2015-11-04 F. Hoffmann-La Roche Ag Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102322B (zh) * 2011-11-14 2016-02-24 上海交通大学 噁唑类化合物及其制备方法、药物组合物及其用途
TWI811428B (zh) 2018-08-21 2023-08-11 日商杏林製藥股份有限公司 雙環雜芳香環衍生物
WO2021062189A1 (en) * 2019-09-27 2021-04-01 Collaborations Pharmaceuticals, Inc. Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
NZ247411A (en) 1994-06-27
MY110191A (en) 1998-02-28
PT566199E (pt) 2000-09-29
CA2094012A1 (en) 1993-10-16
JP3103845B2 (ja) 2000-10-30
DE69327913T2 (de) 2000-10-12
TW239140B (enExample) 1995-01-21
ATE189958T1 (de) 2000-03-15
GR3033486T3 (en) 2000-09-29
EP0566199A1 (en) 1993-10-20
SG50663A1 (en) 1998-07-20
HUT65574A (en) 1994-07-28
SK35393A3 (en) 1994-06-08
HU9301084D0 (en) 1993-06-28
KR100314158B1 (ko) 2002-02-19
FI112229B (fi) 2003-11-14
US5464848A (en) 1995-11-07
CA2094012C (en) 2001-08-21
DK0566199T3 (da) 2000-06-19
US5349068A (en) 1994-09-20
NO931366L (no) 1993-10-18
US5643929A (en) 1997-07-01
IL105372A0 (en) 1993-08-18
UA35557C2 (uk) 2001-04-16
IL105372A (en) 1998-12-27
MX9302169A (es) 1993-10-01
AU666528B2 (en) 1996-02-15
NO302700B1 (no) 1998-04-14
KR930021637A (ko) 1993-11-22
NO931366D0 (no) 1993-04-14
EP0566199B1 (en) 2000-03-01
HU211320A9 (en) 1995-11-28
SK279786B6 (sk) 1999-03-12
RU2114112C1 (ru) 1998-06-27
CZ59793A3 (en) 1994-02-16
AU3688193A (en) 1993-10-21
FI931707L (fi) 1993-10-16
ES2143487T3 (es) 2000-05-16
DE69327913D1 (de) 2000-04-06
CZ285845B6 (cs) 1999-11-17
JPH0649066A (ja) 1994-02-22
FI931707A0 (fi) 1993-04-15
PH30454A (en) 1997-05-28

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Legal Events

Date Code Title Description
DGB9 Succession in title of applicant

Owner name: SANOFI, FR

DGB9 Succession in title of applicant

Owner name: SANOFI-SYNTHELABO, FR

HC9A Change of name, address

Owner name: SANOFI, FR

Free format text: FORMER OWNER(S): SANOFI, FR; SANOFI-SYNTHELABO, FR; STERLING WINTHROP INC., US