HU190684B - Process for producing new fluore-prostacyclin derivatives - Google Patents

Process for producing new fluore-prostacyclin derivatives Download PDF

Info

Publication number
HU190684B
HU190684B HU82714A HU71482A HU190684B HU 190684 B HU190684 B HU 190684B HU 82714 A HU82714 A HU 82714A HU 71482 A HU71482 A HU 71482A HU 190684 B HU190684 B HU 190684B
Authority
HU
Hungary
Prior art keywords
fluoro
formula
methyl
hydrogen
acid
Prior art date
Application number
HU82714A
Other languages
English (en)
Hungarian (hu)
Inventor
George W Holland
Perry Rosen
Hans Maag
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HU190684B publication Critical patent/HU190684B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
HU82714A 1981-03-11 1982-03-09 Process for producing new fluore-prostacyclin derivatives HU190684B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11
US33779182A 1982-01-07 1982-01-07

Publications (1)

Publication Number Publication Date
HU190684B true HU190684B (en) 1986-10-28

Family

ID=26935366

Family Applications (1)

Application Number Title Priority Date Filing Date
HU82714A HU190684B (en) 1981-03-11 1982-03-09 Process for producing new fluore-prostacyclin derivatives

Country Status (19)

Country Link
AT (1) AT381308B (OSRAM)
AU (2) AU558000B2 (OSRAM)
CA (1) CA1208634A (OSRAM)
CH (2) CH648556A5 (OSRAM)
DE (1) DE3208880A1 (OSRAM)
DK (1) DK104882A (OSRAM)
ES (1) ES510286A0 (OSRAM)
FR (3) FR2503161B1 (OSRAM)
GB (2) GB2094310B (OSRAM)
HU (1) HU190684B (OSRAM)
IE (1) IE52388B1 (OSRAM)
IL (1) IL65177A (OSRAM)
IT (1) IT1195917B (OSRAM)
LU (1) LU83992A1 (OSRAM)
NL (1) NL8200992A (OSRAM)
NO (1) NO154494C (OSRAM)
NZ (1) NZ199912A (OSRAM)
PH (2) PH17410A (OSRAM)
SE (2) SE453294B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DK40485A (da) * 1984-03-02 1985-09-03 Hoffmann La Roche Prostaglandin-mellemprodukter
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds
US4680415A (en) * 1985-06-24 1987-07-14 Hoffmann-La Roche Inc. Intermediates for 7-fluoro dihydro PGI compounds
CH674363A5 (OSRAM) * 1986-12-01 1990-05-31 Hoffmann La Roche
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins
RU2239925C1 (ru) * 2003-09-03 2004-11-10 Анисимова Ирина Александровна Свеча зажигания для двигателя внутреннего сгорания

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
DE2811950A1 (de) * 1978-03-18 1979-12-13 Hoechst Ag Neue analoga von prostacyclin
US4254042A (en) * 1979-07-05 1981-03-03 The Upjohn Company 19-Hydroxy-19-methyl-4,5-didehydro-PGI1 compounds
WO1981001002A1 (en) * 1979-10-10 1981-04-16 Univ Chicago Fluoro-substituted prostaglandins and prostacyclins
GB2084991B (en) * 1980-09-22 1984-06-20 Hoffmann La Roche Prostacyclins
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
DE3176313D1 (en) * 1980-12-09 1987-08-20 Teijin Ltd Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
AU8115682A (en) 1982-09-16
CH648556A5 (de) 1985-03-29
IT8219966A0 (it) 1982-03-04
SE8703023L (sv) 1987-07-31
ATA94982A (de) 1986-02-15
GB2094310A (en) 1982-09-15
AT381308B (de) 1986-09-25
FR2503161B1 (fr) 1986-04-18
FR2503161A1 (fr) 1982-10-08
IL65177A0 (en) 1982-05-31
IL65177A (en) 1985-10-31
ES8304934A1 (es) 1983-04-01
CH651033A5 (de) 1985-08-30
CA1208634A (en) 1986-07-29
PH18584A (en) 1985-08-12
NO154494C (no) 1986-10-01
NO154494B (no) 1986-06-23
IT1195917B (it) 1988-11-03
NL8200992A (nl) 1982-10-01
GB2158822B (en) 1986-06-18
LU83992A1 (de) 1983-11-17
IE52388B1 (en) 1987-10-14
AU576441B2 (en) 1988-08-25
FR2515650A1 (fr) 1983-05-06
GB8426077D0 (en) 1984-11-21
SE453294B (sv) 1988-01-25
FR2515650B1 (fr) 1985-08-09
ES510286A0 (es) 1983-04-01
FR2515644B1 (OSRAM) 1984-05-25
GB2158822A (en) 1985-11-20
PH17410A (en) 1984-08-08
NO820779L (no) 1982-09-13
SE8201506L (sv) 1982-09-12
IE820547L (en) 1982-09-11
FR2515644A1 (fr) 1983-05-06
AU558000B2 (en) 1987-01-15
DK104882A (da) 1982-09-12
GB2094310B (en) 1985-07-03
AU6855587A (en) 1987-05-07
SE8703023D0 (sv) 1987-07-31
DE3208880A1 (de) 1982-09-23
NZ199912A (en) 1985-08-30

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee