HRPK20040271B3 - Indole derivatives as cox ii inhibitors - Google Patents

Indole derivatives as cox ii inhibitors

Info

Publication number
HRPK20040271B3
HRPK20040271B3 HR20040271A HRP20040271A HRPK20040271B3 HR PK20040271 B3 HRPK20040271 B3 HR PK20040271B3 HR 20040271 A HR20040271 A HR 20040271A HR P20040271 A HRP20040271 A HR P20040271A HR PK20040271 B3 HRPK20040271 B3 HR PK20040271B3
Authority
HR
Croatia
Prior art keywords
alkyl
hydroxy
hydrogen
halo
alkoxy
Prior art date
Application number
HR20040271A
Other languages
English (en)
Croatian (hr)
Inventor
Allen Broka Chris
Allen Campbell Jeffrey
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20040271A2 publication Critical patent/HRP20040271A2/hr
Publication of HRPK20040271B3 publication Critical patent/HRPK20040271B3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
HR20040271A 2001-09-27 2004-03-19 Indole derivatives as cox ii inhibitors HRPK20040271B3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32538901P 2001-09-27 2001-09-27
PCT/EP2002/010557 WO2003029212A1 (en) 2001-09-27 2002-09-20 Indole derivatives as cox ii inhibitors

Publications (2)

Publication Number Publication Date
HRP20040271A2 HRP20040271A2 (en) 2004-08-31
HRPK20040271B3 true HRPK20040271B3 (en) 2006-02-28

Family

ID=23267681

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040271A HRPK20040271B3 (en) 2001-09-27 2004-03-19 Indole derivatives as cox ii inhibitors

Country Status (25)

Country Link
US (3) US6872744B2 (ja)
EP (1) EP1438289B1 (ja)
JP (1) JP4141954B2 (ja)
KR (1) KR20040047862A (ja)
CN (1) CN1261412C (ja)
AR (1) AR036624A1 (ja)
AT (1) ATE292115T1 (ja)
BR (1) BR0212925A (ja)
CA (1) CA2461670A1 (ja)
CO (1) CO5560557A2 (ja)
DE (1) DE60203529T2 (ja)
DK (1) DK1438289T3 (ja)
ES (1) ES2238616T3 (ja)
HR (1) HRPK20040271B3 (ja)
HU (1) HUP0401499A3 (ja)
IL (1) IL160752A0 (ja)
MX (1) MXPA04002824A (ja)
NO (1) NO20041237L (ja)
NZ (1) NZ531577A (ja)
PL (1) PL370342A1 (ja)
PT (1) PT1438289E (ja)
RU (1) RU2004113111A (ja)
SI (1) SI1438289T1 (ja)
WO (1) WO2003029212A1 (ja)
ZA (1) ZA200402360B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04002824A (es) * 2001-09-27 2004-07-05 Hoffmann La Roche Derivados de indol como inhibidores de cox ii.
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
WO2004014364A1 (en) * 2002-08-07 2004-02-19 Idenix (Cayman) Limited Substituted phenylindoles for the treatment of hiv
CA2550091A1 (en) * 2003-12-19 2005-07-07 Elixir Pharmaceuticals, Inc. Methods of treating a disorder
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
EP1589016A1 (en) * 2004-04-13 2005-10-26 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
KR20070028553A (ko) 2004-06-18 2007-03-12 바이올리폭스 에이비 염증 치료에 유용한 인돌
WO2006041961A1 (en) * 2004-10-05 2006-04-20 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same
KR20070114123A (ko) 2005-01-19 2007-11-29 바이올리폭스 에이비 염증 치료에 유용한 인돌
US7622495B2 (en) * 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
MX2009004898A (es) 2006-11-09 2009-05-19 Hoffmann La Roche Derivados de indol y de benzofurano-2-carboxamida.
CN103201262B (zh) * 2010-08-20 2016-06-01 艾米拉医药股份有限公司 自分泌运动因子抑制剂及其用途
WO2012166415A1 (en) 2011-05-27 2012-12-06 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
WO2015042052A1 (en) 2013-09-17 2015-03-26 Pharmakea, Inc. Heterocyclic vinyl autotaxin inhibitor compounds
EP3046905A4 (en) 2013-09-17 2017-03-22 Pharmakea Inc. Vinyl autotaxin inhibitor compounds
EP3049405A4 (en) 2013-09-26 2017-03-08 Pharmakea Inc. Autotaxin inhibitor compounds
JP6501367B2 (ja) * 2013-11-22 2019-04-17 ファーマケア，インク． オートタキシン阻害剤化合物
EA039684B1 (ru) 2015-05-27 2022-02-28 Сабре Терапьютикс Ллс Ингибиторы аутотаксина и их применения
KR102241064B1 (ko) 2019-07-30 2021-04-16 부산대학교 산학협력단 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물
CN113004187B (zh) * 2021-03-16 2022-09-20 沈阳药科大学 一种具有抑制有机阴离子转运体1活性的化合物及制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654360A (en) * 1984-06-01 1987-03-31 Syntex (U.S.A.) Inc. 1,2,3-trisubstituted indoles for treatment of inflammation
JPH0347123A (ja) 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
DE4338770A1 (de) 1993-11-12 1995-05-18 Matthias Dr Lehr Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
WO1998008818A1 (en) 1996-08-26 1998-03-05 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
WO1998051667A1 (fr) * 1997-05-16 1998-11-19 Chugai Seiyaku Kabushiki Kaisha Derives d'indole et derives de mono- et diazaindole
EE200000522A (et) 1998-02-25 2002-02-15 Genetics Institute, Inc. Fosfolipaas A2 ensüümi inhibiitor, seda sisaldav farmatseutiline kompositsioon ning meetod fosfolipaasensüümi toime pärssimiseks
MXPA00006605A (es) * 1999-07-02 2004-12-09 Pfizer Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
US6306890B1 (en) * 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US6376708B1 (en) * 2000-04-11 2002-04-23 Monsanto Technology Llc Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts
MXPA04002824A (es) * 2001-09-27 2004-07-05 Hoffmann La Roche Derivados de indol como inhibidores de cox ii.
TW200400177A (en) * 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands

Also Published As

Publication number Publication date
SI1438289T1 (ja) 2005-08-31
ES2238616T3 (es) 2005-09-01
EP1438289B1 (en) 2005-03-30
MXPA04002824A (es) 2004-07-05
RU2004113111A (ru) 2005-06-27
NO20041237L (no) 2004-03-24
IL160752A0 (en) 2004-08-31
AR036624A1 (es) 2004-09-22
HUP0401499A2 (hu) 2004-12-28
CN1261412C (zh) 2006-06-28
HUP0401499A3 (en) 2007-05-02
US20060178420A1 (en) 2006-08-10
KR20040047862A (ko) 2004-06-05
US7410994B2 (en) 2008-08-12
PT1438289E (pt) 2005-06-30
US20050176803A1 (en) 2005-08-11
EP1438289A1 (en) 2004-07-21
US7074939B2 (en) 2006-07-11
CN1561334A (zh) 2005-01-05
HRP20040271A2 (en) 2004-08-31
ZA200402360B (en) 2005-04-26
JP2005510474A (ja) 2005-04-21
CA2461670A1 (en) 2003-04-10
DK1438289T3 (da) 2005-08-08
US20030130337A1 (en) 2003-07-10
PL370342A1 (en) 2005-05-16
US6872744B2 (en) 2005-03-29
DE60203529D1 (de) 2005-05-04
NZ531577A (en) 2005-09-30
BR0212925A (pt) 2004-10-13
JP4141954B2 (ja) 2008-08-27
WO2003029212A1 (en) 2003-04-10
ATE292115T1 (de) 2005-04-15
CO5560557A2 (es) 2005-09-30
DE60203529T2 (de) 2006-03-16

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AKOB Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent)
ODRP Renewal fee for the maintenance of a patent

Payment date: 20050713

Year of fee payment: 4

PKB1 Consensual patent granted
PBKO Lapse due to non-payment of renewal fee for consensual patent

Effective date: 20060921