HRP931480B1 - 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A - Google Patents

9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A

Info

Publication number
HRP931480B1
HRP931480B1 HR931480A HRP931480A HRP931480B1 HR P931480 B1 HRP931480 B1 HR P931480B1 HR 931480 A HR931480 A HR 931480A HR P931480 A HRP931480 A HR P931480A HR P931480 B1 HRP931480 B1 HR P931480B1
Authority
HR
Croatia
Prior art keywords
homoerythromycin
deoxo
thiocarbamonyl
carbamonyl
derivates
Prior art date
Application number
HR931480A
Other languages
English (en)
Inventor
Nedjeljko Kujundzic
Gabrijela Kobrehel
Zeljko Kelneric
Original Assignee
Sour Pliva
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sour Pliva, Pliva Pharm & Chem Works filed Critical Sour Pliva
Priority to HR931480A priority Critical patent/HRP931480B1/xx
Priority to US08/350,990 priority patent/US5629296A/en
Priority to SK1469-94A priority patent/SK281200B6/sk
Priority to DE69400817T priority patent/DE69400817T2/de
Priority to AT94118984T priority patent/ATE144778T1/de
Priority to EP94118984A priority patent/EP0657464B1/en
Priority to ES94118984T priority patent/ES2096401T3/es
Priority to CA002137395A priority patent/CA2137395C/en
Priority to RU94042916A priority patent/RU2131878C1/ru
Priority to PL94306154A priority patent/PL176696B1/pl
Priority to CN94112765A priority patent/CN1039417C/zh
Priority to BG99242A priority patent/BG61571B1/bg
Priority to RO94-01958A priority patent/RO113854B1/ro
Priority to HU9403502A priority patent/HU213611B/hu
Priority to CZ19943082A priority patent/CZ288554B6/cs
Priority to JP06303945A priority patent/JP3131546B2/ja
Priority to UA94129154A priority patent/UA39870C2/uk
Priority to SI9400434A priority patent/SI9400434A/sl
Publication of HRP931480A2 publication Critical patent/HRP931480A2/xx
Publication of HRP931480B1 publication Critical patent/HRP931480B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HR931480A 1993-12-08 1993-12-08 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A HRP931480B1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
HR931480A HRP931480B1 (en) 1993-12-08 1993-12-08 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
US08/350,990 US5629296A (en) 1993-12-08 1994-11-29 9A-N-(N'-carbamoyl)and 9A-N-(N'-thiocarbamoyl) derivatives of 9-deoxo-9A-aza-9A-homoerythromycin A
SK1469-94A SK281200B6 (sk) 1993-12-08 1994-11-30 9a-n-(n'-karbamoyl) a 9a-n-(n'-tiokarbamoyl) deriváty 9-deoxo-9a-aza-9a-homoerytromycínu a, spôsob ich prípravy, farmaceutický prostriedok a použitie
DE69400817T DE69400817T2 (de) 1993-12-08 1994-12-01 9a-N-(N'-Carbamoyl)-und 9a-N-(N'Thiocarbamoyl)-Derivate von 9-Deoxo-9a-aza-9a-homoerythromycin A
AT94118984T ATE144778T1 (de) 1993-12-08 1994-12-01 9a-n-(n'-carbamoyl)-und 9a-n-(n'thiocarbamoyl)- derivate von 9-deoxo-9a-aza-9a-homoerythromycin a
EP94118984A EP0657464B1 (en) 1993-12-08 1994-12-01 9a-N-(N'-Carbamoyl) and 9a-N-(N'-Thiocarbamoyl) derivatives of 9-deoxo-9a-aza-9a-homoerythromycin A
ES94118984T ES2096401T3 (es) 1993-12-08 1994-12-01 Derivados de 9a-n-(n'-carbamoil) y de 9a-n-(n'-tiocarbamoil) de 9-desoxo-9a-aza-9a-homoeritromicina a.
CA002137395A CA2137395C (en) 1993-12-08 1994-12-06 9a-n-(n'-carbamoyl) and 9a-n-(n' - thiocarbamoyl) derivatives of 9-deoxo-9a-aza-9a-homoerythromycin a
RU94042916A RU2131878C1 (ru) 1993-12-08 1994-12-06 9а-n-(n'-карбамоил)- или 9а-n-(n'-тиокарбамоил) производные 9-деоксо-9а-аза-9а-гомоэритромицина а, способ их получения и фармацевтическая композиция на их основе
PL94306154A PL176696B1 (pl) 1993-12-08 1994-12-07 Nowe pochodne 9-deokso-9a-aza-9a-homoerytromycyny A, sposób ich wytwarzania oraz środek farmaceutyczny
CN94112765A CN1039417C (zh) 1993-12-08 1994-12-07 新的9a-N-取代的氮杂大环内酯化合物及其制备方法和应用
BG99242A BG61571B1 (bg) 1993-12-08 1994-12-07 9а-n-(n'-карбамоилови) и 9а-n-(n'-тиокарбамоилови) производни на 9-дезоксо-9а-аза-9а-хомоеритромицин а
RO94-01958A RO113854B1 (ro) 1993-12-08 1994-12-07 Derivati ai 9 deoxo-9a-aza-9a-homoeritromicinei a, procedeu de obtinere a acestora si compozitie farmaceutica ce ii contine
HU9403502A HU213611B (en) 1993-12-08 1994-12-07 9a-n-(n`-substituted carbamoyl)-and 9a-n-(n`-substituted thiocarbamoyl) derivs. of 9-deoxo-9a-aza-9a-homoerythromycin a, process to prepare them and medical compns. contg. them
CZ19943082A CZ288554B6 (cs) 1993-12-08 1994-12-07 9a-N-(N´-karbamoyl) a 9a-N-(N´-thiokarbamoyl) derivátů 9-deoxo-9a-aza-9a-homoerythromycinu A, způsob jejich přípravy, farmaceutický prostředek je obsahující a jejich použití
JP06303945A JP3131546B2 (ja) 1993-12-08 1994-12-07 ９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの９ａ−Ｎ−（Ｎ′−カルバモイル）及び９ａ−Ｎ−（Ｎ′−チオカルバモイル）誘導体
UA94129154A UA39870C2 (uk) 1993-12-08 1994-12-08 ПОХІДНІ 9а-N-/N`-КАРБАМOЇЛУ/ ТА 9а-N-/N`-ТІОКАРБАМOЇЛУ/ ВІД 9-ДЕОКСО-9а-А3А-9а ГОМОЕРИТРОМІЦИНУ А, СПОСІБ ОДЕРЖАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ
SI9400434A SI9400434A (en) 1993-12-08 1994-12-08 9a-N-(N'-CARBAMOYL) AND 9a-N-(N'-THIOCARBAMOYL) 9-DEOXO-9a-AZA-9a-HOMOERYTHROMYCINE A DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR931480A HRP931480B1 (en) 1993-12-08 1993-12-08 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A

Publications (2)

Publication Number Publication Date
HRP931480A2 HRP931480A2 (en) 1996-08-31
HRP931480B1 true HRP931480B1 (en) 1997-08-31

Family

ID=10946045

Family Applications (1)

Application Number Title Priority Date Filing Date
HR931480A HRP931480B1 (en) 1993-12-08 1993-12-08 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A

Country Status (18)

Country Link
US (1) US5629296A (xx)
EP (1) EP0657464B1 (xx)
JP (1) JP3131546B2 (xx)
CN (1) CN1039417C (xx)
AT (1) ATE144778T1 (xx)
BG (1) BG61571B1 (xx)
CA (1) CA2137395C (xx)
CZ (1) CZ288554B6 (xx)
DE (1) DE69400817T2 (xx)
ES (1) ES2096401T3 (xx)
HR (1) HRP931480B1 (xx)
HU (1) HU213611B (xx)
PL (1) PL176696B1 (xx)
RO (1) RO113854B1 (xx)
RU (1) RU2131878C1 (xx)
SI (1) SI9400434A (xx)
SK (1) SK281200B6 (xx)
UA (1) UA39870C2 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP970714B1 (en) * 1997-12-31 2003-08-31 Pliva Pharm & Chem Works Beta,beta-disubstituted derivatives of 9-deoxo-9a-n-ethenyl-9a-aza-9a-homoerythromycin a
TR200200435T2 (tr) * 1998-11-03 2002-07-22 Pfizer Products Inc. Yeni makrolit antibiyotikler.
UA70972C2 (uk) * 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
HRP990130B1 (en) * 1999-05-03 2004-06-30 Pliva D D HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A
JP2003500414A (ja) * 1999-05-24 2003-01-07 ファイザー・プロダクツ・インク １３−メチルエリスロマイシン誘導体
KR100428703B1 (ko) * 2000-02-02 2004-04-30 한국과학기술연구원 헬리코박터 파이로리의 성장 억제 효과를 지닌 신규 마크로라이드 화합물
US6787342B2 (en) 2000-02-16 2004-09-07 Merial Limited Paste formulations
HRP20010146B1 (en) * 2001-02-28 2005-10-31 Pliva D.D. 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
HRP20030381B1 (en) * 2003-05-14 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
US20080200403A1 (en) * 2005-01-14 2008-08-21 Glaxosmithkline 9A-Carbamoyl and Thiocarbamoyl Azalides with Anti-Inflammatory Activity
EP1841437B1 (en) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
GB8521402D0 (en) * 1985-08-28 1985-10-02 Beecham Group Plc Chemical compounds
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Also Published As

Publication number Publication date
CN1109890A (zh) 1995-10-11
DE69400817D1 (de) 1996-12-05
SK281200B6 (sk) 2001-01-18
SK146994A3 (en) 1995-07-11
EP0657464B1 (en) 1996-10-30
ES2096401T3 (es) 1997-03-01
CN1039417C (zh) 1998-08-05
UA39870C2 (uk) 2001-07-16
HRP931480A2 (en) 1996-08-31
BG99242A (en) 1995-09-29
JPH07252292A (ja) 1995-10-03
DE69400817T2 (de) 1997-05-22
RU94042916A (ru) 1996-10-10
RO113854B1 (ro) 1998-11-30
CZ308294A3 (en) 1995-07-12
CZ288554B6 (cs) 2001-07-11
HU9403502D0 (en) 1995-02-28
CA2137395C (en) 2000-02-22
JP3131546B2 (ja) 2001-02-05
ATE144778T1 (de) 1996-11-15
CA2137395A1 (en) 1995-06-09
HU213611B (en) 1997-08-28
RU2131878C1 (ru) 1999-06-20
BG61571B1 (bg) 1997-12-30
US5629296A (en) 1997-05-13
EP0657464A1 (en) 1995-06-14
HUT69283A (en) 1995-09-28
PL176696B1 (pl) 1999-07-30
PL306154A1 (en) 1995-06-12
SI9400434A (en) 1995-06-30

Similar Documents

Publication Publication Date Title
HRP931480A2 (en) 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
ES2089863T3 (es) 9a,11-carbamatos ciclicos de 9-desoxo-9a-aza-11-desoxi-9a-homoeritromicina a.
PT1175429E (pt) Derivados halo de 9-desoxo-9a-aza-9a-homoeritromicina a
PL322862A1 (en) Novel compounds 9-n-ethenylic derivtives of 9(s)-erythromycilamine
PT927722E (pt) Derivados beta beta-dissubstituidos de 9-desoxo-9a-n-etenil-9a-aza-9aza-9a-homoeritromicina
PL292767A1 (en) Method of obtaining novel derivatives of 10,11,12,13--tetrahydrodemycosine

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 19991208

Year of fee payment: 7

PBON Lapse due to non-payment of renewal fee

Effective date: 20001209