HU205010B - Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity - Google Patents

Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity Download PDF

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Publication number
HU205010B
HU205010B HU884518A HU451888A HU205010B HU 205010 B HU205010 B HU 205010B HU 884518 A HU884518 A HU 884518A HU 451888 A HU451888 A HU 451888A HU 205010 B HU205010 B HU 205010B
Authority
HU
Hungary
Prior art keywords
component
water
monoester
september
priority
Prior art date
Application number
HU884518A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT49494A (en
Inventor
Lorenz Hahn
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of HUT49494A publication Critical patent/HUT49494A/hu
Publication of HU205010B publication Critical patent/HU205010B/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU884518A 1987-09-15 1988-09-01 Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity HU205010B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3730909 1987-09-15
DE3802355 1988-01-27

Publications (2)

Publication Number Publication Date
HUT49494A HUT49494A (en) 1989-10-30
HU205010B true HU205010B (en) 1992-03-30

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
HU884518A HU205010B (en) 1987-09-15 1988-09-01 Process for producing pharmaceutical compositions comprising compounds soluble up to 1 per cent and having medical activity

Country Status (24)

Country Link
JP (1) JP3090666B2 (no)
KR (1) KR0131084B1 (no)
AT (1) AT395819B (no)
AU (1) AU628787B2 (no)
BE (1) BE1001204A5 (no)
CA (1) CA1338775C (no)
CH (1) CH683672A5 (no)
DK (1) DK175132B1 (no)
ES (1) ES2012118A6 (no)
FI (1) FI94837C (no)
FR (1) FR2620336B1 (no)
GB (1) GB2209671B (no)
GR (1) GR1002243B (no)
HU (1) HU205010B (no)
IE (1) IE61195B1 (no)
IL (1) IL87746A (no)
IT (1) IT1224886B (no)
LU (1) LU87335A1 (no)
MY (1) MY103769A (no)
NL (1) NL195094C (no)
NO (1) NO179434C (no)
NZ (1) NZ226163A (no)
PT (1) PT88492B (no)
SE (1) SE503279C2 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
BE1003009A5 (fr) * 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
WO1993023010A1 (en) 1992-05-13 1993-11-25 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
DK1033128T4 (da) 1993-09-28 2012-03-19 Scherer Gmbh R P Blød gelatinekapselfremstilling
EP0789580B1 (de) 1994-11-03 2002-06-05 Novartis AG Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
TW414696B (en) * 1996-07-01 2000-12-11 Mitsubishi Kagaku Foods Kk Anti-bacteria agent
ES2229473T3 (es) 1997-01-30 2005-04-16 Novartis Ag Composiciones farmaceuticas sin aceite que contienen ciclosporina a.
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2003267747A1 (en) * 2003-10-14 2005-05-05 Ramesh Varada Bapat Sterile gelling agents
JP5422871B2 (ja) * 2006-10-24 2014-02-19 不二製油株式会社 イソフラボン類組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL284933A (no) * 1961-10-31
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
FR5986M (no) * 1966-11-22 1968-06-21
BE787842A (fr) * 1971-08-25 1972-12-18 Sumito Chemical Cy Ltd Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS57128634A (en) * 1981-02-03 1982-08-10 Eisai Co Ltd Elastase-containing compound increasing absorption
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤

Also Published As

Publication number Publication date
GR880100602A (el) 1989-06-22
IT1224886B (it) 1990-10-24
FI884192A0 (fi) 1988-09-13
FI94837B (fi) 1995-07-31
IE882772L (en) 1989-03-15
DK175132B1 (da) 2004-06-14
HUT49494A (en) 1989-10-30
KR890004694A (ko) 1989-05-09
CH683672A5 (de) 1994-04-29
LU87335A1 (fr) 1989-04-06
IL87746A0 (en) 1989-02-28
IL87746A (en) 1992-07-15
BE1001204A5 (fr) 1989-08-16
JP3090666B2 (ja) 2000-09-25
IT8848349A0 (it) 1988-09-14
AT395819B (de) 1993-03-25
GB2209671B (en) 1991-11-13
FR2620336A1 (fr) 1989-03-17
NL8802275A (nl) 1989-04-03
GR1002243B (en) 1996-04-22
AU2217288A (en) 1989-04-27
MY103769A (en) 1993-09-30
JPH01151526A (ja) 1989-06-14
AU628787B2 (en) 1992-09-24
DK511188D0 (da) 1988-09-14
ATA224988A (de) 1992-08-15
NO179434C (no) 1996-10-09
ES2012118A6 (es) 1990-03-01
CA1338775C (en) 1996-12-10
SE503279C2 (sv) 1996-05-13
KR0131084B1 (ko) 1998-04-17
NO179434B (no) 1996-07-01
FI884192A (fi) 1989-03-16
SE8803221L (sv) 1989-03-16
DK511188A (da) 1989-03-16
NL195094C (nl) 2003-12-17
SE8803221D0 (sv) 1988-09-13
GB8821443D0 (en) 1988-10-12
FR2620336B1 (fr) 1991-10-25
GB2209671A (en) 1989-05-24
PT88492B (pt) 1993-03-31
NO884052L (no) 1989-03-16
PT88492A (pt) 1988-10-01
NZ226163A (en) 1991-08-27
IE61195B1 (en) 1994-10-19
NO884052D0 (no) 1988-09-13
FI94837C (fi) 1995-11-10

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HPC4 Succession in title of patentee

Owner name: NOVARTIS A.G., CH