HU198939B - Process for producing neopodophyllotoxin benzylether derivatives - Google Patents

Process for producing neopodophyllotoxin benzylether derivatives Download PDF

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Publication number
HU198939B
HU198939B HU884863A HU486386A HU198939B HU 198939 B HU198939 B HU 198939B HU 884863 A HU884863 A HU 884863A HU 486386 A HU486386 A HU 486386A HU 198939 B HU198939 B HU 198939B
Authority
HU
Hungary
Prior art keywords
formula
compound
viii
vii
neopodophyllotoxin
Prior art date
Application number
HU884863A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT48878A (en
Inventor
Takushi Kaneko
Henry S Wong
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of HUT48878A publication Critical patent/HUT48878A/hu
Publication of HU198939B publication Critical patent/HU198939B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
HU884863A 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin benzylether derivatives HU198939B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/805,484 US4734512A (en) 1985-12-05 1985-12-05 Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Publications (2)

Publication Number Publication Date
HUT48878A HUT48878A (en) 1989-07-28
HU198939B true HU198939B (en) 1989-12-28

Family

ID=25191684

Family Applications (5)

Application Number Title Priority Date Filing Date
HU884863A HU198939B (en) 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin benzylether derivatives
HU864865A HUT47560A (en) 1985-12-05 1986-12-04 Process for production of enol-silil-esthers
HU864862D HU198465B (en) 1985-12-05 1986-12-04 Process for producing 3-/benzyloxymethyl/-aryl-tetralone derivatives
HU865028A HU198938B (en) 1985-12-05 1986-12-04 Process for producing podophyllotoxin and podophyllotoxin derivatives
HU864864A HU198940B (en) 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin derivatives

Family Applications After (4)

Application Number Title Priority Date Filing Date
HU864865A HUT47560A (en) 1985-12-05 1986-12-04 Process for production of enol-silil-esthers
HU864862D HU198465B (en) 1985-12-05 1986-12-04 Process for producing 3-/benzyloxymethyl/-aryl-tetralone derivatives
HU865028A HU198938B (en) 1985-12-05 1986-12-04 Process for producing podophyllotoxin and podophyllotoxin derivatives
HU864864A HU198940B (en) 1985-12-05 1986-12-04 Process for producing neopodophyllotoxin derivatives

Country Status (13)

Country Link
US (2) US4734512A (forum.php)
EP (1) EP0224938B1 (forum.php)
JP (1) JPS62145093A (forum.php)
KR (1) KR900004129B1 (forum.php)
AT (1) ATE77380T1 (forum.php)
AU (2) AU599937B2 (forum.php)
CA (4) CA1318321C (forum.php)
DE (1) DE3685727T2 (forum.php)
ES (1) ES2042488T3 (forum.php)
GR (1) GR3005053T3 (forum.php)
HU (5) HU198939B (forum.php)
IL (3) IL80853A (forum.php)
ZA (1) ZA869184B (forum.php)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6393796A (ja) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd ペプチド合成の脱保護基用薬剤
GB9422946D0 (en) * 1994-11-14 1995-01-04 Univ Salamanca Antineoplastic cyclolignan derivatives
AU2005285953B2 (en) * 2004-09-22 2011-01-20 Nippon Kayaku Kabushiki Kaisha Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
JP5249016B2 (ja) 2006-03-28 2013-07-31 日本化薬株式会社 タキサン類の高分子結合体
US8940332B2 (en) * 2006-05-18 2015-01-27 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of podophyllotoxins
CA2664852A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of resorcinol derivatives
EP2080779B1 (en) 2006-11-06 2016-05-18 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
WO2008056654A1 (en) 2006-11-08 2008-05-15 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
CN101808651B (zh) * 2007-09-28 2013-03-27 日本化药株式会社 类固醇类的高分子结合物
WO2009116509A1 (ja) * 2008-03-18 2009-09-24 日本化薬株式会社 生理活性物質の高分子結合体
EP2284209B1 (en) 2008-05-08 2016-08-31 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
JP5856069B2 (ja) 2010-11-17 2016-02-09 日本化薬株式会社 新規なシチジン系代謝拮抗剤の高分子誘導体
CA2847114C (en) 2011-09-11 2018-08-21 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391982A (en) * 1980-03-05 1983-07-05 The University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4294763A (en) * 1980-03-05 1981-10-13 University Of Rochester Intermediates for the production of picropodophyllin and related compounds and processes for the preparation and use thereof
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US4734512A (en) * 1985-12-05 1988-03-29 Bristol-Myers Company Intermediates for the production of podophyllotoxin and related compounds and processes for the preparation and use thereof

Also Published As

Publication number Publication date
US4845248A (en) 1989-07-04
HU198940B (en) 1989-12-28
CA1321596C (en) 1993-08-24
AU6587086A (en) 1987-06-11
CA1321595C (en) 1993-08-24
KR870006032A (ko) 1987-07-08
GR3005053T3 (forum.php) 1993-05-24
HUT47114A (en) 1989-01-30
KR900004129B1 (ko) 1990-06-16
AU631216B2 (en) 1992-11-19
HUT48878A (en) 1989-07-28
HU198938B (en) 1989-12-28
DE3685727D1 (de) 1992-07-23
CA1321597C (en) 1993-08-24
HUT47560A (en) 1989-03-28
JPS62145093A (ja) 1987-06-29
EP0224938A2 (en) 1987-06-10
ZA869184B (en) 1987-07-29
IL80853A (en) 1991-09-16
IL93999A (en) 1991-09-16
IL94000A0 (en) 1991-01-31
AU599937B2 (en) 1990-08-02
AU5715190A (en) 1990-10-04
EP0224938B1 (en) 1992-06-17
HUT47559A (en) 1989-03-28
CA1318321C (en) 1993-05-25
ATE77380T1 (de) 1992-07-15
DE3685727T2 (de) 1993-01-21
HUT48888A (en) 1989-07-28
ES2042488T3 (es) 1993-12-16
EP0224938A3 (en) 1989-11-02
HU198465B (en) 1989-10-30
US4734512A (en) 1988-03-29
IL94000A (en) 1991-09-16
IL93999A0 (en) 1991-01-31

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee