HU198939B - Process for producing neopodophyllotoxin benzylether derivatives - Google Patents

Process for producing neopodophyllotoxin benzylether derivatives Download PDF

Info

Publication number
HU198939B
HU198939B HU884863A HU486386A HU198939B HU 198939 B HU198939 B HU 198939B HU 884863 A HU884863 A HU 884863A HU 486386 A HU486386 A HU 486386A HU 198939 B HU198939 B HU 198939B
Authority
HU
Hungary
Prior art keywords
formula
compound
viii
vii
neopodophyllotoxin
Prior art date
Application number
HU884863A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT48878A (en
Inventor
Takushi Kaneko
Henry S Wong
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of HUT48878A publication Critical patent/HUT48878A/hu
Publication of HU198939B publication Critical patent/HU198939B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
HU884863A 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin benzylether derivatives HU198939B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/805,484 US4734512A (en) 1985-12-05 1985-12-05 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Publications (2)

Publication Number Publication Date
HUT48878A HUT48878A (en) 1989-07-28
HU198939B true HU198939B (en) 1989-12-28

Family

ID=25191684

Family Applications (5)

Application Number Title Priority Date Filing Date
HU864862D HU198465B (en) 1985-12-05 1986-12-04 Process for producing 3-/benzyloxymethyl/-aryl-tetralone derivatives
HU865028A HU198938B (en) 1985-12-05 1986-12-04 Process for producing podophyllotoxin and podophyllotoxin derivatives
HU864864A HU198940B (en) 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin derivatives
HU884863A HU198939B (en) 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin benzylether derivatives
HU864865A HUT47560A (en) 1985-12-05 1986-12-04 Process for production of enol-silil-esthers

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HU864862D HU198465B (en) 1985-12-05 1986-12-04 Process for producing 3-/benzyloxymethyl/-aryl-tetralone derivatives
HU865028A HU198938B (en) 1985-12-05 1986-12-04 Process for producing podophyllotoxin and podophyllotoxin derivatives
HU864864A HU198940B (en) 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU864865A HUT47560A (en) 1985-12-05 1986-12-04 Process for production of enol-silil-esthers

Country Status (13)

Country Link
US (2) US4734512A (forum.php)
EP (1) EP0224938B1 (forum.php)
JP (1) JPS62145093A (forum.php)
KR (1) KR900004129B1 (forum.php)
AT (1) ATE77380T1 (forum.php)
AU (2) AU599937B2 (forum.php)
CA (4) CA1318321C (forum.php)
DE (1) DE3685727T2 (forum.php)
ES (1) ES2042488T3 (forum.php)
GR (1) GR3005053T3 (forum.php)
HU (5) HU198465B (forum.php)
IL (3) IL94000A (forum.php)
ZA (1) ZA869184B (forum.php)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
GB9422946D0 (en) * 1994-11-14 1995-01-04 Univ Salamanca Antineoplastic cyclolignan derivatives
EP1792927B1 (en) 2004-09-22 2013-03-06 Nippon Kayaku Kabushiki Kaisha Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
WO2007111211A1 (ja) 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha タキサン類の高分子結合体
RU2447095C2 (ru) * 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
EP2070971B1 (en) * 2006-10-03 2016-06-22 Nippon Kayaku Kabushiki Kaisha Compound of resorcinol derivative with polymer
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
JP5548365B2 (ja) 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
JP5349318B2 (ja) * 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
US8920788B2 (en) * 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
WO2009136572A1 (ja) 2008-05-08 2009-11-12 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
WO2010131675A1 (ja) 2009-05-15 2010-11-18 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
TW201304805A (zh) 2010-11-17 2013-02-01 Nippon Kayaku Kk 新穎之胞核苷系代謝拮抗劑之高分子衍生物
AU2012305405B2 (en) 2011-09-11 2016-01-14 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391982A (en) * 1980-03-05 1983-07-05 The University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
CA1318321C (en) 1993-05-25
IL94000A (en) 1991-09-16
GR3005053T3 (forum.php) 1993-05-24
KR900004129B1 (ko) 1990-06-16
CA1321596C (en) 1993-08-24
AU5715190A (en) 1990-10-04
HUT47560A (en) 1989-03-28
EP0224938A2 (en) 1987-06-10
DE3685727T2 (de) 1993-01-21
EP0224938B1 (en) 1992-06-17
HUT47559A (en) 1989-03-28
CA1321597C (en) 1993-08-24
IL93999A0 (en) 1991-01-31
DE3685727D1 (de) 1992-07-23
AU6587086A (en) 1987-06-11
US4845248A (en) 1989-07-04
ES2042488T3 (es) 1993-12-16
ATE77380T1 (de) 1992-07-15
IL94000A0 (en) 1991-01-31
HU198938B (en) 1989-12-28
KR870006032A (ko) 1987-07-08
AU631216B2 (en) 1992-11-19
US4734512A (en) 1988-03-29
HU198940B (en) 1989-12-28
IL80853A (en) 1991-09-16
HUT48888A (en) 1989-07-28
HU198465B (en) 1989-10-30
ZA869184B (en) 1987-07-29
IL93999A (en) 1991-09-16
HUT48878A (en) 1989-07-28
CA1321595C (en) 1993-08-24
JPS62145093A (ja) 1987-06-29
AU599937B2 (en) 1990-08-02
HUT47114A (en) 1989-01-30
EP0224938A3 (en) 1989-11-02

Similar Documents

Publication Publication Date Title
HU198939B (en) Process for producing neopodophyllotoxin benzylether derivatives
Schmid et al. Synthetic studies on polyether antibiotics. 4. Total synthesis of monensin. 1. Stereocontrolled synthesis of the left half of monensin
Kraus et al. A synthetic approach to rocaglamide via reductive cyclization of. delta.-keto nitriles
Ohfune et al. Synthesis of (+)-galantinic acid, a constituent amino acid in the peptide antibiotic galantin I, via the stereoselective epoxidation of a chiral serine equivalent
Katagiri et al. Highly stereoselective total synthesis of. beta.-ribofuranosylmalonate
US5605905A (en) Antitumoral compounds
Mukaiyama et al. A Convenient Method for the Synthesis of Furan derivatives
HU191824B (en) Process for producing new pyridine and pyrimidine derivatives utilizable as intermediares producing antiflogistic and immunkregulating compounds
DE2463173C2 (de) Zwischenprodukte 1,3-Dithiolanyl(2)- und 1,3-Dithianyl(2)-Verbindungen
Giannola et al. Addition reactions of acetylenic esters with monosubstituted thioureas
US4025537A (en) Preparation of 3-carboalkoxy or 3-alkanoyl furans
Hamana et al. An aldol-type reaction of active methyl groups of nitrogen-containing heteroaromatic compounds
Kamimura et al. syn-and anti-Selective preparation of 3-substltuted-Δ2-isoxazolines
GB2036744A (en) Eburnane derivatives
Murthy et al. The reaction of chlorosulfonyl isocyanate with epoxides. A novel conversion of epoxides to cyclic carbonates
US4528372A (en) N-Phthalidyl-5-fluorouracils
Ohshima et al. A convenient method for the preparation of γ-ketosulfides from thioacetals
LaMattina et al. Synthesis of 2-amino-5-hydroxy-4-pyrimidones and 5, 6-biheteroaryls using p-nitrophenyl 3-bromo-2, 2-diethoxypropionate (NPBDP)
HU180927B (en) Process for producing 1k-hydroximino-e-homoe-eburane de rivatives
Lira et al. Synthesis and complete assignments of 1H and 13C NMR spectra of mesoionic 2-(ptrifluoromethylphenyl)-3-methyl-4-(p-tolyl)-1, 3-thiazolium-5-thiolate and 2-(p-chlorophenyl)-3-methyl–4-(p-isopropylphenyl)-1, 3-thiazolium-5-thiolate
DE3780730T2 (de) Optisch wirksame beta-aminosaeure derivate und ihre salze und verfahren zu deren herstellung.
Ahluwalia et al. Synthesis of obtusinin and 7-(3′-hydroxymethylbut-2′-enyloxy)-6-methoxy-2 H-1-benzopyran-2-one
NATSUME et al. Synthetic Studies on Amino-sugars from Pyridines. II. Synthesis of 5-Methoxycarbonylamino-5-deoxy-dl-xylopiperidinose Tetraacetate
DE4333688C2 (de) Verfahren zur Herstellung von 3-Aryl-2-(dialkoxymethyl)-propannitrilen und ihre Umsetzung zu 5-Arylmethyl-2,4-diamino-pyrimidinen, insbesondere zu Trimethoprim
Hamana et al. An aldol-type reaction of acetonitriles using dialkylboryl triflate.

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee