DE69327913T2 - 1,2,4-Oxadiazolyl-Phenoxyalkyl-isoxazole und ihre Anwendung als antivirale Mittel - Google Patents

1,2,4-Oxadiazolyl-Phenoxyalkyl-isoxazole und ihre Anwendung als antivirale Mittel

Info

Publication number
DE69327913T2
DE69327913T2 DE69327913T DE69327913T DE69327913T2 DE 69327913 T2 DE69327913 T2 DE 69327913T2 DE 69327913 T DE69327913 T DE 69327913T DE 69327913 T DE69327913 T DE 69327913T DE 69327913 T2 DE69327913 T2 DE 69327913T2
Authority
DE
Germany
Prior art keywords
mmol
formula
compound
product
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69327913T
Other languages
German (de)
English (en)
Other versions
DE69327913D1 (de
Inventor
Guy Dominic Diana
Theodore John Nitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of DE69327913D1 publication Critical patent/DE69327913D1/de
Application granted granted Critical
Publication of DE69327913T2 publication Critical patent/DE69327913T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69327913T 1992-04-15 1993-04-13 1,2,4-Oxadiazolyl-Phenoxyalkyl-isoxazole und ihre Anwendung als antivirale Mittel Expired - Lifetime DE69327913T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (2)

Publication Number Publication Date
DE69327913D1 DE69327913D1 (de) 2000-04-06
DE69327913T2 true DE69327913T2 (de) 2000-10-12

Family

ID=25353269

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69327913T Expired - Lifetime DE69327913T2 (de) 1992-04-15 1993-04-13 1,2,4-Oxadiazolyl-Phenoxyalkyl-isoxazole und ihre Anwendung als antivirale Mittel

Country Status (26)

Country Link
US (3) US5349068A (enExample)
EP (1) EP0566199B1 (enExample)
JP (1) JP3103845B2 (enExample)
KR (1) KR100314158B1 (enExample)
AT (1) ATE189958T1 (enExample)
AU (1) AU666528B2 (enExample)
CA (1) CA2094012C (enExample)
CZ (1) CZ285845B6 (enExample)
DE (1) DE69327913T2 (enExample)
DK (1) DK0566199T3 (enExample)
ES (1) ES2143487T3 (enExample)
FI (1) FI112229B (enExample)
GR (1) GR3033486T3 (enExample)
HU (2) HU220606B1 (enExample)
IL (1) IL105372A (enExample)
MX (1) MX9302169A (enExample)
MY (1) MY110191A (enExample)
NO (1) NO302700B1 (enExample)
NZ (1) NZ247411A (enExample)
PH (1) PH30454A (enExample)
PT (1) PT566199E (enExample)
RU (1) RU2114112C1 (enExample)
SG (1) SG50663A1 (enExample)
SK (1) SK279786B6 (enExample)
TW (1) TW239140B (enExample)
UA (1) UA35557C2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
CN1638776A (zh) * 2001-06-08 2005-07-13 西托维亚公司 取代的3－芳基－5－芳基－[1,2,4]－噁二唑和类似物
US7129359B2 (en) * 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
US7429606B2 (en) * 2001-08-29 2008-09-30 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
CA2459375A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
NO20025898L (no) 2001-12-07 2003-06-10 Geraldine Mlynarz Zylberberg Fremgangsmater og tilhorende preparater for a oke overlevelsen av akvatiske dyr og andre dyr som utsettes for et akvatisk virus, birnavirus eller annet RNAvirus
CA2475971A1 (en) * 2002-02-14 2003-08-21 Viropharma Incorporated Methods of reducing rhinovirus contagion and related compositions
EP1581213A4 (en) * 2002-12-18 2008-11-19 Cytovia Inc 3,5-DISUBSTITUTED 1,2,4-OXADIAZOLE AND ANALOGUE TO ACTIVATE CASPASE AND INTRODUCTION OF APOPTOSIS AND THEIR USE
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
WO2006017505A2 (en) * 2004-08-04 2006-02-16 Schering Corporation Pharmaceutical formulations comprising pleconaril for the treatment of airway diseases
JP2009526064A (ja) * 2006-02-09 2009-07-16 シェーリング コーポレイション 薬学的調合物
EP1981475A2 (en) * 2006-02-09 2008-10-22 Schering Corporation Pharmaceutical formulations
CA2641616A1 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
CA2671478C (en) 2006-12-13 2015-02-17 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102322B (zh) * 2011-11-14 2016-02-24 上海交通大学 噁唑类化合物及其制备方法、药物组合物及其用途
TWI811428B (zh) 2018-08-21 2023-08-11 日商杏林製藥股份有限公司 雙環雜芳香環衍生物
CA3152534A1 (en) * 2019-09-27 2021-04-01 Collaborations Pharmaceuticals, Inc. Isoxazole-3-carboxamide derivatives and their use for treatment of diseases caused by virus infection
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
CA1299176C (en) * 1985-07-02 1992-04-21 Guy Dominic Diana Process for preparing isoxazole and furan derivatives
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
GB8619433D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
NO931366L (no) 1993-10-18
DE69327913D1 (de) 2000-04-06
DK0566199T3 (da) 2000-06-19
HU9301084D0 (en) 1993-06-28
NZ247411A (en) 1994-06-27
FI931707L (fi) 1993-10-16
KR100314158B1 (ko) 2002-02-19
AU3688193A (en) 1993-10-21
NO302700B1 (no) 1998-04-14
CZ59793A3 (en) 1994-02-16
CA2094012A1 (en) 1993-10-16
MY110191A (en) 1998-02-28
GR3033486T3 (en) 2000-09-29
ATE189958T1 (de) 2000-03-15
PT566199E (pt) 2000-09-29
RU2114112C1 (ru) 1998-06-27
ES2143487T3 (es) 2000-05-16
HUT65574A (en) 1994-07-28
CA2094012C (en) 2001-08-21
IL105372A (en) 1998-12-27
UA35557C2 (uk) 2001-04-16
NO931366D0 (no) 1993-04-14
TW239140B (enExample) 1995-01-21
SK279786B6 (sk) 1999-03-12
IL105372A0 (en) 1993-08-18
US5349068A (en) 1994-09-20
KR930021637A (ko) 1993-11-22
PH30454A (en) 1997-05-28
EP0566199A1 (en) 1993-10-20
HU211320A9 (en) 1995-11-28
JP3103845B2 (ja) 2000-10-30
FI931707A0 (fi) 1993-04-15
CZ285845B6 (cs) 1999-11-17
MX9302169A (es) 1993-10-01
US5643929A (en) 1997-07-01
SK35393A3 (en) 1994-06-08
HU220606B1 (hu) 2002-03-28
AU666528B2 (en) 1996-02-15
EP0566199B1 (en) 2000-03-01
JPH0649066A (ja) 1994-02-22
SG50663A1 (en) 1998-07-20
FI112229B (fi) 2003-11-14
US5464848A (en) 1995-11-07

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Owner name: SANOFI-SYNTHELABO, PARIS, FR

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